Overview

The Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium is a collaboration involving over fifteen longitudinal twin studies of adult development and aging. Funding is from National Institutes of Health Grants No. R01 AG037985, R56 AG037985, RF1 AG058068, R01 AG059329 and R01 AG060470. The aims are to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life. The newest funding specifically addresses the SES-health gradient, as well as risk and protective factors for Alzheimer’s disease and related dementias.

Participating Studies

Australian Over 50’s study (A50)

Older Australian Twin Study (OATS)

Longitudinal Study of Aging Danish Twins (LSADT)

Middle Age Danish Twin study (MADT)

MId-aged Danish Twins (MIDT)

Finnish Twin Cohort (FTC)

Finntwin16

Aging in Women and Men (GENDER)

Study of Origins of Variance in the Oldest-Old (OCTO-Twin)

Swedish Adoption/Twin Study of Aging (SATSA)

Twin and Offspring Study in Sweden (TOSS)

Carolina African-American Twin Study of Aging (CAATSA)

Midlife in the United States Twin Study (MIDUS)

Minnesota Twin Study of Adult Development and Aging (MTSADA)

NAS-NRC Twin Registry and Duke Twins Study (NAS-NRC)

Project Talent Twin Registry (PTTS)

Vietnam Era Twin Study of Aging (VETSA)

Project Publications

  • Pedersen, N.L., Christensen, K., Dahl, A., Finkel, D., Franz, C., Gatz, M., Horwitz, B.N., Johansson, B., Johnson, W., Kremen, W.S., Lyons, M.J., Malmberg, B., McGue, M., Neiderhiser, J.M., Peterson, I., & Reynolds, C. A. (2013). IGEMS: The Consortium on interplay of genes and environment across multiple studies. Twin Research and Human Genetics, 16(1), 481-489. article

    Pedersen, N.L., Gatz, M., Finch, B.K., Finkel, D., Butler, D.A., Dahl Aslan, A., Franz, C.E., Kaprio, J., Lapham, S., McGue, M., Mosing, M.A., Neiderhiser, J., Nygaard, M., Panizzon, M., Prescott, C.A., Reynolds, C.A. Sachdev, P., & Whitfield, K.E. (2019). IGEMS: The Consortium on interplay of genes and environment across multiple studies – an update. Twin Research and Human Genetics. article

  • Jang, J. Y., Beam, C. R., Karlsson, I. K., Pedersen, N. L., & Gatz, M. (2023). Dementia and mortality in older adults: A twin study. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 10.1002/alz.13553. Advance online publication. https://doi.org/10.1002/alz.13553

    Malin Ericsson, Brian Finch, Ida K Karlsson, Margaret Gatz, Chandra A Reynolds, Nancy L Pedersen, Miriam Mosing, Educational influences on late-life health: Genetic propensity and attained education, The Journals of Gerontology: Series B, 2023;, gbad153, https://doi.org/10.1093/geronb/gbad153

    Luczak, S.E., Beam, C.R., Pahlen, S., Lynch, M., Pilgrim, M., Reynolds, C.A., Panizzon, M.S., Catts, V.S., Christensen, K., Finkel, D., Franz, C.E., Kremen, W.S., Lee, T., McGue, M., Nygaard, M., Plassman, B.L., Whitfield, K.E., Gatz, M., Pedersen, N.L., Gatz, M., for the IGEMS Consortium (2023). Remember this: Age moderation of genetic and environmental contributions to verbal episodic memory from midlife through late adulthood. Intelligence, 99. article

    Finkel, D., Zavala, C., Franz, C.E., Pahlen, S., Gatz, M., Pedersen, N.L., Finch, B.K., Dahl Aslan, A., Catts, V.S., Ericsson, M., Krueger, R.F., Martin, N.G., Mohan, A., Mosing, M.A., Prescott, C.A., & Whitfield, K. (2022). Financial strain moderates genetic influences on self-rated health: Support for diathesis-stress model of gene-environment interplay. Biodemography and Social Biology [Epub ahead of print] DOI:10.1080/19485565.2022.2037069 article

    Karlsson, I.K., Ploner, A., Wang, Y., Gatz, M., Pedersen, N.L., & Hägg, S. (2022). Leukocyte DNA methylation in Alzheimer’s disease associated genes: Replication of findings from neuronal cells. Epigenetics [Epub ahead of print]. DOI: 10.1080/15592294.2022.2158285 article

