Our main focus is the structure determination of important membrane proteins, with a focus on G protein-coupled receptors and solute carriers (SLC). These represent the two largest families of membrane proteins in the human genome and have a broad spectrum of targets for medical treatments.
Besides structure determination, we complement our studies with biochemical and biophysical tools.
If you are interested in either of those techniques, or would like to collaborate, please reach out to us.
Single particle CryoEM
Our main structural biology technique is single particle cryoEM.
Useful links:
Biochemistry & biophysical techniques
We deploy standard biochemical purification techniques with various expression systems (Sf9 and HEK293), followed by a range of different reconstitution techniques:
- detergent based micelles
- SMA copolymer nanodiscs
- conventional (MSP-based) nanodiscs
- liposomes
- Lipidic cubic phase (LCP) crystallization
G protein-coupled receptors
Solute carriers & transporters
