Scott Kanoski

• Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009 – 12/31/2012

Tenure Track Appointments

• Assistant Professor, University of Southern California, 01/01/2013 –

PostDoctoral Appointments

• Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009 – 12/31/2012

Summary Statement of Research Interests

Dr. Kanoski’s research focuses on the neurobiological control of food intake and body weight regulation. More specifically his laboratory focuses on understanding how the brain processes peripherally- and centrally-derived hormonal signals to control learned and motivated aspects of feeding behavior, as well as to examine how these neuroendocrine signaling systems contribute to and are compromised by obesity and related metabolic disorders. At the center of this research is the hippocampus; a brain region traditionally linked with memory function, but more recently shown to control higher-order aspects of feeding behavior. The lab also focuses on exploring the relationship between consuming saturated fatty acids and refined carbohydrates (i.e., “Western diets”) and the development of hippocampal dysfunction, cognitive impairment, and Alzheimer’s pathology.

Research Specialties

Behavioral Neuroscience, Ingestive Behavior, Energy Balance, Neuroendocrinology, Learning & Memory, Systems Neuroscience

Book Chapters

• Kanoski, S. E. (2016). Food hedonics: insight from animal models. Neuroendocrinology of Appetite pp. 90-112. Wiley Blackwell.
• Davidson, T. L., Sample, C. H., Kanoski, S. E. (2014). Western diet and cognitive impairment. Diet and Nutrition: Dementia and Cognitive Decline (Elsevier).
• Kanoski, S. E., Hsu, T., Pennell, S. (2014). Obesity, Western diet intake, and cognitive impairment. Fat and Fatty Acids: Brain and Neurological Health (Elsevier).
• Kanoski, S. E. (2012). Working memory and diet. Working Memory: The Connected Intelligence (Psychology Press / Taylor & Francis).

