HEB Faculty


Scott Kanoski

Assistant Professor of Biological Sciences

Contact Information
E-mail: kanoski@usc.edu
Phone: (213) 740-2495
Office: PED 107

LINKS
Personal Website
 

Education

  • B.S. Psychology, University of Illinois at Urbana-Champaign, 5/2000
  • M.S. Psychology, Purdue University, 5/2006
  • Ph.D. Psychology / Behavioral Neuroscience, Purdue University, 8/2009


  • Postdoctoral Training

    • Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  

    Academic Appointment, Affiliation, and Employment History

    Tenure Track Appointments
    • Assistant Professor, University of Southern California, 01/01/2013-  

    PostDoctoral Appointments
    • Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  

    Description of Research

    Summary Statement of Research Interests
    Dr. Kanoski’s research focuses on the neurobiological control of food intake and body weight regulation. More specifically his laboratory focuses on understanding how the brain processes peripherally- and centrally-derived hormonal signals to control learned and motivated aspects of feeding behavior, as well as to examine how these neuroendocrine signaling systems contribute to and are compromised by obesity and related metabolic disorders. At the center of this research is the hippocampus; a brain region traditionally linked with memory function, but more recently shown to control higher-order aspects of feeding behavior. The lab also focuses on exploring the relationship between consuming saturated fatty acids and refined carbohydrates (i.e., "Western diets") and the development of hippocampal dysfunction, cognitive impairment, and Alzheimer's pathology.
    Research Specialties
    Behavioral Neuroscience, Ingestive Behavior, Energy Balance, Neuroendocrinology, Learning & Memory, Systems Neuroscience

    Affiliations with Research Centers, Labs, and Other Institutions

    • Integrative and Evolutionary Biology Graduate Program, Faculty Member, https://dornsife.usc.edu/bisc/heb-graduate-studies/
    • Society for Neuroscience, Faculty Member, http://www.sfn.org/
    • Society for the Study of Ingestive Behavior, Faculty Member, http://www.ssib.org/web/
    • The Obesity Society, Faculty Member, http://www.obesity.org/
    • USC Diabetes and Obesity Research Institute (DORI), Faculty Member, http://usc-dori.org/
    • USC Neuroscience Graduate Program (NGP), Faculty Member, https://ngp.usc.edu/

    Publications


    Book Chapter
    • Davidson, T. L., Sample, C. H., Kanoski, S. E. (2014). Western diet and cognitive impairment. Diet and Nutrition: Dementia and Cognitive Decline (Elsevier).
    • Kanoski, S. E., Hsu, T., Pennell, S. (2014). Obesity, Western diet intake, and cognitive impairment. Fat and Fatty Acids: Brain and Neurological Health (Elsevier).
    • Kanoski, S. E. (2012). Working memory and diet. Working Memory: The Connected Intelligence (Psychology Press / Taylor & Francis).

