USC.edu
Manahan Lab Group

Publications

Journal Articles

  • DellaTorre, M. B., Manahan, D. T. (2023). Increasing temperature results in higher allocation of energy to protein synthesis in sea urchin larvae (Lytechinus pictus). The Biological Bulletin. Vol. 244, pp. 35-50.
  • Pan, F. T., Manahan, D. T., Hedgecock, D. (2023). Within-family variation in larval viability and growth is controlled by different genes: a case study with Crassostrea gigas. Marine Ecology Progress Series. Vol. 704, pp. 149-153.
  • Li, N., Griffith, A. W., DellaTorre, M. B., Manahan, D. T. (2023). Integration of physiological and gene expression analyses to reveal biomarkers for protein dynamic mechanisms regulating higher growth and survival among larval oyster families (Crassostrea gigas). Aquaculture, 577 DOI: 10.1016/j.aquaculture.2023.739918.
  • Li, N., Griffith, A. W., Manahan, D. T. (2023). Integrative biological analyses of responses to food deprivation reveal resilience mechanisms in sea urchin larvae. Molecular Ecology DOI: 10.1111/mec.17120.
  • DellaTorre, M. B., Pan, F. T., Griffith, A. W., Li, N., Manahan, D. T. (2022). Thermal sensitivities of respiration and protein synthesis differ among larval families of the Pacific oyster, Crassostrea gigas. Journal of Experimental Biology (JEB.244518).
  • Pan, F. T., Applebaum, S. L., Manahan, D. T. (2021). Differing thermal sensitivities of physiological processes alter ATP allocation. Journal of Experimental Bioilogy (JEB.233379).
  • Frieder, C. A., Applebaum, S. L., Pan, F. T., Manahan, D. T. (2018). Shifting balance of protein synthesis and degradation sets a threshold for larval growth under environmental stress. The Biological Bulletin. Vol. 234, pp. 45-57.
  • Pan, F. T., Applebaum, S. L., Frieder, C. A., Manahan, D. T. (2018). Biochemical bases of growth variation during development: A study of protein turnover in pedigreed families of bivalve larvae (Crassostrea gigas). Journal of Experimental Biology (JEB.171967).
  • Frieder, C. A., Applebaum, S. L., Pan, F. T., Hedgecock, D., Manahan, D. T. (2017). Metabolic cost of calcification in bivalve larvae under experimental ocean acidification. ICES Journal of Marine Science. Vol. 74, pp. 941-954. doi:10.1093/icesjms/fsw213
  • Lee, J. W., Applebaum, S. L., Manahan, D. T. (2016). Metabolic cost of protein synthesis in larvae of the Pacific oyster (Crassostrea gigas) is fixed across genotype, phenotype, and environmental temperature. The Biological Bulletin. Vol. 230, pp. 175-187.
  • Pan, F. T., Applebaum, S. L., Lentz, B. A., Manahan, D. T. (2016). Predicting phenotypic variation in growth and metabolism of marine invertebrate larvae. Journal of Experimental Marine Biology and Ecology.. Vol. 483, pp. 64-73.
  • Pan, F. T., Applebaum, S. L., Manahan, D. T. (2015). Experimental ocean acidification alters the allocation of metabolic energy. Proceedings of the National Academy of Sciences of the USA. Vol. 112, pp. 4696-4701.
  • Nature, .. (2015). “Sea creatures adapt to acid” [Nature Research Highlight article of PNAS paper (citation above) by Pan, Applebaum, and Manahan. 2015]. Nature. Vol. 520, pp. 134.
  • Pan, F. T., Applebaum, S. L., Manahan, D. T. (2015). Genetically determined variation in developmental physiology of bivalve larvae (Crassostrea gigas). Physiological and Biochemical Zoology. Vol. 88, pp. 128-136.
  • Applebaum, S. L., Pan, F. T., Hedgecock, D., Manahan, D. T. (2014). Separating the Nature and Nurture of the allocation of energy in response to global change. Integrative and Comparative Biology. Vol. 54, pp. 284-295.
  • Applebaum, S. L., Ginsburg, D. W., Capron, C. S., Manahan, D. T. (2013). Expression of amino acid transport genes in developmental stages and adult tissues of Antarctic echinoderms. Polar Biology. Vol. 36, pp. 1257-1267.
