MCB Faculty

Bob Baker

Professor of Biological Sciences

Contact Information
E-mail: baker@usc.edu
Phone: (213) 740-5565
Office: RRI 104A

 

Education

  • Ph.D. Molecular Biology, Brown University
  • B.S. Chemistry, Stanford University


  • Postdoctoral Training

    • Postdoctoral Fellow, Stanford University, 1966-1968  

    Academic Appointment, Affiliation, and Employment History

    • Visiting Associate Professor, Harvard Medical School, 1975-1976  

    Description of Research

    Summary Statement of Research Interests
    Professor Baker studies the manner in which protein monomers participate in protein-protein and protein-nucleic acid interactions. Modifications of monomers that affect shape and charge of the surfaces of proteins are being investigated. Of particular interest are modifications of protein monomers (resulting from changes at the gene level, pre-mRNA splicing alternatives, small molecule-protein interactions and post-translational additions to and cleavage of the folded polypeptide chain) that affect the specificity and affinity of folded polypeptide chains for other proteins and nucleic acids that interact with the monomer. Monomer modifications that result in disease states such as cancer are of special interest. Methods used in this research include computational analyses of protein and nucleic acid sequences in data banks.
    Research Keywords
    cancer, protein, folding, protein-protein interactions, protein-nucleic acid interactions, monomers
    Research Specialties
    Cancer Biology, Signal Transduction and Gene Regulation, Structural Biology





  • Department of Biological Sciences
  • University of Southern California
  • Allan Hancock Foundation Building
  • Los Angeles, CA 90089-0371