Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.

Yang C, Yamaki S, Jung T, Kim B, Huyhn R, McKemy DD. (2023)

J Neurosci. Apr 12;43(15):2803-2814.

Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice

Wei C, Kim B, McKemy DD. (2022)

Pain. Dec 1;163(12):2380-2389.

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization

Jeong SL, Zhang H, Yamaki S, Yang C, McKemy DD, Lieber MR, Pham P, Goodman MF. (2022)

Nucleic Acids Res. Nov 11;50(20):11738-11754

Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor transient receptor potential melastatin 8

Yamaki S, Chau A, Gonzales L, McKemy DD. (2021)

Pain. Feb 1;162(2):609-618.

Editors Choice Video Abstract

Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain

Ramakrishna C, Corleto J, Ruegger PM, Logan GD, Peacock BB, Mendonca S, Yamaki S, Adamson T, Ermel R, McKemy D, Borneman J, Cantin EM.
Sci Rep. 2019 Dec 30;9(1):20324.