Nicos Petasis

• Research Associate and Adjunct Lecturer, University of Pennsylvania, 1984-1987

Summary Statement of Research Interests

Organic Chemistry, Medicinal Chemistry and Chemical Biology

• New organic reactions: New reactions of organotitanium, organoaluminum and organoboron compounds. New methods for asymmetric synthesis and catalysis.
• New technologies: New processes for hydrocarbon and energy-related chemistry. New technologies for process chemistry and sustainability. New advanced materials.
• New strategies: New concepts for the synthesis of amines, amino acids, amino alcohols, amino sugars, peptidomimetics and heterocycles. New strategies for combinatorial chemistry, medicinal chemistry and drug discovery.
• New bioactive molecules: New bioactive heterocycles. New polyunsaturated lipid mediators including lipoxins, resolvins, protectins. New metabolites of omega-3 fatty acids.
• New therapies: Design, synthesis and study of new therapeutic and chemo-preventive agents. Development of new methods for the treatment of inflammation, periodontal disease, cystic fibrosis, neurodegenerative diseases, ophthalmic diseases, and cancer. New small molecule epigenetic modulators.

Conference Presentations

• Multicomponent Reactions with Organoboron Compounds , Quimicuba 2015, 9th Congress of Chemical Sciences, Technology and InnovationKeynote Lecture, Invited, Havana, Cuba, 10/13/2015
• Boron-based multicomponent reactions for the synthesis of nitrogen heterocycles , 6th International Conference on Multi-Component Reactions and Related Chemistry (MCR2015) Conference Presentation, Invited, Brasilia, Brazil, 04/01/2015
• Chemistry of anti-inflammatory and pro-resolving lipid mediators derived from EPA and DHA , 12th Euro Fed Lipid CongressKeynote Lecture, European Federation for the Science and Technology, Invited, Montpellier, France, 09/15/2014
• Synthesis, biosynthesis, and actions of DHA-derived resolvins and maresins , 13th International Conference on Bioactive Lipids in Cancer, Inflammation and Related DiseasesConference Presentation, Invited, San Juan, Puerto Rico, 11/05/2013
• From new methods and new molecules to new medicines , Arthur C. Cope and Arthur C. Cope Scholars Award Symposium, 238th American Chemical Society MeetingAward Lecture, American Chemical Society, Invited, Washington, DC, 08/18/2009
• Synthesis of novel heterocycles from the one-step reaction of amines, carbonyls, and organoboron compounds , 13th International Conference on Boron Chemistry (IMEBORON XIII)Conference Presentation, Invited, Platja d’Aro, Barcelona, Spain, 09/21/2008
• Total organic synthesis of resolvins, protectins, and related molecules , 2nd Workshop on Lipid Mediators and InformaticsKeynote Lecture, Brigham & Women’s Hospital and Harvard Medical Sch, Invited, Boston, MA, 11/29/2007
• From Chemistry to Medicine: New chemical reactions and new synthetic molecules leading to new therapies for inflammation and cancer , International Symposium on “Chemistry, Biology & MedicineConference Presentation, Invited, Paphos, Cyprus, 05/28/2006

Book Chapters

• Petasis, N. A. (2014). Formation and beneficial roles of polyunsaturated lipid mediators: Lipoxins, resolvins, protectins, and maresins. Lipid Oxidation in Health and Disease pp. 173-194. London, UK: Taylor & Francis.
• Petasis, N. A. (2009). Alkenation with metal carbenes and related reactions. pp. 161-246. Science of Synthesis, Vol. 47, Alkenes, Thieme-Verlag.
• Petasis, N. A. (2005). Multicomponent reactions with organoboron compounds. pp. 199-223. Multicomponent Reactions, Wiley-VCH.
• Petasis, N. A. (2004). Titanium-carbene mediated reactions. pp. 427-447. Transition Metals for Organic Synthesis Vol. 1, Wiley-VCH.

