Welcome to the Phillips Lab
Small RNA pathways protect the genome against foreign RNAs, such as viruses, in addition to regulating many endogenous RNAs, including aberrant transcripts, pseudogenes, and non-coding regions. The Phillips lab uses genetics, cell biology, and biochemistry to understand how RNA silencing pathways promote proper gene expression and maintain germline integrity and totipotency. Our research will have important implications in the understanding of how RNA silencing pathways inhibit transposon movement and repress aberrant RNAs to prevent deleterious gene mutations that can result in infertility, birth defects, as well cancer and other diseases.
2 new manuscripts on Biorxiv!
Shihui, Celja, and Sanjana have posted their latest manuscripts!
Chen S, Phillips CM. Germ granule association drives small RNA specificity for a nuclear Argonaute protein. BioRxiv. 2023 doi: 10.1101/2023.08.01.551545 link
Uebel CJ, Rajeev, S, Phillips CM. Caenorhabditis elegans germ granules are present in distinct configurations that differentially associate with RNAi-targeted RNAs. BioRxiv. 2023 doi: 10.1101/2023.05.25.542330 link