HEB Faculty

Scott Kanoski

Assistant Professor of Biological Sciences

Contact Information
E-mail: kanoski@usc.edu
Phone: (213) 740-2495
Office: PED 107

LINKS
Personal Website
 

Education

  • B.S. Psychology, University of Illinois at Urbana-Champaign, 5/2000
  • M.S. Psychology, Purdue University, 5/2006
  • Ph.D. Psychology / Behavioral Neuroscience, Purdue University, 8/2009


  • Postdoctoral Training

    • Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  

    Academic Appointment, Affiliation, and Employment History

    Tenure Track Appointments
    • Assistant Professor, University of Southern California, 01/01/2013-  

    PostDoctoral Appointments
    • Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  

    Description of Research

    Summary Statement of Research Interests
    Dr. Kanoski’s research focuses on the neurobiological control of food intake and body weight regulation. More specifically his laboratory focuses on understanding how the brain processes peripherally- and centrally-derived hormonal signals to control learned and motivated aspects of feeding behavior, as well as to examine how these neuroendocrine signaling systems contribute to and are compromised by obesity and related metabolic disorders. At the center of this research is the hippocampus; a brain region traditionally linked with memory function, but more recently shown to control higher-order aspects of feeding behavior. The lab also focuses on exploring the relationship between consuming saturated fatty acids and refined carbohydrates (i.e., "Western diets") and the development of hippocampal dysfunction, cognitive impairment, and Alzheimer's pathology.
    Research Specialties
    Behavioral Neuroscience, Ingestive Behavior, Energy Balance, Neuroendocrinology, Learning & Memory, Systems Neuroscience

    Affiliations with Research Centers, Labs, and Other Institutions

    • USC Diabetes and Obesity Research Institute (DORI), Faculty Member
    • USC Neuroscience Graduate Program (NGP), Faculty Member

