C. Selected peer-reviewed publications (in chronological order)

  1. Pamela, A., Li, L., Chen, X., Pappone, P.  and McNamee, M. (1991). Effects of pH on acetylcholine receptor function.    Membrane Biology.  120, 67-73.
  2. Chen, X. and Bruening, G. (1992)  Nucleotide sequence and genetic map of cowpea severe mosaic virus RNA 2 and comparisons with RNA 2 of other comoviruses.  Virology.  187, 682-692.
  3. Chen, X. and Bruening, G.  (1992)  Cloned DNA copies of cowpea severe mosaic virus genomic RNAs: infectious transcripts and complete nucleotide sequence of RNA 1. Virology. 191, 607-18..
  4. Chen, X., Stehle, T. and Harrison, S.C. (1998) Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry.  EMBO J.  17 (12), 3233-3240.
  5. Chen, X., Garcea, R., Goldberg, I., Casini, G. and Harrison, S.C. (2000) Structure of Small Virus-like Particles Assembled from the L1 Protein of Human Papillomavirus 16 Molecular Cell  5, 557-567
  6. Chen, X., Casini, G., Harrison, S.C. and Garcea, R. (2001) Papillomavirus Capsid Protein Expression in Escherichia coli: Purification and Assembly of HPV11 and HPV16 L1. Mol. Biol. 307, 173-182
  7. Szakonyi, G., Guthridge, J.,  Li, D., Young, K., Holers, V. M.,  and  Chen, X.   (2001)   Structure of Complement Receptor Type 2 (CR2/CD21) in Complex with Its Ligand C3d.   SCIENCE   292, 1725-1728.
  8. Boackle, S., Holers, M, Chen, X., Szakonyi, G., Karp, D.R, Wakeland, K, and Morel. L. Cr2, a candidate gene in the NZM2410 Sle1c lupus susceptibility locus, encodes a dysfunctional protein.  Immunity, (2001)  15, 729-738.
  9. Guthridge, J., Young, K., Gipson, M., Sarrias, M., Szakonyi, G.,  Chen, X., Malaspina, A., Donoghue, E., James. J., Lambris, J., Moir, S. and Holers, M. (2001).  Epitope  Mapping Using the X-ray Crystallographic Structure of Complement Receptor Type 2 (CR2/CD21): Identification of a Highly Inhibitory Monoclonal Antibody That Directly Recognizes the CR2-C3d Interface.  Immunol.  167 (10) 5758-5766.
  10. Hannan J, Young K, Szakonyi G, Overduin M, Perkins S, Chen X,  Holers VM.  Structure of complement receptor (CR) 2 and CR2-C3d complexes. Biochem Soc Trans. 2002 (Pt6):983-9.
  11. Li, D. Zhao, R. Lilyestrom, W. Gai, D. Zhang, R. DeCaprio, J. Fanning, E. Szakonyi, G and Chen, X. The Structure of the Replicative Helicase of the Transforming Protein SV40 Large T-antigen.  Nature  (2003)  423, 512-518
  12. Finnen, R., Chen, X. Garcea, R. The interactions between Papillomavirus L1 and L2 proteins. Virology  (2003) 77, 4818-4826
  13. Fletcher, R. J, Bishop, B. E, Leon,  P, Sclafani, R. A, Ogata,  C. M, and  Chen, X.      The structure and function of the MCM dodecamer complex from Methanobacterium. Thermoautotrophicum.    Nature  Struct Biol.  (2003) 10, 160-167
  14. Gomez-Lorenzo,M. Valle,M. Frank,J. Gruss,C. Sorzano,C. Chen, X. Carazo, JM. Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication.  EMBO J. (2003) 1;22(23):6205-13
  15. Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.      Genes & Development. (2004) 18(7):739-44.
  16. Gai,D, Li,D, Finkielstein, C. Ott.R, Taneja,P, Fanning,E, Chen XS. Insights into the oligomeric states, conformational changes and helicase activities of SV40 large tumor antigen.   J Biol Chem. (2004) Jul 9
  17. Sclafani, Robert. Fletcher, C. Ryan.  and   Chen, X.     Two Heads Are Better Than One: Regulation of DNA replication by  double-hexameric helicases              Genes & Development. (2004) 18:2039-2045.