    Karlsson I.K., Zhan Y., Wang Y., Li X., Jylhävä J., Hägg S., Dahl Aslan A., Gatz M., Pedersen N.L., & Reynolds C.A. (2022). Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels. European Journal of Epidemiology [Epub ahead of print]. DOI: 10.1007/s10654-022-00918-w. article

    Vo, T.T., Pahlen, S., Kremen, W.S., McGue, M., Dahl Aslan, A., Nygaard, M., Christensen, K., Reynolds, C.A. (2022). Does sleep duration moderate genetic and environmental contributions to cognitive performance? Sleep, 45(10), 140. abstract

    Beam C.R., Luczak S.E., Panizzon M.S., Reynolds C.A., Christensen K., Dahl Aslan A.K., Elman J.A., Franz C.E., Kremen W.S., Lee T., Nygaard M., Sachdev P.S., Whitfield K.E., Pedersen N.L., Gatz M. & the IGEMS Consortium. (2022). Estimating Likelihood of Dementia in the Absence of Diagnostic Data: A Latent Dementia Index in 10 Genetically Informed Studies. Journal of Alzheimers Disease, 90(3), 1187-1201. doi: 10.3233/JAD-220472. article

    Phillips, D.M., Finkel, D., Petkus, A J., Muñoz, E., Pahlen, S., Johnson, W., Reynolds, C.A., & Pedersen, N. (2022). Longitudinal analyses indicate bidirectional associations between loneliness and health. Aging & Mental Health, 1–9. Advance online publication. https://doi.org/10.1080/13607863.2022.2087210. abstract

    Finkel, D., Zavala, C., Franz, C.E., Pahlen, S., Gatz, M., Pedersen, N.L., Finch, B.K., Dahl Aslan, A., Catts, V.S., Ericsson, M., Krueger, R.F., Martin, N.G., Mohan, A., Mosing, M.A., Prescott, C.A., & Whitfield, K.E. (2022). Financial strain moderates genetic influences on self-rated health: Support for diathesis-stress model of gene-environment interplay. Biodemography and Social Biology. https://doi.org/10.1080/19485565.202202037069 article

    Karlsson, I.K., Escott-Price, V., Gatz, M., Hardy, J., Pedersen, N.L., Shoai, M., & Reynolds, C.A. (2022). Measuring heritable contributions to Alzheimer’s disease: Polygenic risk score analysis with twins. Brain Communications, V4, Issue 1. https://doi.org/10.1093/braincomms/fcab308 article

    Karlsson, I.K., Zhan, Y., Gatz, M., Reynolds, C.A., & Dahl-Aslan, A.K. (2021). Change in cognition and body mass index in relation to preclinical dementia. Alzheimer’s & Dementia, 7:e12176. https://doi.org/10.1002/trc2.12176 article

    Karlsson, I.K., Gatz, M., Arpawong, T.E., Dahl-Aslan, A.K., & Reynolds, C.A. (2021). The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences. Scientific Reports, 11, 7206. DOI: 10.1038/s41598-021-86667-4. article

    Gustavson, D.E., Panizzon, M.S., Kremen, W.S., Reynolds, C.A., Pahlen, S., Nygaard, M., Wod, M., Catts, V.S., Lee, T., Gatz. M., & Franz, C.E for the IGEMS Consortium (2021). Genetic and environmental influences on semantic verbal fluency across midlife and later life. Behavior Genetics, 51, 99-109. doi: 10.1007/s10519-021-10048-w. article

    Gustavson, D.E., Franz, C.E., Panizzon, M.S., Lyons, M.J., Kremen, W.S. (2020). Internalizing and externalizing psychopathology in middle age: Genetic and environmental architecture and stability of symptoms over 15 to 20 years. Psychological medicine, 50(9), 1530-1538. abstract

    Finkel, D., Franz, C.E., Christensen, K., Reynolds, C.A., Pedersen, N.L., & the IGEMS consortium (2020). Longitudinal twin study of subjective health: Differences in genetic and environmental components of variance across age and sex. Journals of Gerontology: Psychological Sciences, 75, 1-10. article

    Beam, C.R., Kaneshiro, C., Jang, J.Y., Reynolds, C.A., Pedersen, N.L., & Gatz, M. (2020). A twin study of sex differences in genetic risk for all dementia, Alzheimer’s disease, and non-AD dementia. Journal of Alzheimer’s Disease, 76, 539-551. abstract