Journal Article

• Bhattacharjee, S., Jun, B., Belayev, L., Heap, J., Kautzmann, M., Obenaus, A., Menghani, H., Marcell, S. J., Khoutorova, L., Yang, R., Petasis, N. A., Bazan, N. G. (2017). Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury. Science Advances. Vol. 3 (9), pp. 1-13. PubMed Web Address
• Jun, B., Mukherjee, P. K., Asatryan, A., Kautzmann, M., Heap, J., Gordon, W. C., Bhattacharjee, S., Yang, R., Petasis, N. A., Bazan, N. G. (2017). Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity. Scientific Reports. Vol. 7 (5279), pp. 1-14. PubMed Web Address
• Dalli, J., Vlasakov, I., Riley, I. R., Rodriguez, A. R., Spur, B. W., Petasis, N. A., Chiang, N., Serhan, C. N. (2016). Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proceedings of the National Academy of Sciences. Vol. 113 (43), pp. 12232-12237. PubMed Web Address
• Dalli, J., Vlasakov, I., Riley, I. R., Rodriguez, A. R., Spur, B. W., Petasis, N. A., Chiang, N., Serhan, C. N. (2016). Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proceedings of the National Academy of Sciences. Vol. 113 (43), pp. 12232-12237. PubMed Web Address
• Winkler, J. W., Orr, S. K., Dalli, J., Cheng, C. C., Sanger, J. M., Chiang, N., Petasis, N. A., Serhan, C. N. (2016). Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Scientific Reports/Nature. Vol. 6 (18972), pp. 1-11. PubMed Web Address
• Liepouri, F., Bernasconi, G., Petasis, N. A. (2015). Component-selective and stereocontrolled one-step three-component reaction among aldehydes, amines, and allenyl boronic acids or allenyl pinacolboronates. Organic Letters. Vol. 17 (7), pp. 1628-1631. PubMed Web Address
• Glynn, S. J., Gaffney, K. J., Sainz, M. A., Louie, S. G., Petasis, N. A. (2015). Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols. Organic & Biomolecular Chemistry. Vol. 13 (13), pp. 3887-3899. PubMed Web Address
• Krishnamoorthy, N., Burkett, P. R., Dalli, J., Abdulnour, R. E., Colas, R., Ramon, S., Phipps, R. P., Petasis, N. A., Kuchroo, V. K., Serhan, C. N., Levy, B. D. (2015). Cutting Edge: Maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. The Journal of Immunology. Vol. 194 (3), pp. 863-867. PubMed Web Address
• Musto, A. E., Walker, C. P., Petasis, N. A., Bazan, N. G. (2015). Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1. PLoS ONE/Public Library of Science. Vol. 10 (1), pp. e0116543. PubMed Web Address
• Abdulnour, R. E., Dalli, J., Colby, J. K., Krishnamoorthy, N., Timmons, J. Y., Tan, S. H., Colas, R. A., Petasis, N. A., Serhan, C. N., Levy, B. D. (2014). Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective. Proc. Natl. Acad. Sci. USA. Vol. 111 (462014/11/06), pp. 16526-16531. PubMed Web Address
• Tang, H., Liu, Y., Yan, C., Petasis, N. A., Serhan, C. N., Gao, H. (2014). Protective actions of aspirin-triggered (17R) Resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex–induced inflammation and lung injury. Journal of Immunology. Vol. 193 (7), pp. 3769-3778. PubMed Web Address
• Hua, J., Jin, Y., Chen, Y., Inomata, T., Lee, H., Chauhan, S. K., Petasis, N. A., Serhan, C. N., Dana, R. (2014). The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. Investigative Ophthalmology & Visual Science. Vol. 55 (9), pp. 5944-5951. PubMed Web Address
• Asatryan, L., Yardley, M. M., Khoja, S., Trudell, J. R., Hyunh, N., Louie, S. G., Petasis, N. A., Alkana, R. L., Davies, D. L. (2014). Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders. International Journal of Neuropsychopharmacology. Vol. 17 (6), pp. 907-916.
• Choi, I., Lee, Y. S., Chung, H. K., Choi, D., Ecoiffier, T., Lee, H. N., Kim, K. E., Lee, S., Park, E. K., Maeng, Y. S., Kim, N. Y., Ladner, R. D., Petasis, N. A., Koh, C. J., Chen, L., Lenz, H. -., Hong, Y. -. (2013). Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration. Angiogenesis/Springer Netherlands. Vol. 16 (1), pp. 29-44.
• Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., Serhan, C. N. (2013). The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. The FASEB Journal. Vol. 27 (7), pp. 2573-2583. PubMed Web Address
• Winkler, J. W., Uddin, J., Serhan, C. N., Petasis, N. A. (2013). Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator Resolvin D3 and its aspirin-triggered 17R-epimer. Organic Letters. Vol. 15 (7), pp. 1424-1427. PubMed Web Address
• Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H., Cheng, C. C., Chiang, N., Petasis, N. A., Serhan, C. N. (2013). Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents. Chemistry & Biology. Vol. 20 (2), pp. 188-201. PubMed Web Address
• Sharma, N., Thomas, S., Golden, E., Hofman, F., Chen, T., Petasis, N. A., Schönthal, A. H., Louie, S. G. (2012). Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Letters. Vol. 326 (2), pp. 143-154. PubMed Web Address
• Xu, S., Butkevich, A. N., Yamada, R., Zhou, Y., Debnath, B., Duncan, R., Zandi, E., Petasis, N. A., Neamati, N. (2012). Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proceedings of the National Academy of Sciences. Vol. 109 (40), pp. 16348-16353. PubMed Web Address
• Calandria, J. M., de Rivero Vaccari, J. C., Mukherjee, P. K., Zhu, M., Petasis, N. A., Bazan, N. G. (2012). Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1. Journal of Biological Chemistry. Vol. 287 (28), pp. 23726-23739.
• Bazan, N. G., Eady, T. N., Khoutorova, L., Atkins, K. D., Hong, S., Lu, Y., Zhang, C., Jun, B., Obenaus, A., Fredman, G., Zhu, M., Winkler, J. W., Petasis, N. A., Serhan, C. N., Belayev, L. (2012). Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Experimental Neurology. Vol. 236 (1), pp. 122-130. PubMed Web Address
• Ning, Y., LaBonte, M., Zhang, W., Bohanes, P., Gerger, A., Yang, D., Benhaim, L., Paez, D., Rosenberg, D. O., Nagulapalli Venkata, K. C., Louie, S. G., Petasis, N. A., Ladner, R. D., Lenz, H. (2012). The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models. Molecular Cancer Therapeutics. Vol. 11 (6), pp. 1353-1364.
• Lee, Y. S., Choi, I., Ning, Y., Kim, N. Y., Khatchadourian, V., Yang, D., Chung, H. K., Choi, D., LaBonte, M. J., Ladner, R. D., Nagulapalli Venkata, K. C., Rosenberg, D. O., Petasis, N. A., Lenz, H. J., Hong, Y. K. (2012). Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. British Journal of Cancer /Cancer Research UK. Vol. 106 (11), pp. 1833-1841. PubMed Web Address
• Thomas, S., Sharma, N., Golden, E. B., Cho, H., Agarwal, P., Gaffney, K. J., Petasis, N. A., Chen, T. C., Hofman, F. M., Louie, S. G., Schönthal, A. H. (2012). Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Letters. Vol. 325 (1), pp. 63-71.
• Yardley, M., Wyatt, L., Khoja, S., Asatryan, L., Ramaker, M. J., Finn, D. A., Alkana, R. L., Huynh, N., Louie, S. G., Petasis, N. A., Bortolato, M., Davies, D. L. (2012). Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. Vol. 63, pp. 190-201. PubMed Web Address
• Jayathilaka, N., Han, A., Gaffney, K. J., Dey, R., Jarusiewicz, J. A., Noridomi, K., Philips, M. A., Lei, X., He, J., Ye, J., Gao, T., Petasis, N. A., Chen, L. (2012). Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Research. Vol. 40 (12), pp. 5378-5388. PubMed Web Address
• Petasis, N. A., Yang, R., Winkler, J. W., Zhu, M., Uddin, J., Bazan, N. G., Serhan, C. N. (2012). Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Letters. Vol. 53, pp. 1695-1698. PubMed Web Address
• Serhan, C. N., Dalli, J., Karamnov, S., Choi, A., Park, C., Xu, Z., Ji, R., Zhu, M., Petasis, N. A. (2012). Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. Vol. 26 (4), pp. 1755-1765. PubMed Web Address
• Serhan, C. N., Fredman, G., Yang, R., Karamnov, S., Belayev, L. S., Bazan, N. G., Zhu, M., Winkler, J. W., Petasis, N. A. (2011). Novel proresolving aspirin-triggered DHA pathway. Chemistry & Biology / Cell. Vol. 18 (8), pp. 976-987. PubMed Web Address
• Serhan, C. N., Petasis, N. A. (2011). Resolvins and protectins in inflammation resolution. Chemical Reviews. Vol. 111 (10), pp. 5922-5943. PubMed Web Address
• Morgan, T. E., Davis, D. A., Iwata, N., Tanner, J. A., Snyder, D., Ning, Z., Kam, W., Hsu, Y., Winkler, J. W., Chen, J., Petasis, N. A., Baudry, M., Sioutas, C., Finch, C. E. (2011). Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants. Environmental Health Perspectives. Vol. 119 (7), pp. 1003-1009. PubMed Web Address
• Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., Bazan, N. G. (2011). Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARg-mediated mechanisms in Alzheimer’s disease models. PLoS ONE. Vol. 6 (1), pp. e15816. PubMed Web Address
