{"id":5943,"date":"2016-06-24T08:30:00","date_gmt":"2016-06-24T15:30:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/"},"modified":"2023-04-19T11:11:17","modified_gmt":"2023-04-19T18:11:17","slug":"new-protein-can-modify-brain-function-and-memory","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/","title":{"rendered":"New protein can modify brain function and memory"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379-690x432.jpg\"\n                    data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"New protein can modify brain function and memory\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  A neuron with synapses, left, undergoes a change after the new protein is encoded, center, resulting in the synapses being degraded. The effect of the protein is then reversed. Photo courtesy of Don Arnold.\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>New protein can modify brain function and memory<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Researchers led by neuroscientist Don Arnold develop GFE3, which may help in mapping the brain\u2019s connections and controlling neural activity.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Emily Gersema<\/a><\/strong>\n    \n          <span class=\"post-date-field\">June 24, 2016<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 1.058837 1.0874543 2.51831502 1.6884158 4.03502747 1.6884158 1.44087681 0 2.80427251-.5423678 3.86936601-1.5289606l.1656615-.1594552 2.2321428-2.2321428-1.6311813-1.6311813-2.2321429 2.26076c-.6581959.658196-1.5167124 1.0016026-2.43246332 1.0016026s-1.7742674-.3434066-2.43246337-1.0016026c-.65819597-.6581959-1.00160257-1.5167124-1.00160257-2.4324633 0-.8547009.2991453-1.6595442.87416905-2.2981957l.12743352-.1342677 2.23214286-2.2321429zm6.88661855-.40736607-5.26116068 5.26116075 1.61881868 1.6188186 5.2611607-5.2611607zm1.3837569-5.54501488c-1.4408768 0-2.8042725.54236779-3.869366 1.52896062l-.1656615.15945513-2.23214282 2.23214286 1.63118132 1.63118132 2.2321429-2.23214286c.6581959-.65819597 1.5167124-1.00160256 2.4324633-1.00160256s1.7742674.34340659 2.4324634 1.00160256 1.0016026 1.51671246 1.0016026 2.43246337c0 .85470089-.2991453 1.65954419-.8741691 2.29819559l-.1274335.1342678-2.2321429 2.2321428 1.5739469 1.5739469 2.2321429-2.2321428c1.0874542-1.058837 1.6884157-2.5183151 1.6884157-4.03502751 0-1.51671245-.6009615-2.94757326-1.6884157-4.03502747-1.058837-1.08745421-2.518315-1.68841575-4.0350275-1.68841575z\" transform=\"translate(-3 -3)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Copy Link<\/span>\n          <\/a>\n                                <a class=\"a2a_button_facebook\" target=\"_blank\" href=\"\/#facebook\" rel=\"nofollow noopener\" title=\"Facebook\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_facebook\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m23.9512 6h-16.9024c-.57923625 0-1.0488.46956375-1.0488 1.0488v16.9024c0 .5792362.46956375 1.0488 1.0488 1.0488h9.10024v-7.34768h-2.46772v-2.87584h2.46772v-2.11508c0-2.45404 1.49872-3.79012 3.68828-3.79012.7389668-.00263323 1.4775241.03516995 2.21236.11324v2.56348h-1.51392c-1.18788 0-1.4174.56544-1.4174 1.39612v1.8316h2.84772l-.37088 2.87584h-2.47684v7.34844h4.83284c.5792362 0 1.0488-.4695638 1.0488-1.0488v-16.9024c0-.57923625-.4695638-1.0488-1.0488-1.0488z\" fill-rule=\"evenodd\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Facebook<\/span>\n          <\/a>\n                                <a class=\"a2a_button_twitter\" target=\"_blank\" href=\"\/#twitter\" rel=\"nofollow noopener\" title=\"X\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_twitter\">\n              <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\"\n\t y=\"0px\" viewBox=\"0 0 30 30\" enable-background=\"new 0 0 30 30\" xml:space=\"preserve\" width=\"19\" height=\"19\">\n<path fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M14.5,16.2l-0.8-1.1l-6.3-9h2.7l5.1,7.3l0.8,1.1\n\tl6.6,9.4h-2.7L14.5,16.2L14.5,16.2z M16.9,13.4l7.4-8.7h-1.8l-6.5,7.5L11,4.8H5l7.8,11.4L5,25.2h1.8l6.8-7.9l5.5,7.9h6L16.9,13.4\n\tL16.9,13.4z\"\/>\n<\/svg>\n\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">X<\/span>\n          <\/a>\n                                <a class=\"a2a_button_linkedin\" target=\"_blank\" href=\"\/#linkedin\" rel=\"nofollow