To address “impossible” health challenges that have long eluded conventional approaches, the University of Southern California’s Dornsife College of Letters, Arts and Sciences has established The Bridge@USC. This initiative brings together some of the most creative minds in chemistry, biology, medicine, mathematics, engineering, physics and nanosciences — as well as experts in such areas as animation and cinematography — to build the first atomic resolution structure of man.
Development of this dynamic model will accelerate the creation and implementation of novel therapies and cures for a host of intractable diseases and conditions.
This initiative brings together some of the most creative minds in disciplines across the university - to build the first atomic resolution structure of man. Video by Mira Zimet and Matt Meindl
One of the missions of the Bridge@USC is to train the next generation of scientists. Video by Mira Zimet and Matt Meindl
NCI Biomedical Informatics Program, the Health Datapalooza 2016 was focused on "Collaborating Against Cancer: Inter-Agency Pilots". The Kuhn-Hicks Lab is proud to participate in two innovative inter-agency pilots - Big Data Scientist Training Enhancement Program (BD-STEP) and Analytic Tool for the Objective Monitoring of Human Performance (ATOM-HP) MORE >>
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421. Emily Liman - "Taste Transduction: Molecules and Mechanisms". See Full List of Seminars >>
Congratulations to Michael Morikado, recipient of Provost's Summer Undergrad Research Fellowship! We’re are very proud of our undergraduate students and look forward to a productive summer of research!
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421. Valery Fokin - "Chemical Tools for Studying Biological Complexity". See Full List of Seminars >>
Congratulations to our students Joseph Bae and Serena Zheng, recipients of the Summer 2016 Rose Hills Science and Engineering Fellowship! This fellowship will support their full-time research in science at the Kuhn-Hicks Laboratory.
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421. Andrea Armani - "Portable Diagnostics". See Full List of Seminars >>
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421. Myron Goodman - "Better Living with Hyper-Mutation". See Full List of Seminars >>
Congratulations to Ariel Wein for receiving an Honorable Mention in the National Science Foundation Graduate Research Fellowship Program.
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421. Richard Roberts - "Targeting Proteins Via mRNA Display". See Full List of Seminars >>
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421 Andrew Hires - "Reverse-Engineering the Sense of Touch". See Full List of Seminars >>
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421 Don Arnold - "Changes in Synapses During Memory Formation". See Full List of Seminars >>
Junior Faculty Candidate Mini-Symposium, Broad CIRM Center, First Floor Seminar Room 1425, San Pablo Street, Los Angeles, CA 90033
USC Convergent Faculty Luncheon Seminar Series 2016, Wednesday’s from 12:00pm-1:00pm at RRI 421 Mark Humayun - "Interdisciplinary Medical and Engineering Approaches for Ophthalmology" See Full List of Seminars >>
Short documentary Frontline Scholar video on Sophie Wix, Bridge@USC student, by Mira Zimet. Watch it on YouTube >>
The Bridge@USC Brochure has received a Grand Gold in the 2016 Council for the Advancement and Support of Education District VII Awards of Excellence Competition. MORE ABOUT >>
Ray Stevens was elected to the Norwegian Academy of Science and Letters.
The 1st Annual daVinci Convergence Symposium: A Scientific Summit on Imaging Across the Scales, hosted by Bridge@USC at Annenberg Community Beach House, Santa Monica, CA, USA,
For more information and registration please contact Angela Walker: email@example.com
Symposium Program >>
Congratulations to winners of fellowships: Alfred Raisters Graduate Fellowship: Evan Tedlock (School of Cinematic Arts), Kyle McClary (Bridge@USC) and Nil Patel (Bridge@USC);
Weike Zhang Postdoctoral Fellowship: Dr. Kate White (Bridge@USC);
Bridge@USC Catalyst Grant:
Dr. Art Toga (Keck School of Medicine), Dr. Rosa DiFelice (Dornsife School of Letters, Arts, & Sciences), Richard Weinberg (School of Cinematic Arts), and Dr. Rich Roberts (Viterbi School of Engineering), Dr. Remo Rohs (Dornsife School of Letters, Arts, & Sciences), Dr. Le Trinh (Dornsife School of Letters, Arts, & Sciences)
USC SCIENCE FILM COMPETITION Meet & Greet event at 6:00 P.M. on Tuesday, February 9th in DML 233
USC Stem Cell Distinguished Speakers Series, 11am – 12 pm, Broad CIRM Center, First Floor Seminar Room, Pr. Raymond Stevens will give a talk “Structure and Drug Discovery of the G-protein Coupled Receptor Superfamily”
ChemBio Seminar Series, 12:30pm in Seaver Science Auditorium (SSL):
Dr. Vsevolod (Seva) Katritch,
Department of Biological Sciences, Section of Molecular and Computational Biology, University of Southern California.
