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Lorraine Turcotte

Professor of Biological Sciences

Contact Information
E-mail: turcotte@usc.edu
Phone: (213) 740-8527
Office: PED 107

 

Education

Ph.D. Physiology, University of California, Berkeley, 5/1988
M.S. Exercise Physiology, University of Massachusetts, Amherst, 5/1984
B.Ed. Physical Education, McGill University, Montreal, Canada, 6/1981
 

Postdoctoral Training

Post-Doctoral Fellow, Clinical Research Institute, Montreal, Canada, 08/01/1991-06/30/1993  
Post-Doctoral Fellow, August Krogh Institute, University of Copenhagen, 08/01/1988-07/01/1991  
 

Academic Appointment, Affiliation, and Employment History

Associate Professor, Department of Biological Sciences, University of Southern California, 01/01/2003-  
Associate Professor, Department of Kinesiology, University of Southern California, 01/01/1999-  
Co-Director, Metabolic Regulation Lab, University of Southern California, 01/01/1994-  
Chair, Department of Kinesiology, University of Southern California, 08/15/2004-08/15/2010  
Assistant Professor, University of Southern California, 01/01/1993-01/01/1999  
Post-Doctoral Fellow, Hotel Dieu Hospital, 07/1991-07/1993  
Post-Doctoral Fellow, University of Copenhagen, 08/1988-07/1991  
 

Description of Research

Summary Statement of Research Interests

Our overall research goal is to better understand the regulation of skeletal muscle metabolism. We are specifically interested in unraveling the role of dysfunctional fatty acid metabolism in the development of metabolic pathologies such as obesity, insulin resistance, type II diabetes and cardiovascular diseases. Our research interests have led us to investigate the roles of various signaling cascades in the process of disease development. Thus, we have research projects that focus on (1) the role of AMPK (AMP-activated protein kinase) signaling in the regulation of high fat diet-induced insulin resistance and exercise-induced improvements in insulin sensitivity, (2) the role of pro-inflammatory signaling in the development of insulin resistance with HIV antiretroviral therapy and, (3) the role played by the nuclear factor RIP140 (receptor-interacting protein 140) in the development of fatty acid-induced insulin resistance. 1) Is AMPKa2 pivotal for the regulation of muscle during contractions and with high fat feeding To test these hypotheses, we used a transgenic mouse model that possesses a muscle specific dominant negative (DN) AMPKa2 transgene. Surgically prepared mouse hindlimbs were perfused during muscle contraction or following high fat feeding and metabolic and signaling parameters were measured. Our results showed that knockdown of AMPKa2 prevents contraction-induced changes in fat and carbohydrate metabolism and negatively impacts the regulation of insulin-stimulated metabolism especially in mice fed a high fat diet. 2) does AMPK activation via metformin or resveratrol therapy abrogate the negative effect of antiretroviral therapy on inflammation and metabolic function? The use of antiretroviral therapy in HIV-infected patients has been highly successful in controlling HIV replication. However, antiretroviral therapy is associated with several adverse metabolic disturbances, including insulin resistance. Because the development of insulin resistance is often linked to perturbations in the activation state of pro-inflammatory signaling cascades and metabolic regulation, we have tested the hypothesis that insulin resistance induced by antiretroviral therapy is mediated by an activation of the JNK1/2 pro-inflammatory cascade and that these perturbations can be abrogated via concomitant adjunct therapy with the insulin-sensitizing agents, metformin or resveratrol. Our results showed that metformin and resveratrol can diminish the negative effect of antiretroviral therapy; however, the cellular mechanisms by which this is accomplished are drug-dependent. 3) can low RIP140 expression minimize the negative effects of high fatty acid exposure on metabolism and gene expression? RIP140 is a nuclear factor that negatively regulates oxidative capacity. Because oxidative capacity is a determining factor in the regulation of muscle metabolism especially under the stress of high fatty acid exposure, the purpose of these studies was to determine whether genetically reduced RIP140 expression would positively affect metabolic regulation. Using RNAi technology to genetically silence RIP140, we showed that low RIP140 expression impairs rather than benefits the regulation of muscle metabolism when cells are exposed to high concentrations of fatty acids.
 