• Ferrario, A., Lim, S., Xu, F., Luna, M., Gaffney, K. J., Petasis, N. A., Schönthal, A. H., Gomer, C. J. (2011). Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib. Cancer Letters. Vol. 304 (1), pp. 33-40.
• Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., Serhan, C. N. (2010). Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proceedings of the National Academy of Sciences. Vol. 107 (4), pp. 1660-1665. PubMed Web Address
• Marcheselli, V. L., Mukherjee, P. K., Arita, M., Hong, S., Antony, R., Sheets, K., Winkler, J. W., Petasis, N. A., Serhan, C. N., Bazan, N. G. (2010). Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins, Leukotrienes and Essential Fatty Acids. Vol. 82 (1), pp. 27-34.
• Liu, Z., Virrey, J. J., Cho, H., Kardosh, A., Golden, E. B., Louie, S. G., Gaffney, K. J., Petasis, N. A., Schönthal, A. H., Chen, T. C., Hofman, F. M. (2010). Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Molecular Cancer Therapeutics. Vol. 9 (3), pp. 631-641.
• Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., Serhan, C. N. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. Vol. 461 (7268), pp. 1287-1291. PubMed Web Address
• Golden, E. B., Lam, P. Y., Kardosh, A., Gaffney, K. J., Cadenas, E., Louie, S. G., Petasis, N. A., Chen, T. C., Schonthal, A. H. (2009). Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood. Vol. 113 (23), pp. 5927-5937. PubMed Web Address
• Calandria, J. M., Marcheselli, V. L., Mukherjee, P. K., Uddin, J., Winkler, J. W., Petasis, N. A., Bazan, N. G. (2009). Selective survival rescue in 15-Lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J. Biol. Chem.. Vol. 284 (26), pp. 17877-17882.
• Carlo, T., Petasis, N. A., Levy, B. D. (2009). Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate. Biochemistry. Vol. 48 (13), pp. 2997-3004.
• Cho, H., Thomas, S., Golden, E. B., Gaffney, K. J., Hofman, F. M., Chen, T. C., Louie, S. G., Petasis, N. A., Schonthal, A. H. (2009). Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Letters. Vol. 282 (1), pp. 87-97.
• Petasis, N. A., Butkevich, A. N. (2009). Synthesis of 2H-chromenes and 1,2-dihydroquinolines from aryl aldehydes, amines, and alkenylboron compounds. Journal of Organometallic Chemistry. Vol. 694 (11), pp. 1747-1753.
• Sun, Y., Tjonahen, E., Keledjian, R., Zhu, M., Yang, R., Recchiuti, A., Pillai, P. S., Petasis, N. A., Serhan, C. N. (2009). Anti-inflammatory and pro-resolving properties of benzo-lipoxin A4 analogs. Prostaglandins, Leukotrienes and Essential Fatty Acids. Vol. 81 (5-6), pp. 357-366.
• Petasis, N. A., Keledjian, R., Sun, Y., Nagulapalli, K. C., Tjonahen, E., Yang, R., Serhan, C. N. (2008). Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters. Vol. 18 (4), pp. 1382–1387.
• Schonthal, A. H., Chen, T. C., Hofman, F. M., Louie, S. G., Petasis, N. A. (2008). Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opinion on Investigational Drugs. Vol. 17 (2), pp. 197-208.
• Chuang, H., Kardosh, A., Gaffney, K. J., Petasis, N. A., Schonthal, A. H. (2008). COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro. Molecular Cancer. Vol. 7 (1), pp. 38.
• Kardosh, A., Golden, E. B., Pyrko, P., Uddin, J., Hofman, F. M., Chen, T. C., Louie, S. G., Petasis, N. A., Schonthal, A. H. (2008). Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib. Cancer Research. Vol. 68 (3), pp. 843-851.
• Petasis, N. A. (2007). Expanding roles for organoboron compounds – Versatile and valuable molecules for synthetic, biological, and medicinal chemistry. Australian Journal of Chemistry. Vol. 60 (11), pp. 795-798.
• Pyrko, P., Kardosh, A., Liu, Y. T., Soriano, N., Xiong, W. Y., Chow, R. H., Uddin, J., Petasis, N. A., Mircheff, A. K., Farley, R. A., Louie, S. G., Chen, T. C., Schothal, A. H. (2007). Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Molecular Cancer Therapeutics. Vol. 6 (4), pp. 1262-1275. PubMed Web Address
• Sun, Y. P., Oh, S. F., Uddin, J., Yang, R., Gotlinger, K., Campbell, E., Colgan, S. P., Petasis, N. A., Serhan, C. N. (2007). Resolvin D1 and its aspirin-triggered 17R epimer – Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J. Biol. Chem.. Vol. 282 (13), pp. 9323-9334.
