Faculty

Professor of Biological Sciences

We are using novel recombinant probes, known as intrabodies, to visualize and manipulate synaptic connectivity in vivo. Areas being explored include development, learning and memory, sleep and neurodegenerative disease.

Lecturer

I am a lecturer of biological sciences at USC, and currently teach undergraduate courses on cell biology, anatomy, physiology and neurobiology. My research background combines neuroanatomy and behavioral statistics to study reading in children with dyslexia. Additionally, I serve as a curriculum advisor for the Neighborhood Academic Initiative (NAI) program, designed to increase higher education access for scholars from the South-Central and East Los Angeles areas.

Professor of Biological Sciences and Psychology

Our lab studies how neural circuits that traverse the cortex and basal ganglia mediate motor skill learning during development. Skill learning entails the acquisition of a new behavior as trial and error of variable actions are refined into a stereotyped pattern. Acquisition of new motor skills depends on neural circuits that compare feedback of self-generated movements to a desired goal and reinforce “correct” movements that match that goal. We use multidisciplinary behavioral and systems neuroscience approaches to study the function of cortico-basal ganglia circuits during developmental skill learning. Understanding the normal function of these circuits is a necessary prerequisite to understanding the multiple diseases associated with disorders of the basal ganglia.

Associate Professor of Biological Sciences

Our lab is interested in synapse development, function, and plasticity in general, and the mechanisms that homeostatically tune synaptic strength stabilize neural function. We use Drosophila melanogaster as a genetic model organism and apply a combination of genetic, electrophysiological, imaging, and behavioral approaches to discover the molecular, cellular, and synaptic mechanisms that achieve and maintain the stability of synaptic transmission. Our research aims to determine how dysfunction in these processes contributes to the etiology of cognitive, neurological, neurodegenerative, and neuropsychiatric diseases.

University Professor, ARCO/William F. Kieschnick Chair in the Neurobiology of Aging and Professor of Gerontology, Biology and Psychology

Dr. Finch’s main interests are the genomic regulation of aging processes. He has authored three books: Longevity, Senescence, and the Genome (1990); Aging: A Natural History (1995, with R. Ricklefs); Chance, Development, and Aging (2000, with TBL Kirkwood); and The Biology of Human Longevity (2007). In 450 reports and reviews since 1966, Finch has lead several developments in the fields of the neuroendocrinology and pharmacology of normal aging and Alzheimer disease, and in the biodemography of aging.

Associate Professor (Research) of Biological Sciences

Within the broad field of systems neuroscience, my research interests encompass investigations into brain-wide neuronal network architecture, the structure and function of specific neuronal circuits (especially hypothalamic) involved in the control of physiological and behavioral processes that support survival and reproduction, and the development and application of informatics research tools.

Professor of Biological Sciences

I am interested in understanding the embryonic development of synapses in the vertebrate nervous system, using the neuromuscular junction as a model system. Current research focuses on synapse elimination, the process by which the abundant but labile connections formed early in development are reduced to a smaller but stable number. This process largely determines the connectivity between neurons in adulthood.

Assistant Professor of Biological Sciences

We combine innovative genetic approaches with electrophysiology and super-resolution imaging techniques to gain insight into the molecular underpinnings of mammalian synaptic function. More specifically, my lab is interested in the molecular mechanisms governing synaptic plasticity and how dysregulation of these mechanisms gives rise to neuropsychiatric and neurodevelopmental disease.

Associate Professor of Biological Sciences

Our lab seeks to understand the role the cortex plays in the processing of tactile sensations and generation of perception.  To do so, we record from cortical neurons during quantified behavior, correlate sensory input to neural activity and modify, delete or synthesize perceptions via patterned photostimulation of cortex.  In other words, our work aims to provide read, translation and write access to cortical circuits. Ultimately, we seek to develop therapeutic interventions for neurological disorders of sensory processing and tactile feedback systems for prosthetics.

Professor of Biological Sciences: Section Head

Our research explores the earliest stages of visual cortical processing. Specifically, we ask how thalamocortical connections and circuits within the striate cortex itself resolve basic features of the visual scene. Individual projects are designed to explore key aspects of cortical integration, such as interaction between synaptic input and intrinsic properties of the membrane, functional specializations of intracortical pathways and the synaptic basis and physiology of responses to visual pattern.

