Skip to main content

Oscar Aparicio

Professor of Biological Sciences

Contact Information
Phone: (213) 821-1269
Office: RRI 219B



Ph.D. Molecular Genetics & Cell Biology, University of Chicago, 12/1993
B.S. Microbiology, University of Florida, 5/1987

Postdoctoral Training

Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  

Academic Appointment, Affiliation, and Employment History

Tenure Track Appointments

Associate Professor, University of Southern California, 05/01/2005-  
Assistant Professor, University of Southern California, 09/01/1999-05/01/2005  

PostDoctoral Appointments

Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  

Other Employment

Congressional Science Fellow, American Society for Microbiology, 09/01/1993-08/31/1994  

Description of Research

Summary Statement of Research Interests

The Aparicio lab studies the mechanisms of cell cycle and checkpoint regulation of chromosomal DNA replication as well as how the three-dimensional organization and chromatin structure of chromosomes regulates this process. We use cell biological, molecular, biochemical, genetic, and genomic approaches using the model organism, S. cerevisiae (aka: Baker’s yeast). We have recently identified the Forkhead Box (Fox) proteins Fkh1 and Fkh2 as regulators of replication origin initiation, and are investigating their role in regulating the dynamics and three-dimensional organization of chromosomes. We also work on the development of methods to study genomic activities such as protein-DNA interactions that underlie fundamental processes such as DNA replication and epigenetic control.

Research Keywords

DNA replication, genome dynamics and structure, chromatin, checkpoints, cell cycle, replication origins, replication forks, budding yeast, S. cerevisiae

Research Specialties

Biochemistry, Molecular Biology, DNA replication, Genetics, S. cerevisiae

Affiliations with Research Centers, Labs, and Other Institutions

USC/Norris Comprehensive Cancer Center, Member,
Faculty may update their profile by visiting