Funded Research

Contracts and Grants Awarded

HAART protease inhibitor-induced insulin resistance in skeletal muscle (American College of Sports Medicine), Lorraine P Turcotte, Lindsey D Bogachus, $5,000, 07/01/2010-06/30/2011  
Connecting physiological systems and human movement using multimedia tools (National Science Foundation), Lorraine Turcotte and Jill McNitt-Gray, $119,163, 08/01/2000-06/30/2004  
Exercise and skeletal muscle fatty acid metabolism (National Institutes of Health), Lorraine Turcotte, $350,000, 07/01/1998-06/30/2003  
 

USC Funding

WiSE Programs. Antiretroviral therapy and skeletal muscle insulin resistance: IR induced by antiretroviral therapy is due to decreased insulin signaling and is mediated by a decrease in FA oxidative capacity and an increase in the activation of nuclear factor kappaB., $25,000, 07/2009-06/2011  
Undergraduate Reseach Associates Program. The role of AMP-activated protein kinase in the prevention of obesity and type II diabetes: The role of AMPK in the development of obesity and type II diabetes will be tested in transgenic that do not express AMPK in muscle. , $10,000, 2008-2009   
WiSE Faculty Research Award. Regulation of muscle fatty acid metabolism: To collect data on the effects of downregulation of AMPKalpha2 on the regulation of fatty acid metabolism during muscle contractions and during high fat feeding. , $21,533, 07/01/2004-06/30/2006  
Innovative Undergraduate Teaching, Center for Excellence in Teaching. Using multimedia tools in laboratory sessions to enhance the learning of muscle physiologic concepts and to promote the understanding of the integration of the concepts with mechanical principles: CD-ROM of metabolic pathways was completed. , $9,138, 2002-2003   
WiSE Faculty Research Award. Fatty acid metabolism in muscle cells: We showed that AMP-activated protein kinase is critical to the regulation of muscle metabolism. , $24,600, 07/01/2001-06/30/2003  
Zumberge Interdisciplinary Research Grant. Fatty acid metabolism and intracellular signaling: Gene expression of SIRT1 and RIP140 was genetically silenced in L6 cells. Results showed that both intracellular cascades have important roles in the regulation of metabolism. , $43,000, 07/01/2001-06/30/2003  
Innovative Undergraduate Teaching, Center for Excellence in Teaching. Using multimedia techniques in laboratory sessions to enhance learning of the metabolic pathways in lecture: Development of incubated muscle preparation in undergraduate physiology labs., $6,000, 2000-2001   
Undergraduate Research Associated Program. Effects of aging on muscle fatty acid metabolism: Effects of aging on the content of proteins and transporters implicated in the regulation of fatty acid metabolism were investigated in the Fischer 344/Brown Norway rat model. , $6,900, 2000-2001   
 