    Journal Article
    • Kanoski, S. E., Ong, Z., Fortin, S. M., Schlessinger, E., Grill, H. J. (2015). Liraglutide, leptin, and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanisms. Diabetes, Obesity and Metabolism. Vol. 17 (3), pp. 285-93. PubMed Web Address
    • Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., Kanoski, S. E. (2015). Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus. PubMed Web Address
    • Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., Kanoski, S. E. (2015). Hippocampal GLP-1 receptors influence food intake and effort-based responding for food through volume transmission. Neuropsychopharmacology. PubMed Web Address
    • Ozek, C., Kanoski, S. E., Zhang, Z., Grill, H. J., Bence, K. K. (2014). Protein tyrosine phosphatase 1B is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B signaling. Journal of Biological Chemistry. Vol. 289 (46), pp. 31682-92. PubMed Web Address
    • Hsu, T., Kanoski, S. E. (2014). Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Frontiers in Aging Neuroscience. Vol. 6 (88) PubMed Web Address
    • Kanoski, S. E., Alhadeff, A. L., Fortin, S. F., Gilbert, J. R., Grill, H. J. (2014). Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food. Neuropsychopharmacology. Vol. 39 (3), pp. 605-613. PubMed Web Address
    • Hayes, M. R., Mietlicki-Baase, E. G., Kanoski, S. E., De Jonghe, B. C. (2014). Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose. Nutrition Reviews. Vol. IN PRESS
    • Kanoski, S. E., Fortin, S. M., Ricks, K. M., Grill, H. J. (2013). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biological psychiatry. Vol. 73 (9), pp. 915-23. PubMed Web Address
    • Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R. J., Yan, J., De Jonghe, B. C., Bence, K. K., Hayes, M. R., Grill, H. J. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism. Vol. 303 (4), pp. E496-503. PubMed Web Address
    • De Jonghe, B. C., Hayes, M. R., Kanoski, S. E., Zimmer, D. J., Grill, H. J., Bence, K. K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism. PubMed Web Address
    • Kanoski, S. E. (2012). Cognitive and neuronal systems underlying obesity. Physiology & behavior. Vol. 106 (3), pp. 337-44. PubMed Web Address
    • Spaeth, A. M., Kanoski, S. E., Hayes, M. R., Grill, H. J. (2012). TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. American journal of physiology. Endocrinology and metabolism. Vol. 302 (10), pp. E1252-60. PubMed Web Address
    • Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., Hayes, M. R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology. Vol. 62 (5-6), pp. 1916-27. PubMed Web Address
    • Zhao, S., Kanoski, S. E., Yan, J., Grill, H. J., Hayes, M. R. (2012). Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. International Journal of Obesity. PubMed Web Address
    • McKay, N. J., Kanoski, S. E., Hayes, M. R., Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (6), pp. R1755-64. PubMed Web Address
    • Hayes, M. R., Kanoski, S. E., De, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (5), pp. R1479-85. PubMed Web Address
    • Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., Hayes, M. R. (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. Vol. 152 (8), pp. 3103-12. PubMed Web Address
    • Kanoski, S. E., Hayes, M. R., Greenwald, H. S., Fortin, S. M., Gianessi, C. A., Gilbert, J. R., Grill, H. J. (2011). Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Vol. 36 (9), pp. 1859-70. PubMed Web Address
    • Hayes, M. R., Kanoski, S. E., Alhadeff, A. L., Grill, H. J. (2011). Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity (Silver Spring, Md.). Vol. 19 (7), pp. 1342-9. PubMed Web Address
    • De Jonghe, B. C., Hayes, M. R., Banno, R., Skibicka, K. P., Zimmer, D. J., Bowen, K. A., Leichner, T. M., Alhadeff, A. L., Kanoski, S. E., Cyr, N. E., Nillni, E. A., Grill, H. J., Bence, K. K. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism. Vol. 300 (6), pp. E1002-11. PubMed Web Address
    • Kanoski, S. E., Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & behavior. Vol. 103 (1), pp. 59-68. PubMed Web Address
    • Hayes, M. R., Leichner, T. M., Zhao, S., Lee, G. S., Chowansky, A., Zimmer, D., De, B. C., Kanoski, S. E., Grill, H. J., Bence, K. K. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism. Vol. 13 (3), pp. 320-30. PubMed Web Address
    • Hayes, M. R., Valmer, J., De Jonghe, B. C., Kanoski, S. E. (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior. Vol. 100 (5), pp. 503-10. PubMed Web Address
    • Kanoski, S. E., Davidson, T. L. (2010). Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. Journal of experimental psychology. Animal behavior processes. Vol. 36 (2), pp. 313-9. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Chan, K., Clegg, D. J., Benoit, S. C., Jarrard, L. E. (2010). Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral neuroscience. Vol. 124 (1), pp. 97-105. PubMed Web Address
    • Kanoski, S. E., Zhang, Y., Zheng, W., Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer's disease : JAD. Vol. 21 (1), pp. 207-19. PubMed Web Address
    • Davidson, T. L., Chan, K., Jarrard, L. E., Kanoski, S. E., Clegg, D. J., Benoit, S. C. (2009). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Vol. 19 (3), pp. 235-52. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight regulation. Current opinion in pharmacology. Vol. 7 (6), pp. 613-6. PubMed Web Address
    • Kanoski, S. E., Meisel, R. L., Mullins, A. J., Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. Vol. 182 (1), pp. 57-66. PubMed Web Address
    • Kanoski, S. E., Walls, E. K., Davidson, T. L. (2007). Interoceptive "satiety" signals produced by leptin and CCK. Peptides. Vol. 28 (5), pp. 988-1002. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Walls, E. K., Jarrard, L. E. (2005). Memory inhibition and energy regulation. Physiology & behavior. Vol. 86 (5), pp. 731-46. PubMed Web Address
    • Davidson, T. L., Kanoski, S. E., Tracy, A. L., Walls, E. K., Clegg, D., Benoit, S. C. (2005). The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. Vol. 26 (9), pp. 1602-10. PubMed Web Address





  • Department of Biological Sciences
  • University of Southern California
  • Allan Hancock Foundation Building
  • Los Angeles, CA 90089-0371