Gati Lab explores immune system signaling using cryo-EM.
The lab of MCB faculty member Dr. Cornelius Gati has just published a breakthrough paper in Cell titled “Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors”. The study reveals 9 cryo-EM structures of the key immune system receptors C5aR1 and C3aR in complex with different G proteins and ligands, explaining their biological and pathological mechanisms. Read the paper here and more coverage can be found here.
Michael Lab graduate students explore the mystery of how gene expression is regulated on a genome-wide basis.
Graduate students Mezmer Belew and Emilie Chien of Matt Michael’s laboratory have just published an exciting new paper in PLoS Genetics! The paper addresses a long-standing problem in reproductive and developmental biology: when oocytes undergo long-term arrest, how do they repress transcription globally during the arrest? In humans, females produce all of their germ cells before they are born, and as these cells develop they ultimately enter a long-term arrest that can last for decades. During this quiescent period transcription is repressed on a genome-wide level. The arrest occurs in meiotic prophase and is a highly conserved feature of oogenesis from humans to the nematode C. elegans. Belew, Chien, and Michael used C. elegans to study transcriptional quiescence and by doing so were able to identify several of the molecular players involved. Read all about it here! Lastly, the Michael Lab said goodbye to Dr. Belew last month as he defended his thesis and is off to do postdoc work with Scott Kennedy at the Harvard Medical School. Good luck Mezmer!
Lauryn Higginson wins prestigious fellowship; two other MCB Graduate Students earn Honorable Mention
MCB is excited to announce that Lauryn Higginson has won a 2023 National Science Foundation Graduate Research Fellowship! These are not easy to get so great job Lauryn! We are also proud to announce that two more MCB students, Brandy Weathers and Maeve Secor, earned an “Honorable Mention” in the NSF competition. Pictured here from left to right are Lauryn, Brandy, and Maeve.
Shihui Chen is awarded a Gold Family Graduate Fellowship
Congratulations Shihui! This is a well-deserved award!
Derrick Morton awarded a 2023 Sloan Research Fellowship
MCB is excited to announce that Assistant Professor Derrick Morton has been awarded a 2023 Sloan research Fellowship. According to the Sloan Foundation:
These two-year, $75,000 fellowships are awarded yearly to early career researchers in recognition of distinguished performance and a unique potential to make substantial contributions to their field.
Good job, Derrick!