  18. Gai, D. Zhao, R. Finkielstein,C.V. and Chen, X   (2004)  The Mechanisms of Conformational Change for A Replicative Hexameric Helicase of SV40 Large T Antigen.   Cell   119:47-60 (2004)
  19. Hannan J, Young K, Guthridge JM, Asokan R, Szakonyi G, Chen XS  and  Holers V.    Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.    J MOL BIOL.  (2005) 25;346(3):845-58.
  20. Yang R, Wheeler C, Chen X,  Uematsu S, Takeda K, Akira S, Pastrana D, Viscidi R, Roden R. Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.     J VIROL. (2005)  79(11):6741-50.
  21. Shen J, Gai D, Patrick A, Greenleaf WB, Chen XS.    The roles of the residues on the channel -hairpin and loop structures of simian virus 40 hexameric helicase.    (2005) 102:11248-53.
  22. Gomez-Llorente Y, Fletcher R, Chen X, Carazo JM, SanMartin C.    Polymorphism and double hexamer structure in the helicase MCM from Methanobacterium thermoautotrophicum.  J Biol Chem. (2005) 11.
  23. Fletcher R, Shen J, Gomez-Llorente Y, SanMartin C, Carazo JM, Chen XS.      Double hexamer disruption and helicase activities of M. thermoautotrophicum MCM.   J Biol Chem. (2005)Oct 11.
  24. Yang, R, Wheeler, C.M, Chen, X, Uematsu, S, Takeda, K, Akira, S, Pastrana, D.V, Viscidi, R.P, Roden, R.B. Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.   Virology (2005) 79(11):6741-50.
  25. Hannan,J., Szakonyi,G., Asokan,R., Chen, X.,  Holers, M. “Complement Receptor CR2/CD21 and CR2–C3d complexes” in  Structural Biology of the Complement System. (2005)  Edt by Morikis, D., Lambris, JD., Publisher:Marcel Dekker Inc.
  26. Garcea, RL and Chen, X. (2006)  “Papillomavirus Structure And Assembly” in The Papillomaviruses, eds. By Garcea, R.L. and DiMaio, D.
  27. Valle M, Chen X, Donate LE, Fanning E, Carazo JM. Structural basis for the cooperative assembly of large T antigen of simian virus 40 on the origin of replication.  J Mol Biol. 2006  357(4):1295-305.
  28. Fletcher R, Chen XS Biochemical Activities of BOB1 Mutant in Methanobacterium Biochemistry, (2006), 45(2):462-7.
  29. Lilyestrom W, Klein MG, Zhang R, Joachimiak A, Chen XS Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor.  Genes & Development. (2006);20(17):2373-82.
  30. Asokan R, Hua J, Young K, Gould H, Hannan J, Kraus D, Szakonyi G, Grundy G, Chen X, Crow M, Holers VM Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. J Immunol. 2006 Jul 1;177(1):383-94.
  31. Szakonyi G, Klein M, Hannan J, Young K, Ma R, Asokan R, Holers VM, and Chen XS. Structure of The Epstein Barr Virus Major Envelope Glycoprotein   Nature  Mol. Biology  2006 Nov;13(11):996-1001. doi: 10.1038/nsmb1161. Epub 2006 Oct 29. PMID: 17072314
  32. Chen P, Jiang M, Hu T, Liu Q, Chen XS, Guo D. – Biochemical Characterization of Exoribonuclease Encoded by SARS Coronavirus. – J Biochem Mol Biol [ 2007 ] Sep 30;40(5):649-55 .