Affiliations with Research Centers, Labs, and Other Institutions

Diabetes Research Center, Member
Metabolic Regulation Lab, Co-Director
 

Conferences and Other Presentations

Conference Presentations

"AMPKa2 down-regulation prevents voluntary wheel running-induced changes in glucose uptake but not in fatty acid uptake in mouse skeletal muscle", American College of Sports Medicine, Poster, Refereed Abstract, San Francisco, American College of Sports Medicine, Spring 2012   
"Low RIP140 expression rescues basal FA uptake via differential expression of FATP1 and CD36 in skeletal muscle cells exposed to high palmitate", Experimental Biology, Poster, Refereed Abstract, San Diego, American Physiological Society, Spring 2012   
"Low RIP140 expression uncovers the central role of the AKT-PKCzeta axis in the regulation of insulin-mediated fatty acid oxidation in skeletal muscle cells", American College of Sports Medicine, Poster, Refereed Abstract, San Francisco, American College of Sports Medicine, Spring 2012   
"Under insulin-mediated conditions, resveratrol restores glucose uptake but not fatty acid oxidation in skeletal muscle cells made insulin resistant by treatment with protease inhibitors", American College of Sports Medicine, Poster, Refereed Abstract, San Francisco, American College of Sports Medicine, Spring 2012   
"Calcium and Metabolic Regulation", 5th Asia-Pacific Conference on Exercise and Sports Science, Talk/Oral Presentation, Paper, Shanghai, China, Chinese Ministry, Invited, Fall 2011   
"Atazanavir sulfate induces insulin resistance in part via an increase in JUNK1/2 phosphorylation in skeletal muscle cells", American College of Sports Medicine, Poster, Refereed Denver, American College of Sports Medicine, Spring 2011   
"Contraction-induced signaling: Evidence of convergent cascades in the regulation of muscle metabolism", 4th Basel Muscle Symposium, Talk/Oral Presentation, Paper, Basel, Switzerland, Swiss Medical Research Council, Invited, Spring 2011   
"Low Receptor Interacting Protein 140 (RIP140) expression adversely impacts proximal insulin signaling in L6 skeletal muscle cells", Experimental Biology, Poster, Abstract, Washington, DC, American Physiological Society, Spring 2011   
"Metformin blunts highly active antiretroviral therapy-induced insulin resistance in skeletal muscle cells", American College of Sports Medicine, Talk/Oral Presentation, Refereed Denver, American College of Sports Medicine, Spring 2011   
"AMPK-SIRT1 signaling: Can drinking red wine really help in preventing insulin resistance?", Southwest American College of Sports Medicine, Talk/Oral Presentation, San Diego, Southwest American College of Sports Medicine, Invited, Fall 2010   
"AMP-activated protein kinase provides evidence for a Metformin-induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 skeletal muscle cells", Experimental Biology, Poster, Refereed Abstract, Anaheim, American Physiological Society, Spring 2010   
"AMPKa2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high-fat-fed mice", Experimental Biology, Poster, Refereed Abstract, Anaheim, American Physiological Society, Spring 2010   
"AMPKa2 is not necessary to increase the activation state of ERK1/2, CaMKI, or AS160 during moderate intensity muscle contraction in perfused mouse muscle", Experimental Biology, Poster, Refereed Abstract, Anaheim, American Physiological Society, Spring 2010   
"Low RIP140 expression partially restores metabolic flexibility in L6 muscle cells treated with high FA", Annual Biology Interdisciplinary Graduate Student Symposium, Poster, USC, Biology Interdepartmental Graduate Student Associa, Invited, Spring 2010   
"Low RIP140 expression partially restores metabolic flexibility in L6 muscle cells treated with high FA", Experimental Biology, Poster, Refereed Abstract, Anaheim, American Physiological Society, Spring 2010   
"Receptor Interacting Protein 140 (RIP140) silencing via RNAi interferes with fatty acid metabolism but not with glucose uptake in L6 cells", RNAi & miRNA World Congress, Poster, Refereed Boston, RNAi miRNA World Congress, Spring 2010   
"AICAR and Metformin preferentially activate different AMP-activated protein kinase (AMPK) isozymes to regulate muscle metabolism and SIRT1 activity in L6 muscle cells", SouthWest American College of Sports Medicine, Talk/Oral Presentation, Abstract, San Diego, SouthWest American College of Sports Medicine, Invited, Fall 2009   
"Deletion of muscle AMPKa2 abrogates high fat diet-induced IL6 expression in adipose tissue", SouthWest American College of Sports Medicine, Poster, Refereed Abstract, San Diego, SouthWest American College of Sports Medicine, Fall 2009   
"Suppression of Receptor Interacting Protein 140 (RIP140) expression in L6 cells impairs the regulation of insulin-sensitive FA uptake and oxidation but not that of insulin-sensitive glucose uptake", SouthWest American College of Sports Medicine, Poster, Refereed Abstract, San Diego, SouthWest American College of Sports Medicine, Fall 2009   
