2025
Qiu C, Perry S, Chen C, Han Y, Goel P, and Dickman D. Non-ionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity (2025). Manuscript in revision.
Chen J, Lin J, He K, Wang L, Han Y, Qiu C, and Dickman D. Resolving synaptic events using subsynaptically targeted GCaMP8 variants (2025). eLife, in revision. LINK
Stark R, Dehn C, Abadi N, Xiong Y, Porter L, Chen X, and Dickman D. Genetic dissection of the Drosophila BLOC-1 complex reveals distinctions in synaptic localization and homeostatic plasticity (2025). Molecular Biology of the Cell, 10.1091/mbc.E24-09-0392. LINK
He K and Dickman D. Building and modifying diverse synaptic properties: Insights from Drosophila (2025). Current Opinion in Neurobiology, 92: 102995. LINK
Chien C, He K, Perry S, Tchitchkan E, Han Y, Li X, and Dickman D. Distinct input-specific mechanisms enable presynaptic homeostatic plasticity (2025). Science Advances 11(7): eadr0262. LINK
Li Q, Lim K, Altawell R, Verderose F, Li X, Dong W, Martinex J, Dickman D, and Stavropoulos N. The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis (2025). PLoS Genetics, 21(1): e1011574. LINK
2024
Chen J, He K, Han Y, and Dickman D. Ca2+ imaging of synaptic compartments using subcellularly-targeted GCaMP8f in Drosophila (2024). STAR Protocols 5(1): 102832. LINK
Chen X, Perry S, Fan Z, Wang B, Loxterkamp E, Wang S, Hu J, Dickman D, and Han C. Tissue-specific knockout in the Drosophila neuromuscular system reveals ESCRT’s role in formation of synapse-derived extracellular vesicles (2024). PLoS Genetics 20(10): e1011438. LINK
Chen J, He K, Han Y, and Dickman D. Ca2+ imaging of synaptic compartments using subcellularly-targeted GCaMP8f in Drosophila (2024). STAR Protocols 5(1): 102832. LINK
2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell. 2023 Feb 16;186(4):786-802.e28. doi: 10.1016/j.cell.2023.01.005. Epub 2023 Feb 7. PubMed PMID: 36754049; PubMed Central PMCID: PMC10062012. LINK
Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons. J Neurosci. 2023 Jun 21;43(25):4598-4611. doi: 10.1523/JNEUROSCI.0046-23.2023. Epub 2023 May 23. PubMed PMID: 37221096; PubMed Central PMCID: PMC10286941. LINK
Excess glutamate release triggers subunit-specific homeostatic receptor scaling. Cell Rep. 2023 Jul 25;42(7):112775. doi: 10.1016/j.celrep.2023.112775. Epub 2023 Jul 11. PubMed PMID: 37436892; PubMed Central PMCID: PMC10529671. LINK
2022
One domain to rule them all: “In synapse” reconstitution of core active zone functions. Neuron. 2022 May 4;110(9):1435-1438. doi: 10.1016/j.neuron.2022.04.004. PubMed PMID: 35512634. LINK
Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila. Elife. 2022 Aug 22;11. doi: 10.7554/eLife.77924. PubMed PMID: 35993544; PubMed Central PMCID: PMC9439677. LINK
Rapid homeostatic modulation of transsynaptic nanocolumn rings. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2119044119. doi: 10.1073/pnas.2119044119. Epub 2022 Nov 2. PubMed PMID: 36322725; PubMed Central PMCID: PMC9659372. LINK
A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling. Nat Commun. 2022 Dec 10;13(1):7656. doi: 10.1038/s41467-022-35417-9. PubMed PMID: 36496500; PubMed Central PMCID: PMC9741633. LINK
2021
Voltage Imaging in Drosophila Using a Hybrid Chemical-Genetic Rhodamine Voltage Reporter. Kirk MJ, Benlian BR, Han Y, Gold A, Ravi A, Deal PE, Molina RS, Drobizhev M, Dickman D, Scott K, Miller EW. Front Neurosci. 2021 Nov 16;15:754027. doi: 10.3389/fnins.2021.754027. eCollection 2021. PMID: 34867164. LINK
Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression. Li X, Chien C, Han Y, Sun Z, Chen X, Dickman D. Sci Adv. 2021 Dec 3;7(49):eabj1215. doi: 10.1126/sciadv.abj1215. Epub 2021 Dec 1. PMID: 34851664. LINK
Santoso JW, Li X, Gupta D, Suh GC, Hendricks E, Lin S, Perry S, Ichida JK, Dickman D, McCain ML. APL Bioeng. 2021 Jul 13;5(3):036101. doi: 10.1063/5.0054984. eCollection 2021 Sep. PMID: 34286174. LINK
Chen X, Dickman D. Methods Mol Biol. 2021;2252:175-188. doi: 10.1007/978-1-0716-1150-0_7. PMID: 33765275. LINK
Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly. Ramesh N, Escher MJF, Mampell MM, Böhme MA, Götz TWB, Goel P, Matkovic T, Petzoldt AG, Dickman D, Sigrist SJ. Curr Biol. 2021 Apr 26;31(8):1711-1725.e5. doi: 10.1016/j.cub.2021.01.093. Epub 2021 Mar 1. PMID: 33651992. LINK
Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction. Goel P, Dickman D. Cell Mol Life Sci. 2021 Apr;78(7):3159-3179. doi: 10.1007/s00018-020-03732-3. Epub 2021 Jan 15. PMID: 33449150. LINK
2020
Sarah Perry, Pragya Goel, Nancy L. Tran, Cristian Pinales, Christopher Buser, Daniel L. Miller, Barry Ganetzky, Dion Dickman. Developmental arrest of Drosophila larvae elicits presynaptic depression and enables prolonged studies of neurodegeneration (2020). Development 2020 : dev.186312 doi: 10.1242/dev.186312. LINK
Beril Kiragasi, Pragya Goel, Sarah Perry, Yifu Han, Xiling Li, Dion Dickman. The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation (2020). Proceedings of the National Academy of Sciences Sep 2020, 201915464; DOI: 10.1073/pnas.1915464117. LINK
Goel P, Nishimura S, Chetlapalli K, Li X, Chen C and Dickman D (2020) Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments (2020). Front. Cell. Neurosci. 14:196. doi: 10.3389/fncel.2020.00196. LINK
2019
Keke Ding, Yifu Han, Taylor W Seid, Christopher Buser, Tomomi Karigo, Shishuo Zhang, Dion K Dickman, David J Anderson. Imaging neuropeptide release at synapses with a genetically engineered reporter (2019). eLife 2019;8:e46421 LINK
Koto Kikuma, Xiling Li, Sarah Perry, Qiuling Li, Pragya Goel, Catherine Chen, Daniel Kim, Nicholas Stavropoulos & Dion Dickman. Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling (2019). Nature Communications 10: 2998 LINK
Goel P, Bergeron D, Bohme M, Nunnelly L, Buser C, Lehmann M, Walter AW, Sigrist SJ, and Dickman D. Homeostatic scaling of active zone components stabilizes global synaptic strength (2019). Journal of Cell Biology. 218 (5): 1706-1724 LINK
Goel P, Khan M, Howard S, Kim G, Kiragasi B, Kikuma K, and Dickman D. A screen for synaptic growth mutants reveals mechanisms that stabilize synaptic strength (2019). Journal of Neuroscience 10.1523 LINK
Goel P, Li X, and Dickman D. Estimation of the readily releasable synaptic vesicle pool at the Drosophila larval neuromuscular junction (2019). Bio-protocol 9(1): e3127 LINK
Gratz S, Goel P, Bruckner J, Hernandez R, Khateeb K, Macleod G, Dickman D, and O’Connor-Giles K. Endogenous tagging reveals differential regulation of Ca2+ channels at single AZs during presynaptic homeostatic potentiation and depression (2019). Journal of Neuroscience: 3068 LINK
Bohme M, McCarthy A, Grasskamp A, Beuschel C, Goel P, Jusyte M, Laber D, Huang S, Rey U, Petzoldt A, Lehmann M, Gottfert F, Haghighi P, Hell SW, Owald D, Dickman D, Sigrist SJ, and Walter AW. Rapid active zone remodeling consolidates presynaptic potentiation (2019). Nature Communications 10(1): 1085 LINK
Russo A, Goel P, Brace EJ, Buser C, Dickman D, and DiAntonio A. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. EMBO reports: 20(3): e46975 LINK
2018
Li X, Goel P, Chen C, Angajala V, Chen X, and Dickman D. Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation (2018). eLife e34338 LINK
Goel P and Dickman D. Presynaptic DLK signaling reduces postsynaptic receptivity that is stabilized through distinct modulations to two forms of homeostatic plasticity (2018). Nature Communications 9(1): 1856-1866 LINK
Li X, Goel P, Wondolowski J, Paluch J, and Dickman D. A glutamate homeostat controls the presynaptic inhibition of neurotransmitter release (2018). Cell Reports 23(6): 1716-1727 LINK
2017
Chen X and Dickman D. Ribosome profiling reveals post-translational mechanisms drive the retrograde enhancement of presynaptic efficacy (2017). PLoS Genetics, 13(12): e1007117 LINK
Goel P, Li X, and Dickman D. Disparate postsynaptic induction mechanisms ultimately converge to drive the retrograde enhancement of presynaptic efficacy (2017). Cell Reports, 21(9): 2339-2347 LINK
Perry S, Han Y, Das A, and Dickman D. Homeostatic plasticity can be induced and expressed to restore synaptic strength at neuromuscular junctions undergoing ALS related neurodegeneration (2017). Human Molecular Genetics, 26(21): 4153-4167 LINK
Kikuma K, Kim D, Sutter D, Li X, and Dickman D. Extended Synaptotagmin localizes to presynaptic ER and promotes neurotransmission and synaptic growth in Drosophila (2017). Genetics, 3: 993-1006 LINK
