{"id":474,"date":"2025-03-19T10:27:34","date_gmt":"2025-03-19T17:27:34","guid":{"rendered":"https:\/\/dornsife.usc.edu\/sbc\/?page_id=474"},"modified":"2025-06-17T10:49:55","modified_gmt":"2025-06-17T17:49:55","slug":"publications","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/sbc\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n\n \n \n\n\n\n\n\n\n\n
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2025:<\/h2>\n
    \n
  1. A.S. Tyson, S. Khan, Z. Motiwala, G.W. Han, Z. Zhang, M. Ranjbar, D. Styrpejko, N. Ramos-Gonzalez, S. Woo, K. Villers, D. Landaker, T. Kenakin, R. Shenvi, S. Majumdar, C. Gati (2025). Molecular mechanisms of inverse agonism via \u03ba-opioid receptor-G protein complexes.<\/strong> Nat Chem Biol. 2025 Jan 7.<\/em> PMID: 39775170. PDB ID:<\/strong> 8VVE<\/a>,\u00a08VVF<\/a>,\u00a08VVG<\/a>,\u00a09D61<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

    2024:<\/h2>\n
      \n
    1. L. Posa, G. Romano, X. Ji, S. Khan, B.M. Paz, G.W. Han, A.L. Nazarova, S.A. Zaidi, M. Ranjbar, K. Pleil, V. Katritch, C. Gati, D. Trauner, J. Levitz (2024). An opioid efficacy switch for reversible optical control of peripheral analgesia.<\/strong> bioRxiv [Preprint]. 2025 Feb 13:2024.<\/em> PMID: 39764058; PMCID: PMC11702541. PDB ID:<\/strong>\u00a09MGC<\/u>,\u00a09MGD<\/u>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
    2. M. Barekatain, L.C. Johansson, J.H. Lam, H. Chang, A.V. Sadybekov, G.W. Han, J. Russo, J. Bliesath, N.L. Brice, M.B.L. Carlton, K.S. Saikatendu, H. Sun, S.T. Murphy, H. Monenschein, H.H. Schiffer, P. Popov, C.A. Lutomski, C.V. Robinson, Z.J. Liu, T. Hua, V. Katritch, V. Cherezov (2024). Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease.<\/strong> Sci Signal. 2024 Dec 3;17(865):eado8741. 2024 Dec 3.<\/em> PMID: 39626010; PMCID: PMC11850111. PDB ID:<\/strong>\u00a08T1V<\/a>,\u00a08T1W<\/a>,\u00a08TF5<\/a>,\u00a08TYW<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
    3. G. Kao, X.N. Zhang, F. Nasertorabi, B.B. Katz, Z. Li, Z. Dai, Z. Zhang, L. Zhang, S.G. Louie, V. Cherezov, Y. Zhang (2024). Nicotinamide Riboside and CD38: Covalent Inhibition and Live-Cell Labeling<\/strong>.\u00a0 JACS Au. 2024 Oct 30;4(11):4345-4360.<\/em> PMID: 39610739, PDB ID:<\/strong> 8VAU<\/a>, PubMed>><\/strong><\/span><\/a><\/li>\n
    4. L.E. Gimenez, C. Martin, J. Yu, C. Hollanders, C.C. Hernandez, Y. Wu, D. Yao, G.W. Han, N.S. Dahir, L. Wu, O. Van der Poorten, A. Lamouroux, M. Mannes, S. Zhao, D. Tourw\u00e9, R.C. Stevens, R.D. Cone, S. Ballet (2024). Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.<\/strong> J Med Chem. 2024 Feb 22;67(4):2690-2711. 2024 Feb 12.<\/em> PMID: 38345933. PDB ID:<\/strong>\u00a08WKY<\/a>,<\/u>\u00a08TKZ,\u00a0 PubMed>><\/strong><\/span><\/a><\/li>\n
    5. P.-W. Yu, G. Kao, Z. Dai, F. Nasertorabi, Y. Zhang (2024). Rational design of humanized antibody inhibitors for cathepsin S<\/strong>. Arch Biochem Biophys, 2024 Jan:751:109849.<\/em> PMID: 38061628. PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

