2025:

  1. A.S. Tyson, S. Khan, Z. Motiwala, G.W. Han, Z. Zhang, M. Ranjbar, D. Styrpejko, N. Ramos-Gonzalez, S. Woo, K. Villers, D. Landaker, T. Kenakin, R. Shenvi, S. Majumdar, C. Gati (2025). Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes. Nat Chem Biol. 2025 Jan 7. PMID: 39775170. PDB ID: 8VVE, 8VVF, 8VVG, 9D61, PubMed>>

2024:

  1. L. Posa, G. Romano, X. Ji, S. Khan, B.M. Paz, G.W. Han, A.L. Nazarova, S.A. Zaidi, M. Ranjbar, K. Pleil, V. Katritch, C. Gati, D. Trauner, J. Levitz (2024). An opioid efficacy switch for reversible optical control of peripheral analgesia. bioRxiv [Preprint]. 2025 Feb 13:2024. PMID: 39764058; PMCID: PMC11702541. PDB ID: 9MGC, 9MGD, PubMed>>
  2. M. Barekatain, L.C. Johansson, J.H. Lam, H. Chang, A.V. Sadybekov, G.W. Han, J. Russo, J. Bliesath, N.L. Brice, M.B.L. Carlton, K.S. Saikatendu, H. Sun, S.T. Murphy, H. Monenschein, H.H. Schiffer, P. Popov, C.A. Lutomski, C.V. Robinson, Z.J. Liu, T. Hua, V. Katritch, V. Cherezov (2024). Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease. Sci Signal. 2024 Dec 3;17(865):eado8741. 2024 Dec 3. PMID: 39626010; PMCID: PMC11850111. PDB ID: 8T1V, 8T1W, 8TF5, 8TYW, PubMed>>
  3. G. Kao, X.N. Zhang, F. Nasertorabi, B.B. Katz, Z. Li, Z. Dai, Z. Zhang, L. Zhang, S.G. Louie, V. Cherezov, Y. Zhang (2024). Nicotinamide Riboside and CD38: Covalent Inhibition and Live-Cell Labeling.  JACS Au. 2024 Oct 30;4(11):4345-4360. PMID: 39610739, PDB ID: 8VAU, PubMed>>
  4. L.E. Gimenez, C. Martin, J. Yu, C. Hollanders, C.C. Hernandez, Y. Wu, D. Yao, G.W. Han, N.S. Dahir, L. Wu, O. Van der Poorten, A. Lamouroux, M. Mannes, S. Zhao, D. Tourwé, R.C. Stevens, R.D. Cone, S. Ballet (2024). Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J Med Chem. 2024 Feb 22;67(4):2690-2711. 2024 Feb 12. PMID: 38345933. PDB ID: 8WKY, 8TKZ,  PubMed>>
  5. P.-W. Yu, G. Kao, Z. Dai, F. Nasertorabi, Y. Zhang (2024). Rational design of humanized antibody inhibitors for cathepsin S. Arch Biochem Biophys, 2024 Jan:751:109849. PMID: 38061628. PubMed>>

2023:

  1. Y. Yang, H.J. Kang, R. Gao, J. Wang, G.W. Han, J.F. DiBerto, L. Wu, J. Tong, L. Qu, Y. Wu, R. Pileski, X. Li, X.C. Zhang, S. Zhao, T. Kenakin, Q. Wang, R.C. Stevens, W. Peng, B.L. Roth, Z. Rao, Z.J. Liu (2023). Structural insights into the human niacin receptor HCA2-Gi signalling complex. Nat Commun. 2023 Mar 27;14(1):1692. PMID: 36973264; PMCID: PMC10043007. PDB ID: 7ZLY, 7ZL9, 7XK2, PubMed>>
  2. X. Lin, S. Jiang, Y. Wu, X. Wei, G.W. Han, L. Wu, J. Liu, B. Chen, Z. Zhang, S. Zhao, V. Cherezov, F. Xu (2023) The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov. 2023 Feb 28;9(1):23. PMID: 36849514; PMCID: PMC9971246. PDB ID: 8HS2, 8HS3, 8HSC,  PubMed>>

2022:

  1. Z. Motiwala, N.G. Aduri, H. Shaye, G.W. Han, J.H. Lam, V. Katritch, V. Cherezov, C. Gati (2022). Structural basis of GABA reuptake inhibition. Nature 606: 820-826. PMID: 35676483; PMCID: PMC9394549. PDB ID: 7SK2, PubMed>>
  2. A. Shiriaeva, D. Park, G. Kim, Y. Lee, X. Hou, D.B. Jarhad, G. Kim, J. Yu, Y.E. Hyun, W. Kim, Z.G. Gao, K.A.  Jacobson, G.W. Han, R.C. Stevens, L.S. Jeong, S. Choi, V. Cherezov (2022). GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor. J Med Chem. 2022 Sep 8;65(17):11648-11657. PMID: 35977382; PMCID: PMC9469204. PDB ID: 8CU6, 8CU7, PubMed>>
  3. R. Bolteau, R. Duroux, A. Laversin, B. Vreulz, A. Shiriaeva, B. Stauch, G.W. Han, V. Cherezov, N. Renault, A. Barczyk, S. Ravez, M. Coevoet, P. Melnyk, M. Liberelle, S. Yous (2022). High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists. Eur J Med Chem. 2022 Nov 5;241:114620. PMID: 35933788.  PDB ID: 8DU3, PubMed>>
  4. R. Perryman, A. Renziehausen, H. Shaye, A.D. Kostagianni, A.D. Tsiailanis, T. Thorne, M.V. Chatziathanasiadou, G.B. Sivolapenko, M.A. El Mubarak, G.W. Han, B. Zarzycka, V. Katritch, G. Lebon, C. Lo Nigro, L. Lattanzio, S.V. Morse, J.J. Choi, K. O’Neill, Z. Kanaki, A. Klinakis, T. Crook, V. Cherezov, A.G. Tzakos, N. Syed(2022). Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. PMID: 35917342; PMCID: PMC9371711. PDB ID: 7JNI, PubMed>>
  5. Y. Yue, L. Liu, L.J. Wu, Y. Wu, L. Wang, F. Li, J. Liu, G.W. Han, B. Chen, X. Lin, R.L. Brouillette, É. Breault, J.M. Longpré, S. Shi, H. Lei, P. Sarret, R.C. Stevens, M.A. Hanson, F. Xu (2022). Structural insight into apelin receptor-G protein stoichiometry. Nat Struct Mol Biol. 2022 Jul;29(7):688-697. PMID: 35817871 PDB ID: 7SUS, PubMed>>

2021:

  1. L. Xu, B. Chen, H. Schihada, S.C. Wright, A. Turku, Y. Wu, G.W. Han, M. Kowalski-Jahn, P. Kozielewicz, C.F. Bowin, X. Zhang, C. Li , M. Bouvier, G. Schulte, F. Xu (2021). Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell Res. 2021 Dec;31(12):1311-1314.  PDB ID: 8YY8, PubMed>>
  2. N. Michaelian , A. Sadybekov, É. Besserer-Offroy, G.W. Han, H. Krishnamurthy, B.A. Zamlynny , X. Fradera, P. Siliphaivanh, J. Presland, K.B. Spencer, S.M. Soisson, P. Popov , P. Sarret, V. Katritch, V. Cherezov (2021). Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nat Commun. 2021 May 20;12(1):2971. PDB ID: 7K15, PubMed>>

2020:

  1. Z. Dai, X.N. Zhang, F. Nasertorabi, Q. Cheng, J. Li, B.B. Katz, G. Smbatyan, H. Pei, S.G. Louie, H.J. Lenz, R.C. Stevens, Y. Zhang (2020).  Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases. Sci Adv. 2020 Jun 3;6(23):eaba6752. PMID: 32537509, PDB ID: 6VUA, PubMed>>
  2. C. Zambaldo, M. Koh, F. Nasertorabi, G.W. Han, A. Chatterjee, R.C. Stevens, P.G. Schultz(2020). An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.  Bioorg Med Chem. 2020 Oct 15;28(20):115662. PMID: 33069069, PDB ID: 6X94, PubMed>>

2019:

  1. J.C. Li, F. Nasertorabi, W. Xuan, G.W. Han, R.C. Stevens, P.G. Schultz (2019). A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure . ACS Chem Biol. 2019 Jun 21;14(6):1150-1153. PMID: 33006884, PDB ID: 6MTG, PubMed>>

2018:

  1. Z. Dai, X.N. Zhang, F. Nasertorabi, Q. Cheng, H. Pei, S.G. Louie, R.C. Stevens, Y. Zhang (2018). Facile chemoenzymatic synthesis of a novel stable mimic of NAD . Chem Science 15;9(44):8337-8342. PMID: 30568770, PDB ID: 6EDR, PubMed>>

2017:

  1. M. Koh, F. Nasertorabi, G.W. Han, R.C. Stevens ,P.G. Schultz (2017). Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. J Am Chem Soc. 2017 Apr 26;139(16):5728-5731. PubMed>>

2015:

  1. A.D. Pearson, J.H. Mills, Y. Song, F. Nasertorabi, G.W. Han, D. Baker, R.C. Stevens, P.G. Schultz . (2015). Transition states. Trapping a transition state in a computationally designed protein bottle. Science. 2015 Feb 20;347(6224):863-7. PubMed>>
  2. H. Xiao, F. Nasertorabi, S.H. Choi, G.W. Han, S.A. Reed, R.C. Stevens, P.G. Schultz. (2015). Exploring the potential impact of an expanded genetic code on protein function. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6961-6. PubMed>>
  3. G.J. Forse, M.L. Uson, F. Nasertorabi, A. Kolatkar, I. Lamberto, E.B. Pasquale, P. Kuhn. (2015). Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PLoS One. 2015 May 20;10(5):e0127081. PubMed>>