Journal Article

• Liu, C. M., Hsu, T. M., Suarez, A. N., Subramanian, K. S., Fatemi, R., Cortella, A. M., Noble, E. E., Roitman, M. F., Kanoski, S. E. (2020). Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues. Hormones and Behavior. Vol. In Press
• Quigley, K. S., Kanoski, S. E., Grill, W. M., Barrett, L. F., Tsakiris, M. (2020). The Functions of interoception: from energy regulation to experience of the self. Trends in Neuroscience. Vol. In Press
• Davis, E. A., Wald, H. S., Suarez, A. N., Zubcevic, J., Liu, C. M., Cortella, A. M., Kamitakahara, A. K., Polson, J. W., Arnold, M., Grill, H. J., de Lartigue, G., Kanoski, S. E. (2020). Ghrelin signaling affects feeding behavior, metabolism, and memory through the vagus nerve. Current Biology. PubMed Web Address
• Terrill, S. J., Subramanian, K. S., Lan, R., Liu, C. M., Cortella, A. M., Noble, E. E., Kanoski, S. E. (2020). Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner. Neuropharmacology. Vol. In Press PubMed Web Address
• Suarez, A. N., Liu, C. M., Cortella, A. M., Noble, E. E., Kanoski, S. E. (2020). Ghrelin and orexin interact to increase meal size through a descending hippocampus to hindbrain signaling pathway. Biological Psychiatry. Vol. 87 (11), pp. 1001-1011. PubMed Web Address
• Konanur, V. R., Hsu, T. M., Kanoski, S. E., Hayes, M. R., Roitman, M. F. (2020). Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4. Physiology and Behavior. Vol. In Press PubMed Web Address
• Liu, C. M., Davis, E. A., Suarez, A. N., Noble, E. E., Kanoski, S. E. (2020). Sex differences and estrous influences on oxytocin control of food intake. Neuroscience. Vol. In Press PubMed Web Address
• Noble, E. E., Wang, Z., Liu, C. M., Davis, E. A., Suarez, A. N., Stein, L. P., Tsan, L., Terrill, S. J., Hsu, T. M., Jung, A., Raycraft, L. M., Hahn, J. D., Darvas, M., Cortella, A. M., Schier, L. A., Johnson, A. W., Hayes, M. R., Holschneider, D. P., Kanoski, S. E. (2019). Hypothalamic-hippocampal circuitry regulates impulsivity via melanin-concentrating hormone. Nature Communications. Vol. 10 (4923)
• Kanoski, S. E. (2019). Sex differences and estrous influences on oxytocin control of food intake. Neuroscience. Vol. IN PRESS
• Suarez, A. N., Liu, C. M., Cortella, A. M., Noble, E. E., Kanoski, S. E. (2019). Ghrelin and orexin interact to increase meal size through a descending hippocampus to hindbrain signaling pathway. Biological Psychiatry. Vol. IN PRESS
• Kanoski, S. E. (2019). Regulation of memory function by feeding-relevant biological systems: following the breadcrumbs to the hippocampus. Frontiers in Molecular Neuroscience. Vol. 12 (101) PubMed Web Address
• Noble, E. E., Hsu, T. M., Liang, J., Kanoski, S. E. (2019). Early life sugar consumption has long-term negative effects on memory function in male rats. Nutritional Neuroscience. Vol. 22 (4), pp. 273-282. PubMed Web Address
• Hsu, T. M., Noble, E. E., Liu, C. M., Cortella, A. M., Konanur, V. R., Suarez, A. N., Reiner, D. J., Hahn, J. D., Hayes, M. R., Kanoski, S. E. (2018). A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling. Molecular Psychiatry. Vol. 23, pp. 1555-1565. PubMed Web Address
• Noble, E. E., Hahn, J. D., Konanur, V. R., Hsu, T. M., Page, S. J., Cortella, A. M., Liu, C. M., Song, M. Y., Suarez, A. N., Szujewski, C. C., Rider, D. R., Clarke, J. E., Darvas, M., Appleyard, S. M., Kanoski, S. E. (2018). Control of feeding behavior by cerebral ventricular volume transmission of melanin-concentrating hormone. Cell Metabolism. Vol. 28 (1), pp. 55-68. PubMed Web Address
• Suarez, A. N., Hsu, T. M., Noble, E. E., Cortella, A. M., Nakamoto, E. M., Hahn, J. D., de Lartigue, G., Kanoski, S. E. (2018). Gut vagal sensory signaling regulates hippocampus function through multi-order pathways. Nature Communications. Vol. 9 (1), pp. 2181. PubMed Web Address
• Lopez-Ferrars, L., Richard, J. E., Eerola, K., Anderberg, R. H., Hayes, M. R., Kanoski, S. E., Noble, E. E., Taing, L., Skibicka, K. P. (2018). Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior, and body weight. Molecular Psychiatry. Vol. 23 (5), pp. 1157-1168. PubMed Web Address
• Hsu, T. M., Noble, E. E., Reiner, D. J., Liu, C. M., Suarez, A. N., Konanur, V. R., Hayes, M. R., Kanoski, S. E. (2018). Endogenous hippocampal ghrelin receptor signaling promotes socially-mediated learned food preference. Neuropharmacology. Vol. 131, pp. 487-496. PubMed Web Address
• Lee, S. J., Sanchez-Watts, G., Krieger, J., Pignalosa, A., Norell, P., Cortella, A. M., Pettersen, K., D, V., Hayes, M. R., Kanoski, S. E., Langhans, W., Watts, A. G. (2018). Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity. Molecular Metabolism. Vol. 11, pp. 33-46. PubMed Web Address
