Scientists identify genes connected to well-being, depression and neuroticism
An international group of more than 190 scientists who analyzed the genomes of nearly 300,000 individuals have found genetic variants that may influence our sense of well-being, depression and neuroticism.
The study is one of the largest genomic studies to date on behavioral genetics.
“We have known for a long time that these traits have a genetic component, but until now, we had identified only a few specific genetic variants related to these traits,” said Daniel Benjamin, corresponding author and an associate professor (research) of economics at USC Dornsife’s Center for Economic and Social Research.
Associate Professor (Research) of Economics Daniel Benjamin.
Benjamin said that the genetic variants do not determine whether someone develops depressive symptoms, neuroticism or a poor sense of well-being.
“Psychological well-being is jointly influenced by genes and environment,” he said. “The genetic variants that we found account for a small fraction of these genetic associations.”
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The scientists found three genetic variants associated with subjective well-being — how happy or satisfied a person reports feeling about his or her life. The researchers also found two genetic variants associated with depressive symptoms and 11 genetic variants associated with neuroticism.
“We found that most of the genetic variants associated with depressive symptoms and/or neuroticism also were linked to subjective well-being and vice versa,” Benjamin said. “When examined individually, each genetic variant explains very little about these traits. But when taken together, these findings imply that the genetic influences on depression, neuroticism and subjective well-being result from the cumulative effects of at least thousands, if not millions, of different variants.”
The study also revealed that subjective well-being, neuroticism and depression are predominantly influenced by the same set of genes. The scientists said this finding indicates that researchers may want to consider studying these traits jointly for future work.
The interdisciplinary team — which included medical researchers and psychologists — also studied whether the genetic variants that they had identified overlap with genetic variants associated with other diseases and disorders, including Alzheimer’s, anxiety, autism spectrum disorder, bipolar disorder and schizophrenia.
The strongest link was with anxiety disorders. The researchers also found the genetic variants tied to subjective well-being, depression and neuroticism moderately overlap with the variants that are associated with schizophrenia and bipolar disorder.
Because the study has found some of the first genetic variants associated with well-being, depression and neuroticism, it is too soon to draw conclusions about how the genes affect biological mechanisms, Benjamin said.
The scientists issued several cautions for interpreting the results of their study.
“Genetics is only one factor that influences these psychological traits. The environment is at least as important, and it interacts with the genetic effects,” Benjamin said.
The study was led by the Social Science Genetic Association Consortium co-founded by Benjamin, David Cesarini of New York University and Phillip Koellinger of the University of Amsterdam. The consortium investigates the influence of genetics on human behavior, well-being and social science-related outcomes through large-scale studies of human genomes.
Funding for the study came from several sources, including the National Science Foundation, National Institute of Health Office of Behavioral and Social Science Research, the Ragnar Soderberg Foundation, the Swedish Research Council, the Jan Wallander and Tom Hedelius Foundation, an ERC Consolidator Grant, the Pershing Square Fund of the Foundations of Human Behavior and National Institute on Aging/National Institutes of Health grants.