    Karlsson, I.K., Lehto, K., Gatz, M., Reynolds, C.A., Dahl-Aslan, A.K. (2020). Age-dependent effects of body mass index across the adult life span on the risk of dementia: A cohort study with a genetic approach. BMC Medicine, 18(1), 131. article

    Luo, J., Beam, C.R., Karlsson, I.K., Pike, C.J., Reynolds, C.A., & Gatz, M. (2020). Dementia risk in women higher in same-sex than opposite-sex twins. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 12(1), e12049. article

    Finch, B.K., Gatz, M., & Pedersen, N.L. (2019). Consortium on interplay of genes and environment across multiple studies. Encyclopedia of Gerontology and Population Aging. doi: 10.1007/978-3-319-69892-2_648-1 article

    Reynolds, C.A., Tan, Q., Munoz, E., Jylhava, J., Hjelmborg, J., Christiansen, L., Hagg, S., & Pedersen, N.L. (2019). A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation. bioRxiv, 778555. doi:10.1101/778555 article

    Gustavson, D.E., Franz, C.E., Panizzon, M.S., Lyons, M.J., & Kremen, W.S. (2019). Internalizing and externalizing psycholopathology in middle age: Genetic and environmental architecture and stability of symptoms over 15 to 20 years. Psychol Med. [Epub ahead of print]. article

    Sanerson-Cimino, M., Panizzon, M.S., Elman, J.A., Gustavson, D.E., Franz, C.E., Reynolds, C.A., Toomey, R., Lyons, M.J., & Kremen, W.S. (2019). Genetic and environmential arcitecture of processing speed across midlife. Neurophychology, 33, 862-871. article

    Franz, C.E., Xian, H., Lew, D., Hatton S.N., Puckett, O., Whitsel, N., Beck, A., Dale, A.M., Fang, B., Fennema-Notestine, C., Hauger, R.L., Jacobson, K.C., Lyons, M.J., Reynolds, C.A., & Kremen, W.S. (2019). Body mass trajectories and cortical thickness in middle-aged men: A 42-year longitudinal study starting in young adulthood. Neurobiol Aging. [Epub ahead of print]. article

    Gustavson, D. E., Panizzon, M. S., Kremen, W. S., Reynolds, C. A., Pahlen, S., Nygaard, M., Wod, M., Catts, V. S., Lee, T., Gatz, M., Franz, C. E., & IGEMS Consortium (2021). Genetic and Environmental Influences on Semantic Verbal Fluency Across Midlife and Later Life. Behavior genetics51(2), 99–109. https://doi.org/10.1007/s10519-021-10048-w

    Mosing, M.A, Lundholm, C., Cnattingius, S., Gatz, M., & Pedersen, N.L. (2018). Associations between birth characteristics and age-related cognitive impairment and dementia: A registry-based cohort study. PLoS Medicine, 15. article

    Zavala, C., Beam, C.R., Finch, B.K., Gatz, M., Johnson, W., Kremen, W.S., Neiderhiser, J.M., Pedersen, N.L., & Reynolds, C.A. (2018). Attained SES as a moderator of adult cognitive performance: Testing gene-environment interaction in various cognitive domains. Developmental Psychology, 54, 2356-2370. article

    Finkel, D., Franz, C.E., Christensen, K., Reynolds, C.A., & Pedersen, N.L. (2018). Longitudinal twin study of subjective health: Differences in genetic and environmental components of variance across age and sex. Journals of Gerontology: Psychological Sciences. [Epub ahead of print] article

    Pahlen, S., Hamdi, H.R., Dahl Aslan, A.K., Horwitz, B.N., Panizzon, I., Zavala, C., Christensen, K., Finkel, D., Franz, C.E., Gatz, M., Johnson, W., Kremen, W.S., Krueger, R.F., Neiderhiser, J.M., Reynolds, C.A., Pedersen, N.L., & McGue, M. (2018). Age-moderation of genetic and environmental contributions to cognitive functioning in mid- and late-life for specific cognitive abilities. Intelligence, 68, 70-81. article

    Ericsson, M., Lundholm, C., Fors, S., Dahl-Aslan, A.K., Zavala, C., Reynolds, C.A., & Pedersen, N.L. (2017). Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7001-7006. article

    Petkus, A.J., Beam, C.R., Johnson, W., Kaprio, J., Korhonen, T., McGue, M., Neiderhiser, J.M., Pedersen, N.L., Reynolds, C.A., Gatz, M. & the IGEMS Consortium (2017). Gene–environment interplay in depressive symptoms: moderation by age, sex, and physical illness. Psychological Medicine, 47(10), 1836-1847. article scripts