• Reiner, D. J., Leon, R., McGrath, L. E., Koch-Laskowski, K., Hahn, J. D., Kanoski, S. E., Mietlicki-Baase, E. G., Hayes, M. R. (2018). Glucagon-like peptide-1 receptor signaling in the lateral dorsal tegmental nucleus regulates energy balance. Neuropsychopharmacology. Vol. 43 (3), pp. 627-37. PubMed Web Address
• Liu, C. M., Kanoski, S. E. (2018). Homeostatic and non-homeostatic controls of feeding behavior: distinct vs. common neural systems. Physiology and Behavior. Vol. Epub ahead of print PubMed Web Address
• Reiner, D. J., Mietlicki-Baase, E. G., Olivos, D. R., McGrath, L. E., Zimmer, D. J., Kock-Laskowski, K., Turner, C., Noble, E. E., Hahn, J. D., Schmidt, H. D., Kanoski, S. E., Hayes, M. R. (2017). Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through GABA signaling. Biological Psychiatry. Vol. 82 (11), pp. 828-838. PubMed Web Address
• Lopez-Ferrars, L., Richard, J. E., Anderberg, R. H., Nilsson, F. H., Olandersson, K., Kanoski, S. E., Skibicka, K. P. (2017). Ghrelin’s control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic. Physiology and Behavior. Vol. 176, pp. 40-49. PubMed Web Address
• Noble, E. E., Hsu, T. M., Kanoski, S. E. (2017). Gut to brain dysbiosis: Mechanisms linking Western Diet consumption, the microbiome, and cognitive impairment. Frontiers in Behavioral Neuroscience. Vol. 11, pp. 1-10. PubMed Web Address
• Kanoski, S. E., Grill, H. J. (2017). Hippocampus contributions to food intake control: mnemonic, neuroanatomical, and endocrine mechanisms. Biological Psychiatry. Vol. 81 (9), pp. 748-756. PubMed Web Address
• Noble, E. E., Hsu, T. M., Jones, R. B., Fodor, A. A., Goran, M. I., Kanoski, S. E. (2017). Early life sugar consumption affects the rat microbiome independent of obesity. The Journal of Nutrition. Vol. 147 (1), pp. 20-28. PubMed Web Address
• Hsu, T. M., Suarez, A. N., Kanoski, S. E. (2016). Ghrelin: A link between memory and ingestive behavior. Physiology and Behavior. Vol. 162 PubMed Web Address
• Kanoski, S. E., Hayes, M. R., Skibicka, K. P. (2016). GLP-1 and weight loss: unraveling the diverse neural circuitry. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. Vol. 310 (10), pp. R885-95. PubMed Web Address
• De Jonghe, B. C., Holland, R., Olivos, D. R., Rupprecht, L. E., Kanoski, S. E., Hayes, M. R. (2016). Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea. Physiology and Behavior. Vol. 153, pp. 109-14. PubMed Web Address
• Reiner, D. J., Mietlicki-Baase, E. G., McGrath, L. E., Zimmer, D. J., Bence, K. K., Sousa, G. L., Konanur, V. R., Krawczyk, J., Burk, D. H., Kanoski, S. E., Hermann, G. G., Rogers, R. C., Hayes, M. R. (2016). Astrocytes regulate GLP-1-mediated effects on energy balance. Journal of Neuroscience. Vol. 36 (12), pp. 3531-40. PubMed Web Address
• Noble, E. E., Kanoski, S. E. (2016). Early life exposure to obesogenic diets and learning and memory dysfunction. Current Opinion in Behavioral Sciences. Vol. 9, pp. 7-14. PubMed Web Address
• Hsu, T. M., Hahn, J. D., Konanur, V. R., Noble, E. E., Suarez, A. N., Thai, J., Nakamoto, E. M., Kanoski, S. E. (2015). Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways. eLife. Vol. 4, pp. e11190. PubMed Web Address
• Kanoski, S. E., Ong, Z., Fortin, S. M., Schlessinger, E., Grill, H. J. (2015). Liraglutide, leptin, and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanisms. Diabetes, Obesity and Metabolism. Vol. 17 (3), pp. 285-93. PubMed Web Address
• Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., Kanoski, S. E. (2015). Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus. PubMed Web Address
• Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., Kanoski, S. E. (2015). Hippocampal GLP-1 receptors influence food intake and effort-based responding for food through volume transmission. Neuropsychopharmacology. PubMed Web Address
• Ozek, C., Kanoski, S. E., Zhang, Z., Grill, H. J., Bence, K. K. (2014). Protein tyrosine phosphatase 1B is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B signaling. Journal of Biological Chemistry. Vol. 289 (46), pp. 31682-92. PubMed Web Address
• Hsu, T., Kanoski, S. E. (2014). Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Frontiers in Aging Neuroscience. Vol. 6 (88) PubMed Web Address
• Kanoski, S. E., Alhadeff, A. L., Fortin, S. F., Gilbert, J. R., Grill, H. J. (2014). Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food. Neuropsychopharmacology. Vol. 39 (3), pp. 605-613. PubMed Web Address
• Hayes, M. R., Mietlicki-Baase, E. G., Kanoski, S. E., De Jonghe, B. C. (2014). Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose. Nutrition Reviews. Vol. 34, pp. 237-60. PubMed Web Address