  33. Young KA, Chen XS, Holers VM, Hannan JP. – Isolating the Epstein-Barr virus (EBV) GP350/220 binding site on complement receptor type 2 (CR2/CD21). – J Biol Chem [ 2007 ] Oct 9;
  34. Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS. – Crystal structures of four types of HPV L1 capsid proteins: Understanding the specificity of neutralizing monoclonal antibodies. – J Biol Chem [ 2007 ] Sep 4;
  35. Knappe M, Bodevin S, Selinka HC, Spillmann D, Streeck RE, Chen XS, Lindahl U, Sapp M. – Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate. – J Biol Chem [ 2007 ] Sep 21;282(38):27913-22 .
  36. Zhang Y, Dasgupta J, Ma RZ, Banks L, Thomas M, Chen XS. – Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. – J Virol [ 2007 ] Apr;81(7):3618-26
  37. Prochnow C., Bransteitter R.,  Klein M.,  Goodman MF.,   Chen XS.   The APOBEC2 Crystal Structure and the Functional Implications for AID.   Nature   2007, 445(7126):447-51
  38. Chang YP, Wang G, Bermudez V, Hurwitz J, Chen XS. – Crystal structure of the GINS complex and functional insights into its role in DNA replication. – Proc Natl Acad Sci U S A [ 2007 ] Jul 31;104(31):12685-90
  39. Bishop B, Dasgupta J, Chen XS. – Structure-based engineering of papillomavirus major capsid l1: controlling particle assembly. – Virol J Jan 8;4:3
  40. Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS. The structure of a DnaB-family replicative helicase and its interactions with primase. Nature Struct Mol Biol. 2008 Jan;15(1):94-100. doi: 10.1038/nsmb1356. Epub 2007 Dec 23.
  41. Thomas M, Dasgupta J, Zhang Y, Chen XS and Banks L.  Analysis of specificity determinants in the interactions of HPV-18 E6 with its PDZ domain-containing substrates. Virology, 5;376(2):371-8.
  42. Greenleaf W. B, Shen J, Gai D, and Chen XS. A Systematic Study Of The Functions For The Residues Around The Nucleotide Pocket In SV40 AAA+ Large T Hexameric Helicase. J Virol.  2008 Jun;82(12):6017-23. doi: 10.1128/JVI.00387-08. Epub 2008 Apr 9.
  43. Fletcher RJ, Shen J, Holden LG, Chen XS. Identification of amino acids important for the biochemical activity of Methanothermobacter thermautotrophicus MCM.  Biochemistry. 2008 23;47(38):9981-6.
  44. Holden L, Prochnow C, Chang YP, Bransteitter R, Stevens R, Goodman M, and Chen XS.  Structure of the Anti-Viral APOBEC3G Catalytic Domain and Functional Implications, Nature, 2008 6;456(7218):121-4.  (NIHMSID #115824)
  45. Brewster AS, Wang G, Yu X, Greenleaf WB, Carazo JM, Tjajadia M, Klein M, Chen XS. Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase.  PNAS  2008  105(51):20191-6.
  46. Chiang A, Valderramos J, Balachandran R, Chovatiya R, Mead B, Schneider C, Bell S, Klein M, Huryn D, Chen X, Day B, Fidock D, Wipf P, Brodsky J. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorg Med Chem. 2009  17(4):1527-33.
  47. Prochnow, C., Bransteitter, R., Goodman, M.,F., and Chen, X.     The Prospect of APOBEC3G for Future HIV Therapy.   Future HIV Therapy  (2009) 3(1)7-10
  48. Orrú V, Tsai S, Rueda B, Fiorillo E, Stanford S, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D’Alfonso S; Arnett F, Wu H, Gonzalez-Gay M, Tsao B, Pons-Estel B, Alarcon-Riquelme M, He Y, Zhang Z, Allayee H, Chen X, Martin J, Bottini N. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.   Hum Mol Genet.  2009 18(3):569-79.
  49. Liu H, Shi Y, Chen X,  Warshel A.   Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases.  PNAS. (2009) 106(18):7449-54.
  50. Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orru V, Bottini N, Chen XS. Crystal Structure Of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights Into Redox Regulation. Biochemistry. 2009 48(22):4838-45.