    Conferences and Other Presentations


    Conference Presentations
    • "How do glucagon-like peptide-1 ligands reduce food intake and body weight (1st author)", The University of Southern California Diabetes and Obesity Research Institute (DORI) (Annual Symposi, Talk/Oral Presentation, Abstract, Los Angeles, CA, Invited, Spring 2014   
    • "Reduction of food intake via glucagon-like peptide-1 receptor signaling in the ventral hippocampus (senior author)", The University of Southern California Neuroscience Graduate Program (Annual Symposium), Poster, Abstract, Los Angeles, CA, Spring 2014   
    • "A novel role for PTP1B in BDNF/TrkB signaling in the context of metabolism (2nd author)", The Society for Neuroscience (Annual Meeting), Poster, Refereed Abstract, San Diego, CA, Fall 2013   
    • "The hippocampus: the hypothalamus of the telencephalon (1st author)", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Atlanta, GA, Invited, Fall 2013   
    • "Appetite and satiation: distinct or common neural and biochemical substrates? (1st author)", The Benjamin Franklin Lafayette Seminar, Talk/Oral Presentation, Abstract, Frejus, France, Invited, Spring 2013   
    • "Leptin signaling in the nucleus tractus solitarius suppresses motivation to obtain rewarding food (1st author; Ethan Sims award winner)", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, San Antonio, TX, Fall 2012   
    • "Western diets and cognitive impairment: neuronal and psychological mechanisms (1st author)", American Psychological Association (Annual Meeting), Talk/Oral Presentation, Orlando, FL, Invited, Fall 2012   
    • "Ghrelin signaling in the hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling (1st author)", The Institute for Diabetes, Obesity, and Metabolism (Annual symposium), Poster, Philadelphia, PA, Spring 2012   
    • "Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Zurich, Switzerland, Spring 2012   
    • "How your gut tells your brain you have eaten enough: role for glucagon-like peptide-1 (1st author)", American Pediatric Society (Annual Meeting), Talk/Oral Presentation, Abstract, Boston, MA, Invited, Spring 2012   
    • "Leptin signaling in the nucleus tractus solitarius suppresses motivation to obtain rewarding food (2nd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Poster, Refereed Abstract, Zurich, Switzerland, Spring 2012   
    • "The control of food intake by NTS leptin receptor-expressing neurons may involve monosynaptic communication with hypothalamic and mesolimbic nuclei (2nd author)", The Institute for Diabetes, Obesity, and Metabolism (Annual symposium), Poster, Philadelphia, PA, Spring 2012   
    • "The control of food intakeby NTS leptin receptor-expressing neurons may involve communication with reward-related brain nuclei (2nd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Zurich, Switzerland, Spring 2012   
    • "Body weight and food intake suppression by glucagon-like peptide-1 receptor agonists, exendin-4 and liraglutide, may require nausea and aversion (1st author)", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Orlando, FL, Fall 2011   
    • "Vagal and brain GLP-1 receptor populations mediate the hypophagic effects of peripheral GLP-1 receptor agonists (1st author)", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Orlando, FL, Fall 2011   
    • "Body weight and food intake suppression by glucagon-like peptide-1 receptor agonists, exendin-4 and liraglutide, may require nausea and malaise (1st author)", The Institute for Diabetes, Obesity, and Metabolism (Annual symposium), Poster, Spring 2011   
    • "Glucagon-like peptide-1 receptor agonists suppress water intake (2nd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Poster, Refereed Abstract, Clearwater, FL, Spring 2011   
    • "Neurohormonal and dietary influences on hippocampal-dependent inhibitory controls of food intake (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Clearwater, FL, Invited, Spring 2011   
    • "NTS leptin signaling contributes to meal size control and suppression of food intake by intestinally-derived satiation signals (2nd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Poster, Refereed Abstract, Clearwater, FL, Spring 2011   
    • "POMC-PTP1B-/- mice show increased sensitivity to hindbrain MTII-induced reductions of food intake (3rd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Poster, Refereed Abstract, Clearwater, FL, Spring 2011   
    • "Comparative effects of the DPP-IV-resistant GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression (1st author)", The Society for Neuroscience (Annual Meeting), Poster, Refereed Abstract, San Diego, CA, Fall 2010   
    • "Endogenous leptin signaling in the nucleus tractus solitarius, not the area postrema, is required for energy balance regulation (3rd author)", The Society for Neuroscience (Annual Meeting), Poster, Refereed Abstract, San Diego, CA, Fall 2010   
    • "Anorectic effects of the DPP-IV-resistant GLP-1 receptor ligands, liraglutide and exendin-4, in rats (1st author)", Institute for Diabetes, Obesity, and Metabolism (Gastrointestinal Surgery Retreat), Poster, Philadelphia, PA, Spring 2010   
    • "Hindbrain leptin and glucagon-like peptide-1 receptor signaling interact in control of food intake (3rd author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Pittsburg, PA, Spring 2010   
    • "Hippocampal leptin signaling reduces food intake and body weight and influences appetitive spatial memory (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Pittsburg, PA, Spring 2010   
    • "Hippocampal leptin signaling reduces food intake and body weight and influences spatial memory in rats (1st author)", The Institute for Diabetes, Obesity, and Metabolism (Annual symposium), Poster, Philadelphia, PA, Spring 2010   
    • "The impact of Western diet intake on memory and blood-brain barrier integrity in rats (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Portland, OR, Spring 2009   
    • "The effects of high-energy diets on modulatory learning processes (1st author; G.P. Smith award winner)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Paris, France, Spring 2008   
    • "Interoceptive signals and postingestive consequences produced by regulatory peptides (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Steamboat Springs, CO, Spring 2007   
    • "Interoceptive signals and postingestive properties of CCK, leptin, and ghrelin (1st author)", Tri-State Conference on Animal Learning (Annual Meeting), Talk/Oral Presentation, West Lafayette, IN, Spring 2007   
    • "Hippocampus and the inhibition of food intake and body weight gain (1st author)", Tri-State Conference on Animal Learning (Annual Meeting), Talk/Oral Presentation, Windsor, Canada, Spring 2006   
    • "The impact of high-fat diets on hippocampal-dependent learning processes (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Naples, FL, Spring 2006   
    • "Leptin and cholecystokinin combine to reduce intake and produce a satiety cue (1st author)", The Society for Neuroscience (Annual Meeting), Poster, Refereed Abstract, Washington, D.C., Fall 2005   
    • "The hippocampus and energy regulation (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Pittsburg, PA, Spring 2005   
    • "A role for the hippocampus in the inhibitory control of food intake and body weight (2nd author)", The Society for Neuroscience (Annual Meeting), Poster, Abstract, San Diego, CA, Fall 2004   
    • "Role for ghrelin as an interoceptive discriminative cue (1st author)", The Society for the Study of Ingestive Behavior (Annual Meeting), Poster, Refereed Abstract, Cincinnati, OH, Spring 2004   