Kiragasi B, Wondolowski J, Li Y, and Dickman D. A presynaptic glutamate receptor subunit confers robustnessto neurotransmission and homeostatic potentiation (2017). Cell Reports19(13): 2694-2706 LINK
Chen X, Ma W, Zhang S, Paluch P, Guo W, and Dickman D. The BLOC-1 subunit Pallidin facilitates activity-dependent synaptic vesicle recycling (2017). eNeuro 4(1): 335-347 LINK
Genc O, Dickman D, Ma W, Tong A, and Davis GW. MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity (2017). eLife 6: 22904-22916 LINK
Hill A, Zheng X, Li X, McKinney R, Dickman D, and Ben-Shahar Y. The Drosophila postsynaptic DEG/ENaC channel ppk29 contributes to excitatory neurotransmission (2017). Journal of Neuroscience37(12): 3171-3180 LINK
Perry S, Kiragasi B, Dickman D, and Ray A. The role of histone deacytlase 6 in synaptic plasticity and memory (2017). Cell Reports18(6): 1337-1345 LINK
2016
Gokhale A, Hartwig C, Freeman A, Das R, Zlatic S, Vistein R, Burch A, Guillemette C, Lewis A, Nelms S, Dickman D, Puthenveedu M, Cox D, and Faundez V. The proteome of BLOC-1 genetic defects identifies the Arp2/3 actin polymerization complex to function downstream of the schizophrenia susceptibility factor Dysbindin at the synapse (2016). Journal of Neuroscience, 36(49): 12393-12411 LINK
Robins J, Paluch J, Dickman D, and Joiner W. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity (2016). Nature Communications7: 10512 LINK
2015
Harris N, Braisier D, Dickman D, and Davis GW. The innate-immune receptor PGRP-LC controls presynaptic homeostatic plasticity (2015). Neuron 88(6): 1157-64 LINK
Subramanian J and Dickman D. Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity (2015). Frontiers in Cellular Neuroscience 9: 380 LINK
Mullin AP, Sadanandappa MK, Ma W, Dickman D, Vijay Raghavan K, Ramaswami M, Sanyal S, Faundez V. (2015). Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. Journal of Neuroscience 35: 325-338. PMID: 25568125 LINK
2014
Wang TT, Hauswirth A, Tong A, Dickman D, and Davis GW. Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity (2014). Neuron 83: 616-629 LINK
Chen CK, Bregere C, Paluch J, Lu J, Dickman D, and Chang KT. Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase (2014). Nature Communications5: 4246 LINK
2013
Wondolowski J and Dickman D. Emerging links between homeostatic synaptic plasticity and neurological disease (2013). Frontiers in Cellular Neuroscience 7: 223-231 LINK
Frank CA, Wang X, Collins CA, Rodal AA, Yuan Q, Verstreken P, and Dickman D. New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system (2013). Journal of Neuroscience33(45): 17560-17568 LINK
Before USC
Dickman D, Tong A, and Davis, GW. Snapin is critical for presynaptic homeostatic plasticity (2012). Journal of Neuroscience 32(25): 8716-8724 LINK
Bergquist S, Dickman D, and Davis GW. A hierarchy of cell intrinsic and target derived homeostatic signaling (2010). Neuron 66(2): 220-234 LINK
Higashi-Kovtun ME, Mosca TJ, Dickman D, Meinertzhagen IA, and Schwarz TL. importin-β11regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction (2010). Journal of Neuroscience 30(15): 5253-5268 LINK
Dickman D and Davis GW. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis (2009). Science 326(5956): 1127-1130 LINK
Dickman D, Kurshan P, and Schwarz TL. Mutations in a Drosophila α2δ voltage-gated calcium channel subunit reveal a crucial synaptic function (2008). Journal of Neuroscience 28(1): 31-38 LINK
Pack-Chung E, Kurshan P, Dickman D, and Schwarz TL. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport (2007). Nature Neuroscience 10(8): 980-989 LINK
Dickman D, Lu Z, Meinertzhagen IA, and Schwarz TL. Altered synaptic development and active zone spacing at the neuromuscular junctions of endocytosis mutants (2006). Current Biology 16: 591-598 LINK
Dickman D, Horne JA, Meinertzhagen IA, and Schwarz TL. A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin (2005). Cell123: 521-533 LINK
Burgess RW, Dickman D, Nunez L, Glass D, and Sanes JR. Mapping sites responsible for interactions of agrin with neurons (2002). Journal of Neurochemistry 83(2): 271-284 LINK