Oscar Aparicio

• Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994 – 08/31/1999

Tenure Track Appointments

• Professor and Section Head, University of Southern California, 2018 –
• Professor, University of Southern California, 2012 –
• Associate Professor, University of Southern California, 2005 – 2012
• Assistant Professor, University of Southern California, 09/01/1999 – 05/01/2005

PostDoctoral Appointments

• Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994 – 08/31/1999

Other Employment

• Congressional Science Fellow, American Society for Microbiology, 09/01/1993 – 08/31/1994

Summary Statement of Research Interests

The Aparicio lab studies the mechanisms of cell cycle and checkpoint regulation of chromosomal DNA replication as well as how the three-dimensional organization and chromatin structure of chromosomes regulates this process. We use cell biological, molecular, biochemical, genetic, and genomic approaches using the model organism, S. cerevisiae (aka: Baker’s yeast). We have recently identified the Forkhead Box (Fox) proteins Fkh1 and Fkh2 as regulators of replication origin initiation, and are investigating their role in regulating the dynamics and three-dimensional organization of chromosomes. We also work on the development of methods to study genomic activities such as protein-DNA interactions that underlie fundamental processes such as DNA replication and epigenetic control.

Research Keywords

DNA replication, genome dynamics and structure, chromatin, checkpoints, cell cycle, replication origins, replication forks, budding yeast, S. cerevisiae

Research Specialties

Biochemistry, Molecular Biology, DNA replication, Genetics, S. cerevisiae

Administrative Appointments

• Section Head, 10/01/2018 – 08/15/2021