{"id":772,"date":"2022-05-19T10:35:00","date_gmt":"2022-05-19T17:35:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/protein-protects-cells-from-stressful-forces-and-diseases-such-as-muscular-dystrophy-by-forming-nanoclusters\/"},"modified":"2023-06-06T15:22:18","modified_gmt":"2023-06-06T22:22:18","slug":"emerin-protein-protects-cells-nanoclusters","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/emerin-protein-protects-cells-nanoclusters\/","title":{"rendered":"Protein protects cells from stressful forces, and diseases such as muscular dystrophy, by forming \u2018nanoclusters\u2019"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3705-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3705-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"Protein protects cells from stressful forces, and diseases such as muscular dystrophy, by forming \u2018nanoclusters\u2019\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  From left, cells (green) and their nuclei (blue) at rest and subjected to increasing mechanical stress on rectangular micropatterns having widths of 15, 10 and 5 micrometers. (Image: Reproduced and adapted with permission of the <em>Journal of Cell Science<\/em>.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Protein protects cells from stressful forces, and diseases such as muscular dystrophy, by forming \u2018nanoclusters\u2019<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  A team of USC Dornsife scientists finds new evidence of how the protein emerin functions and how it may be linked to the rare and debilitating Emery-Dreifuss muscular dystrophy.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Darrin S. Joy<\/a><\/strong>\n    \n          <span class=\"post-date-field\">May 19, 2022<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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10.8c-1.087-2.114-4.046-6.053-6.798-7.995C2.566.944 1.561 1.266.902 1.565C.139 1.908 0 3.08 0 3.768c0 .69.378 5.65.624 6.479c.815 2.736 3.713 3.66 6.383 3.364c.136-.02.275-.039.415-.056c-.138.022-.276.04-.415.056c-3.912.58-7.387 2.005-2.83 7.078c5.013 5.19 6.87-1.113 7.823-4.308c.953 3.195 2.05 9.271 7.733 4.308c4.267-4.308 1.172-6.498-2.74-7.078a8.741 8.741 0 0 1-.415-.056c.14.017.279.036.415.056c2.67.297 5.568-.628 6.383-3.364c.246-.828.624-5.79.624-6.478c0-.69-.139-1.861-.902-2.206c-.659-.298-1.664-.62-4.3 1.24C16.046 4.748 13.087 8.687 12 10.8\"  fill-rule=\"evenodd\" \/>\n              <\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Bluesky<\/span>\n          <\/a>\n                                <a class=\"a2a_button_email\" target=\"_blank\" href=\"\/#email\" rel=\"nofollow noopener\" title=\"E-mail\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_print\">\n              <svg height=\"12\" viewBox=\"0 0 18 12\" width=\"18\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Scientists have revealed how a protein called emerin works to enable cells to adapt to stressful physical forces. The work brings new understanding of the protein&rsquo;s role in diseases such as&nbsp;<a href=\"https:\/\/www.mda.org\/disease\/emery-dreifuss-muscular-dystrophy\" target=\"_blank\">Emery-Dreifuss muscular dystrophy<\/a>&nbsp;(EDMD).<\/p>\n<p><strong>The news:<\/strong>&nbsp;Scientists at the USC Dornsife College of Letters, Arts and Sciences found that emerin responds to harmful mechanical forces on the cell by bunching together to form so-called &ldquo;nanoclusters.&rdquo;<\/p>\n<ul>\n<li>The emerin nanoclusters help stabilize and protect the nuclear envelope, the membrane surrounding the nucleus, from damage and rupture.<\/li>\n<li>The nucleus houses the cell&rsquo;s genetic material and the machinery that translates DNA&rsquo;s genetic code into proteins.<\/li>\n<li>Emerin comes together with other proteins in the nuclear membrane to help maintain the membrane&rsquo;s shape and integrity.<\/li>\n<\/ul>\n<p><strong>In their words:<\/strong><\/p>\n<p>&ldquo;The rearrangement of emerin into nanoclusters is crucial for properly adapting the nucleus to mechanical stress. In fact, cells without emerin or with defective emerin assemblies could not properly respond to mechanical stress.&rdquo; &mdash;&nbsp;<a href=\"https:\/\/dornsife.usc.edu\/cf\/faculty-and-staff\/faculty.cfm?pid=1038347\">Fabien Pinaud<\/a>, associate professor of&nbsp;<a href=\"https:\/\/dornsife.usc.edu\/bisc\">biological sciences<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/dornsife.usc.edu\/physics\">physics and astronomy<\/a> at USC Dornsife and corresponding author.<\/p>\n<p><strong>Also important:<\/strong>&nbsp;Emerin is a key molecular player in cells&rsquo; ability to cope with mechanical stress and must function normally for cells to properly respond to those forces.<\/p>\n<ul>\n<li>The researchers found that mutant forms of emerin known to cause EDMD were unable to correctly self-assemble, causing the cell nucleus to be &ldquo;impotent in its response to mechanical challenges.&rdquo;<\/li>\n<li>These results provide further evidence and understanding of emerin&rsquo;s role in EDMD.<\/li>\n<\/ul>\n<p><strong>About EDMD<\/strong><\/p>\n<p>Emery-Dreifuss muscular dystrophy is a rare genetic disease affecting muscles.