About this page: This table was intended to provide a quick translation from S. pombe to S. cerevisiae homologues prior to the genome publication and curation. It is no longer maintained but is left here because it may be helpful in some circumstances. For details and most up to date information, we suggest you go to genedb. There is also a group particularly interested in orthologues to which you can subscribe here: http://publists.sanger.ac.uk/mailman/listinfo/yeast_orthologous_group
Fission yeast genes are listed alphabetically under just one name, but their aliases are listed alongside. If you can’t find the gene you want in its alphabetical position, use the search feature of your browser to see if it is listed under a synonym. One yeast may have a pair of genes where the other has just one. These cases are indicated by the word “and”; otherwise multiple gene names are aliases. In a few cases, the same gene designation may have been used for different genes which we have noted.
Recall that just because there is a cerevisiae homologue of a pombe gene doesn’t mean they work the same way, and that genes without primary sequence homology can be functional homologues.
S. pombe gene and aliases | S. cerevisiae sequence homologue(s) | Fission yeast gene product or protein function | Metazoan homologue? (definitely incomplete!) |
---|---|---|---|
abp1+ | no homologue | CENP-B homologue; see cbh1+ and cbh2+ | Y |
abt2+ | TUB3 | alpha tubulin (a2); not essential | Y |
ade6+ | ADE2 | phosphoribosylaminoimidazole carboxylase | |
alp2+ | SPC97 | gamma-tubulin interactor | |
alp4+ | SPC98 | gamma-tubulin interactor | |
alp6+ | GCP3 | gamma-tubulin interactor | |
slp16+ | GCP6 | gamma-tubulin interactor | |
apc10+ | APC10 | APC subunit | Y |
ark1+ | IPL1 | Aurora kinase | Y |
atb2+ alp2+ ban5+ tub1+ | TUB3 | alpha-2 tubulin; see also nda2+ | |
btf3+ | EGD1 and BTT1 | binds nascent RNAs | |
byr1+ ste1+ | STE7 | MAPKKK, pheromone signalling | Y |
byr2+ | STE11 | MAPKK, pheromone signalling | Y |
byr4+ | BYR4? | With Cdc16p, a two-component GEF for the GTPase spg1 (involved in cytokinesis) | |
cbh1+ | no homologue | CENP-B homologue; see cbh2+ and apb1+ | Y |
cbh2+ | no homologue | CENP-B homologue; see cbh1+ and abp1+ | Y |
cdc1+ | HYS2/HUS2/POL31/SDP5 | DNA pol delta subunit | |
cdc2+ | CDC28 | CDK | Y |
cdc3+ | PFY1 | profilin | Y |
cdc4+ | KAP122/PDR6 | myosin light chain | Y |
cdc5+ | CEF1 | MYB-type splicing factor | Y |
cdc6+ pol3+ pold+ | POL3 /CDC2 | DNA polymerase delta | Y |
cdc7+ | CDC15 | septation kinase | |
cdc8+ | TPM1 and TPM2 | tropomyosin | Y |
cdc10+ | SWI6 | G1 phase transcription factor | |
cdc11+ | NUD1 | required for cytokinesis | |
cdc12+ | BNI1 | required for actin ring assembly | |
cdc13+ | CLB1, CLB2, CLB3, and CLB4 | B type cyclin, M phase. Essential. | Y |
cdc14+ | no homologue | required for septation | |
cdc15+ | HOF1/YMR032wp | required for septation | |
cdc16+ | BUB2 | checkpoint/cytokinesis protein. With Byr4, part of the GEF for spg1 | |
cdc17+ | CDC9 | DNA ligase | Y |
cdc18+ | CDC6 | S phase initiator / MCM loader | Y |
cdc20+ pol2+ pole+ | POL2 | pol epsiolon | Y |
cdc22+ | RNR1 | lg subunit ribonucleotide reductase | Y |
cdc23+ | MCM10/DNA43 | S phase factor | |
cdc24+ | no homologue | required for completion of S phase, possibly in Okazaki fragment maturation | |
cdc25+ | MIH1 | CDK tyrosine phosphatase | Y |
cdc27+ | POL32 | DNA pol delta subunit | |
cdc28+ prp8+ | no homologue | helicase | |
cdc45+ sna41+ goa1+ | CDC45 | replication initiation factor | Y |
cdm1+ | no homologue?? | DNA pol delta subunit | |
cds1+ | RAD53 | checkpoint kinase; not essential in pombe | Y |
cdt1+ | TAH11/SID2 | required for replication initiation | Y |
