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Matthew Pratt

Assistant Professor of Chemistry

Contact Information
Phone: (213) 740-3014
Office: LJS 250

Personal Website


Ph.D. Chemistry, University of California Berkeley, 5/2004
B.S. Biochemistry, University of Arizona, 5/1999

Postdoctoral Training

Postdoctoral Fellow, The Rockefeller University, 08/2004-07/2009  

Academic Appointment, Affiliation, and Employment History

Assistant Professor, University of Southern California, 08/2009-  

Description of Research

Summary Statement of Research Interests

The overall theme of the lab is understanding the molecular consequences of posttranslational modifications (PTMs) including glycosylation and ubiquitination. These modifications expand the chemical diversity available to cells and living organisms. We specifically focus on the development of chemical tools as attractive methods for dissecting these biochemical pathways. Currently we are applying these chemical approaches to reveal roles for PTMs in cellular responses is processes associated with changes in metabolism and stress. Recent evidence suggests that these pathways are important contributors to a variety of human diseases including neurodegeneration and cancer. To accomplish our scientific goals, members of the lab use combinations of organic synthesis, genetics, protein biochemistry, and cellular biology.


Journal Article

Zaro, B. W., Yang, Y., Hang, H. C., Pratt, M. R. (2011). Chemical Reporters for Fluorescent Detection and Identification of O-GlcNAc Modified Proteins. Proceedings of the National Academy of Sciences USA. Vol. 108 (20), pp. 8146-8151. PubMed Web Address
Zaro, B. W., Bateman, L. A., Pratt, M. R. (2011). Robust In-Gel Fluorescence Detection of Mucin-Type O-Linked Glycosylation. Bioorganic & Medicinal Chemistry Letters. Vol. 21 (17), pp. 5062-5066. PubMed Web Address
Lau, H. D., Yaegashi, J., Zaro, B. W., Pratt, M. R. (2010). Precise Control of Protein Concentration in Living Cells. Angewandte Chemie International Edition. Vol. 49 (45), pp. 8458-8461. PubMed Web Address

Honors and Awards

Damon Runyon Innovation Award, 1/1/2012-12/31/2015  
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