{"id":691,"date":"2025-04-28T11:52:03","date_gmt":"2025-04-28T18:52:03","guid":{"rendered":"https:\/\/dornsife.usc.edu\/sbc\/?page_id=691"},"modified":"2025-06-20T17:41:37","modified_gmt":"2025-06-21T00:41:37","slug":"structure-determination-and-refinement","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/sbc\/structure-determination-and-refinement\/","title":{"rendered":"Structure Determination and Refinement"},"content":{"rendered":"\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><span style=\"font-size: 80%;\">*The rates are subject to change without prior notice.<\/span><\/p>\n<table style=\"margin-top: 0px; margin-bottom: 0px; overflow-x: auto;\" width=\"auto\">\n<tbody>\n<tr align=\"center\">\n<td><b>X-Ray Structure Determination<\/b><\/td>\n<td><b>Bridge Institute<\/b><\/td>\n<td><b>USC Users\/ Collaboration<\/b><\/td>\n<td><b>Non-profit org\/ Collaborator<\/b><\/td>\n<td><b>Industry\/ Collaborators<\/b><\/td>\n<\/tr>\n<tr style=\"background-color: #d0dceb;\" align=\"center\">\n<td><b>Structure Determination<sup>1<\/sup><\/b><\/td>\n<td><b>$1100<\/b><\/td>\n<td><b>$1400<\/b><\/td>\n<td><b>$1740<\/b><\/td>\n<td><b>Upon request<\/b><\/td>\n<\/tr>\n<tr style=\"background-color: #e1edfb;\" align=\"center\">\n<td><b>Refinement and Validation<\/b><\/td>\n<td><b>$1800<\/b><\/td>\n<td><b>$2200<\/b><\/td>\n<td><b>$2750<\/b><\/td>\n<td><b>Upon request<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><sup>1<\/sup>The X-ray data will be processed, and the structure of the target protein will be determined using Molecular Replacement (MR)or any other methods.<\/p>\n<table style=\"margin-top: 0px; margin-bottom: 0px; overflow-x: auto;\" width=\"auto\">\n<tbody>\n<tr align=\"center\">\n<td><b>Cryo-EM Structure Determination<\/b><\/td>\n<td><b>Bridge Institute<\/b><\/td>\n<td><b>USC Users\/ Collaboration<\/b><\/td>\n<td><b>Non-profit org\/ Collaborator<\/b><\/td>\n<td><b>Industry\/ Collaborators<\/b><\/td>\n<\/tr>\n<tr style=\"background-color: #d0dceb;\" align=\"center\">\n<td><b>Structure Determination<sup>2<\/sup> Refinement and Validation<\/b><\/td>\n<td><b>$2800<\/b><\/td>\n<td><b>$3500<\/b><\/td>\n<td><b>$4650<\/b><\/td>\n<td><b>Upon request<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><sup>2<\/sup>Cryo-EM structure determination and refinement will be carried out using well-processed data provided by the client.<\/p>\n<p class=\"p1\">Structure determination will provide you a correct model while refinement will take care of all the details in the structure and produces a finely refined structure. We will provide the final 3D structure, a table of refinement statistics, and a draft of the Materials and Methods section for publication.<\/p>\n<p class=\"p1\">The rates may vary based on the number of residues of the molecule, number of the molecules in the asymmetric unit and of course the resolution.<\/p>\n<p><strong><span data-olk-copy-source=\"MessageBody\">Please complete the <a href=\"https:\/\/dornsife.usc.edu\/sbc\/wp-content\/uploads\/sites\/470\/2025\/06\/SBC-Service-Request-Form-A.docx\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #990000;\">Service Request Form<\/span><\/a> and email it to<\/span> <a href=\"mailto:sbc-bridge-l@maillist.usc.edu\">sbc-bridge-l@maillist.usc.edu<\/a><\/strong><\/p>\n<p><a href=\"https:\/\/dornsife.usc.edu\/sbc\/services\/\"><strong>More Available Services <span style=\"background-color: #ffcc00; padding-left: 0.2em; padding-right: 0.2em;\">\u2794<\/span><\/strong><\/a><\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":89,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-691","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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