    Franz, C.E., Finkel, D., Panizzon, M.S., Spoon, K., Christensen, K., Gatz, M., Kremen, W.S., Kruger, R.F., Neiderhiser, J.M., Reynolds, C.A., Pedersen, N.L., & the IGEMS consortium (2016). Facets of subjective health from early adulthood to old age. Journal of Aging and Health, 29, 149-171. article

    Mosing, M., Cnattingius, S., Gatz, M., Neiderhiser, J.M., & Pedersen, N.L. (2016). Associations between fetal growth and self-perceived health throughout adulthood: A co-twin control study. Behavior Genetics, 46(3), 457-466. article

    Reynolds, C.A., Gatz, M., Christensen, K., Christiansen, L., Dalh Aslan, A.K., Kaprio, J., Korhonen, T., Kremen, W.S., Kruegar, R., McGue, M., Neiderhiser, J.M., & Pedersen, N.L. (2016). Gene-environment interplay in physical, psychological, and cognitive domains in mid to late adulthood: Is APOE a variability gene? Behavior Genetics, 46(1), 4-19. article

    Petersen, I., Pedersen, N.L., Rantanen, T., Kremen, W.S., Johnson, W., Panizzon, M.S., Christiansen, L., Franz, C.E., McGue, M., Christensen K., Hamdi, N.R., Krueger, R.F., & Reynolds, C.A. (2016). GxE interaction influences trajectories of hand grip strength. Behavior Genetics, 46(1), 20-30. article

    Finkel, D., Franz, C.E., Horwitz, B., Christensen, K., Gatz, M., Johnson, W., Kaprio, J., Korhonen, T., Neiderhiser, J., Petersen, I., Rose, R.J., Silventoinen, K. & IGEMS Consortium. (2016). Gender differences in marital status moderation of genetic and environmental influences on subjective health. Behavior Genetics, 46(1), 114-123. article

    Reynolds, C.A., & Finkel, D. (2016). Cognitive and physical aging: Genetic influences and gene-environment interplay (pp.125-146). In W. K. Schaie & S. L. Willis, Handbook of the Psychology of Aging, 8th Edition. New York: Elsevier.

    Gatz, M., Reynolds, C.A., Finkel, D., Hahn, C.J., Zhou, Y., & Zavala, C. (2015). Data harmonization in aging research: Not so fast. Experimental Aging Research, 41, 475-495. article

    Pedersen, N.L., & Gerritsen, L. (2015). Genetics of brain and cognitive aging: Introduction to the special issue of Neuropsychology Review. Neuropsychology Review, 25(1), 1-2. article

    Reynolds, C.A., & Finkel, D. (2015). A meta-analysis of heritability of cognitive aging: Minding the “Missing Heritability” gap. Neuropsychology Review, 25(1), 97-112. article

    Reynolds, C.A., Finkel, D., & Zavala, C. (2014). Gene by environment interplay in cognitive aging (pp. 169-199). In D. Finkel and C.A. Reynolds (Eds.) Behavior Genetics of Cognition Across the Lifespan. Springer.

  • Finch, B. K., Mosing, M., Reynolds, C., Pedersen, N., Finkel, D., Gatz, M., Catts, V. (2023). The Validity of Self-Rated Health for Mortality: Family-Background and Genetic Precursors. Behavior Genetics, 53, 445-446. abstract

    Finkel D, Ericsson M (2023 GSA). Within and between pair differences indicate genetic effects of SES indicators on Longitudinal change in physical aging. abstract

    Nygaard, M., Finkel, D., Plassman, B.L, McGue, M. (2023). A Biometric Investigation of Leisure-Time Activities Across IGEMS Studies with a Focus on Moderation by Sex, Age, and Country. abstract

    Finch, B.K., Thomas, K., Gatz, M., Pedersen, N., Ericsson, M., Mosing, M., Finkel, D. (2022). Are Education/Mortality Disparities Widening in Countries Other Than the US?: Twin-Differenced Models of Age and Cohort in IGEMS. abstract

    Finkel, D. (2022). Genetic Architecture of Self-rated Health: Relationship with Physical Health, Cognition Function, and Depression. In Behavior Genetics (Vol. 52, No. 6, pp. 359-359). abstract

    Finkel, D. & Ernsth-Bravell, M. (2020). Cohort by education interactions in longitudinal changes in functional abilities. Journal of Aging and Health, 32, 208-215. abstract