  51. Shi Y, Liu H, Gai D, Ma JP, Chen XS A Computational Analysis of ATP Binding of SV40 Large Tumor Antigen Helicase Motor   PloS Computational Biol, 2009, 5 (9) 1-13 [e1000514]
  52. Ahuja D, Rathi AV, Greer AE, Chen X, Pipas J A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation.  Virol. 2009 Sep;83(17):8781-8.
  53. Bransteitter R, Prochnow C, Chen XS. The current structural and functional understanding of APOBEC deaminases.      Cell  Mol  Life Sci.  2009 Jun 23. [Epub ahead of print]
  54. Prochnow C, Bransteitter R, Chen XS. APOBEC deaminases-mutases with defensive roles for immunity. Science China C Life Sci. 2009 Oct;52(10):893-902. Epub 2009 Nov 13.
  55. Cuesta I, Núñez-Ramírez R, Scheres SH, Gai D, Chen XS, Fanning E, Carazo JM. Conformational rearrangements of SV40 large T antigen during early replication events. J Mol Biol.  2010 16;397(5):1276-86.
  56. Brewster AS, Chen XS. Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.  Crit Rev Biochem Mol Biol. 2010 45(3):243-56.
  57. Brewster AS, Slaymaker IM, Afif SA, Chen XS. Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding.   BMC Mol Biol. 2010 Aug 18;11:62.
  58. Chelico L, Prochnow C, Erie DA, Chen XS, Goodman MF. Structural model for deoxycytidine deamination mechanisms of the HIV-1 inactivation enzyme APOBEC3G. J Biol Chem. 2010 May 21;285(21):16195-205. doi: 10.1074/jbc.M110.107987. Epub 2010 Mar 8.
  59. Gai D, Chang YP, Chen XS. Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding. Curr Opin Struct Biol.   2010 Dec;20(6):756-62. Epub 2010 Oct 1.
  60. Dasgupta J, Bienkowska-Haba M, Ortega ME, Patel HD, Bodevin S, Spillmann D, Bishop B, Sapp M, Chen XS. Structural basis of oligosaccharide receptor recognition by human Papillomavirus.  J Biol Chem. 2011 Jan 28;286(4):2617-24
  61. Slaymaker IM, Chen XS. MCM Structure and Mechanics: What We Have Learned from Archaeal MCM.  Subcell Biochem. 2012;  62:89-111.
  62. Asokan R, Banda NK, Szakonyi G, Chen XS, Holers VM. Human complement receptor 2 (CR2/CD21) as a receptor for DNA: Implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE).  Mol Immunol. 2012 Aug 9;53(1-2):99-110.
  63. Mu Y, Prochnow C, Pham P, Chen XS, Goodman MF. A Structural Basis for the Biochemical Behavior of Activation-induced Deoxycytidine Deaminase Class-switch Recombination-defective Hyper-IgM-2 Mutants. J Biol Chem. 2012 Aug 10;287(33):28007-16.
  64. Ian M. Slaymaker, Xiaojiang Chen. “MCM Structure and Mechanics; what we have learned from Archaeal MCM”. In Eukaryotic Replisome, A Guide To Protein Structure And Function. (2012) Publishing Editor: Thijs van Vlijmen, Springer Science
  65. Zhou B, Arnett DR, Yu X, Brewster A, Sowd GA, Xie CL, Vila S, Gai D, Fanning E, Chen XS. Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase α-Primase. J Biol Chem. 2012 Aug 3;287(32):26854-66.
  66. Wang W, Nie J, Prochnow C, Jia Z, Wang S, Chen XS, Wang Y A Systematic Study of the N-glycosylation Sites of HIV-1 Envelope Protein on Infectivity and Antibody-mediated Neutralization. Retrovirology 2013 Feb 6;10:14.
  67. Slaymaker I, Fu Y, Toso D, Ranatunga N, Brewster A, Forsburg S, Zhou H, Chen XS Mini-chromosome Maintenance Complexes Form A Filament To Remodel DNA Structure and Topology  Nucleic Acid Research  2013  41(5):3446-56.