"Suppression of receptor interacting protein (RIP140) expression in L6 cells impairs the regulation of insulin-sensitive FA uptake and oxidation but not that of insulin-sensitive glucose uptake ", USC Graduate and Professional Student Appreciation Week Research Fair, Poster, Refereed Los Angeles, USC, Fall 2009   
"AICAR and Metformin increase SIRT1 activity despite preferentially phosphorylating different AMPK isoforms", International Biochemistry of Exercise, Talk/Oral Presentation, Abstract, Guelph, Ontario, International Biochemistry of Exercise, Invited, Spring 2009   
"AMPKa2 is not necessary in the regulation of Ca2+-induced FA metabolism in perfused mouse muscle", Internatioal Biochemistry of Exercise, Poster, Refereed Abstract, Guelph, Ontario, Internatioal Biochemistry of Exercise, Spring 2009   
"AMPKa2 is not necessary in the regulation of Ca2+-induced FA metabolism in perfused mouse muscle", USC Biology Interdepartmental Graduate Symposium, Talk/Oral Presentation, USC, USC Biology Interdepartmental Graduate Student Ass, Invited, Spring 2009   
"Contrary to AICAR, Metformin regulates fatty acid metabolism by preferentially phosphorylating AMPKa1 in L6 myotubes", USC Graduate and Professional Student Appreciation Week Research Fair , Poster, Refereed USC, Graduate & Professional Student Association, Spring 2009   
"Fatty acid metabolism and glucose uptake are differently affected by aspirin treatment in muscle cells exposed to high saturated fatty acid availability", USC Graduate and Professional Student Appreciation Week Research Fair , Poster, Refereed USC, Graduate & Professional Student Association, Spring 2009   
"Key role for AMPKa2 in the regulation of contraction-mediated fatty acid metabolism in perfused mouse muscle ", American College of Sports Medicine, Talk/Oral Presentation, Abstract, Seattle, American College of Sports Medicine, Invited, Spring 2009   
"Selective AMPKa1 and AMPKa2 deficiency uncovers isozyme-specific regulation of metabolism and SIRT1 activation in L6 muscle cells", USC Biology Interdepartmental Graduate Symposium, Poster, Refereed USC, USC Biology Interdepartmental Graduate Student Ass, Spring 2009   
"Selective AMPKa1 and AMPKa2 deficiency uncovers isozyme-specific regulation of metabolism and SIRT1 activation in L6 muscle cells ", American College of Sports Medicine, Poster, Refereed Abstract, Seattle, American College of Sports Medicine, Spring 2009   
"Evidence for the involvement of CaMKKbeta in the regulation of glucose uptake in perfused rat muscle", Biology of Exercise, Poster, Refereed Abstract, Hilton Head, American Physiological Society, Fall 2008   
"Contraction-induced fatty acid uptake and oxidation are regulated in part via CaMKKbeta-dependent AMPK activation in perfused rat muscle", Experimental Biology, Poster, Abstract, San Diego, American Physiological Society, Spring 2008   
"Calcium/calmodulin-dependent protein kinase regulates fatty acid uptake and oxidation during moderate intensity muscle contraction in part via activation of AMP-activated protein kinase", Southwest American College of Sports Medicine, Talk/Oral Presentation, Abstract, San Diego, American College of Sports Medicine, Invited, Fall 2007   
"Acute and chronic elevations in intracellular calcium increases FA uptake an oxidation via different molecular mechanisms in L6 myotubes", Medicine and Science in Sports and Exercise, Talk/Oral Presentation, Abstract, New Orleans, American College of Sports Medicine, Invited, Spring 2007   
"Chronic activation of AMPK enhances insulin-sensitive fatty acid uptake but not oxidation in L6 cells", Experimental Biology, Talk/Oral Presentation, Abstract, San Francisco, American Physiological Society, Invited, Spring 2006   
"Cross-talk between CaMKII and AMPK is associated with increased FA metabolism in contracting rodent muscle", Experimental Biology, Poster, Abstract, San Francisco, American Physiological Society, Spring 2006   
"ERK1/2 inhibition prevents the contraction-induced increase in FA metabolism and plasma membrane CD36 content, without affecting AMPKalpha2 activity, in a dose-dependent manner in rodent muscle", Southwest American College of Sports Medicine, Talk/Oral Presentation, Abstract, Las Vegas, American College of Sports Medicine, Invited, Fall 2005   
"Contraction-induced ERK1/2 activation is not involved in the regulation of muscle FA oxidation during contraction of increasing intensity", Experimental Biology, Poster, Abstract, San Diego, American Physiological Society, Spring 2005   
"Inhibition of PI3K but not PKB/Akt prevents the insulin-induced effects on LCFA metabolism", Experimental Biology, Poster, Abstract, San Diego, American Physiological Society, Spring 2005   
"Regulation of contraction-induced FA uptake by AMPK and ERK1/2 is intensity-dependent in rodent muscle", Medicine and Science in Sports and Exercise, Talk/Oral Presentation, Abstract, Nashville, American College of Sports Medicine, Invited, Spring 2005   
"aPKC-zeta inhibition abolishes insulin-induced LCFA uptake but does not prevent the insulin-induced decreased in LCFA oxidation", Medicine and Science in Sports and Exercise, Talk/Oral Presentation, Abstract, Nashville, American College of Sports Medicine, Spring 2005   
 