  • Curole, J., Meyer, E., Manahan, D. T., Hedgecock, D. (2010). Unequal and genotype-dependent expression of mitochondrial genes in larvae of the Pacific oyster (Crassostrea gigas). The Biological Bulletin. Vol. 218, pp. 122-131.
  • Meyer, E., Manahan, D. T. (2010). Gene expression profiling of genetically-determined growth variation in bivalve larvae (Crassostrea gigas). Journal of Experimental Biology. Vol. 213, pp. 749-758.
  • Pace, D. A., Maxson, R., Manahan, D. T. (2010). Ribosomal analysis of rapid rates of protein synthesis in the Antarctic sea urchin, Sterechinus neumayeri. The Biological Bulletin. Vol. 218, pp. 48-60.
  • Ginsburg, D. W., Manahan, D. T. (2009). Developmental physiology of Antarctic asteroids with different life-history modes. Marine Biology. Vol. 156, pp. 2391-2402.
  • Meyer, E., Manahan, D. T. (2009). Nutrient uptake by marine invertebrates: Cloning and functional analysis of amino acid transporter genes in developing sea urchins (Strongylocentrotus purpuratus). The Biological Bulletin. Vol. 217, pp. 6–24.
  • Pace, D. A., Manahan, D. T. (2007). Efficiencies and costs of larval growth in different food environments (Asteroidea: Asterina miniata). Journal of Experimental Marine Biology and Ecology. Vol. 353, pp. 89-106.
  • Meyer, E., Green, A. J., Moore, M., Manahan, D. T. (2007). Food availability and physiological state of sea urchin larvae (Strongylocentrotus purpuratus). Marine Biology. Vol. 152, pp. 179-191.
  • Pace, D. A., Manahan, D. T. (2007). Cost of protein synthesis and energy allocation during development of Antarctic sea urchin embryos and larvae. The Biological Bulletin. Vol. 212, pp. 115-129.
  • Hedgecock, D., Lin, J., DeCola, S., Haudenschild, C. D., Meyer, E., Manahan, D. T., Bowen, B. (2007). Transcriptomic analysis of growth heterosis in larval Pacific oysters (Crassostrea gigas). Proc. Natl. Acad. Sci. USA. Vol. 104, pp. 2312-2318.
  • Moore, M., Manahan, D. T. (2007). Variation among females in egg lipid content and developmental success of echinoderms from McMurdo Sound, Antarctica. Polar Biology. Vol. 30, pp. 1245-1252.
  • Pace, D. A., Manahan, D. T. (2006). Fixed metabolic costs for highly variable rates of protein synthesis in sea urchin embryos and larvae. Journal of Experimental Biology. Vol. 209, pp. 158-170.
  • Pace, D. A., Marsh, A. G., Leong, P. K., Green, A. J., Hedgecock, D., Manahan, D. T. (2006). Physiological bases of genetically determined variation in growth of marine invertebrate larvae: A study of growth heterosis in the bivalve Crassostrea gigas. Journal of Experimental Marine Biology and Ecology. Vol. 335, pp. 188-209.
  • Moran, A. L., Manahan, D. T. (2004). Physiological recovery from prolonged starvation in larvae of the Pacific oyster Crassostrea gigas. Journal of Experimental Marine Biology and Ecology. Vol. 306, pp. 17-36.
  • Moran, A. L., Manahan, D. T. (2003). Energy metabolism during larval development of green and white abalone, Haliotis fulgens and H. sorenseni. Biological Bulletin. Vol. 204, pp. 270-277.
  • Marsh, A. G., Mullineaux, L. S., Young, C. M., Manahan, D. T. (2001). Larval dispersal potential of the tubeworm Riftia pachyptila at deep-sea hydrothermal vents. Nature. Vol. 411, pp. 77-80.
  • Marsh, A. G., Maxson, R., Manahan, D. T. (2001). High macromolecular synthesis with low metabolic cost in Antarctic sea urchin embryos. Science. Vol. 291, pp. 1950-1952.
  • Marsh, A. G., Leong, P. K., Manahan, D. T. (2000). Gene expression and enzyme activities of the sodium pump during sea urchin development: Implications for indices of physiological state. Biological Bulletin. Vol. 199, pp. 100-107.