Title: "Computational Modeling of GPCRs: Understanding Receptor Signaling for Biology and Drug Discovery"
Global Conference 2015, Grand Hyatt Shanghai · Shanghai, China MORE >>
The work entitled
"Spatiotemporal progression of metastatic breast cancer: a Markov chain model highlighting the role of early metastatic sites" by Paul K. Newton and colleagues is the featured article in the last edition of npj Breast Cancer. Read the full article at >>
Congratulations to THE Bridge UnderGraduate Science (BUGS) students, three of whom received the Fall 2015 Provost’s Research Fellowship and one who received the Dornsife Fall 2015 SOAR Fellowship.
Joseph Bae, Sophie Wix and Serena Zheng (PRF recipients) spent the summer in Peter Kuhn’s laboratory investigating and understanding the fluid phase of solid tumors. Tiffany Lian (SOAR recipient) worked in Ray Stevens’ laboratory on biochemical and structural characterization of the “Venus fly trap” domain of the TAS1R subfamily of taste receptors. These energetic students took full advantage of the opportunity to engage in cross-disciplinary research toward the ultimate assembly of an atomic resolution model of man as part of the Bridge@USC initiative. Check out this video >>
Watch the Michelson building construction progress. MORE >>
Bridge@USC Faculty Listed Among Highly Cited Researchers
A number of faculty members at the Bridge@USC have been named among the Thomson Reuters 2015 Highly Cited Researchers, an annual list recognizing leading researchers in the sciences and social sciences from around the world. They include:
According to Thomson Reuters, highly cited papers rank in the top one percent by citations in their subject field and publication year (from 2003 to 2013) in the Web of Science Core Collection, a leading global citation database. MORE >>
Disruptive Science -
article about Bridge @ USC
is published in USC News,
With six high-profile papers published in the past seven months, biochemists in The Bridge@USC are poised to disrupt the future of pharmaceutical development and enable the advancement of personalized medicine. MORE >>
Los Angeles and Shanghai - GPCR Consortium Exceeds Goal with Addition of Four New Pharma Members
Academia and Industry Members Helping to Advance Structure-Function Database of G-protein Coupled Receptors for Drug Discovery MORE >>
Workshop "Quantifying Human Performance To Optimize Patient Outcomes" (The Bridge@USC). This program is a joint effort of the National Cancer Institute’s Center for Strategic Initiatives and the Department of Defense’s Rapid Response Technology Office. It is aimed at improving the lives of cancer patients undergoing treatment and the successful mission completion/survival of warfighters. Both the patient and the warfighter suffer from treatment/duty-induced fatigue that impairs their ability to survive/perform. While the sources of the fatigue might be different, the measurement approaches might be similar. The goal of this workshop is to bring together intellectual competencies from around USC and our collaborating institutions to frame the problem and look at paths for solutions that can effect outcomes for patients undergoing treatment.
Bridge UnderGraduate Science (BUGS) Program Kicks Off! MORE >>
Conformational states of the full-length glucagon receptor is published in Nature Communications MORE >>
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser is published in Nature
Layer By Layer. Article about Bridge@USC by Emily Cavalcanti and Lynell George is published in the USC Dornsife Magazine MORE >>
Circulating Tumor Cell Analysis. On the Frontlines of Cancer Diagnosis and Management. Article by Curtis Balmer is published online in the AACC, Clinical Laboratory News MORE >>
Quantitative Biology: From Molecules to Man. Presented by The University of Southern California and the New York Academy of Sciences MORE >>
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 is published in Cell MORE >>
Targeting Hearts. Inspired to find answers by her grandfather’s heart disease, Tiffany Lian (laboratory of Professor Raymond Stevens, The Bridge@USC) is conducting research on taste receptors that may benefit drug discovery and development. MORE >>
Researchers at the Bridge Institute at the University of Southern California and the Sanford-Burnham Medical Research Institute (La Jolla, CA) report the first crystal structure of the ligand binding domain of human EphA3 receptor in complex with its preferred ligand, ephrin-A5. EphA3 receptor, a member of the receptor tyrosine kinase family, is a frequently mutated gene in lung cancer and is also implicated in many other cancer types. This structure reveals a distinct binding orientation of ephrin-A5 with EphA3 compared to its orientation when bound to other members of the Eph receptor family.