Publications

Abstract

Turcotte, L. P., Bogachus, L. D. (2012). Under insulin-mediated conditions, resveratrol restores glucose uptake but not fatty acid oxidation in skeletal muscle cells made insulin resistant by treatment with protease inhibitors. Medicine and Science in Sports and Exercise.
Constantinescu, S., Turcotte, L. P. (2012). Low RIP140 expression uncovers the central role of the AKT-PKCzeta axis in the regulation of insulin-mediated fatty acid oxidation in skeletal muscle cells. Medicine and Science in Sports and Exercise.
Abbott, M. J., Turcotte, L. P. (2012). AMPKa2 down-regulation prevents voluntary wheel running-induced changes in glucose uptake but not in fatty acid uptake in mouse skeletal muscle. Medicine and Science in Sports and Exercise.
Constantinescu, S., Turcotte, L. P. (2012). Low RIP140 expression rescues basal FA uptake via differential expression of FATP1 and CD36 in skeletal muscle cells exposed to high palmitate. FASEB Journal.
Turcotte, L. P., Bogachus, L. D. (2011). Atazanavir sulfate induces insulin resistance in part via increased JNK1/2 phosphorylation in skeletal muscle cells. Medicine and Science in Sports and Exercise.
Bogachus, L. D., Turcotte, L. P. (2011). Metformin blunts highly active antiretroviral therapy-induced insulin resistance in skeletal muscle cells. Medicine and Science in Sports and Exercise.
Constantinescu, S., Turcotte, L. P. (2011). Low Receptor Interacting Protein 140 (RIP140) expression adversely impacts proximal insulin signaling in L6 skeletal muscle cells. FASEB Journal.
Constantinescu, S., Turcotte, L. P. (2011). Up-regulation of oxidative capacity by genetic manipulation uncovers the central role of AKT signaling in the regulation of fatty acid oxidation in skeletal muscle cells. Proceedings of the Southwest Regional Conference of the American College of Sports Medicine.
Constantinescu, S., Turcotte, L. P. (2010). Low RIP140 expresseion partically restores metabolic flexibility in L6 muscle cells treated with high FA. FASEB Journal.
Bogachus, L. D., Turcotte, L. P. (2010). AMP-activated protein kinase alpha1 silencing provides evidence for a metformin-induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 muscle cells. FASEB Journal.
Abbott, M. J., Turcotte, L. P. (2010). AMPKalpha2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high-fat-fed mice. FASEB Journal.
Abbott, M. J., Turcotte, L. P. (2010). AMPKalpha2 is not necessary to increase the activation state of ERK1/2, CaMKI, or AS160 during moderate intensity muscle contraction in perfused mouse muscle. FASEB Journal.
Abbott, M. J., Turcotte, L. P. (2009). Key role for AMPKa2 in the regulation of contraction-mediated fatty acid metabolism in perfused mouse muscle. Med Sci Sports Exerc.
Bogachus, L. D., Turcotte, L. P. (2009). Metformin and AICAR regulate fatty acid metabolism in L6 myotubes via difference cellular mechanisms. Med Sci Sports Exerc.
Bogachus, L. D., Turcotte, L. P. (2009). AICAR and Metformin increase SIRT1 activity despite preferentially phosphorylating different AMPK isoforms. Applied Physiology, Nutrition and Metabolism.
Bogachus, L. D., Turcotte, L. P. (2009). AMPKa2 is not necessary in the regulation of Ca2+-induced FA metabolism in perfused mouse muscle. Applied Physiology, Nutrition and Metabolism.
El-Fakih, N., Abbott, M. J., Turcotte, L. P. (2009). Deletion of muscle AMPKalpha2 abrogates high fat diet-induced IL6 expression in adipose tissue. Proceedings of the Southwest Regional Conference of the American College of Sports Medicine.
Constantinescu, S., Turcotte, L. P. (2009). Suppressin of Receptor Interacting Protein 140 (RIP140) expression in L6 cells impairs the regulation of insulin-sensitive FA uptake and oxidation but not that of insulin-sensitive glucose uptake. Proceedings of the Southwest Regional Conference of the American College of Sports Medicine.
Bogachus, L. D., Turcotte, L. P. (2009). AICAR and Metformin preferentially activate different AMP-activated protein kinase (AMPK) isoforms to regulate muscle metabolism and SIRT1 activity in L6 muscle cells. Proceedings of the Southwest Regional Conference of the American College of Sports Medicine.