    Finkel, D., & Ernsth-Bravell, M. (2018). Cohort By Education Differences In Longitudinal Change In Functional Ability. Innovation in Aging, 2 (Suppl 1), 477. abstract

    Finkel, D., & Gatz, M. (2022). Genetic architecture of subjective health: Relationship with physical health, cognition, and depression. Innovation in Aging 6(1), 448. abstract

    Finch, B., Thomas, K., Gatz, M., Pedersen, N., Ericsson, M., Mosing, M., & Finkel, D. (2022). Are education/mortality disparities widening in countries other than the US?: Twin-differenced models of age and cohort in IGEMS. Behavior Genetics, 52(6), 358-359. abstract

    Finkel, D., for the IGEMS Consortium (2022). Genetic architecture of self-rated health: Relationship with physical health, cognition function, and depression. Behavior Genetics, 52(6), 359. abstract

    Vo, T., Pahlen, S., Kremen, W.S., McGue, M., Dahl Aslan, A.K., Nygaard, M., Christensen, K., Reynolds, C.A., for the IGEMS Consortium (2022). Gene-environmental interplay of verbal fluency and episodic memory: Evaluating moderation by sleep duration and educational attainment. Behavior Genetics, 52(6), 397. abstract

    Finch, B. (2021). Social mobility and the genome: Testing a unified stratification theory. Presented at Integrating Genetics and the Social Sciences Conference. Boulder, CO.

    Pahlen, S., Franz, C.E., Kremen, W.S., Dahl Aslan, A K., Lee, T., Sachdev, P., Catts, V.S., & Reynolds, C A., for the IGEMS Consortium (2021). Genetic and environmental moderation of cognitive performance by smoking behavior. Behavior Genetics, 51(6), 731-732. abstract

    Vo, T.T., Pahlen, S., Kremen, W.S., Mc Gue, M., Dahl Aslan, A.K., Nygaard, M., & Reynolds, C.A. (2021). The consortium on Interplay of Genes and Environment Across Multiple Studies (IGEMS): Does sleep duration moderate genetic and environmental contributions to cognitive performance? Behavior Genetics, 51(6), 752. abstract

    Gatz, M., Luczak, S.E., Pahlen, S., Lee, T., Nygaard, M., Panizzon, M.S., Plassman, B.L., Reynolds, C.A., & Whitfield, K.E., for the IGEMS Consortium (2020). Remember this: Harmonization of episodic memory measures across twin studies of aging. Behavior Genetics, 50, 455-456. abstract PowerPoint Presentation

    Vo, T., Pahlen, S., Kremen, W., McGue, M., & Reynolds, C.A. (2020). Testing for moderation of mid-life cognitive performance by sleep duration. Behavior Genetics, 50, 488. abstract

    Gustavson, D.E., Panizzon, M.S., Kremen, W.S., Reynolds, C.A., Pahlen, S., Nygaard, M., Wod, M., Catts, V.S., Lee, T., Gatz, M., & Franz C.E. (2020). Genetic and environmental influences on semantic verbal fluency across midlife. Alzheimer’s & Dementia, 16 (Supp 3):e037410. https://doi.org/10.1002/alz.037410. abstract article

    Kim, A.J., & Beam, C.R. (2020). Are life event differentially associated with dementia risk by gender? Alzheimer’s & Dementia, 16 (Issue S10):e038673. https://doi.org/10.1002/alz.038673. abstract

    Karlsson, I.K., Lehto, K., Reynolds, C.A., Dahl-Aslan, A.D. (2019), Age-dependent effects of body mass index on the risk of dementia. European Neuropsychopharmacology, 29, S180-181. abstract

    Lehto, K., Karlsson, I.K., Gatz, M., Pedersen, N.L. (2019). Does depression in old age reflect prodromal dementia? A polygenic risk score approach in two longitudinal studies. European Neuropsychopharmacology, 29, S181-182. abstract

    Luczak, S.E., Beam, C.R., Panizzon, M.S., Reynolds, C.A., Sachdev, P.S., & Gatz, M., for the IGEMS consortium (2019). Refining a latent dementia indicator for a multi-study consortium. Alzheimer’s & Dementia, 15(75), 483. poster

    Karlsson, I., Escott-Price, V., Gatz, M., Hardy, J., Pedersen, N.L., Shoai, M., & Reynolds, C.A. (2019). Measuring heritable contributions to AD: Polygenic risk score analysis in biometric, SNP-based & AUC models in twins. Alzheimer’s & Dementia, 15 (7S, Part 25), P1307. poster abstract