Link to PLoS ONE article >>
At the University Park Campus, TRF (corner of Vermont and Jefferson), Los Angeles, CA. The Kuhn Laboratory at the Bridge Institute will be hosting a "Night at the Lab" and will be welcoming METAvivors – a group of metastatic breast cancer patients, survivors and family members. This outreach event provides an informal setting for cancer researchers and people affected by breast cancer to share research advancements, concerns and perspectives.
Professor Valery Fokin will join top scientists in USC’s aim to be among the world’s pre-eminent institutions for convergent biomedical research.
A Structure of the Angiotensin Receptor revealed by Serial Femtosecond Crystallography is published online in Cell
USC cancer experts lead launch of convergent science journal. The project mirrors increasing collaboration among researchers, marking a new direction for scientific publications
Bridge@USC supports local STEAM/STEM events, participating in the Brentwood School STEAM event by having “Making cool things with your own DNA ” Tinkershop >>
Structures of human P2Y1 receptor bring new excitement to GPCR research SHANGHAI, CHINA – March 31, 2015 – A team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that plays a critical role in thrombosis, or blood clot, formation. In a paper published in Nature on March 30 London time, the researchers at Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, collaborating with research groups from National Institutes of Health (NIH, U.S.), Bridge Institute at University of Southern California (U.S.) and iHuman Institute of ShanghaiTech University (China), provide a detailed molecular map of the human P2Y1 receptor (P2Y1R), a GPCR, in complex with a nucleotide antagonist MRS2500 and a non-nucleotide antagonist BPTU.
PAPER ONLINE >>
A Century of Waiting for New Brain Imaging is Over. A team of USC scientists and engineers from the Bridge Institute, USC Dornsife, Viterbi School of Engineering and the Keck School of Medicine received a $9.7-million Transformative Grant from the National Institutes of Health to perform the first direct study of living synapses in the intact brain of a zebrafish. MORE >>
The Bridge@USC brochure is now available online in Issuu (flipbook) and PDF formats.
Please GO TO >>
IOP Publishing has launched a new journal: Convergent Science Physical Oncology (CSPO). The aim is to bring together all researchers working within the physics of cancer and create a new forum for this exciting field of research. MORE >>
Mark your calendars now for the workshop "Spatiotemporal dynamics of single cell trafficking" at Bridge@USC
February 20, 2015 at 10a.m., Ray Irani Hall, Room 101 - Biochemistry Seminar Bridge Instutute together with MCB, Department of Biological Sciences and Department of Chemistry present a seminar by Prof. Dr. Ehud M. Landau from the Department of Chemistry, University of Zurich "Concepts and Applications of Lipidic Mesophases in Biomedicine" Host: Vadim Cherezov. The Scientific Community is Invited MORE >>
Researchers at Bridge Institute at the University of Southern California in collaboration with University of North Carolina Chapel Hill Medical School, Vrije Universiteit Brussel in Belgium, Clinical Research Institute of Montreal in Canada, Arizona State University, Deutsches Elektronen-Synchrotron DESY in Germany and SLAC National Accelerator Laboratory report the structure of the human delta-opioid receptor in complex with a bifunctional peptide ligand. The structure, published Feb. 16 in Nature Structural & Molecular Biology, paves road to the structure-based development of pain-killers with reduced tolerance and dependency. MORE >>
P. Kuhn, USC Dornsife Dean’s Special Lecture, "Convergent Science: Life Sciences and Engineering in Oncology", Joyce J. Cammilleri Hall, Dornsife Neuroscience Pavilion, USC, University Park Campus, Los Angeles CA. MORE >>