Abbott, M. J., Turcotte, L. P. (2008). Evidence for the involvement of CaMKKbeta in the regulation of glucose uptake in perfused rat muscle. The Physiologist.
Kelly, K. R., Turcotte, L. P. (2007). Acute and chronic elevations in intracellular calcium increases FA uptake and oxidation via different molecular mechanisms in L6 myotubes. Medicine and Science in Sports and Exercise.
Kelly, K. R., Turcotte, L. P. (2006). Chronic activation of AMPK enhances insulin-sensitive fatty acid uptake but not oxidation in L6 cells. FASEB J.
Raney, M. A., Turcotte, L. P. (2006). Cross-talk between CaMKII and AMPK is associated with increased FA metabolism in contracting rodent muscle. FASEB J.
Todd, M. K., Turcotte, L. P. (2003). Effect of training on malonyl-CoA inhibition of palmitoyl-CoA generated electron transport in different fiber types. Medicine and Science in Sports and Exercise.
Todd, M. K., Hevener, A. L., Turcotte, L. P. (2002). Troglitazone normalises plasma FA levels in high fat fed rats by increasing FA uptake in skeletal muscle. Diabetes.
Turcotte, L. P., Muoio, D. M., Jensen, M. D., Kiens, B. (2002). Muscle triglyceride metabolism in exercise and disease. Medicine and Science in Sports and Exercise.
Yee, A. J., Ver, M., Turcotte, L. P. (2002). Dichloroacetate is associated with an increase in malonyl-CoA but no corresponding decrease in FA oxidation. Medicine and Science in Sports and Exercise.
Todd, M. K., Turcotte, L. P. (2002). High fat diet causes an increase in resting FA oxidation which is insufficient to restore normal metabolism in skeletal muscle. Medicine and Science in Sports and Exercise.
Yee, A. J., Sacman, M. L., Todd, M. K., Turcotte, L. P. (2001). High carbohydrage availability is associated with increased FA uptake but no change in FA oxidation in perfused contracting muscle. FASEB Journal.
Turcotte, L. P., Sacman, M. L., Yee, A. J., Todd, M. K. (2001). The glucose-fatty acid cycle is not operative in muscle perfused with high glucose and insulin levels. Diabetes.
Yee, A. J., Sacman, M. L., Todd, M. K., Turcotte, L. P. (2001). Insulin fails to modify plasma FFA kinetics in muscle perfused at a pre-determined glucose uptake. Diabetes.
Todd, M. K., Yee, A. J., Kennedy, S. L., Mazzeo, R. S., Turcotte, L. P. (2001). Exposure to altitude does not alter FABPpm content in sedentary rat heart, skeletal muscle or liver. Medicine and Science in Sports and Exercise.
Todd, M. K., Messer, J. I., Willis, W. T., Turcotte, L. P. (2001). Using cytochrome-c reductase (CR) activity to demonstrate the effects of muscle cell type and environmental conditions on in vitro carbohydrate oxidation in an undergraduate Exercise Physiology lab. FASEB Journal.
Tucker, M. Z., Turcotte, L. P. (2001). Brief food restriction is associated with increased FA oxidation and glycogen synthesis in muscle perfused under hyperglycemic-hyperinsulinemic conditions. FASEB Journal.
Sacman, M. L., Yee, A. J., Todd, M. K., Turcotte, L. P. (2001). High CHO availability in the presence of high FA availability is associated with increased muscle FA uptake but no change in percent FA oxidation. FASEB Journal.
Swenberger, J. R., Tucker, M. Z., Yee, A. J., Turcotte, L. P. (2000). Incorporation of palmitate into triglycerides is increased with enhanced carbohydrate supply in perfused muscle. FASEB Journal.
Yee, A. J., Swenberger, J. R., Tucker, M. Z., Turcotte, L. P. (2000). Malonyl-CoA levels correlate with fatty acid oxidation in perfused muscle. FASEB Journal.
Tucker, M. Z., Turcotte, L. P. (2000). Aging is associated wtih increased palmitate uptake in hyperglycemic-hyperinsulinemic perfused muscle. FASEB Journal.
Yee, A. J., Swenberger, J. R., Tucker, M. Z., Turcotte, L. P. (2000). Greater carbohydrate availability is associated with increased FFA uptake and decrease FFA oxidation in perfused muscle. Medicine and Science in Sports and Exercise.
Tucker, M. Z., Turcotte, L. P. (2000). Decreased fat oxidation by skeletal muscle in middle-aged and old adult Fischer 344/Brown Norway rats. Medicine and Science in Sports and Exercise.
 