      2023:<\/h2>\n
        \n
      1. Y. Yang, H.J. Kang, R. Gao, J. Wang, G.W. Han, J.F. DiBerto, L. Wu, J. Tong, L. Qu, Y. Wu, R. Pileski, X. Li, X.C. Zhang, S. Zhao, T. Kenakin, Q. Wang, R.C. Stevens, W. Peng, B.L. Roth, Z. Rao, Z.J. Liu (2023). Structural insights into the human niacin receptor HCA2-Gi<\/sub> signalling complex<\/strong>. Nat Commun. 2023 Mar 27;14(1):1692.<\/em> PMID: 36973264; PMCID: PMC10043007. PDB ID:<\/strong>\u00a07ZLY<\/a>, 7ZL9<\/a>, 7XK2<\/a><\/u>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
      2. X. Lin, S. Jiang, Y. Wu, X. Wei, G.W. Han, L. Wu, J. Liu, B. Chen, Z. Zhang, S. Zhao, V. Cherezov, F. Xu (2023) The activation mechanism and antibody binding mode for orphan GPR20.<\/strong> Cell Discov. 2023 Feb 28;9(1):23.<\/em> PMID: 36849514; PMCID: PMC9971246. PDB ID:<\/strong>\u00a08HS2<\/a>,\u00a08HS3<\/a>,\u00a08HSC<\/a>,\u00a0 PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

        2022:<\/h2>\n
          \n
        1. Z. Motiwala, N.G. Aduri, H. Shaye, G.W. Han, J.H. Lam, V. Katritch, V. Cherezov, C. Gati (2022). Structural basis of GABA reuptake inhibition.<\/strong>\u00a0Nature<\/em>\u00a0606:\u00a0820-826. <\/em>PMID:\u00a035676483; PMCID:\u00a0PMC9394549<\/a>. <\/u>PDB ID:<\/strong>\u00a07SK2<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
        2. A. Shiriaeva, D. Park, G. Kim, Y. Lee, X. Hou, D.B. Jarhad, G. Kim, J. Yu, Y.E. Hyun, W. Kim, Z.G. Gao, K.A.\u00a0 Jacobson, G.W. Han, R.C. Stevens, L.S. Jeong, S. Choi, V. Cherezov (2022). GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A<\/sub> Adenosine Receptor.<\/strong> J Med Chem.<\/em> 2022 Sep 8;65(17):11648-11657.<\/em> PMID: 35977382; PMCID: PMC9469204. PDB ID:<\/strong>\u00a08CU6<\/a>,\u00a08CU7<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
        3. R. Bolteau, R. Duroux, A. Laversin, B. Vreulz, A. Shiriaeva, B. Stauch, G.W. Han, <\/strong>V. Cherezov, N. Renault, A. Barczyk, S. Ravez, M. Coevoet, P. Melnyk, M. Liberelle, S. Yous (2022). High ligand efficiency quinazoline compounds as novel A2A<\/sub> adenosine receptor antagonists<\/strong>.<\/strong> Eur J Med Chem. 2022 Nov 5;241:114620.<\/em> PMID: 35933788. \u00a0PDB ID:<\/strong>\u00a08DU3<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
        4. R. Perryman, A. Renziehausen, H. Shaye, A.D. Kostagianni, A.D. Tsiailanis, T. Thorne, M.V. Chatziathanasiadou, G.B. Sivolapenko, M.A. El Mubarak, G.W. Han, B. Zarzycka, V. Katritch, G. Lebon, C. Lo Nigro, L. Lattanzio, S.V. Morse, J.J. Choi, K. O’Neill, Z. Kanaki, A. Klinakis, T. Crook, V. Cherezov, A.G. Tzakos, N. Syed(2022). Inhibition of the angiotensin II type 2 receptor AT2<\/sub>R is a novel therapeutic strategy for glioblastoma.<\/strong> Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119.<\/em> PMID: 35917342; PMCID: PMC9371711. PDB ID:<\/strong>\u00a07JNI<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
        5. Y. Yue, L. Liu, L.J. Wu, Y. Wu, L. Wang, F. Li, J. Liu, G.W. Han, B. Chen, X. Lin, R.L. Brouillette, \u00c9. Breault, J.M. Longpr\u00e9, S. Shi, H. Lei, P. Sarret, R.C. Stevens, M.A. Hanson, F. Xu (2022). Structural insight into apelin receptor-G protein stoichiometry.<\/strong> Nat Struct Mol Biol.<\/em> 2022 Jul;29(7):688-697.<\/em> PMID: 35817871 PDB ID:<\/strong>\u00a07SUS<\/u><\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

