Research & Practice Areas
Cancer Biology, Signal Transduction and Gene Regulation, Structural Biology
- Ph.D. Molecular Biology, Brown University
- B.S. Chemistry, Stanford University
- Postdoctoral Fellow, Stanford University, 1966-1968
Visiting and Temporary Appointments
- Visiting Associate Professor, Harvard Medical School, 1975-1976
Summary Statement of Research Interests
Professor Baker studies the manner in which protein monomers participate in protein-protein and protein-nucleic acid interactions. Modifications of monomers that affect shape and charge of the surfaces of proteins are being investigated. Of particular interest are modifications of protein monomers (resulting from changes at the gene level, pre-mRNA splicing alternatives, small molecule-protein interactions and post-translational additions to and cleavage of the folded polypeptide chain) that affect the specificity and affinity of folded polypeptide chains for other proteins and nucleic acids that interact with the monomer.
Monomer modifications that result in disease states such as cancer are of special interest. Methods used in this research include computational analyses of protein and nucleic acid sequences in data banks.
cancer, protein, folding, protein-protein interactions, protein-nucleic acid interactions, monomers