  68. Schmitt K, Guo K, Katuwal M, Wilson D, Prochnow C Bransteitter R, Chen XS, Santiago ML, Stephens EB. Lentivirus restriction by diverse primate APOBEC3A proteins. Virology. 2013. 20;442(1):82-96.
  69. Xu M, Chang YP, Chen XS. Expression, purification and biochemical characterization of Schizosaccharomyces pombe Mcm4, 6 and 7. BMC Biochemistry 2013 Feb 27;14:5.
  70. Chang Y, Xu M, Machado C, Yu X, Rohs R, Chen XS Origin DNA Recognition by the SV40 Large Tumor Antigen: Insights into the Mechanism of Initiator Assembly Cell  Reports  2013 25;3(4):1117-27
  71. Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R. Structure-function analyses of the SIX1-EYA2 complex from human reveal mechanistic insight into metastasis and branchio-oto-renal (BOR) syndrome. Nature Struct Mol Biol. 2013 Apr;20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24. PMID: 23435380 Free PMC article.
  72. Richards KF, Bienkowska-Haba M, Dasgupta J, Chen XS, Sapp M. Multiple Heparan Sulfate Binding Site Engagements are Required for the Infectious Entry of Human Papillomavirus Type 16. J Virol.  2013 Aug 21.
  73. Jin S, Pan D, Zha X, Yu X, Wu Y, Liu Y, Yin F, Chen XS.  The critical residues of helix 5 for in vitro pentamer formation and stability of the papillomavirus capsid protein, L1.  Mol Biosyst.  2014 Apr;10(4):724-7.
  74. Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS. The 1.8-Å crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament. J Mol Biol. 2014 Apr 3;426(7):1512-23
  75. Yu, J., et al., Mechanism of Subunit Coordination of An AAA+ Hexameric Molecular Nanomachine. Nanomedicine. 2015 Apr;11(3):531-41. doi: 10.1016/j.nano.2014.11.005.
  76. Wang, W., Zirkle, B., Nie, J., Ma, J., Gao, K., Chen, X. S., Huang, W., Kong, W. & Wang, Y. N463 Glycosylation Site on V5 Loop of a Mutant gp120 Regulates the Sensitivity of HIV-1 to Neutralizing Monoclonal Antibodies VRC01/03. Acquir Immune Defic Syndr. 2015 Jul 1;69(3):270-7.
  77. Fu Y, Ito F, Zhang G, Fernandez B, Yang H, Chen XS. DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.  Biochem J. 2015 Oct 1;471(1):25-35. doi: 10.1042/BJ20150382. Epub 2015 Jul 20.
  78. Xia Y, Niu Y, Cui J, Fu Y, Chen XS, Lou H, Cao Q. The Helicase Activity of Hyperthermophilic Archaeal MCM is Enhanced at High Temperatures by Lysine Methylation.  Front Microbiol. 2015 Nov 9;6:1247. doi: 10.3389/fmicb.2015.01247.
  79. Quan Y, Xia Y, Liu L, Cui J, Li Z, Cao Q, Chen XS, Campbell J, Lou H.  Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell  Reports  2015 Dec 22;13(11):2576-86. doi: 10.1016/j.celrep.2015.11.018.
  80. Chen, L., Wolfe, A., Xiao, X., Chen, X.S. The in vitro Biochemical Characterization of an HIV-1 Restriction  Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA binding and Deamination. J Mol Biol. 2016 Jul 3;428(13):2661-70. doi: 10.1016/j.jmb.2016.03.031.
  81. Gu, J., Chen, L., Wolfe, A., Chen XS. Studies of the Enzymatic Activities of All Isophorms of APOBEC3H: Implications for the Molecular Mechanisms of HIV Restriction By Different Isotypes of APOBEC3H.  J Mol Biol. 2016 Nov 20;428(23):4626-4638. doi: 10.1016/j.jmb.2016.08.012.
  82. Gai D., Wang D., Chen XS. The Structure of SV40 Large T Hexameric Helicase in Complex with AT-rich Origin DNA.  Elife.  2016 Dec 6;5. pii: e18129. doi: 10.7554/eLife.18129.