    Kim, A.J., Munoz, E. & Beam, C.R. (2019). Which life event domains are associated with dementia risk? Alzheimer’s & Dementia, 15 (7S, Part 16), P821. https://doi.org/10.1016/j.jalz.2019.06.2937. poster abstract

    Luo, J., Beam, C.R., Pike, C.J., Karlsson, I., & Gatz, M. (2019). Sex differences in dementia risk: The effects of prenatal testosterone exposure, APOE4, and their interaction. Alzheimer’s & Dementia, 15 (7S, Part 22), P1183-1184. https://doi.org/10.1016/j.jalz.2019.06.3585. poster abstract

    Catts, V., Thalamuthu, A., Lee, T., Crawford, J., & Sachdev, P. (2019). Heritability of subjective cognitive decline in Older Australian Twins. Behavior Genetics, 49, 516. poster abstract

    Ericsson, M., Pedersen, N.L., Fors, S., Kuja-Halkola, R., Mosing, M., Li, X., Jylhava, J., & Dahl Aslan, A. (2019). Frailty and mortality: Sex differences and socioeconomic influences in Swedish twins. Behavior Genetics, 49, 523. poster abstract

    Finkel, D., & Ernsth Bravell, M. (2019). Genetic influences on lung function contribute to subsequent age changes in motor and cognitive function. Behavior Genetics, 49, 492. abstract

    Kim, A., Munoz, E. & Beam, C.R. (2019). Common genetic and shared environmental confounds in the association between stressful life events and dementia. Behavior Genetics, 49, 502. poster abstract

    Lehto, K., Karlsson, I., Gatz, M., & Pedersen, N.L. (2019). Does depression in old age reflect prodromal dementia? A polygenic risk score approach. Behavior Genetics, 49, 512. abstract

    Pahlen, S., Kremen, W.S., Reynolds, C., and the IGEMS consortium (2019). Smoking behaviors and cognitive functioning in mid-to late-adulthood: Gene-environment interplay. Behavior Genetics, 49, 550. abstract

    Phillips, D., Wang, Y., Pedersen, N.L., Hagg, S., & Reynolds C. (2019). Loneliness and DNA methylation of variants in the conserved transcriptional response to adversity (CTRA) pathway. Behavior Genetics, 49, 532. abstract

    Reynolds, C., Tan, Q., Munoz, E., Jylhava, J., Hjelmborg, J., Christiansen, L., Hagg, S., & Pedersen, N.L. (2019). 10-year epigenetic change: Age-associated CpGs are differentially heritable. Behavior Genetics, 49, 527. abstract

    Zavala, C., Arpawong, T., & Prescott, C. (2019). You are only as old as you feel. Behavior Genetics, 49, 516. abstract

    Ericsson, M., Pedersen, N.L., Fors, S., Kuja-Halkola, R., Mosing, M., Li, X., Jylhava, J. & Dahl Aslan, A. (2019, May). Frailty and mortality: Investigating sex differences and socioeconomic influences using Swedish twins. Poster presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. poster

    Finkel, D. (2019, May). Longitudinal relationships between cognitive and functional aging. Paper presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. abstract

    Jylhava, J., Raymond, E., Reynolds, C., Finkel, D., Ericsson, M., Dahl Aslan, A., Hagg, S., & Pedersen, N. (2019, May). Drivers of frailty from adulthood into old age: Results from a 27-year longitudinal population-based study in Sweden. Paper presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. abstract

    Nyman, R., & Finkel, D. (2019, May). Living urban or rural in late adulthood: What is important and what is the difference? Poster presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. poster

    Pedersen, N.L. & Dahl Aslan, A. (2019, May). Gene-environment interplay to explain health heterogeneity: Results from the Swedish Twin Registry. Paper presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. abstract

    Pedersen J.K. & Christensen, K. (2019, May). Medication in the last years of life: A population-based comparison of two Danish birth cohorts ten years apart. Paper presented at the International Association of Gerontology and Geriatrics European Region Congress, Gothenburg, Sweden. abstract

    Gatz, M., Finch, B., Beam, C., & Thomas, K., for the IGEMS Consortium. (2018). Interplay of a country’s income inequality in childhood and adult depressive symptoms. Behavior Genetics, 48, 472. abstract PowerPoint Presentation

    Mosing, M., Dahlstrom, V., Lehto, K., & Pedersen, N.L., for the IGEMS Consortium. (2018). Associations between loneliness, social isolation and mortality in older twins: Familial confounding? Behavior Genetics, 48, 499. abstract