noopener\" title=\"Linkedin\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_linkedin\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m25 21.4220779c0 1.974026-1.6038961 3.5779221-3.5779221 3.5779221h-11.84415582c-1.97402598 0-3.57792208-1.6038961-3.57792208-3.5779221v-11.84415582c0-1.97402598 1.6038961-3.57792208 3.57792208-3.57792208h11.84415582c1.974026 0 3.5779221 1.6038961 3.5779221 3.57792208zm-14.5584416-12.21428569c-.98701295 0-1.60389606.61688311-1.60389606 1.48051949-.12337663.8636364.49350649 1.4805195 1.48051946 1.4805195.987013 0 1.6038961-.6168831 1.6038961-1.4805195 0-.86363638-.6168831-1.48051949-1.4805195-1.48051949zm1.3571429 12.70779219v-8.6363636h-2.83766234v8.6363636zm10.2402597 0v-4.9350649c0-2.5909091-1.3571428-3.8246753-3.3311688-3.8246753-1.4805195 0-2.0974026.8636363-2.4675325 1.4805194v-1.2337662h-2.8376623v8.6363636h2.8376623v-4.9350649c0-.2467532 0-.4935065.1233767-.7402597.1233766-.4935065.6168831-.987013 1.4805194-.987013.987013 0 1.4805195.7402597 1.4805195 1.974026v4.564935z\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">LinkedIn<\/span>\n          <\/a>\n                                <a class=\"a2a_button_bluesky\" target=\"_blank\" href=\"\/#bluesky\" rel=\"nofollow noopener\" title=\"Bluesky\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_bluesky\">\n              <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50px\" height=\"50px\" viewBox=\"0 0 24 24\">\n                <path fill=\"#00000\" d=\"M12 10.8c-1.087-2.114-4.046-6.053-6.798-7.995C2.566.944 1.561 1.266.902 1.565C.139 1.908 0 3.08 0 3.768c0 .69.378 5.65.624 6.479c.815 2.736 3.713 3.66 6.383 3.364c.136-.02.275-.039.415-.056c-.138.022-.276.04-.415.056c-3.912.58-7.387 2.005-2.83 7.078c5.013 5.19 6.87-1.113 7.823-4.308c.953 3.195 2.05 9.271 7.733 4.308c4.267-4.308 1.172-6.498-2.74-7.078a8.741 8.741 0 0 1-.415-.056c.14.017.279.036.415.056c2.67.297 5.568-.628 6.383-3.364c.246-.828.624-5.79.624-6.478c0-.69-.139-1.861-.902-2.206c-.659-.298-1.664-.62-4.3 1.24C16.046 4.748 13.087 8.687 12 10.8\"  fill-rule=\"evenodd\" \/>\n              <\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Bluesky<\/span>\n          <\/a>\n                                <a class=\"a2a_button_email\" target=\"_blank\" href=\"\/#email\" rel=\"nofollow noopener\" title=\"E-mail\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_print\">\n              <svg height=\"12\" viewBox=\"0 0 18 12\" width=\"18\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Scientists at USC have developed a new tool to modify brain activity and memory in targeted ways, without the help of any drugs or chemicals.<\/p>\n<p>The GFE3 protein may help researchers map the brain&rsquo;s connections and better understand how inhibitory synapses modulate brain function, said lead author <a href=\"https:\/\/dornsife.usc.edu\/arnold\" target=\"_blank\">Don Arnold<\/a>, a professor of <a href=\"https:\/\/dornsife.usc.edu\/bisc\/\" target=\"_blank\">biological sciences<\/a>.<\/p>\n<p>It also may enable them to control neural activity and lead to advancements in research for diseases or conditions ranging from schizophrenia to cocaine addiction, Arnold said.<\/p>\n<p>The new tool is a protein that carries a death sentence for synaptic proteins in specific cells. The protein can be encoded in animal genomes to effectively switch off their inhibitory <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/2009\/the-waiting-is-over\/\" target=\"_blank\">synapses<\/a> &mdash; connections between neurons &mdash; thus, increasing their electrical activity.<\/p>\n<p>&ldquo;GFE3 harnesses a little known and remarkable property of proteins within the brain,&rdquo; Arnold said.<\/p>\n<p><strong>Hijacking the process<\/strong><\/p>\n<p>The protein takes advantage of an intrinsic process &mdash; the brain&rsquo;s cycle of degrading and replacing proteins. Most brain proteins last only a couple of days before they are actively degraded and replaced by new proteins. GFE3 targets proteins that hold inhibitory synapses together, presenting them to this degradation system. As a result, the synapses fall apart.