University of Southern California
USC Dana and David Dornsife College of Letters, Arts and Sciences
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About
Matthew Robert PrattAssistant Professor of Chemistry and Biological SciencesContact Information E-mail: matthew.pratt@usc.edu Phone: (213) 740-3014 Office: LJS 250 LINKS Personal Website |
Education |
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 Ph.D. Chemistry, University of California Berkeley, 5/2004
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B.S. Biochemistry, University of Arizona, 5/1999
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Postdoctoral Training |
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Postdoctoral Fellow, The Rockefeller University, 08/2004-07/2009
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Academic Appointment, Affiliation, and Employment History |
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Assistant Professor, University of Southern California, 08/2009-
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Description of Research |
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Summary Statement of Research Interests |
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| The overall theme of the lab is understanding the molecular consequences of posttranslational modifications (PTMs) including glycosylation and ubiquitination. These modifications expand the chemical diversity available to cells and living organisms. We specifically focus on the development of chemical tools as attractive methods for dissecting these biochemical pathways. Currently we are applying these chemical approaches to reveal roles for PTMs in cellular responses is processes associated with changes in metabolism and stress. Recent evidence suggests that these pathways are important contributors to a variety of human diseases including neurodegeneration and cancer. To accomplish our scientific goals, members of the lab use combinations of organic synthesis, genetics, protein biochemistry, and cellular biology. | |
Publications |
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Journal Article |
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Zaro, B. W., Yang, Y., Hang, H. C., Pratt, M. R.
(2011).
Chemical Reporters for Fluorescent Detection and Identification of O-GlcNAc Modified Proteins. Proceedings of the National Academy of Sciences USA.
Vol. 108 (20), pp. 8146-8151. PubMed Web Address
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Zaro, B. W., Bateman, L. A., Pratt, M. R.
(2011).
Robust In-Gel Fluorescence Detection of Mucin-Type O-Linked Glycosylation. Bioorganic & Medicinal Chemistry Letters.
Vol. 21 (17), pp. 5062-5066. PubMed Web Address
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Lau, H. D., Yaegashi, J., Zaro, B. W., Pratt, M. R.
(2010).
Precise Control of Protein Concentration in Living Cells. Angewandte Chemie International Edition.
Vol. 49 (45), pp. 8458-8461. PubMed Web Address
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Honors and Awards |
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Damon Runyon Innovation Award, 1/1/2012-12/31/2015
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