Selected Publications Prior to 2000

  • Manahan, D.T., S.H. Wright, G.C. Stephens, and M.A. Rice, 1982. Transport of dissolved amino acids by the mussel Mytilus edulis: Demonstration of net uptake from natural seawater. Science, 215: 1253-1255.
  • Manahan, D.T. and D.J. Crisp, 1982. The role of dissolved organic material in the nutrition of pelagic larvae: Amino acid uptake by bivalve veligers. American Zoologist, 22: 635-646.
  • Manahan, D.T., J.P. Davis, and G.C. Stephens, 1983. Bacteria-free sea urchin larvae: Selective uptake of neutral amino acids from seawater. Science, 220: 204-206.
  • Stephens, G.C. and D.T. Manahan, 1984. Technical advances in the study of nutrition of marine molluscs. Aquaculture, 39: 155-164.
  • Manahan, D.T, 1989. Amino acid fluxes to and from seawater in axenic veliger larvae of a bivalve (Crassostrea gigas). Marine Ecology Progress Series, 53: 247-255.
  • Manahan, D.T., W.B. Jaeckle, and S. Nourizadeh, 1989. Ontogenic changes in the rates of amino acid transport from seawater by marine invertebrate larvae (Echinodermata, Echiura, Mollusca). Biological Bulletin, 176: 161-168.
  • Wright, S.H. and D.T. Manahan, 1989. Integumental nutrient uptake by aquatic organisms. Annual Review of Physiology, 51: 585-600.
  • Manahan, D.T., 1990. Adaptations by invertebrate larvae for nutrient acquisition from seawater. American Zoologist, 30: 147-160.
  • Shilling, F.M. and D.T. Manahan, 1990. The energetics of early development for the sea urchins Strongylocentrotus purpuratus and Lytechinus pictus and the crustacean Artemia sp. Marine Biology, 106: 119-127.
  • Welborn, J.R and D.T. Manahan, 1990. Direct measurements of sugar uptake from seawater into molluscan larvae. Marine Ecology Progress Series, 65: 233-239.
  • Jaeckle, W.B. and D.T. Manahan, 1992. Experimental manipulations of the organic chemistry of seawater: implications for studies of energy budgets in marine invertebrate larvae. Journal of Experimental Marine Biology and Ecology, 156: 273-284.
  • Shilling, F.M. and D.T. Manahan, 1994. Energy metabolism and amino acid transport during early development of antarctic and temperate echinoderms. Biological Bulletin, 187: 398-407.
  • Hoegh-Guldberg, O. and D.T. Manahan, 1995. Coulometric measurement of oxygen consumption during development of marine invertebrate embryos and larvae. Journal of Experimental Biology, 198: 19-30.
  • Welborn, J.R. and D.T. Manahan, 1995. Taurine metabolism in larvae of marine invertebrate molluscs (Bivalvia, Gastropoda). Journal of Experimental Biology, 198: 1791-1799.
  • Shilling, F.M., O. Hoegh-Guldberg, and D.T. Manahan, 1996. Sources of energy for increased metabolic demand during metamorphosis of the abalone Haliotis rufescens (Mollusca). Biological Bulletin, 191: 402-412.
  • Leong, P.K.K. and D.T. Manahan, 1997. Metabolic importance of Na+, K+-ATPase activity during sea urchin development. Journal of Experimental Biology, 200: 2881-2892.
  • Vavra, J.S. and D.T. Manahan, 1999. Protein metabolism in lecithotrophic larvae (Gastropoda: Haliotis rufescens). Biological Bulletin, 196: 177-186..
  • Leong, P.K.K. and D.T. Manahan, 1999. Na+, K+-ATPase activity during early development and growth of an Antarctic sea urchin. Journal of Experimental Biology, 202: 2051-2058.
  • Marsh, A.G., P.K.K. Leong and D.T. Manahan, 1999. Energy metabolism during embryonic development and larval growth of an Antarctic sea urchin. Journal of Experimental Biology, 202: 2041-2050.
  • Marsh, A.G. and D.T. Manahan, 1999. Accurate measurements of the respiration rates of marine invertebrate embryos and larvae. Marine Ecology Progress Series, 184:1-10.

