# 1st author, * corresponding author, Lab members
C3aR / C5aR1, GPCR, H. sapiens
M K Yadav#, J Maharana#, R Yadav#, S Saha#, P Sarma, C Soni, V Singh, S Saha, M Ganguly, XX Li, S Mahapatra, S Mishra, HA Khant, M Chami, TM Woodruff, R Banerjee*, AK Shukla* and C Gati*
Molecular basis of anaphylatoxin recognition, activation, and signaling-bias at complement receptors.
Cell. 2023.
GAT1, SLC, H. sapiens
Z Motiwala, NG Aduri, H Shaye, GW Han, JH Lam, V Katritch, V Cherezov, C Gati*
Structural basis of GABA reuptake inhibition.
Nature. 2022.
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Fzd5, GPCR, H. sapiens
N Tsutsumi, S Mukherjee, D Waghray, CY Janda, KM Jude, Y Miao, JS Burg, NG Aduri, AA Kossiakoff, C Gati*, KC Garcia*
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
eLife. 2020.
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GABA(B), GPCR, H. sapiens
H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C Gati*, V Cherezov*
Structural basis of the activation of a metabotropic GABA receptor.
Nature. 2020.
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Rv1819c, ABC Transporter, M. tuberculosis
S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A Guskov*, DJ Slotboom*.
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
Nature. 2020.
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beta2-adrenergic receptor, B2AR, GPCR, H. sapiens
A Ishchenko, B Stauch, GW Han, A Batyuk, A Shiriaeva, C Li, N Zatsepin, U Weierstall, W Liu, E Nango, T Nakane, R Tanaka, K Tono, Y Joti, S Iwata, I Moraes, C Gati, V Cherezov.
Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
IUCrJ. 2019.
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Melatonin receptor 1A, MT1, GPCR, H. sapiens
B Stauch, LC Johansson, JD McCorvy, N Patel, GW Han, XP Huang, C Gati, A Batyuk, ST Slocum, A Ishchenko, W Brehm, TA White, N Michaelian, C Madsen, L Zhu, TD Grant, JM Grandner, A Shiriaeva, RHJ Olsen, AR Tribo, S Yous, RC Stevens, U Weierstall, V Katritch, BL Roth, W Liu, V Cherezov.
Structural basis of ligand recognition at the human MT 1 melatonin receptor.
Nature. 2019.
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Melatonin receptor 1B, MT2, GPCR, H. sapiens
LC Johansson, B Stauch, JD McCorvy, GW Han, N Patel, XP Huang, A Batyuk, C Gati, ST Slocum, C Li, JM Grandner, S Hao, RHJ Olsen, AR Tribo, S Zaare, L Zhu, NA Zatsepin, U Weierstall, S Yous, RC Stevens, W Liu, BL Roth, V Katritch, V Cherezov.
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.
Nature. 2019.
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A Ishchenko, C Gati, V Cherezov.
Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM.
Current Opinion in Structural Biology. 2018.
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- PMID: 29554543
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Neutral amino acid transporter B(0), ASCT2, SLC, H. sapiens
AA Garaeva, GT Oostergetel, C Gati, A Guskov, C Paulino, DJ Slotboom.
Cryo-EM structure of the human neutral amino acid transporter ASCT2.
Nature Structural and Molecular Biology. 2018.
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