• Arita, M., Oh, S. F., Chonan, T., Hong, S., Elangovan, S., Sun, Y. P., Uddin, J., Petasis, N. A., Serhan, C. N. (2006). Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. Journal of Biological Chemistry. Vol. 281 (32), pp. 22847-22854.
• Bonnans, C., Fukunaga, K., Keledjian, R., Petasis, N. A., Levy, B. D. (2006). Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. Journal of Experimental Medicine. Vol. 203 (4), pp. 857-863.
• Serhan, C. N., Gotlinger, K., Hong, S., Lu, Y., Siegelman, J., Baer, T., Yang, R., Colgan, S. P., Petasis, N. A. (2006). Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. Journal of Immunology. Vol. 176 (3), pp. 1848-1859.
• Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., Serhan, C. N. (2005). Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. Journal of Experimental Medicine. Vol. 201 (5), pp. 713-722. PubMed Web Address
• Karp, C. L., Flick, L. M., Yang, R., Uddin, J., Petasis, N. A. (2005). Cystic fibrosis and lipoxins. Prostaglandins Leukotrienes and Essential Fatty Acids. Vol. 73 (3-4), pp. 263-270.
• Levy, B. D., Hickey, L., Morris, A. J., Larvie, M., Keledjian, R., Petasis, N. A., Bannenberg, G., Serhan, C. N. (2005). Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. British Journal of Pharmacology. Vol. 146 (3), pp. 344-351.
• Petasis, N. A., Akritopoulou-Zanze, I., Fokin, V. V., Bernasconi, G., Keledjian, R., Yang, R., Uddin, J., Nagulapalli, K. C., Serhan, C. N. (2005). Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukotrienes and Essential Fatty Acids. Vol. 73 (3-4), pp. 301-321.
• Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., Belkaid, Y., Xu, Y., Whitsett, J. A., Accurso, F. J., Wills-Karp, M., Petasis, N. A. (2004). Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nature Immunology. Vol. 5 (4), pp. 388-392. PubMed Web Address
• Prakash, G. K., Mandal, M., Schweizer, S., Petasis, N. A., Olah, G. A. (2002). Stereoselective synthesis of anti-alpha-(difluoromethyl)-beta-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine. Journal of Organic Chemistry. Vol. 67 (11), pp. 3718-3723.
• Petasis, N. A., Boral, S. (2001). One-step three-component reaction among organoboronic acids, amines and salicylaldehydes. Tetrahedron Letters. Vol. 42 (4), pp. 539-542.
• Petasis, N. A., Patel, Z. D. (2000). Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids. Tetrahedron Letters. Vol. 41 (49), pp. 9607-9611.
• Prakash, G. K., Mandal, M., Schweizer, S., Petasis, N. A., Olah, G. A. (2000). A facile stereocontrolled synthesis of anti-alpha-(trifluoromethyl)-beta-amino alcohols. Organic Letters. Vol. 2 (20), pp. 3173-3176.
• You, Y. J., He, Y. K., Borrows, P. E., Forrest, S. R., Petasis, N. A., Thompson, M. E. (2000). Fluorophores related to the green fluorescent protein and their use in optoelectronic devices. Advanced Materials. Vol. 12 (22), pp. 1678-1679.
• Petasis, N. A., Zavialov, I. A. (1998). Highly stereocontrolled one-step synthesis of anti-beta-amino alcohols from organoboronic acids, amines, and alpha-hydroxy aldehydes. Journal of the American Chemical Society. Vol. 120 (45), pp. 11798-11799.
• Levy, B. D., Petasis, N. A., Serhan, C. N. (1997). Polyisoprenyl phosphates in intracellular signalling. Nature. Vol. 389 (6654), pp. 985-990.
• Petasis, N. A., Goodman, A., Zavialov, I. A. (1997). A new synthesis of alpha-arylglycines from aryl boronic acids. Tetrahedron. Vol. 53 (48), pp. 16463-16470.
• Petasis, N. A., Hu, Y. H. (1997). Allenation of carbonyl compounds with alkenyltitanocene derivatives. Journal of Organic Chemistry. Vol. 62 (4), pp. 782-783.
• Petasis, N. A., Zavialov, I. A. (1997). A new and practical synthesis of alpha-amino acids from alkenyl boronic acids. Journal of the American Chemical Society. Vol. 119 (2), pp. 445-446.
• Petasis, N. A., Lu, S. P. (1995). New Stereocontrolled Synthesis of Substituted Tetrahydrofurans from 1,3-Dioxolan-4-Ones. Journal of the American Chemical Society. Vol. 117 (23), pp. 6394-6395.
• Petasis, N. A., Bzowej, E. I. (1990). Titanium-Mediated Carbonyl Olefinations .1. Methylenations of Carbonyl-Compounds with Dimethyltitanocene. Journal of the American Chemical Society. Vol. 112 (17), pp. 6392-6394.

