{"id":9834,"date":"2013-02-27T09:30:00","date_gmt":"2013-02-27T17:30:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/beyond-headache-relief\/"},"modified":"2023-04-19T11:18:28","modified_gmt":"2023-04-19T18:18:28","slug":"beyond-headache-relief","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/beyond-headache-relief\/","title":{"rendered":"Beyond Headache Relief"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n  \n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Beyond Headache Relief<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  USC Dornsife scientists unlock the why and how of an age-old treatment \u2014 exploring how aspirin triggers the production of resolvins, shutting off heart-disease-causing inflammation.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Robert Perkins<\/a><\/strong>\n    \n          <span class=\"post-date-field\">February 27, 2013<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 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6.383-3.364c.246-.828.624-5.79.624-6.478c0-.69-.139-1.861-.902-2.206c-.659-.298-1.664-.62-4.3 1.24C16.046 4.748 13.087 8.687 12 10.8\"  fill-rule=\"evenodd\" \/>\n              <\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Bluesky<\/span>\n          <\/a>\n                                <a class=\"a2a_button_email\" target=\"_blank\" href=\"\/#email\" rel=\"nofollow noopener\" title=\"E-mail\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_print\">\n              <svg height=\"12\" viewBox=\"0 0 18 12\" width=\"18\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>A team from USC Dornsife and Harvard University has uncovered a key biological mechanism that makes aspirin and omega-3 fatty acids effective at reducing inflammation.<\/p>\n<p>Doctors have long prescribed aspirin together with a diet rich in omega-3s as a way to reduce inflammation caused by the body&rsquo;s own immune system, which can exacerbate heart disease, lung and kidney disease, as well as arthritis and cancer, among other ailments.<\/p>\n<p>Thanks to research led by Nicos Petasis, the Harold and Lillian Moulton Chair in Chemistry and professor of chemistry and pharmacology in USC Dornsife, and Charles Serhan of Harvard, now they know why.<\/p>\n<p>Studying inflammation in mice, the team determined that aspirin triggers the production of a new form of molecules called resolvins, which are naturally made by the body from omega-3 fatty acids to shut off inflammation. In particular, Serhan found that one type of resolvin &mdash; resolvin D3 &mdash; lingers at the site of inflammation, suggesting that it plays a particular role in helping to conclude this immune process.<\/p>\n<p>After making its discovery, the team explored the structure of resolvin D3 to better understand why and how it works to shut off inflammation.<\/p>\n<p>&ldquo;Aspirin is able to modify an inflammatory enzyme to stop forming molecules that propagate inflammation and instead produce molecules from omega-3 fatty acids, like resolvin D3, that help inflammation to end,&rdquo; said Petasis, who has joint appointments at the USC School of Pharmacy and the USC Norris Comprehensive Cancer Center. &ldquo;We were able to produce by chemical synthesis both resolvin D3 and aspirin-triggered resolvin D3 in pure form that allowed us to establish their complete structures and biological activities.&rdquo;<\/p>\n<p>Serhan, of Brigham and Women&rsquo;s Hospital and Harvard Medical School, added: &ldquo;We also identified the human receptor that is activated by resolvin D3, which is critical in understanding how resolvin D3 works in the body to resolve inflammation. With this information, other investigators will now also be able to study the pro-resolving actions and anti-inflammatory properties of resolvin D3.&rdquo;<\/p>\n<p>&nbsp;<\/p>\n<div style=\"border-width: 0px; padding-left: 100px; padding-bottom: 5px; width: 225px; padding-top: 0px;\"><img loading=\"lazy\" decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/7\/migration-uploads\/NicosPetasis-1333.jpg\" alt=\"\" width=\"225\" height=\"350\"><\/p>\n<h5>Nicos Petasis, the Harold and Lillian Moulton Chair in Chemistry and professor of chemistry and pharmacology in USC Dornsife, led the research with a collaborator from Harvard Medical School. Photo by Alexandra Bissonnette.<\/h5>\n<\/div>\n<p>The research by Petasis and Serhan was recently published in <em>Chemistry &amp; Biology<\/em>. Other co-authors of the paper included Jeremy Winkler, a Ph.D. student in USC Dornsife; and Jesmond Dalli, Romain Colas, Hildur Arnardottir, Chien-Yee Cheng and Nan Chiang of Harvard.<\/p>\n<p>Now that the mechanism behind omega-3s and aspirin treatment is better understood, future research by the teams of Petasis and Serhan will focus on determining which other diseases might best be treated by natural anti-inflammatory molecules.<\/p>\n<p>The research was funded by the National Institutes of Health (grant P01GM095467). It is the latest joint effort of a 20-year research collaboration among the research teams.<\/p>\n<p>Serhan and Petasis are inventors on patents (resolvins) assigned, respectively, to Brigham and Women&rsquo;s Hospital and USC, and licensed for clinical development to Resolvyx Pharmaceuticals. As scientific co-founders of Resolvyx, the researchers own equity in the company.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>USC Dornsife scientists unlock the why and how of an age-old treatment \u2014 exploring how aspirin triggers the production of resolvins, shutting off heart-disease-causing inflammation.<\/p>\n","protected":false},"author":0,"featured_media":9837,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10,17],"tags":[78,1528],"class_list":["post-9834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","category-student","tag-chemistry","tag-nicos-petasis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Beyond Headache Relief<\/title>\n<meta name=\"robots\" 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