<\/p>\n<ul>\n<li>Symptoms usually begin to show by age 10 and progressively worsen with time.<\/li>\n<li>Early symptoms include weakness and degeneration of leg, arm and shoulder muscles as well as stiff joints. Later, the heart often is affected as well as muscles involved in breathing.<\/li>\n<li>Patients frequently become dependent on a wheelchair and other assistance, and usually die by mid-adulthood.<\/li>\n<\/ul>\n<p><strong>In the lab:<\/strong>&nbsp;To test the role of emerin, Anthony Fernandez and other graduate students in the Pinaud lab induced mechanical stress on cells by forcing them to take unusual rectangular shapes, then used highly advanced microscopy techniques to see how emerin responded.<\/p>\n<ul>\n<li>The researchers were able to produce images of emerin in cells at resolutions never achieved before.<\/li>\n<li>The ultrahigh-resolution images revealed how emerin rearranges at a molecular scale of just a few nanometers, according to Pinaud.<\/li>\n<\/ul>\n<p><strong>In their words:<\/strong><\/p>\n<p>&ldquo;Shaping the cells&rsquo; silhouette and using highly advanced microscopy techniques were both key to showing that the reorganization of emerin on a scale of a few nanometers is critical for cell adaptation and to survive changes in mechanical conditions, such as one would find when muscles are working,&rdquo; Pinaud said.<\/p>\n<p><strong>What else?<\/strong><\/p>\n<p>Pinaud says the research provides deeper insight into the importance of the nucleus in responding to mechanical stress on cells.<\/p>\n<p>&ldquo;The average person generally thinks of the nucleus as simply housing our genetic material,&rdquo; he said. &ldquo;Our findings show how important the nucleus is to the cell&rsquo;s mechanical response, and that the nucleus itself must be able to adapt to mechanical challenges to prevent cell injury and death.&rdquo;<\/p>\n<p><strong>Furthermore:<\/strong>&nbsp;Pinaud says the study also demonstrates the important role advanced imaging plays in revealing how cellular processes work and may lead to disease.<\/p>\n<p>&ldquo;Importantly, we showed that these crucial reorganizations take place over just a few tens of nanometers, a length scale that remains inaccessible by conventional optical microscopy imaging,&rdquo; he said. &ldquo;Our results underline the importance of peering into biological processes with the highest possible optical resolution and looking within intact cells to better comprehend fundamental cell biology systems and the onset of diseases.&rdquo;<\/p>\n<p><strong>Up next:<\/strong>&nbsp;Pinaud says the team wants to know more about the forces that act on the nuclear membrane and the role of other proteins in helping cells respond to mechanical forces.<\/p>\n<ul>\n<li>The team is developing methods that use light to directly measure the forces exerted on the nuclear membrane. These forces are in the range of a few tens of piconewtons &mdash; about 1 billion times less than the force needed to keep a dollar bill from falling to the ground.<\/li>\n<li>They also want to explore the interaction of emerin with the LINC complex &mdash; a group of cell proteins that plays multiple vital roles, including sensing forces on the cell.<\/li>\n<\/ul>\n<p><strong>About the study<\/strong><\/p>\n<p>Authors on&nbsp;<a href=\"https:\/\/journals.biologists.com\/jcs\/article-abstract\/135\/6\/jcs258969\/274890\/Emerin-self-assembly-and-nucleoskeletal-coupling?redirectedFrom=fulltext\" target=\"_blank\">the study<\/a>, which appears in the&nbsp;<i>Journal of Cell Science<\/i>, include Pinaud, Fernandez, and PhD students Markville Bautista and Liying Wu, all of USC Dornsife.<\/p>\n<p>The research was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases grant number R21AR076514.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A team of USC Dornsife scientists finds new evidence of how the protein emerin functions and how it may be linked to the rare and debilitating Emery-Dreifuss muscular dystrophy.<\/p>\n","protected":false},"author":13,"featured_media":775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10,17],"tags":[117,217,96,216],"class_list":["post-772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","category-student","tag-biology","tag-fabien-pinaud","tag-natural-sciences","tag-physics-and-astronomy"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Protein protects cells from stressful forces, and diseases such as muscular dystrophy, by forming \u2018nanoclusters\u2019<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/emerin-protein-protects-cells-nanoclusters\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protein protects cells from stressful forces, and diseases such as muscular dystrophy, by forming \u2018nanoclusters\u2019\" \/>\n<meta property=\"og:description\" content=\"A team of USC Dornsife scientists finds new evidence of how the protein emerin functions and how it may be linked to the rare and debilitating Emery-Dreifuss muscular dystrophy.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/news\/stories\/emerin-protein-protects-cells-nanoclusters\/\" \/>\n<meta property=\"og:site_name\" content=\"USC Dornsife News\" \/>\n<meta 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