{"id":9176,"date":"2013-10-09T08:15:00","date_gmt":"2013-10-09T15:15:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/arieh-warshel-wins-nobel-prize\/"},"modified":"2024-10-28T18:05:52","modified_gmt":"2024-10-29T01:05:52","slug":"arieh-warshel-wins-nobel-prize","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/arieh-warshel-wins-nobel-prize\/","title":{"rendered":"Arieh Warshel Wins Nobel Prize"},"content":{"rendered":"\n\n\n    \n                                \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n  \n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Arieh Warshel Wins Nobel Prize<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Nobel Laureate Arieh Warshel, Distinguished Professor of Chemistry, discusses how he develops computer models to understand and predict chemical processes.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Carl Marziali<\/a><\/strong>\n    \n          <span class=\"post-date-field\">October 9, 2013<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div 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0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n \n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Arieh Warshel, Distinguished Professor of Chemistry at the USC Dornsife College of Letters, Arts and Sciences and fellow of the National Academy of Sciences, has earned a new title: Nobel Laureate.<\/p>\n<div>\n<p>The Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry for 2013 on Oct. 9 to Warshel and two colleagues for developing the key principles behind computer simulations that are now indispensable in the study of chemical reactions.<\/p>\n<p>Warshel, Martin Karplus of the Universit\u00e9 de Strasbourg in France and Harvard University, and Michael Levitt of Stanford University were recognized for \u201cthe development of multiscale models for complex chemical systems.\u201d Their crucial achievement was to marry classical and quantum mechanics in order to model both the relatively large-scale movements of atoms in a molecule, and the minute dances of the free electrons that shuttle between atoms and spark many chemical reactions.<\/p>\n<p>\u201cWe are particularly proud that Distinguished Professor Warshel has had such a long and illustrious career at USC,\u201d said USC President C. L. Max Nikias.\u00a0\u201cOver nearly four decades, his pioneering computer simulations and multiscale models have advanced the field of chemistry and advanced human knowledge and understanding. This tremendous honor speaks volumes about the quality of his research and the quality of USC\u2019s faculty.\u201d<\/p>\n<figure style=\"width: 350px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/7\/migration-uploads\/Warshel2-1508.jpg\" alt=\"Photo of two men and one woman standing and smiling in front of a photo backdrop that says USC.\" width=\"350\" height=\"225\" \/><figcaption class=\"wp-caption-text\">USC Dornsife Distinguished Professor Arieh Warshel (second from left) celebrates his 2013 Nobel Prize with (from left), USC President C. L. Max Nikias, USC Provost Elizabeth Garrett and USC Dornsife Dean Steve Kay. Photo by Gus Ruelas.<\/figcaption><\/figure>\n<p>USC Dornsife Dean Steve Kay called Warshel a trailblazer of the highest order.<\/p>\n<p>\u201cHaving co-founded the field of\u00a0computational enzymology, Dr. Warshel\u2019s work\u00a0modeling the functions of biological molecules has allowed us to understand how life processes operate on the protein level,\u201d Kay said. \u201cFor more than 35 years, it has been our privilege at USC Dornsife to work alongside him and to bear witness to his pioneering efforts. In addition, he is a beloved teacher and mentor who has guided countless students toward making their own marks on the field.\u201d<\/p>\n<p>In a <a href=\"http:\/\/youtu.be\/0HeQAyvxBe8\">press conference<\/a> organized by the academy shortly after the announcement, Warshel described the three scientists\u2019 achievement as having found a way through computer simulation \u201cto take the structure of a protein (or other molecule) and then eventually to understand how exactly it does what it does.\u201d<\/p>\n<p>In response to another question, he said he was feeling \u201cextremely well\u201d after the early morning phone call announcing the prize.<\/p>\n<p>Warshel\u2019s first breakthrough was his simulation of a key protein in the eye in collaboration with Karplus in 1972. Karplus was an expert in quantum mechanics, which explains physical behavior at an extremely small scale. Warshel and Levitt as PhD classmates had developed a pioneering computer modeling program based on classical mechanics that could be used on molecules of any size.<\/p>\n<p>Warshel then reunited with Levitt in 1976 to publish the revolutionary first computerized model of an enzymatic reaction, scalable to molecules of any size. That year also marked Warshel\u2019s arrival at USC.<\/p>\n<p>Warshel had long been interested in enzymes, which control almost all chemistry in the body, and continues to study their reactive properties to this day. The methods he and his collaborators developed can be used on a practical level to develop new drugs, he explained at the news conference, \u201cor just in my case to satisfy your curiosity.\u201d<\/p>\n<p>Scientists today use the methods developed by Warshel and his colleagues to model chemical processes both accurately and efficiently. They apply the quantum mechanical half of the method only to the free electrons and nuclei directly involved in a reaction, and use classical mechanics to study the rest of a molecule.<\/p>\n<p>Warshel has been applying his method to study how proteins are responsible for transferring signals within a single cell. One of his recent studies explained the essential workings of adenosine triphosphate, the energy factory for the body.<\/p>\n<p>He will receive one third of the Nobel Prize total award of 8 million Swedish kronor, equivalent to approximately $1.2 million.<\/p>\n<div class=\"video-embed\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/FDj4rhbf3gg\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div>\n<\/div>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n\n\n\n  \n        \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-related-stories \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-related-stories\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n    \n                  <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/nobel-laureate-chemisry-arieh-warshel-autobiography\/\" \n                        class=\"\" \n      >Nobel laureate reveals his odyssey from working the fishponds in a Kibbutz to reaching the pinnacle of science<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n              <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/chinese-university-inaugurates-namesake-institute-for-usc-nobel-laureate\/\" \n                        class=\"\" \n      >Chinese university inaugurates namesake institute for USC Nobel laureate<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n              <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/arieh-warshel-elected-to-royal-society-of-chemistry\/\" \n                        class=\"\" \n      >Arieh Warshel Elected to Royal Society of Chemistry<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n            <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nobel Laureate Arieh Warshel, Distinguished Professor of Chemistry, discusses how he develops computer models to understand and predict chemical processes.<\/p>\n","protected":false},"author":52,"featured_media":9179,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[960,78,96,316],"class_list":["post-9176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-arieh-warshel","tag-chemistry","tag-natural-sciences","tag-nobel-prize"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Arieh Warshel Wins Nobel Prize<\/title>\n<meta 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