Chen S, Phillips CM. Germ granule association drives small RNA specificity for a nuclear Argonaute protein. BioRxiv. 2023 doi: 10.1101/2023.08.01.551545 link
Uebel CJ, Rajeev, S, Phillips CM. Caenorhabditis elegans germ granules are present in distinct configurations that differentially associate with RNAi-targeted RNAs. BioRxiv. 2023 doi: 10.1101/2023.05.25.542330 link
Phillips CM, Updike DL. Germ granules and gene regulation in the C. elegans germline. Genetics. 2022 Mar 3;220(3):iyab195. doi: 10.1093/genetics/iyab195. PMCID: PMC8893257 PDF
Schreier J, Dietz S, Boermel M, Oorschot V, Seistrup A, de Jesus Domingues AM, Bronkhorst AW, Nguyen DH, Phillis S, Gleason EJ, L’Hernault SW, Phillips CM, Butter F, Ketting RF. Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans. Nat Cell Biol. 2022 Feb;24(2):217-229. doi: 10.1038/s41556-021-00827-2. PMCID: PMC9973253 PDF
Nguyen DAH, Phillips CM. Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1. Nat Commun. 2021 Jul 9;12(1):4212. doi: 10.1038/s41467-021-24526-6. PMCID: PMC8270938 PDF
Uebel CJ, Manage KI, Phillips CM. SIMR foci are found in the progenitor germ cells of C. elegans embryos. microPublication Biology. 2021 2021:374. doi: 10.17912/micropub.biology.000374. PMCID: PMC7900827 PDF
Rogers AK, Phillips CM. A small RNA feedback loop maintains proper levels of 22G-RNAs in C. elegans. Cell Reports. 2020Oct 20;33(3):108279. doi: 10.1016/j.celrep.2020.108279. PMCID: PMC7603289 PDF
Uebel CJ, Agbede D, Wallis DC, Phillips CM. Mutator foci are regulated by developmental stage, RNA, and the germline cell cycle in Caenorhabditis elegans. G3 (Bethesda). 2020 Oct 5;10(10):3719-3728. doi: 10.1534/g3.120.401514. PMCID: PMC7534428 [Featured Article and Cover] PDF
Rogers AK, Phillips CM. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. microPublication Biology. 2020 2020:252. doi: 10.17912/micropub.biology.000252. PMCID: PMC7295153 PDF
Manage KI, Rogers AK, Wallis DC, Uebel CJ, Anderson DC, Nguyen DAH, Arca K, Brown KC, Cordeiro Rodrigues RJ, de Albuquerque BFM, Ketting RF, Montgomery TA, Phillips CM. A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. eLife. 2020 Apr 27;9:e56731 doi: 10.7554/eLife.56731. PMCID: PMC7255803 PDF
Rogers AK, Phillips CM. RNAi pathways repress reprogramming of C. elegans germ cells during heat stress. Nucleic Acids Research. 2020 May 7;48(8):4256-4273. doi: 10.1093/nar/gkaa174. PMCID: PMC7192617 PDF
Svendsen JM, Reed KJ, Vijayasarathy T, Montgomery BE, Tucci RM, Brown KC, Marks TN, Nguyen DH, Phillips CM, Montgomery TA. henn-1/HEN1 promotes germline immortality in Caenorhabditis elegans. Cell Reports. 2019 Dec 3;29:3187-3199. doi: 10.1016/j.celrep.2019.10.114. PMCID: PMC6922003 PDF
Wallis DC, Nguyen DH, Uebel CJ, Phillips CM. Visualization and quantification of transposon activity in C. elegans RNAi pathway mutants. G3 (Bethesda). 2019 Nov 5;9(11):3825-3832. doi: 10.1534/g3.119.400639. PMCID:PMC6829131 PDF
Winkenbach LP, Doser R, Reed KJ, Pasquinelli AE, Phillips CM, Claycomb JC. Todos Santos Small RNA Symposium. RNA Biology. 2019 Aug;16(11):1526-1530. doi: 10.1080/15476286.2019.1649586. PMCID: PMC6779373 [Meeting Review] PDF
Uebel, CJ, Phillips, CM. Phase-separated protein dynamics are affected by fluorescent tag choice. microPublication Biology. 2019 2019:143. doi: 10.17912/micropub.biology.000143. PMCID: PMC7241484 PDF
Uebel CJ, Anderson DC, Mandarino LM, Manage KI, Aynaszyan S, Phillips CM. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. PLoS Genet. 2018 July;14(7):e1007542. doi: 10.1371/journal.pgen.1007542. PMCID: PMC6072111 PDF
Wan G, Fields BD, Spracklin G, Shukla A, Phillips CM, Kennedy S. Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance. Nature. 2018 May 16;557(7707):679–683. doi: 10.1038/s41586-018-0132-0. PMCID: PMC6479227 PDF
Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA. piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway. Dev Cell. 2015 Aug 24;34(4):457-65. doi: 10.1016/j.devcel.2015.07.009. PMCID:PMC4550515 PDF
Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Curr Biol. 2014 Apr 14;24(8):839-44. doi: 10.1016/j.cub.2014.02.060. PMCID:PMC4010136 PDF
Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012 Jul 1;26(13):1433-44. doi: 10.1101/gad.193904.112. PMCID: PMC3403012 PDF
Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012 Apr;8(4):e1002616. doi: 10.1371/journal.pgen.1002616. PMCID: PMC3334881 PDF
Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011Jan 25;108(4):1201-8. doi: 10.1073/pnas.1018695108. PMCID: PMC3029761 [Inaugural Article] PDF
Sato A, Isaac B, Phillips CM, Rillo R, Carlton PM, Wynne DJ, Kasad RA, and Dernburg AF. Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis. Cell. 2009 Nov 25;139(5):907-19. doi: 10.1016/j.cell.2009.10.039. PMCID: PMC2825574 [Featured Research Article] PDF
Phillips CM, Meng X, Zhang L, Chretien JH, Urnov FD, and Dernburg AF. Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans. Nat Cell Biol. 2009 Aug;11(8):934-42. doi: 10.1038/ncb1904. PMCID: PMC4001799 [Featured Research Article] PDF
Phillips CM, McDonald KL, Dernburg AF. Cytological Analysis of Meiosis in Caenorhabditis elegans. Methods Mol Biol. 2009;558:171-95. doi: 10.1007/978-1-60761-103-5_11. PMCID: PMC3644504 [Book Chapter] PDF
Phillips CM and Dernburg AF. A family of zinc finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans. Dev. Cell. 2006 Dec;11(6):817-29. doi: 10.1016/j.devcel.2006.09.020. [Cover] PDF
Phillips CM, Wong C, Bhalla N, Carlton PM, Weiser P, Meneely PM, Dernburg AF. HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. Cell. 2005 Dec 16;123(6):1051-63. doi: 10.1016/j.cell.2005.09.035. PMCID: PMC4435792 [Featured Research Article] PDF
MacQueen AJ, Phillips CM, Bhalla N, Weiser P, Villeneuve AM, Dernburg AF. Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans. Cell. 2005 Dec 16;123(6):1037-50. doi: 10.1016/j.cell.2005.09.034. PMCID: PMC4435800 [Featured Research Article] PDF
Collins-Schramm HE, Phillips CM, Operario DJ, Lee JS, Weber JL, Hanson RL, Knowler WC, Cooper R, Li H, Seldin MF. Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet. 2002 Mar;70(3):737-50. doi: 10.1086/339368. PMCID: PMC384950 PDF