Conferences

  • “2022. (1) Cost-of-Living for larvae in a changing ocean: Insights from integrating genetic and physiological analyses (D.T. Manahan, F.T.C. Pan, M.B. DellaTorre, A.W. Griffith, N. Li, and D. Hedgecock)”, The 45th Annual Larval Fish Conference & 13th International Larval Biology Symposium, Talk/Oral Presentation, 2022-
  • “2022. (2) Maternal investment does not explain starvation resilience in marine larvae (A.W. Griffith, N. Li, and D.T. Manahan)”, The 45th Annual Larval Fish Conference & 13th International Larval Biology Symposium, Talk/Oral Presentation, 2022-
  • “2022. (3) Biochemical strategies to manage food availability during the “best and worst of times” (N. Li, A.W. Griffith, F.T. C. Pan, M.B. DellaTorre, and D.T. Manahan)”, The 45th Annual Larval Fish Conference & 13th International Larval Biology Symposium, Talk/Oral Presentation, 2022-
  • “2022. (4) Within family variation in growth and survival is controlled by different genes (F.T. C. Pan, D.T. Manahan, and D. Hedgecock)”, The 45th Annual Larval Fish Conference & 13th International Larval Biology Symposium, Talk/Oral Presentation, 2022-
  • “2022. (5) Physiological responses to a warming ocean: Phenotypic contrasts among larval families (M.B. DellaTorre, F.T. C. Pan, N. Li, A.W. Griffith, and D.T. Manahan)”, International Larval Biology Symposium and Larval Fish Conference , Poster, 2022-
  • “2022. Power, problems, and predictions of omic-based analysis for physiological processes (N. Li, F.T.C. Pan, A.W. Griffith, and D.T. Manahan)”, American Physiological Society (conference theme): From Organisms to Omics in an Uncertain World, Poster, 2022-
  • “2020. Shifts in allocation of metabolic energy highlight biochemical bases of resilience to environmental change (F. T. C. Pan, S. L. Applebaum, and D. T. Manahan)”, Ocean Sciences 2020 Annual Meeting, Talk/Oral Presentation, Invited, 2020-
  • “2020. Temperature differentially affects feeding, metabolism, and biosynthesis in larval forms (J. Wang, M. B. DellaTorre, and D. T. Manahan)”, Ocean Sciences 2020 Annual Meeting, Poster, Invited, 2020-
  • “2019. Decoupled physiological responses to increased temperature: implications for adaptation potential to ocean change (M. DellaTorre, J. Wang, and D.T. Manahan)”, 100th Annual Meeting of the Western Society of Naturalists, Talk/Oral Presentation, 2019-
  • “2019. Physiological processes underlying food conversion efficiency during growth of sea urchin larvae (Wang, J. and D. T. Manahan)”, 100th Annual Meeting of the Western Society of Naturalists, Talk/Oral Presentation, 2019-
  • “2018. Advancements in quantifying energy costs for organisms to respond to ocean change (C.A. Frieder, S.L. Applebaum, T-C. F. Pan, and D.T. Manahan)”, Ocean Sciences 2018 Annual Meeting, Talk/Oral Presentation, 2018-
  • “2018. Bioenergetics of protein metabolism under experimental environmental change (Pan, T-C. F., S.L. Applebaum, and D.T. Manahan)”, American Physiological Society 2018 meeting – Comparative Physiology: Complexity & Integration, Talk/Oral Presentation, 2018-
  • “2018. Predicting adaptive responses to ocean change: Implications for aquaculture (D.T. Manahan)”, National Shellfisheries Association, 110th Annual Meeting, Keynote Lecture, Invited, 2018-
  • “2018. Protein turnover: A biochemical basis for endogenous variation in growth and energy metabolism (S.L. Applebaum, T-C. F. Pan, D. Hedgecock, and D.T. Manahan)”, American Physiological Society 2018 meeting – Comparative Physiology: Complexity & Integration, Talk/Oral Presentation, 2018-
