Test tubes lying on a lable with an illustration of a DNA inside of them.
USC Dornsife researchers invented a way to efficiently create chromosomes from existing pieces. (Image source: iStock.)

How researchers are “CReATiNG” synthetic chromosomes faster and cheaper

A new process to assemble DNA, developed by USC Dornsife scientists, could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.
ByUSC Dornsife News Staff

A groundbreaking new technique invented by researchers at the USC Dornsife College of Letters, Arts and Science may revolutionize the field of synthetic biology. Known as CReATiNG (Cloning Reprogramming and Assembling Tiled Natural Genomic DNA), the method offers a simpler and more cost-effective approach to constructing synthetic chromosomes. It could significantly advance genetic engineering and enable a wide range of advances in medicine, biotechnology, biofuel production and even space exploration.

CReATiNG works by cloning and reassembling natural DNA segments from yeast, allowing scientists to create synthetic chromosomes that can replace their native counterparts in cells. The innovative technique enables researchers to combine chromosomes between different yeast strains and species, change chromosome structures, and delete multiple genes simultaneously.

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