{"id":5903,"date":"2016-07-15T09:00:00","date_gmt":"2016-07-15T16:00:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/"},"modified":"2023-04-19T11:11:12","modified_gmt":"2023-04-19T18:11:12","slug":"fasting-like-diet-turns-the-immune-system-against-cancer","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/","title":{"rendered":"Fasting-like diet turns the immune system against cancer"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389-689x432.jpg\"\n                    data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"Fasting-like diet turns the immune system against cancer\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  Valter Longo, director of the USC Longevity Institute. Photo by John Skalicky.\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Fasting-like diet turns the immune system against cancer<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  A low-calorie, fasting-like diet plus chemotherapy enables the immune system to recognize and kill skin and breast cancer cells, according to a new study. A second study in human patients shows that fasting is safe and may protect against chemotherapy\u2019s side effects.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Emily Gersema<\/a><\/strong>\n    \n          <span class=\"post-date-field\">July 15, 2016<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 1.058837 1.0874543 2.51831502 1.6884158 4.03502747 1.6884158 1.44087681 0 2.80427251-.5423678 3.86936601-1.5289606l.1656615-.1594552 2.2321428-2.2321428-1.6311813-1.6311813-2.2321429 2.26076c-.6581959.658196-1.5167124 1.0016026-2.43246332 1.0016026s-1.7742674-.3434066-2.43246337-1.0016026c-.65819597-.6581959-1.00160257-1.5167124-1.00160257-2.4324633 0-.8547009.2991453-1.6595442.87416905-2.2981957l.12743352-.1342677 2.23214286-2.2321429zm6.88661855-.40736607-5.26116068 5.26116075 1.61881868 1.6188186 5.2611607-5.2611607zm1.3837569-5.54501488c-1.4408768 0-2.8042725.54236779-3.869366 1.52896062l-.1656615.15945513-2.23214282 2.23214286 1.63118132 1.63118132 2.2321429-2.23214286c.6581959-.65819597 1.5167124-1.00160256 2.4324633-1.00160256s1.7742674.34340659 2.4324634 1.00160256 1.0016026 1.51671246 1.0016026 2.43246337c0 .85470089-.2991453 1.65954419-.8741691 2.29819559l-.1274335.1342678-2.2321429 2.2321428 1.5739469 1.5739469 2.2321429-2.2321428c1.0874542-1.058837 1.6884157-2.5183151 1.6884157-4.03502751 0-1.51671245-.6009615-2.94757326-1.6884157-4.03502747-1.058837-1.08745421-2.518315-1.68841575-4.0350275-1.68841575z\" transform=\"translate(-3 -3)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Copy Link<\/span>\n          <\/a>\n                                <a class=\"a2a_button_facebook\" target=\"_blank\" href=\"\/#facebook\" rel=\"nofollow noopener\" title=\"Facebook\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_facebook\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m23.9512 6h-16.9024c-.57923625 0-1.0488.46956375-1.0488 1.0488v16.9024c0 .5792362.46956375 1.0488 1.0488 1.0488h9.10024v-7.34768h-2.46772v-2.87584h2.46772v-2.11508c0-2.45404 1.49872-3.79012 3.68828-3.79012.7389668-.00263323 1.4775241.03516995 2.21236.11324v2.56348h-1.51392c-1.18788 0-1.4174.56544-1.4174 1.39612v1.8316h2.84772l-.37088 2.87584h-2.47684v7.34844h4.83284c.5792362 0 1.0488-.4695638 1.0488-1.0488v-16.9024c0-.57923625-.4695638-1.0488-1.0488-1.0488z\" fill-rule=\"evenodd\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Facebook<\/span>\n          <\/a>\n                                <a