• American Association for the Advancement of Science Fellow, , 2013
• American Chemical Society Arthur C. Cope Scholar Award, 2009
• USC Associates Award For Creativity In Research And Scholarship, , 2008
• Novartis Chemistry Lectureship, 2007
• Frontiers in Chemistry Lecturer, Case Wester Reserve University, 2005
• Boron Americas Award for Distinguished Achievements in Boron Science, 2002
• USC Endowed Chair, Harold and Lillian Moulton Chair in Organic/Polymer Chemistry, 2001/09/01-2019/08/15
• USC Academic Senate Executive Board, Secretary General, 1998-2000

Administrative Appointments

• Head, Organic/Materials Division, Department of Chemistry, 2005

Committees

• Strategic Missions & Planning Committee, Department of Chemistry, 2012-CONT
• USC Stevens Institute’s Faculty Advisory Committee on Technology Translation, 2011-CONT
• Executive Committee, Department of Chemistry, 2005-CONT
• Faculty Search Committee, Organic/Materials Division, Department of Chemistry, 2005-2012
• University Committee on Academic Program Review, 2007-2010
• Faculty Search Committee for Medicinal/Computational Chemistry, Department of Pharmacology & Pharmaceutical Sciences, USC School of Pharmacy
  , 2007-2008
• USC College, Natural Sciences and Mathematics Personnel Committee
  , 2005-2007
• Faculty Search Committee, Organic/Materials Division, Department of Chemistry, 2003-2007
• University Research Committee, 1998-2000
• Provost’s Special Committee on Faculty Review, 1998-1999
• Committee on General Education, USC College, 1997-1998

Conferences Organized

• Organizer, Special Symposium on “Discovery and Development of Novel Therapeutics: Recent Advances and Future Trends”, USC, 05/18/2012
• Organizer, Stauffer Symposium on “Function-Oriented Synthesis: From New Reactions to New Medicines”, USC, 04/26/2011
• Organizer, Stauffer Symposium on “New Aspects of Catalysis and Total Organic Synthesis”, USC, 03/27/2008
• Co-organizer and Host, International Symposium on Chemistry, Biology & Medicine, Paphos, Cyprus, 05/28/2006 – 06/01/2006
• Co-organizer, Symposium on “Boronic Acids: Synthetic and Biological Applications,” Pacifichem 2005, International Chemical Congress, Honolulu, HI, 12/15/2005 – 12/20/2005

Editorships and Editorial Boards

• Chief Editor, Frontiers in Chemical Biology”, 2012 –
• Member, Editorial Board, Organic Chemistry International”, 2010 –
• Member, Editorial Board, Research Letters in Organic Chemistry”, 2007 – 2009

Professional Memberships

• American Association for Cancer Research, 2013 –
• New York Academy of Sciences, 2005 –
• American Association for the Advancement of Science, 1987 –
• American Chemical Society, 1987 –