  83. Xiao, X., Yang, H., Li, S, Wolfe, A., Chen, X.S. Structure of N-Terminal Domain of a Primate APOBEC3G: the Interplay of DNA Binding, Oligomerization and HIV Vif Targeting of APOBEC3G.  Nature Comm. 2016 Aug 2;7:12193. doi: 10.1038/ncomms12193
  84. Wang D, Alvarez-Canbrera Al, Chen XS. Study of SV40 large T antigen nucleotide specificity for DNA unwinding. Virol J. 2017 Apr 14;14(1):79. doi: 10.1186/s12985-017-0733-5.
  85. Ning T, Wolfe A, Nie J, Huang W, Chen XS, Wang Y. Naturally Occurring Single Amino Acid Substitution in the L1 Major Capsid Protein of Human Papillomavirus Type 16: Alteration of Susceptibility to Antibody-Mediated Neutralization. Infect Dis. 2017 Oct 17;216(7):867-876.
  86. Ito, F., Fu, Y., Kao, SA., Yang, H., Chen, XS  Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins JMB. 2017, 16;429(12):1787-1799
  87. Xiao, X., Yang, H., Arutiunuan, V., Fang, Y., Besse, G., Morimoto, C., Zirkle, B., Chen, XS. Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation. NAR, 2017 1–14  doi: 10.1093/nar/gkx362.
  88. Fang Y, Xiao X, Li SX, Wolfe A, Chen XS. Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA. J Mol Biol. 2018 Jan 5;430(1):87-101.
  89. Ito F, Yang H, Xiao X, Li SX, Wolfe A, Zirkle B, Arutiunian V, Chen XS. Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.  Reports.  2018 Feb 28;8(1):3763.
  90. Wang W, Ma J, Nie J, Li J, Cao S, Wang L, Yu C, Huang W, Li Y, Yu Y, Liang M, Zirkle B, Chen XS, Li X, Kong W, Wang Y. Antigenic variations of recent street rabies virus. Emerg Microbes Infect. 2019; 8(1):1584-1592. doi: 10.1080/22221751.2019.1683436. PubMed PMID: 31682199; PubMed Central PMCID: PMC6844422.
  91. Schlierf M, Wang G, Chen XS, Ha T. Hexameric helicase G40P unwinds DNA in single base pair steps. Elife. 2019 Jan 28;8. pii: e42001. doi: 10.7554/eLife.42001. PubMed PMID: 30688211; PubMed Central PMCID: PMC6370340.
  92. Wolfe, A.D., Arnold, D.B. and Chen, X.S. Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells. Journal of molecular biology, (2019) 431, 1506-1517. NIHMS 1524218, PMCID: PMC6443457
  93. Baumert R, Ji H, Paulucci-Holthauzen A, Wolfe A, Sagum C, Hodgson L, Arikkath J, Chen XS, Bedford MT, Waxham MN, McCrea PD. Novel phospho-switch function of delta-catenin in dendrite development.  J Cell Biol.,  2020 Nov 2;219(11). doi: 10.1083/jcb.201909166.
  94. Yang, H., Ito, F., Wolfe, A., Li, S., Love, R.P., Yan, M., Gaba, A., Chelico, L. and Chen, X.S. Structural Basis of Domain Organization, Dimerization, RNA binding, and HIV-1 Restriction of Full Length APOBEC3G. Nature Comm. 11(1):632. (2020). PMID: 32005813. PMCID: PMC6994475, DOI: 10.1038/s41467-020-14377-y
  95. Wolfe, A., Goedderz, C. and Chen, X.S. The structure of APOBEC1 and insights into RNA and DNA substrate selectivity. NAR Cancer, 2020 Dec;2(4):zcaa027. doi: 10.1093/narcan/zcaa027. Epub 2020 Oct 9. PMID: 33094286
  96. Du Y, Zhang T, Meng X, Shi Y, Hu M, Yuan S, La C, Liu S, Li J, Huang H, Jian H, Chen D, Sheng L, Hong M, Olson A, Liao H, Chen XS, Li M, Zhao G, Roberts R, Chan J, Jin D, Chen I, Chen H, Yuen K, Hao Q, Sun R. Development of high affinity monobodies recognizing SARS-CoV-2 antigen. Squ. 2020. DOI: 10.21203/rs.3.rs-25828/v1
  97. Chen XS, Pomerantz RT. DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity. Genes (Basel). 2021 Jul 27;12(8):1146. doi: 10.3390/genes12081146.
