Somatomotor topography (left) and association megaclusters (right) observed in the cerebral cortex (top), striatum (middle), and cerebellum (bottom).

Within-Individual Organization of the Human Cognitive Cerebellum: Evidence for Closely Juxtaposed, Functionally Specialized Regions

Peer reviewed publication, Science Advances
BySaadon-Grosman N, Du J, Kosakowski HL, Eldaief MC, Buckner RL. (2024)

Summary

Specific regions in the cognitive cerebellum are connected to distinct cerebral association networks. Here, we that individual participants have large association megaclusters that extend across Crus I/II was consistently found with subregions linked to five higher-order association networks. Similarly organized clusters also exist in the caudate consistent with the presence of multiple basal ganglia–cerebellar–cerebral cortical circuits that maintain functional specialization across their entire distributed extents.

Open Source Materials

All MRI data are publicly available on NIMH Data Archive (NDA ID #3536; R01MH124004; PI Randy Buckner).