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Oscar Aparicio

Professor of Biological Sciences

Contact Information
E-mail: oaparici@usc.edu
Phone: (213) 821-1269
Office: RRI 219B

 

Education

Ph.D. Molecular Genetics & Cell Biology, University of Chicago, 12/1993
B.S. Microbiology, University of Florida, 5/1987
 

Postdoctoral Training

Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  
 

Academic Appointment, Affiliation, and Employment History

Tenure Track Appointments

Associate Professor, University of Southern California, 05/01/2005-  
Assistant Professor, University of Southern California, 09/01/1999-05/01/2005  
 

PostDoctoral Appointments

Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  
 

Other Employment

Congressional Science Fellow, American Society for Microbiology, 09/01/1993-08/31/1994  
 

Description of Research

Summary Statement of Research Interests

Professor Aparicio's research is focused on three related topics: (1) regulation of chromosomal DNA replication and the cell cycle in eukaryotic cells; (2) the role of cell cycle checkpoints in monitoring the integrity of chromosomal DNA replication and linking replication to cell cycle progression, DNA repair, and mitosis; (3) the influence of higher order chromatin structures/modifications (e.g.: heterochromatin) on the activity, timing, or replication origin activation during S phase. Aparicio employs a combination of molecular genetic, biochemical, physiological, and genomic methods in his studies. A full understanding of these mechanisms will provide important insights into the regulation of gene expression and organismal development under normal circumstances and the development of cancer when these processes go awry.
 

Research Keywords

DNA replication, DNA repair, chromatin, checkpoints, cell cycle, replication origins, replication forks, budding yeast, S. cerevisiae, genome
 

Research Specialties

Biochemistry, Molecular Biology, DNA replication, Genetics, S. cerevisiae
 

Affiliations with Research Centers, Labs, and Other Institutions

USC/Norris Comprehensive Cancer Center, Member, http://ccnt.hsc.usc.edu/
 
 
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