<\/p>\n<div class=\"news-image-landscape news-image-right\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/7\/migration-uploads\/Arnold2-2379.jpg\" alt=\"Landscape Right\"><\/p>\n<p>Neuroscientist Don Arnold has developed a powerful tool for studying neural activity. Photo by Peter Zhaoyu Zhou.<\/p>\n<\/div>\n<p>&ldquo;Rather than a cell deciding when a protein needs to be degraded, we sort of hijack the process,&rdquo; Arnold said.<\/p>\n<p>For the study, published in the journal&nbsp;<em>Nature Methods<\/em>, the team of scientists studied the protein&rsquo;s effect in both mice and zebrafish. The researchers found that GFE3 caused neurons on the two sides of the spine to work in opposition, generating uncoordinated movements.<\/p>\n<p>Certain drugs are known to hinder inhibitory synapses in the brain. Examples include benzodiazepines, which treat anxiety, insomnia or seizures. But the drugs inhibit all the cells in a particular area, not just the neurons that are the intended targets.<\/p>\n<p>&ldquo;Unfortunately, cells that have very different, even opposite functions tend to be right next to each other in the brain,&rdquo; Arnold said. &ldquo;Thus, pharmacological experiments are especially difficult to interpret. By encoding GFE3 within the genome, we can target and modulate the inhibitory synapses of specific cells without affecting other cells that have different functions.&rdquo;<\/p>\n<p>Study co-authors included Garrett Gross, William Dempsey and Jason Junge of USC Dornsife; Provost Professor Scott Fraser of USC Dornsife; Christoph Straub and Bernardo Sabitini of Harvard Medical School; and Jimena Perez Sanchez, Yves De Koninck and Paul De Koninck of the Universit&eacute; Laval in Canada.<\/p>\n<p>The research was supported by a National Institutes of Health grant (NS-081687).<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Researchers led by neuroscientist Don Arnold develop GFE3, which may help in mapping the brain\u2019s connections and controlling neural activity.<\/p>\n","protected":false},"author":0,"featured_media":5946,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[113,311,96,314],"class_list":["post-5943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-brain","tag-don-arnold","tag-natural-sciences","tag-scott-fraser"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New protein can modify brain function and memory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New protein can modify brain function and memory\" \/>\n<meta property=\"og:description\" content=\"Researchers led by neuroscientist Don Arnold develop GFE3, which may help in mapping the brain\u2019s connections and controlling neural activity.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\" \/>\n<meta property=\"og:site_name\" content=\"USC Dornsife News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uscdornsife\" \/>\n<meta property=\"article:published_time\" content=\"2016-06-24T15:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-19T18:11:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dornsife.usc.edu\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"690\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uscdornsife\" \/>\n<meta name=\"twitter:site\" content=\"@uscdornsife\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"New protein can modify brain function and memory\",\"datePublished\":\"2016-06-24T15:30:00+00:00\",\"dateModified\":\"2023-04-19T18:11:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\"},\"wordCount\":8,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg\",\"keywords\":[\"brain\",\"don arnold\",\"natural sciences\",\"scott fraser\"],\"articleSection\":[\"Faculty\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\",\"name\":\"New protein can modify brain function and memory\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg\",\"datePublished\":\"2016-06-24T15:30:00+00:00\",\"dateModified\":\"2023-04-19T18:11:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg\",\"width\":690,\"height\":450,\"caption\":\"New protein can modify brain function and memory\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dornsife.usc.edu\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New protein can modify brain function and memory\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#website\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/\",\"name\":\"USC