    Munoz, E., & Reynolds, C.A., for the IGEMS Consortium. (2018). Life event severity moderates genetic influences on cognitive function. Behavior Genetics, 48, 500. abstract

    Pahlen, S., & Reynolds, C.A., for the IGEMS Consortium. (2018). The relationship between smoking, years of education, and cognitive functioning in mid- and late-life: A co-twin control study. Behavior Genetics, 48, 504-505. abstract

    Foebel, A., Pedersen, N., & Bravell, M.E. (2017). Self-rated health over time: The role of chronic disease, physical function and social networks. Innovation in Aging, 1, 982. abstract

    Franz, C., Yao, A., Panizzon, M., & Kremen, W. (2017). Genetic and environmental influences on medical burden and subjective health in midlife. Innovation in Aging, 1, 982. abstract

    Finkel, D., for the IGEMS Consortium. (2017). Sex differences in longitudinal changes in genetic and environmental influences on subjective health. Innovation in Aging, 1, 982. abstract

    Mosing, M., & Pedersen, N. (2017). Can genetic variants underlying subjective well-being predict age-related health problems? Innovation in Aging, 1, 982. abstract

    Finkel, D., Reynolds, C., & Zavala, C., (2017). Age and sex moderation of genetic and environmental influences on a harmonized measure of financial stain: IGEMS. Behavior Genetics, 47, 687. abstract

    Finkel, D., & Zavala C., for the IGEMS Consortium. (2016). Sex differences in financial strain moderation of genetic influences on subjective health. The Gerontologist, 56(Suppl 3), 339. abstract

    Munoz, E., & Reynolds, C., for the IGEMS Consortium. (2016). The role of life events on cognitive function among older adults. The Gerontologist, 56(Suppl 3), 380-381. abstract

    Mosing, M., Cnattingius, S., Gatz, M., & Pedersen, N. (2016). Associations between adverse birth characteristics, cognitive dysfunction and dementia late in life. The Gerontologist, 56(Suppl 3), 386. abstract

    Phillips, D.M., & Reynolds, C.A., for the IGEMS Consortium. (2016). Exploring potential mechanisms for the association between loneliness and cognition. The Gerontologist, 56(Suppl 3), 534. abstract Poster

    Phillips, D.M., Petkus, A.J., Johnson, W., Franz, C., & Reynolds, C.A., for the IGEMS Consortium (2015). Exploring a potential role for education in the relation between loneliness and cognition. The Gerontologist, 55(Suppl 2), NP. abstract Poster

    Gatz, M., Petkus, A., Reynolds, C.A., Franz, C., Kaprio, J., & Christensen, K. for the IGEMS Consortium. (2015). Age moderation of individual differences in chronic medical illness burden. Behavior Genetics, 45, 657. abstract PowerPoint Presentation

    Mosing, M.A., Cnattingius, S., Gatz, M., Neiderhiser, J.M., & Pedersen, N.L. (2015). Associations between fetal growth and self-perceived health throughout adulthood: A co-twin control study. Behavior Genetics, 45, 675. abstract

    Horwitz, B.N., Marceau, K.P., & Neiderhiser, J.M. for the IGEMS Consortium. (2015). Genetic and environmental influences on marital quality: Examining age, country and construct differences. Behavior Genetics, 45, 675-676. abstract

    Phillips, D.M., Petkus, A., McGue, M., & Reynolds, C.A., for the IGEMS Consortium. (2015). Testing for age moderation of heritability of loneliness across adulthood. Behavior Genetics, 45, 679-680. abstract

    Vasilopoulos, T., Franz, C.E., Finkel, D., McGue, M., Kaprio, J., & Pedersen, N.L. for the IGEMS Consortium. (2015). Smoking moderates the importance of genetic and environmental influences on lung function. Behavior Genetics, 45, 691. abstract

    Petkus, A., Reynolds, C.A., Gatz, M., Wetherell, J., Kremen, W.S., & Pedersen, N.L. (2014). Anxiety and dementia in older Swedish twins. The Gerontologist, 54(S2), 588. abstract

    Reynolds, C.A. for the IGEMS consortium. (2014). Gene-environment interplay contributes to health, well-being and cognitive performance in mid to late adulthood. The Gerontologist, 54(S2) 647. abstract

    Zavala, C., Johnson, W., & Reynolds, C.A. for the IGEMS consortium. (2014). Socioeconomic status and age as moderators of cognitive performance. The Gerontologist, 54(S2) 647. abstract

