{"id":7658,"date":"2014-11-18T12:35:00","date_gmt":"2014-11-18T20:35:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/recognition-for-pratts-work\/"},"modified":"2023-04-19T11:14:24","modified_gmt":"2023-04-19T18:14:24","slug":"recognition-for-pratts-work","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/recognition-for-pratts-work\/","title":{"rendered":"Recognition for Pratt\u2019s Work"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n  \n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Recognition for Pratt\u2019s Work<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Matthew Pratt receives major awards for his work finding clues to how cancer hijacks cell biology to thrive \u2014 and how it might be stopped.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Robert Perkins<\/a><\/strong>\n    \n          <span class=\"post-date-field\">November 18, 2014<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" 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href=\"http:\/\/www.acs.org\/content\/acs\/en\/funding-and-awards\/awards\/division\/carbohydrate\/carb-new-investigator-award.html\">David Y. Gin New Investigator Award<\/a><\/li>\n<li>The Susan G. Komen <a href=\"http:\/\/ww5.komen.org\/ResearchGrants\/FundingOpportunities.html\">Career Catalyst Award<\/a><\/li>\n<li>The American Cancer Society <a href=\"http:\/\/www.cancer.org\/research\/codelyforaresearchgrant\/granttypes\/research-scholar-grants\">Research Scholar Award<\/a><\/li>\n<\/ul>\n<p>The awards represent more than $1 million in encouragement and funding to support his ongoing efforts.<\/p>\n<p>The assistant professor of chemistry is interested in how glycosylation is linked to glycolysis, the process that the body uses to break down sugars to create the fuel that keeps cells running. Cancer is able to co-opt glycosylation to stay alive and grow.<\/p>\n<p>Cancer cells use glycolysis in a counterintuitive manner, in part because they live under extreme oxidative stress from having to grow so quickly, and yet it does not kill them.<\/p>\n<p>Researchers have found that cancer cells are able to slow down glycosylation so that it yields more of the specific types of fuel that they need to survive. Further, they&rsquo;re able to turn off the &ldquo;self-destruct&rdquo; switch that oxidative stress would otherwise activate, prolonging their lives.<\/p>\n<p>Pratt studies the biochemical reactions behind these processes with an eye toward using or developing pharmaceuticals to interrupt them &mdash; taking the teeth out of cancer.<\/p>\n<p>&ldquo;We hope that by understanding how the well-established changes in cancer glycolysis are translated into protein glycosylation, we will both discover important fundamental biochemical mechanisms and identify places where we can potentially block this link for the development of therapeutics,&rdquo; Pratt said.<\/p>\n<p>Within the past six months, Pratt has received three high-profile awards &mdash; all three targeted at young researchers with promising careers.<\/p>\n<p>&ldquo;These young investigator awards are a measure of the excitement the research community has for the highly innovative approaches Pratt&rsquo;s lab is taking &mdash; we are delighted that he is receiving this recognition,&rdquo; said Stephen Bradforth, chair of the Department of Chemistry.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Matthew Pratt receives major awards for his work finding clues to how cancer hijacks cell biology to thrive \u2014 and how it might be stopped.<\/p>\n","protected":false},"author":0,"featured_media":7661,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[902,78,1087,1330,96,60,299],"class_list":["post-7658","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-award","tag-chemistry","tag-grants","tag-matthew-pratt","tag-natural-sciences","tag-research","tag-stephen-bradforth"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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