• Kanoski, S. E., Fortin, S. M., Ricks, K. M., Grill, H. J. (2013). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biological psychiatry. Vol. 73 (9), pp. 915-23. PubMed Web Address
• Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R. J., Yan, J., De Jonghe, B. C., Bence, K. K., Hayes, M. R., Grill, H. J. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism. Vol. 303 (4), pp. E496-503. PubMed Web Address
• De Jonghe, B. C., Hayes, M. R., Kanoski, S. E., Zimmer, D. J., Grill, H. J., Bence, K. K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism. PubMed Web Address
• Kanoski, S. E. (2012). Cognitive and neuronal systems underlying obesity. Physiology & behavior. Vol. 106 (3), pp. 337-44. PubMed Web Address
• Spaeth, A. M., Kanoski, S. E., Hayes, M. R., Grill, H. J. (2012). TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. American journal of physiology. Endocrinology and metabolism. Vol. 302 (10), pp. E1252-60. PubMed Web Address
• Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., Hayes, M. R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology. Vol. 62 (5-6), pp. 1916-27. PubMed Web Address
• Zhao, S., Kanoski, S. E., Yan, J., Grill, H. J., Hayes, M. R. (2012). Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. International Journal of Obesity. PubMed Web Address
• McKay, N. J., Kanoski, S. E., Hayes, M. R., Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (6), pp. R1755-64. PubMed Web Address
• Hayes, M. R., Kanoski, S. E., De, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (5), pp. R1479-85. PubMed Web Address
• Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., Hayes, M. R. (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. Vol. 152 (8), pp. 3103-12. PubMed Web Address
• Kanoski, S. E., Hayes, M. R., Greenwald, H. S., Fortin, S. M., Gianessi, C. A., Gilbert, J. R., Grill, H. J. (2011). Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Vol. 36 (9), pp. 1859-70. PubMed Web Address
• Hayes, M. R., Kanoski, S. E., Alhadeff, A. L., Grill, H. J. (2011). Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity (Silver Spring, Md.). Vol. 19 (7), pp. 1342-9. PubMed Web Address
• De Jonghe, B. C., Hayes, M. R., Banno, R., Skibicka, K. P., Zimmer, D. J., Bowen, K. A., Leichner, T. M., Alhadeff, A. L., Kanoski, S. E., Cyr, N. E., Nillni, E. A., Grill, H. J., Bence, K. K. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism. Vol. 300 (6), pp. E1002-11. PubMed Web Address
• Kanoski, S. E., Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & behavior. Vol. 103 (1), pp. 59-68. PubMed Web Address
• Hayes, M. R., Leichner, T. M., Zhao, S., Lee, G. S., Chowansky, A., Zimmer, D., De, B. C., Kanoski, S. E., Grill, H. J., Bence, K. K. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism. Vol. 13 (3), pp. 320-30. PubMed Web Address
• Hayes, M. R., Valmer, J., De Jonghe, B. C., Kanoski, S. E. (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior. Vol. 100 (5), pp. 503-10. PubMed Web Address
• Kanoski, S. E., Davidson, T. L. (2010). Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. Journal of experimental psychology. Animal behavior processes. Vol. 36 (2), pp. 313-9. PubMed Web Address
• Davidson, T. L., Kanoski, S. E., Chan, K., Clegg, D. J., Benoit, S. C., Jarrard, L. E. (2010). Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral neuroscience. Vol. 124 (1), pp. 97-105. PubMed Web Address
• Kanoski, S. E., Zhang, Y., Zheng, W., Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer’s disease : JAD. Vol. 21 (1), pp. 207-19. PubMed Web Address
• Davidson, T. L., Chan, K., Jarrard, L. E., Kanoski, S. E., Clegg, D. J., Benoit, S. C. (2009). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Vol. 19 (3), pp. 235-52. PubMed Web Address
• Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight regulation. Current opinion in pharmacology. Vol. 7 (6), pp. 613-6. PubMed Web Address
• Kanoski, S. E., Meisel, R. L., Mullins, A. J., Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. Vol. 182 (1), pp. 57-66. PubMed Web Address
• Kanoski, S. E., Walls, E. K., Davidson, T. L. (2007). Interoceptive “satiety” signals produced by leptin and CCK. Peptides. Vol. 28 (5), pp. 988-1002. PubMed Web Address
• Davidson, T. L., Kanoski, S. E., Walls, E. K., Jarrard, L. E. (2005). Memory inhibition and energy regulation. Physiology & behavior. Vol. 86 (5), pp. 731-46. PubMed Web Address
• Davidson, T. L., Kanoski, S. E., Tracy, A. L., Walls, E. K., Clegg, D., Benoit, S. C. (2005). The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. Vol. 26 (9), pp. 1602-10. PubMed Web Address