    Other Presentations
    • "GLP-1 and food intake reduction: nausea, reward, and the hippocampus", Seminar: The University of Pennsylvania Center for Weight and Eating Disorders, Philadelphia, PA, Spring 2014   
    • "The higher-order control of feeding behavior", Seminar: Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, Spring 2014   
    • "The hippocampus and food intake cotnrol", Seminar: Bucknell University, Dept. of Psychology, Lewisburg, PA, Spring 2014   
    • "Neuroendocrine control of "higher-order" aspects of feeding", Seminar: The University of Pennsylvania, Department of Psychology, Behavioral Neuroscience, Philadelphia, PA, Spring 2012   
    • "Ghrelin modulates feeding via signaling in the hippocampus", Seminar: The University of Pennsylvania, Neuroscience of Obesity, Philadelphia, PA, Fall 2011   
    • "Role for hippocampal leptin signaling in appetitive behavior", Seminar: The University of Pennsylvania, Department of Psychology, Behavioral Neuroscience, Philadelphia, PA, Fall 2010   
    • "Melanocortin-4 receptor modulation of vagal satiation signals", Seminar: The University of Pennsylvania, Neuroscience of Obesity, Philadelphia, PA, Fall 2009   
    • "High fat diets impair learning and alter BDNF", Seminar: Purdue University, Department of Psychology, West Lafayette, IN, Fall 2008   

    Publications


    Book Chapter
    • Kanoski, S. E., Hsu, T., Pennell, S. (2014). Obesity, Western diet intake, and cognitive impairment. Fat and Fatty Acids: Brain and Neurological Health (Elsevier).
    • Davidson, T. L., Sample, C. H., Kanoski, S. E. (2013). Western diet and cognitive impairment. Diet and Nutrition: Dementia and Cognitive Decline (Elsevier).
    • Kanoski, S. E. (2012). Working memory and diet. Working Memory: The Connected Intelligence (Psychology Press / Taylor & Francis).

    Journal Article
    • Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., Kanoski, S. E. (2014). Hippocampal GLP-1 receptors influence food intake and effort-based responding for food through volume transmission. Neuropsychopharmacology. PubMed Web Address
    • Hsu, T., Kanoski, S. E. (2014). Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Frontiers in Aging Neuroscience. Vol. 6 (88) PubMed Web Address
    • Kanoski, S. E., Alhadeff, A. L., Fortin, S. F., Gilbert, J. R., Grill, H. J. (2014). Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food. Neuropsychopharmacology. Vol. 39 (3), pp. 605-613. PubMed Web Address
    • Hayes, M. R., Mietlicki-Baase, E. G., Kanoski, S. E., De Jonghe, B. C. (2014). Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose. Nutrition Reviews. Vol. IN PRESS
    • Kanoski, S. E., Fortin, S. M., Ricks, K. M., Grill, H. J. (2013). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biological psychiatry. Vol. 73 (9), pp. 915-23. PubMed Web Address
    • Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R. J., Yan, J., De Jonghe, B. C., Bence, K. K., Hayes, M. R., Grill, H. J. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism. Vol. 303 (4), pp. E496-503. PubMed Web Address
    • De Jonghe, B. C., Hayes, M. R., Kanoski, S. E., Zimmer, D. J., Grill, H. J., Bence, K. K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism. PubMed Web Address
    • Kanoski, S. E. (2012). Cognitive and neuronal systems underlying obesity. Physiology & behavior. Vol. 106 (3), pp. 337-44. PubMed Web Address
    • Spaeth, A. M., Kanoski, S. E., Hayes, M. R., Grill, H. J. (2012). TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. American journal of physiology. Endocrinology and metabolism. Vol. 302 (10), pp. E1252-60. PubMed Web Address
    • Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., Hayes, M. R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology. Vol. 62 (5-6), pp. 1916-27. PubMed Web Address
    • Zhao, S., Kanoski, S. E., Yan, J., Grill, H. J., Hayes, M. R. (2012). Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. International Journal of Obesity. PubMed Web Address
    • McKay, N. J., Kanoski, S. E., Hayes, M. R., Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (6), pp. R1755-64. PubMed Web Address
    • Hayes, M. R., Kanoski, S. E., De, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (5), pp. R1479-85. PubMed Web Address
    • Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., Hayes, M. R. (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. Vol. 152 (8), pp. 3103-12. PubMed Web Address
    • Kanoski, S. E., Hayes, M. R., Greenwald, H. S., Fortin, S. M., Gianessi, C. A., Gilbert, J. R., Grill, H. J. (2011). Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Vol. 36 (9), pp. 1859-70. PubMed Web Address
    • Hayes, M. R., Kanoski, S. E., Alhadeff, A. L., Grill, H. J. (2011). Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity (Silver Spring, Md.). Vol. 19 (7), pp. 1342-9. PubMed Web Address
    • De Jonghe, B. C., Hayes, M. R., Banno, R., Skibicka, K. P., Zimmer, D. J., Bowen, K. A., Leichner, T. M., Alhadeff, A. L., Kanoski, S. E., Cyr, N. E., Nillni, E. A., Grill, H. J., Bence, K. K. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism. Vol. 300 (6), pp. E1002-11. PubMed Web Address
    • Kanoski, S. E., Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & behavior. Vol. 103 (1), pp. 59-68. PubMed Web Address
    • Hayes, M. R., Leichner, T. M., Zhao, S., Lee, G. S., Chowansky, A., Zimmer, D., De, B. C., Kanoski, S. E., Grill, H. J., Bence, K. K. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism. Vol. 13 (3), pp. 320-30. PubMed Web Address
    • Hayes, M. R., Valmer, J., De Jonghe, B. C., Kanoski, S. E. (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior. Vol. 100 (5), pp. 503-10. PubMed Web Address
    • Kanoski, S. E., Davidson, T. L. (2010). Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. Journal of experimental psychology. Animal behavior processes. Vol. 36 (2), pp. 313-9. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Chan, K., Clegg, D. J., Benoit, S. C., Jarrard, L. E. (2010). Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral neuroscience. Vol. 124 (1), pp. 97-105. PubMed Web Address
    • Kanoski, S. E., Zhang, Y., Zheng, W., Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer's disease : JAD. Vol. 21 (1), pp. 207-19. PubMed Web Address
    • Davidson, T. L., Chan, K., Jarrard, L. E., Kanoski, S. E., Clegg, D. J., Benoit, S. C. (2009). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Vol. 19 (3), pp. 235-52. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight regulation. Current opinion in pharmacology. Vol. 7 (6), pp. 613-6. PubMed Web Address
    • Kanoski, S. E., Meisel, R. L., Mullins, A. J., Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. Vol. 182 (1), pp. 57-66. PubMed Web Address
    • Kanoski, S. E., Walls, E. K., Davidson, T. L. (2007). Interoceptive "satiety" signals produced by leptin and CCK. Peptides. Vol. 28 (5), pp. 988-1002. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Walls, E. K., Jarrard, L. E. (2005). Memory inhibition and energy regulation. Physiology & behavior. Vol. 86 (5), pp. 731-46. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Tracy, A. L., Walls, E. K., Clegg, D., Benoit, S. C. (2005). The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. Vol. 26 (9), pp. 1602-10. PubMed Web Address