  • “2017. (1) Predicting adaptive responses to the Anthropocene [invited plenary lecture]. (D.T. Manahan) “, XIth International Larval Biology Symposium, Talk/Oral Presentation, Invited, 2017-
  • “2017. (2) Physiological bases for genetic variation in growth: The necessity of functional validation of ‘-omic’ studies (S.L. Applebaum and D. T. Manahan)”, XIth International Larval Biology Symposium, Talk/Oral Presentation, 2017-
  • “2017. (3) Metabolic costs of environmental stressors in feeding larval forms (C.A. Frieder, S. L. Applebaum, T.-C. F.. Pan, and D.T. Manahan)”, XIth International Larval Biology Symposium, Talk/Oral Presentation, 2017-
  • “2017. (4) Metabolic energy tradeoffs in fast-growing phenotypes of bivalve larvae (T-C. F. Pan, C.A. Frieder, S.L. Applebaum, and D.T. Manahan)”, XIth International Larval Biology Symposium, Talk/Oral Presentation, 2017-
  • “2017. Biochemical bases for growth phenotype variation in marine larvae of different genotypes (Pan, T-C.F., S.L. Applebaum, and D.T. Manahan)”, Integrative and Comparative Biology, Volume 57 (Issue Supplemental 1): E373., Talk/Oral Presentation, 2017-
  • “2017. Differential temperature sensitivity of respiration rate, protein synthesis, and ion transport in bivalve larvae (S.L. Applebaum, Pan, T-C.F., and D.T. Manahan)”, Integrative and Comparative Biology, Volume 57 (Issue Supplemental 1): E7, Talk/Oral Presentation, 2017-
  • “2017. Energy metabolism and shell formation in bivalve larvae under different environmental conditions (C.A. Frieder, S.L. Applebaum, T-C.F. Pan, D. Hedgecock, and D.T. Manahan)”, Integrative and Comparative Biology, Volume 57 (Issue Supplemental 1): E265., Talk/Oral Presentation, 2017-
  • “2016. Bioenergetic approaches to define resilience potential to compounding environmental stressors (D.T. Manahan, S.L. Applebaum, C.A. Frieder, T-C. F. Pan and D. Hedgecock)”, Ocean Sciences 2016 Annual Meeting, New Orleans, LA, USA, Talk/Oral Presentation, 2016-
  • “2016. Metabolic energy demand is not increased during initial shell formation of bivalves exposed to aragonite undersaturation (T-C. F. Pan, C.A. Frieder, S.L. Applebaum and D.T. Manahan)”, Ocean Sciences 2016 Annual Meeting, New Orleans, LA, USA, Poster, 2016-
  • “2016. Ocean acidification causes increased calcium carbonate turnover during larval shell formation (C.A. Frieder, T-C. F. Pan, S.L. Applebaum and D.T. Manahan)”, Ocean Sciences 2016 Annual Meeting, New Orleans, LA, USA, Talk/Oral Presentation, 2016-
  • “2015. Characterization of coastal CO2 dynamics and physiological responses of larval Pacific oyster to experimental ocean acidification (C.A. Frieder, S.L. Applebaum, T-C. F. Pan, and D.T. Manahan)”, National Shellfisheries Association, 107th Annual Meeting, Poster, 2015-
  • “2015. Genetic and physiological approaches to improved prediction of the potential for adaptation to environmental change (D.T. Manahan and D. Hedgecock) “, National Shellfisheries Association, 107th Annual Meeting, Talk/Oral Presentation, 2015-
  • “2014. Controlling Nature & Nurture: Why experiments with wild type are insufficient for understanding adaptation to environmental change (Hedgecock, D. and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, Paper, Integrative and Comparative Biology Vol. 54, E87, Invited, 2014-
  • “2014. Genes, genomes and proteins: the challenge of making physiological predictions (Manahan, D.T., S.L. Applebaum, and T.-C.F. Pan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, Paper, Integrative and Comparative Biology Vol. 54, E131, Invited, 2014-