  98. Chen XS. Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions. Viruses. 2021 Mar 17;13(3):497. doi: 10.3390/v13030497. PMID: 33802945. Review
  99. Liu Y, Qin C, Rao Y, Ngo C, Feng JJ, Zhao J, Zhang S, Wang TY, Carriere J, Savas AC, Zarinfar M, Rice S, Yang H, Yuan W, Camarero JA, Yu J, Chen XS, Zhang C, Feng P. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. 2021 Sep 21:e0233521. doi: 10.1128/mBio.02335-21. Epub ahead of print. PMID: 34544279.
  100. Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT. Polθ reverse transcribes RNA and promotes RNA-templated DNA repair. Science Advance 2021 Jun 11;7(24):eabf1771. doi: 10.1126/sciadv.abf1771. Print 2021 Jun.PMID: 34117057
  101. Kim K, Calabrese P, Wang S, Qin C, Rao Y, Feng P, Chen XS. The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness. Scientific Reports 2022 Sep 13;12(1):14972. doi: 10.1038/s41598-022-19067-x. PMID: 36100631; PMCID: PMC9470679.
  102. Yang H, Kim K, Li S, Pacheco J, Chen XS. Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nature Comm. 2022, 13, 7498. doi.org/10.1038/s41467-022-35201-9
  103. Tredinnick T, Kent T, Minakhin L, Li Z, Madzo J, Chen XS. and Pomerantz R. Promoter-Independent Synthesis of Chemically Modified RNA by Polymerase θ Variants. RNA 2023, rna.079396.122.
  104. Ito F, Alvarez A, Liu S, Yang H, Shiriaeva A, Zhou H, Chen XS. Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science Adv 2023, Vol 9 (1) 1-12 doi: 10.1126/sciadv.ade316
  105. Kim K, Shi A, Kelly K, Chen XS. Unraveling the Enzyme-Substrate Properties for APOBEC3A-mediated RNA Editing. Journal of molecular biology, 2023, https://doi.org/10.1016/j.jmb.2023.168198.
  106. Ngo C, Fried W, Aliyari S, Feng S, Zhang S, Yang H, Feng P, Cheng C, Chen XS, Zhang C. Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. Journal of Medicinal Chemistry.  66(17):12237-12248. doi: 10.1021/acs.jmedchem.3c00810.
  107. Ito F, Alvarez A, Liu S, Zhou H, Chen XS. Structural basis of HIV-1 Vif mediated E3 ligase targeting of host APOBEC3H.  Nature Comm. 14(1):5241. PMCID: PMC10462622. DOI: 10.1038/s41467-023-40955-x.

 

Book Chapters:

  1. Hannan,J., Szakonyi,G., Asokan,R., Chen, X.,  Holers, M. “Complement Receptor CR2/CD21 and CR2–C3d complexes” in  Structural Biology of the Complement System. (2005)  Edt by Morikis, D., Lambris, JD., Publisher:Marcel Dekker Inc.
  2. Garcea, RL and Chen, X.    “Papillomavirus Structure And Assembly” in The Papillomaviruses, (2007) eds. By Garcea, R.L. and DiMaio, D. Springer, Boston.
  3. Ian M. Slaymaker, Xiaojiang Chen. “MCM Structure and Mechanics; what we have learned from Archaeal MCM”.  In Eukaryotic Replisome, A Guide To Protein Structure And Function.  Publishing Editor: Thijs van Vlijmen, Stuard MacNeil. Springer Science, London