Book Chapter

Turcotte, L. P. (2006). Lipid metabolism during exercise. pp. p.105-136. Champaign, Illinois: Exercise Metabolism/Human Kinetics.
Turcotte, L. P. (1999). Fatty acid binding proteins and lipid metabolism in skeletal muscle. pp. 201-215. Champaign, Illinois: Human Kinetics Publishers.
 

Journal Article

Abbott, M. J., Constantinescu, S., Turcotte, L. P. (2012). AMPKa2 is an essential signal in the regulation of insulin-stimulated fatty acid uptake in control-fed and high fat-fed mice. Experimental Physiology. PubMed Web Address
Kelly, K. R., Turcotte, L. P. (2012). AMP-regulated kinase and calcium/calmodulin-dependent kinase II co-regulate fatty acid uptake and oxidation in L6 muscle cells. Recent Research Development in Physiology. Vol. 5, pp. 15-26.
Abbott, M. J., Bogachus, L. D., Turcotte, L. P. (2011). AMPKalpha2 deficiency uncovers time-dependency in the regulation of cotnraction-induced palmitate and glucose uptake in mouse muscle. Journal of Applied Physiology. Vol. 111, pp. 125-134.
Ali, A. H., Koutsari, C., Mundi, M., Stegall, M. D., Heimbach, J. K., Taler, S. J., Nygren, J., Thorell, A., Bogachus, L. D., Turcotte, L. P., Bernlohr, D., Jensen, M. D. (2011). Free fatty acid storage in omental and abdominal subcutaneous adipose tissue - effects of sex, lipogenic enzyme activity and transport proteins. Diabetes. Vol. 60, pp. 2300-2307.
Bogachus, L. D., Turcotte, L. P. (2011). HIV protease inhibitors induce metabolic dysfunction in part via increased JNK1/2 pro-inflammatory signaling in L6 cells. Antiviral Research. Vol. 92, pp. 415-423.
Bogachus, L. D., Turcotte, L. P. (2010). Genetic downregulation of AMPKalpha1 and AMPKalpha2 uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells. America Journal of Physiology, Cell. Vol. 299, pp. C1549-C1561.
Kelly, K. R., Abbott, M. J., Turcotte, L. P. (2010). Short-term AMPK activation enhances insulin-sensitive FA uptake and increases the effects of insulin on FA oxidation in L6 muscle cells. Exper Biol Med. Vol. 235, pp. 514-521.
Abbott, M. J., Edelman, A. M., Turcotte, L. P. (2009). CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. Am J Physiol Regul Integr Comp Physiol. Vol. 297, pp. R1724-R1732.
Turcotte, L. P., Fisher, J. S. (2008). Skeletal muscle insulin resistance: Roles of fatty acid metabolism and exercise. Physical Therapy. Vol. 88 (11), pp. 1279-1296.
Kelly, K. R., Sung, C. K., Abbott, M. J., Turcotte, L. P. (2008). Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 cells: involvement of atypical protein kinase C-zeta in LCFA uptake but not oxidation. Journal of Endocrinology. Vol. 198, pp. 375-384.
Raney, M. A., Turcotte, L. P. (2008). Evidence for the involvement of CaMKII and AMPK in Ca+2-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle. Journal of Applied Physiology. Vol. 104, pp. 1366-1373.
Berthiaume, M., Laplante, M., Festuccia, W., Cianflore, K., Turcotte, L., Joanisse, D., Olivecrone, G., Deshaies, Y. (2007). 11-ß-HSD-1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids towards oxidative tissues. Am J Physiol Endocrinol Metab. Vol. 293, pp. E1054-E1052.
Raney, M. A., Turcotte, L. P. (2007). Evidence for the regulation of contraction-induced fatty acid oxidation via extracellular signal-regulated kinase 1/2 activation independent of changes in fatty acid uptake. Metabolism. Vol. 56, pp. 1192-1200.
Todd, M. K., Watt, M. J., Le, J., Hevener, A. L., Turcotte, L. P. (2007). Thiazolidinediones enhance skeletal muscle triacylglecerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance. Am J Physio Endocrinol Metab. Vol. 292, pp. E485-E493.
Raney, M. A., Turcotte, L. P. (2006). Regulation of contraction-induced FA uptake and oxidation by AMPK and ERK1/2 is intensity dependent in rodent muscle. Am J Physiol Endocrinol Metab. Vol. 291, pp. E1220-E1227.
Raney, M. A., Yee, A. J., Todd, M. K., Turcotte, L. P. (2005). AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. Am J Physiol Endocrinol Metab. Vol. 288, pp. E592-E598.
Turcotte, L. P., Raney, M. A., Todd, M. K. (2005). ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle. Acta Physiol Scand. Vol. 184, pp. 131-139.
Tucker, M. Z., Turcotte, L. P. (2005). Brief food restriction in old animals decreases TG content and insulin-stimulated TG synthesis. J Gerontol Biol Sci. Vol. 60A, pp. 157-164.
Todd, M. K., Yaspelkis III, B. B., Turcotte, L. P. (2005). Short-term leptin treatment increases fatty acid uptake and oxidation in muscle of high fat-fed rats. Metabolism. Vol. 54, pp. 1218-1224.
Tucker, M. Z., Turcotte, L. P. (2003). Aging is associated with elevated muscle triglyceride content and increased insulin-stimulated fatty acid uptake. Am J Physiol Endocrinol Metab. Vol. 283, pp. E827-E835.
Turcotte, L. P. (2003). Mitochondria: Biogenesis, structure and function. Med Sci Sports & Exerc. Vol. 35, pp. 82-85.
Tucker, M. Z., Turcotte, L. P. (2002). Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions. Am J Physiol Endocrinol Metab. Vol. 282, pp. E1102-E1109.
Turcotte, L. P., Tucker, M. Z. (2002). Brief food restriction increases FA oxidation and glycogen synthesis under insulin-stimulated conditions. Am J Physiol Regulatory Integrative and Comp Physiol. Vol. 282, pp. R1210-R1218.
Yee, A. J., Turcotte, L. P. (2002). Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake. Am J Physiol Endocrinol Metab. Vol. 283, pp. E73-E77.
Turcotte, L. P. (2002). High carbohydrate availabillity increases LCFA uptake and decreases LCFA oxidation in perfused muscle. Am J Physiol Endocrinol Metab. Vol. 282, pp. E177-E183.
Luiken, J. F., Arumugan, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M., Turcotte, L. P., Tandon, N. N., Glatz, J. C., Bonen, A. (2001). Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats. J Biol Chem. Vol. 276, pp. 40567-40573.
Turcotte, L. P., Swenberger, J. R., Tucker, M. Z., Yee, A. J. (2001). Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats. Diabetes. Vol. 50, pp. 1389-1396.
Turcotte, L. P. (2000). Muscle fatty acid uptake during exercise: Possible mechanisms. Exercise and Sport Sciences Reviews. Vol. 28, pp. 4-9.
Turcotte, L. P., Swenberger, J. R., Tucker, M. Z., Yee, A. J., Trump, G., Luiken, J. F., Bonen, A. (2000). Muscle palmitate transport and binding are saturable and inhibited by antibodies to FABP (PM). Mol Cell Biochem. Vol. 210, pp. 53-63.
Gazdag, A. C., Wetter, T. J., Davidson, R. T., Robinson, K. A., Buse, M. G., Yee, A. J., Turcotte, L. P., Carter, G. D. (2000). Lower calorie intake enhances muscle insulin action and reduces hexosamine levels. Am J Physiol Regulatory Integrative & Comp Physiol. Vol. 278, pp. R504-R512.
Turcotte, L. P. (1999). Nutritional aspects of exercise. Role of fats in exercise: Types and quality. Clinics in Sports Medicine. Vol. 18, pp. 485-498.
Simoneau, J., Veerkamp, J. H., Turcotte, L. P., Kelley, D. E. (1999). Metabolic markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance, obesity and weight loss. FASEB Journal. Vol. 13 (2051-2060)
Luiken, J. J., Turcotte, L. P., Bonen, A. (1999). Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles. Journal of Lipid Research. Vol. 40, pp. 1007-1016.
Turcotte, L. P., Swenberger, J. R., Tucker, M. Z., Yee, A. J. (1999). Training-induced elevation in FABPpm is associated with increased palmitate use in contracting muscle. Journal of Applied Physiology. Vol. 87, pp. 285-293.
 