  • “2014. Genetically determined shifts in metabolic energy allocation in response to ocean acidification (Applebaum, S. L., T.-C. F. Pan, D. Hedgecock, and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, Paper, Integrative and Comparative Biology Vol. 54, E7, Invited, 2014-
  • “2014. Ocean acidification alters energy allocation in developing sea urchins (Pan, T.-C. F., S.L. Applebaum, R.J. Sawyer, and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, Paper, Integrative and Comparative Biology Vol. 54, E159, Invited, 2014-
  • “2014. Genetically determined variation in metabolic allocation – potential for adaptation to environmental change (Applebaum, S. L., T.-C.F. Pan, B.A. Lentz, D. Hedgecock, and D.T. Manahan)”, American Physiological Society: Comparative Approaches to Grand Challenges in Physiology, Poster, www.the-aps.org/mm/Conferences/APS-Conferences/2014-Conferences/Comparative, 2014-
  • “2014. Molecular biological and genomic analysis of the developmental physiology of integumental transport (Manahan, D.T., S.L. Applebaum, and T.-C.F. Pan)”, American Physiological Society: Comparative Approaches to Grand Challenges in Physiology, Talk/Oral Presentation, Abstract, www.the-aps.org/mm/Conferences/APS-Conferences/2014-Conferences/Comparative, Invited, 2014-
  • “2014. Reallocation of ATP in response to the stress of ocean acidification (Pan, T.-C.F, S.A. Applebaum, C.A. Frieder, and D.T. Manahan)”, American Physiological Society: Comparative Approaches to Grand Challenges in Physiology, Poster, www.the-aps.org/mm/Conferences/APS-Conferences/2014-Conferences/Comparative, 2014-
  • “2013. Amino acid transport as an index of growth potential in larvae of the Pacific oyster, Crassostrea gigas. (Pan, T.-C. F., S.L. Applebaum, and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2013-
  • “2013. Developmental physiology: Predicting “Winners and Losers” to environmental change. (Manahan, D.T. and D. Hedgecock)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2013-
  • “2013. Differential energy allocation for protein synthesis is genetically determined during marine larval development. (Lee, J.W., S.L. Applebaum, and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2013-
  • “2013. Global metabolite profiles as predictors of physiological traits in bivalve larvae with genetically-determined differential growth rates. (Applebaum, S.L., J.W. Lee and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2013-
  • “2012. Well-fed but metabolically starving: implications of genotype for energy allocation in bivalve larvae, Crassostrea gigas. (Manahan, D.T., J.W. Lee, and S.L. Applebaum)”, Journal of Shellfish Research, 31: 317, Talk/Oral Presentation, 2012-
  • “2011. Environmental and physiological genomics of larvae (D.T. Manahan)”, Journal of Shellfish Research, 30: 530, Keynote Lecture, National Shellfisheries Assoc., Invited, 2011-
  • “2011. Genes underlying amino acid transport differences in echinoderms from contrasting polar and temperate environments (Applebaum, S.L., D.W. Ginsburg and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2011-
  • “2011. Protein metabolism and genotype-dependent differential growth of bivalve larvae (Lee, J.W., E. Meyer and D.T. Manahan)”, Society of Integrative and Comparative Biology, Talk/Oral Presentation, 2011-

Contact

Faculty Profile

Professor Donal T. Manahan

Department of Biological Sciences
USC Dornsife College of Letters, Arts and Sciences
University of Southern California
Los Angeles, CA 90089-0371

(213) 740-5793