Professor of Biological Sciences

Studies in the Liman lab use tools of molecular biology, structural biology, patch-clamp electrophysiology, and cellular imaging to uncover fundamental mechanisms underlying the senses of taste, smell, and pain. We recently identified a receptor for sour taste, OTOP1, showed that it forms a proton ion channel, and described the basic mechanisms by which it is gated. These studies ultimately form the basis for drug discovery to modify or restore sensation and give us a deeper appreciation of the sensory worlds which we and other organisms inhabit.

Assistant Professor of Biological Sciences

Our lab investigates the organization and function of motor circuits using multidisciplinary cellular and systems neuroscience approaches. We aim to identify how distinct brain regions and cell types interact to select and control movements. Our major focus is on the basal ganglia, a critical network in the motor system whose dysregulation underlies several common movement disorders.­­

Professor of Biological Sciences

Peripheral somatosensory neurons critically differentiate innocuous stimuli from those that cause tissue damage and pain (nociception). We use a combination of cellular, genetic, and behavioral approaches to understand how these cells transduce these discrete environmental stimuli, and their contribution to inflammatory and neuropathic pain.

Assistant Professor of Biological Sciences

The goal of my lab is to understand how networks of connected neurons interact to organize complex behaviors. To do this, we investigate how neuronal sensorimotor circuits in the brainstem control innate behaviors, and how higher order brain structures engage these circuits to appropriately regulate these behaviors. The laboratory uses a combination of molecular, systems, and theoretical neurobiological techniques to address these important topics.

Milo Don and Lucille Appleman Professor of Biological Sciences and Professor of Biological Sciences, Neurology and Psychology; Provost Professor; Member National Academy of Sciences

We are interested in the organization of neural networks that control motivated behavior in mammals. The approach is mostly structural, and to display and model results we are developing computer graphics and database approaches.

Professor of Biological Sciences

Our work is directed towards understanding the structure and function of the brain networks that control energy homeostasis. We are interested in how these networks control eating behaviors, blood glucose, and the secretion of hormones from the pancreas and adrenal gland, and particularly how they contribute to the development, manifestation, and complications of diabetes and obesity.

Associate Professor of Biological Sciences

My research focuses on the neurobiological control of food intake and body weight regulation. More specifically, our laboratory focuses on understanding how the brain processes peripherally- and centrally-derived hormonal signals to control learned and motivated aspects of feeding behavior, as well as to examine how these neuroendocrine signaling systems contribute to and are compromised by obesity and related metabolic disorders. At the center of this research is the hippocampus; a brain region traditionally linked with memory function, but more recently shown to control higher-order aspects of feeding behavior. Our research also explores the relationship between consuming saturated fatty acids and refined carbohydrates (i.e., “Western diets”) and the development of hippocampal dysfunction, cognitive impairment, and Alzheimer’s pathology.

University Professor, Fletcher Jones Chair in Computer Science, and Professor of Computer Science, Biological Sciences, and Psychology

The thrust of Michael Arbib’s work is expressed in the title of his first book, Brains, Machines and Mathematics (McGraw-Hill, 1964). The brain is not a computer in the current technological sense, but he has based his career on the argument that we can learn much about machines from studying brains, and much about brains from studying machines. He has thus always worked for an interdisciplinary environment in which computer scientists and engineers can talk to neuroscientists and cognitive scientists.

Professor Emeritus of Biological Sciences

Our research work focused on synaptic structure, function, formation, repair, maintenance, and synapse-glia interactions, as well as diseases at the neuromuscular junction. Latterly, our focus shifted to the cellular and molecular mechanisms of the pathogenesis and translational research of Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality characterized by the synaptic defects, loss of spinal motor neurons and widespread muscle atrophy.

Professor Emeritus of Biological Sciences

Professor McClure’s research has focused on the effects of mild prenatal stress on the development of adult rats. His interest in this work stemmed from the hypothesis that the devastating human disease, schizophrenia, is caused, at least in part, by a prenatal effect: a challenge presented to the mother causes changes in the structure of the brain, which in turn lead to development of the disease when the affected child reaches young adulthood.