Dornsife News\",\"description\":\"USC Dornsife news and events\",\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dornsife.usc.edu\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\",\"name\":\"USC Dornsife News\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"width\":1000,\"height\":330,\"caption\":\"USC Dornsife News\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uscdornsife\",\"https:\/\/x.com\/uscdornsife\",\"https:\/\/www.instagram.com\/uscdornsife\/\",\"https:\/\/www.youtube.com\/user\/USCCollege\",\"https:\/\/www.linkedin.com\/school\/uscdornsife\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New protein can modify brain function and memory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/","og_locale":"en_US","og_type":"article","og_title":"New protein can modify brain function and memory","og_description":"Researchers led by neuroscientist Don Arnold develop GFE3, which may help in mapping the brain\u2019s connections and controlling neural activity.","og_url":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/","og_site_name":"USC Dornsife News","article_publisher":"https:\/\/www.facebook.com\/uscdornsife","article_published_time":"2016-06-24T15:30:00+00:00","article_modified_time":"2023-04-19T18:11:17+00:00","og_image":[{"width":690,"height":450,"url":"https:\/\/dornsife.usc.edu\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_creator":"@uscdornsife","twitter_site":"@uscdornsife","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#article","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/"},"author":{"name":"","@id":""},"headline":"New protein can modify brain function and memory","datePublished":"2016-06-24T15:30:00+00:00","dateModified":"2023-04-19T18:11:17+00:00","mainEntityOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/"},"wordCount":8,"commentCount":0,"publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg","keywords":["brain","don arnold","natural sciences","scott fraser"],"articleSection":["Faculty"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/","url":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/","name":"New protein can modify brain function and memory","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg","datePublished":"2016-06-24T15:30:00+00:00","dateModified":"2023-04-19T18:11:17+00:00","breadcrumb":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#primaryimage","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2379.jpg","width":690,"height":450,"caption":"New protein can modify brain function and memory"},{"@type":"BreadcrumbList","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/new-protein-can-modify-brain-function-and-memory\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dornsife.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"New protein can modify brain function and memory"}]},{"@type":"WebSite","@id":"https:\/\/dornsife.usc.edu\/news\/#website","url":"https:\/\/dornsife.usc.edu\/news\/","name":"USC Dornsife News","description":"USC Dornsife news and events","publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dornsife.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dornsife.usc.edu\/news\/#organization","name":"USC Dornsife News","url":"https:\/\/dornsife.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","width":1000,"height":330,"caption":"USC Dornsife News"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uscdornsife","https:\/\/x.com\/uscdornsife","https:\/\/www.instagram.com\/uscdornsife\/","https:\/\/www.youtube.com\/user\/USCCollege","https:\/\/www.linkedin.com\/school\/uscdornsife"]}]}},"_links":{"self":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5943","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=5943"}],"version-history":[{"count":2,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5943\/revisions"}],"predecessor-version":[{"id":5945,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5943\/revisions\/5945"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media\/5946"}],"wp:attachment":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=5943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=5943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=5943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}