Honors and Awards

Recognition Award, SouthWest American College of Sports Medicine, Fall 2009   
Mellon Award for Excellence in Mentoring, University of Southern California, Spring 2008   
Remarkable Women Award, University of Southern California, 2004  
Innovative Teaching Award: USC Center for Excellence in Teaching Innovative Undergraduate Teaching Award, 2002-2003  
Faculty of the Month, Mortar Board National Honor Society, 2001  
Innovative Teaching Award: USC Center for Excellence in Teaching Innovative Undergraduate Teaching Award, 2000-2001  
Professor of the Year, Gamma Sigma Alpha Honor Society, 1999  
Fellow, American College of Sports Medicine, Fellow, Spring 1996   
 

Service to the University

Administrative Appointments

Chair of the Department of Kinesiology, 08/15/2007-08/15/2010  
Chair of the Department of Kinesiology, 09/01/2004-08/15/2007  
 

Service to the Profession

Administrative Appointments

Chair, Conference Exhibit Committee, American College of Sports Medicine, Southwest Chapter, 07/01/2000-06/30/2003  
Chair, International Scholar Award Committee, International Relations Committee, American College of Sports Medicine, 07/01/1997-06/30/2003  
Presidential Task Force, American College of Sports Medicine, 07/01/2001-06/30/2002  
 

Editorships and Editorial Boards

Associate Editor, Canadian Journal of Physiology and Pharmacology, 2011-2014  
Review Editor, Frontiers in Fatty Acid and Lipid Physiology, 2011-2014  
Associate Editor, Exercise and Sport Sciences Reviews, 2002-2005  
Editorial Board, Health and Fitness Journal, 2001-2004  
 

Professional Offices

Trustee (National election), Board of Trustees, American College of Sports Medicine, 05/2009-06/2012  
Executive Council Member, American College of Sports Medicine, Southwest Chapter, 07/01/2000-06/30/2003  
 

Professional Memberships

American Physiological Society, Member, 1993-  
American College of Sports Medicine, Fellow, 1982-  
American Diabetes Association, Member Council on Exercise, 1988-2010  
International Society for the Study of Fatty Acids and Lipids, Member, 1995-2004  
 
 
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