    Petersen, I., Christensen, K., McGue, K., & Reynolds, C.A. for the IGEMS Consortium. (2014). Gene-by-environment interaction partly explains the hand grip strength levels as well as decline. The Gerontologist, 54(S2) 647. abstract PowerPoint Presentation

    Finkel, D., Franz, C.E., & Horwitz, B. for the IGEMS Consortium. (2014). Marital status moderates gender differences in genetic and environmental influences on subjective health. The Gerontologist, 54(S2) 647. abstract

    Finkel, D., Franz, C., Horwitz, B., & IGEMS Consortium. (2014). Gender and age differences in the impact of marital status on genetic and environmental influences on subjective health. Behavior Genetics, 44, 658. abstract

    Petersen, I., Christensen, K., McGue, M., Reynolds, C., & IGEMS consortium. (2014). Contribution of gene-by-environment interaction at baseline and change of hand grip strength. Behavior Genetics, 44, 677. abstract PowerPoint Presentation

    Reynolds, C. & IGEMS Consortium. (2014). MZ within pair tests of gene-environment interaction: Examinations of health, well-being and cognitive performance. Behavior Genetics, 44, 679. abstract

    Zavala, C., Johnson, W., Kremen, W., & Reynolds, C. (2014). Socioeconomic status moderates cognitive performance in older adults: Variation by country and sex. Behavior Genetics, 44, 689. abstract

    Finkel, D., Franz, C. E., & Horwitz, B. for the IGEMS Consortium. (2014, May). Gene by environment interactions impacting subjective health in the IGEMS sample. Nordic Congress of Gerontology, Gothenburg, Sweden.

    Reynolds, C.A. & Pedersen, N.L. (2014, May). Gene-environment dynamics contribute to cognitive and depressive symptom trajectories. Nordic Congress of Gerontology, Gothenburg, Sweden.

    Petersen, I., Pedersen, N.L., McGue, M., Christensen, K., & Reynolds, C.A. for the IGEMS Consortium. (2014, May). Longitudinal study of hand grip strength in a large sample of twins from USA, Sweden, and Denmark. Nordic Congress of Gerontology, Gothenburg, Sweden. PowerPoint Presentation

    Pahlen, S., McGue, M., Reynolds, C.A., & Kremen, W.S. for the IGEMS Consortium (2014, April). Age moderation of genetic and environmental influences on cognitive functioning across the life span: Findings from the Consortium on Interplay of Genes and Environment across Multiple Studies (IGEMS). Cognitive Aging Conference, Atlanta, GA.

    Gatz, M. for the IGEMS Consortium (2013). Harmonizing measures of depressive symptoms: the IGEMS consortium. Behavior Genetics, 43, 519. abstract PowerPoint Presentation

    Reynolds, C., & Pedersen, N. (2013). GxE contributions to cognitive aging: An MZ twin pair comparison. Behavior Genetics, 43, 537. abstract poster

    Johnson, W., Dahl, A., Pedersen, N., Christensen, K., Finkel, D., Gatz, M., Johansson, B., Lichtenstein, P., McGue, M., Neiderhiser, J., Reynolds, C., Hahn, C., Zavala, C., & Zhou, Y. (2012). Education moderates genetic and environmental influences on body mass index: Findings from the consortium on Interplay of Genes and Environment across Multiple Studies (IGEMS). The Gerontologist, 52(S1), 793. abstract poster

    Pedersen, N.L., Christensen, K., Dahl, A.K., Finkel, D., Franz, C.E., Gatz, M., Horwitz, B.N., Johansson, B., Johnson, W., Kremen, W.S., Lyons, M.J., Malmberg, B., McGue, M., Neiderhiser, J.M., Petersen, I., Reynolds, C.A., Dahl, A., Hahn, C., De Araujo-Held, M., Horwitz, B., Petersen, I., Zavala, C., & Zhou, Y. (2012). Gene–environment interplay in adult depression symptomatology: Initial findings from IGEMS. Behavior Genetics, 42, 926. abstract poster

Resource Sharing

  • Script for the univariate age moderation models with qualitative and quantitative sex limitation

    Script for bivariate depressive symptoms and CIRS with age and CIRS moderation for men

    Script for bivariate depressive symptoms and CIRS with age and CIRS moderation for women

  • Script for IGEMS bivariate education moderation and sex differences

    Script for univmodplots by age linear

    Script for univmodplots by education

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