cek1+ | RIM15 | kinase | |
cgs1+ | BCY1 | regulatory subunit of PKA | |
cgs2+ pde1+ | PDE1 and PDE2 | cAMP phosphodiesterase | |
chk1+ rad27+ | CHK1 | checkpoint kinase, damage response | Y |
chp1+ | ? | chromodomain protein, required for centromere function | |
chp2+ clo2+ | no homologue | chromodomain protein, related to Swi6p and HP1 | Y |
cig1+ | ? | B-type cyclin, function not clear. Not essential. See cdc13+ | |
cig2+ | CLB5 and CLB6 | B-type cyclin in S phase, not essential. See cdc13+ | |
clp1+ cfh1+ flp1+ | CDC14 | phosphatase, involved in septation. Not essential in pombe | |
clr1+ | no homologue | DNA binding protein | |
clr3+ | HDA1 | histone deacetylase | |
clr4+ | no homologue | histone H3 methyl transferase | Y; Drosphila Su(var) 3-9 |
clr6+ | RPD3 | Histone deacetylase | Y |
cmb1+ | no homologue | Mismatch and damage recognition/HMG protein | |
cnd1+ | YCS4/LOC7 | condensin subunit; XCAP-D2 | Y |
cnd2+ | BRN1 | condensin subunit; XCAP-H | Y |
cnd3+ | YCG1/TIE1/YCS5 | condensin subunit; XCAP-G | Y |
cnp1+ | CSE4 | CENP-A homologue; centromere specific H3 histone | Y |
cps1+ drc1+ | GLS1 and GLS2 | 1,3-(beta)-glucan synthase. | |
csk1+ | CAK/CIV1 | CAK-activating kinase | Y |
csn1+ | no homologue | Signalosome subunit 1 | Y |
csn2+ | no homologue | Signalosome subunit 2 | Y |
csn4+ | no homologue | Signalosome subunit 4 | Y |
csn5+ | RRI1 | Signalosome subunit 5 | Y |
csn7+ | no homologue | Signalosome subunit 7 | Y |
ctf18+ chl12+ | CTF18/CHL12 | RFC-1 related protein required for chromosome transmission | |
ctr4+ | CTR1 and CTR3 | High affinity copper transporter | |
cuf1+ | MAC1 | Copper-sensing transcription factor | |
cuf2+ | no homologue? | Metal ion homeostasis protein | |
cut1+ | ESP1 | promotes anaphase. Separin. | |
cut2+ | PDS1 | APC substrate, blocks cut1. Securin. | |
cut3+ | SMC4 | condensin, SMC4 subunit | Y |
cut4+ | APC1 | APC subunit | Y |
cut6+ | ACC1 | acetyl coA carboxylase | |
cut7+ | CIN8 and KIP1 | kinesin | Y |
cut8+ | DBF8 | ? regulates APC? | |
cut9+ | CDC16 | APC subunit | Y |
cut11+ | NDC1 | nuclear envelope protein at SPBs and NPCs | |
cut12+ | no homologue | required for spindle formation | |
cut14+ | SMC2 | condensin, SMC2 subunit | Y |
cut17+ bir1+ | BIR1 | Bir1/Survivin, chromosomal passenger protein | Y |
cut20+ lid1+ | APC4 | APC subunit | Y |
cut23+ | CDC23/APC8 | TPR-protein, APC component | Y |
cyr1+ git2+ | CYR1 | adenylate cyclase | |
dfp1+ him1+ rad35+ | DBF4 | regulatory subunit of CDC7-type kinase | Y |
dhc1+ | DYN1 | dynein motor protein | |
dim1+ | DIB1 | Required for mitosis. | |
Note the designation Dim1 was used later for a different gene encoding a dimethylase. | |||
dis1+ | STU1 | TOG-family microtubule associated proteins (also see Mtc1/Alp14) | Y |
dis2+ | GLC7 | PPI-class phosphatase. Also see Sds21 | |
dmc1+ | DMC1 | meiosis specific Rhp51 (RAD51) homologue, presumed required for meiotic pairing | |
dna2+ | DNA2 | helicase | Y |
drc1+ | DRC1/SLD2 | CDK target, binds Rad4/Cut5, required for S phase. | |
<font=”-1″note that=”” the=”” name=”” drc1=”” has=”” also=”” been=”” used=”” for=”” a=”” glucan=”” synthase;=”” see=”” cps1<=”” font=””> | |||
eso1+ | CTF7/ECO1 (C-terminal) | ||
RAD30 (N-terminal) | Required for sister chromatid cohesion and possibly for repair. A gene fusion: the C-terminus looks like CTF7/ECO1, and the N-terminus looks like RAD30 | Y |
S.cerevisiae genes without pombe homologues (decidedly incomplete) | Gene product or protein function |
---|---|
IME1 | Transcription factor, required for meiosis |
RME1 | Zinc finger protein |
SPO13 | meiosis regulator |
MSH4 | recombination factor required in meiosis |
MSH5 | recombination factor required in meiosis |