          2021:<\/h2>\n
            \n
          1. L. Xu, B. Chen, H. Schihada, S.C. Wright, A. Turku, Y. Wu, G.W. Han, M. Kowalski-Jahn, P. Kozielewicz, C.F. Bowin, X. Zhang, C. Li , M. Bouvier, G. Schulte, F. Xu (2021). Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs<\/sub><\/strong>. Cell Res. 2021 Dec;31(12):1311-1314.<\/em> \u00a0PDB ID: <\/strong>8YY8<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n
          2. N. Michaelian , A. Sadybekov, \u00c9. Besserer-Offroy, G.W. Han, H. Krishnamurthy, B.A. Zamlynny , X. Fradera, P. Siliphaivanh, J. Presland, K.B. Spencer, S.M. Soisson, P. Popov , P. Sarret, V. Katritch, V. Cherezov (2021). Structural insights on ligand recognition at the human leukotriene B4 receptor 1.<\/strong> Nat Commun. 2021 May 20;12(1):2971. <\/i>PDB ID: <\/strong>7K15<\/a>,\u00a0PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

            2020:<\/h2>\n
              \n
            1. Z. Dai, X.N. Zhang, F. Nasertorabi, Q. Cheng, J. Li, B.B. Katz, G. Smbatyan, H. Pei, S.G. Louie, H.J. Lenz, R.C. Stevens, Y. Zhang (2020).\u00a0 Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.<\/strong>\u00a0Sci Adv. 2020 Jun 3;6(23):eaba6752.<\/em> PMID: 32537509, PDB ID:<\/strong> 6VUA<\/a>, PubMed>><\/strong><\/span><\/a><\/li>\n
            2. C. Zambaldo, M. Koh, F. Nasertorabi, G.W. Han, A. Chatterjee, R.C. Stevens, P.G. Schultz(2020). An orthogonal seryl-tRNA synthetase\/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli<\/em><\/strong>.\u00a0 Bioorg Med Chem. 2020 Oct 15;28(20):115662.<\/em> PMID: 33069069, PDB ID:<\/strong> 6X94<\/a>, PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

              2019:<\/h2>\n
                \n
              1. J.C. Li, F. Nasertorabi, W. Xuan, G.W. Han, R.C. Stevens, P.G. Schultz (2019). A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure<\/strong> . ACS Chem Biol. 2019 Jun 21;14(6):1150-1153<\/em>. PMID: 33006884, PDB ID:<\/strong> 6MTG<\/a>, PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

                2018:<\/h2>\n
                  \n
                1. Z. Dai, X.N. Zhang, F. Nasertorabi, Q. Cheng, H. Pei, S.G. Louie, R.C. Stevens, Y. Zhang (2018). Facile chemoenzymatic synthesis of a novel stable mimic of NAD<\/strong> . Chem Science 15;9(44):8337-8342<\/em>. PMID: 30568770, PDB ID:<\/strong> 6EDR<\/a>, PubMed>><\/strong><\/span><\/a><\/li>\n<\/ol>\n

                  2017:<\/h2>\n
                    \n
                  1. M. Koh, F. Nasertorabi, G.W. Han, R.C. Stevens ,P.G. Schultz (2017).\u00a0Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.<\/b>\u00a0J Am Chem Soc. 2017 Apr 26;139(16):5728-5731.\u00a0<\/i>PubMed>><\/a><\/strong><\/span><\/li>\n<\/ol>\n

                    2015:<\/h2>\n
                      \n
                    1. A.D. Pearson, J.H. Mills, Y. Song, F. Nasertorabi, G.W. Han, D. Baker, R.C. Stevens, P.G. Schultz . (2015).\u00a0Transition states. Trapping a transition state in a computationally designed protein bottle.\u00a0<\/b>Science. 2015 Feb 20;347(6224):863-7. <\/i>PubMed>><\/a><\/strong><\/span><\/li>\n
                    2. H. Xiao, F. Nasertorabi, S.H. Choi, G.W. Han, S.A. Reed, R.C. Stevens, P.G. Schultz. (2015).\u00a0Exploring the potential impact of an expanded genetic code on protein function.<\/b>\u00a0Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6961-6.\u00a0<\/i>PubMed>><\/a><\/strong><\/span><\/li>\n
                    3. G.J. Forse, M.L. Uson, F. Nasertorabi, A. Kolatkar, I. Lamberto, E.B. Pasquale, P. Kuhn. (2015).\u00a0Distinctive Structure of the EphA3\/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5.<\/b>\u00a0PLoS One. 2015 May 20;10(5):e0127081.\u00a0<\/strong><\/i>PubMed>><\/a><\/strong><\/span><\/li>\n<\/ol>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":89,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-content-detail.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-474","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - Bridge Structural Biology Core<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/sbc\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - 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