    Guest Lectures in Courses

    • Neuroscience 599: The neural controls of learning and memory, Spring 2013   
    • Health Promotion 200: The regulation of food intake, Spring 2013   

    New Courses Developed

    • HBIO 435: The Neurobiology of Feeding Behavior and Obesity, Biological Sciences, Fall 2014   

    Honors and Awards

    • National Research Service Award (NIDDK), 2010-2013  
    • Ethan Sims Young Investigator Award - Finalist Winner (The Obesity Society), Fall 2012   
    • Pat Simmons Travel Award (The Obesity Society), Fall 2012   
    • New Investigator Travel Award (Society for the Study of Ingestive Behavior), Spring 2012   
    • Early Career Research Grant (The Obesity Society), 2010-2011   
    • Bilsland Fellowship, 2008-2009   
    • Gerry P. Smith Award (Society for the Study of Ingestive Behavior), 2008-2009   
    • New Investigator Travel Award (Society for the Study of Ingestive Behavior), Spring 2008   

    Service to the University

    Committees
    • Member, Neuroscience Graduate Program: Admissions Committee, 2013-2014   
    Other Service to the University
    • Neuroscience Graduate Program, Annual Symposium: Faculty Poster Judge, Spring 2014   

    Service to the Profession


    Editorships and Editorial Boards
    • Associate Editor, Journal of Alzheimer's Disease, 2011-2012   

    Professional Memberships
    • The Obesity Society, 2010-  
    • The Society for Neuroscience (SFN), 2004-  
    • The Society for the Study of Ingestive Behavior, 2004-  

    Other Service to the Profession
    • Reviewer for Biotechnology and Biological Sciences Research Council (BBSRC), United Kingdom, 12/01/2012-  
    • Scientific Review Committee Member (The Obesity Society), 2012-  
    • Program Committee Member: Society for the Study of Ingestive Behavior, 06/01/2013-05/31/2015  
    • Abstract Rater (The Obesity Society: Annual Conference), 03/01/2012-03/01/2014  
    • Oral Symposium Chair (Society for the Study of Ingestive Behavior: Annual Conference), Fall 2013   
    • Oral Symposium Chair (The Obesity Society: Annual Conference), Spring 2012   


  • Department of Biological Sciences
  • University of Southern California
  • Allan Hancock Foundation Building
  • Los Angeles, CA 90089-0371