class=\"a2a_button_twitter\" target=\"_blank\" href=\"\/#twitter\" rel=\"nofollow noopener\" title=\"X\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_twitter\">\n              <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\"\n\t y=\"0px\" viewBox=\"0 0 30 30\" enable-background=\"new 0 0 30 30\" xml:space=\"preserve\" width=\"19\" height=\"19\">\n<path fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M14.5,16.2l-0.8-1.1l-6.3-9h2.7l5.1,7.3l0.8,1.1\n\tl6.6,9.4h-2.7L14.5,16.2L14.5,16.2z M16.9,13.4l7.4-8.7h-1.8l-6.5,7.5L11,4.8H5l7.8,11.4L5,25.2h1.8l6.8-7.9l5.5,7.9h6L16.9,13.4\n\tL16.9,13.4z\"\/>\n<\/svg>\n\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">X<\/span>\n          <\/a>\n                                <a class=\"a2a_button_linkedin\" target=\"_blank\" href=\"\/#linkedin\" rel=\"nofollow noopener\" title=\"Linkedin\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_linkedin\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m25 21.4220779c0 1.974026-1.6038961 3.5779221-3.5779221 3.5779221h-11.84415582c-1.97402598 0-3.57792208-1.6038961-3.57792208-3.5779221v-11.84415582c0-1.97402598 1.6038961-3.57792208 3.57792208-3.57792208h11.84415582c1.974026 0 3.5779221 1.6038961 3.5779221 3.57792208zm-14.5584416-12.21428569c-.98701295 0-1.60389606.61688311-1.60389606 1.48051949-.12337663.8636364.49350649 1.4805195 1.48051946 1.4805195.987013 0 1.6038961-.6168831 1.6038961-1.4805195 0-.86363638-.6168831-1.48051949-1.4805195-1.48051949zm1.3571429 12.70779219v-8.6363636h-2.83766234v8.6363636zm10.2402597 0v-4.9350649c0-2.5909091-1.3571428-3.8246753-3.3311688-3.8246753-1.4805195 0-2.0974026.8636363-2.4675325 1.4805194v-1.2337662h-2.8376623v8.6363636h2.8376623v-4.9350649c0-.2467532 0-.4935065.1233767-.7402597.1233766-.4935065.6168831-.987013 1.4805194-.987013.987013 0 1.4805195.7402597 1.4805195 1.974026v4.564935z\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">LinkedIn<\/span>\n          <\/a>\n                                <a class=\"a2a_button_bluesky\" target=\"_blank\" href=\"\/#bluesky\" rel=\"nofollow noopener\" title=\"Bluesky\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_bluesky\">\n              <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50px\" height=\"50px\" viewBox=\"0 0 24 24\">\n                <path fill=\"#00000\" d=\"M12 10.8c-1.087-2.114-4.046-6.053-6.798-7.995C2.566.944 1.561 1.266.902 1.565C.139 1.908 0 3.08 0 3.768c0 .69.378 5.65.624 6.479c.815 2.736 3.713 3.66 6.383 3.364c.136-.02.275-.039.415-.056c-.138.022-.276.04-.415.056c-3.912.58-7.387 2.005-2.83 7.078c5.013 5.19 6.87-1.113 7.823-4.308c.953 3.195 2.05 9.271 7.733 4.308c4.267-4.308 1.172-6.498-2.74-7.078a8.741 8.741 0 0 1-.415-.056c.14.017.279.036.415.056c2.67.297 5.568-.628 6.383-3.364c.246-.828.624-5.79.624-6.478c0-.69-.139-1.861-.902-2.206c-.659-.298-1.664-.62-4.3 1.24C16.046 4.748 13.087 8.687 12 10.8\"  fill-rule=\"evenodd\" \/>\n              <\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Bluesky<\/span>\n          <\/a>\n                                <a class=\"a2a_button_email\" target=\"_blank\" href=\"\/#email\" rel=\"nofollow noopener\" title=\"E-mail\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_print\">\n              <svg height=\"12\" viewBox=\"0 0 18 12\" width=\"18\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>A fasting-like diet with chemotherapy strips away the guard that protects breast cancer and skin cancer cells from the immune system, according to a new study in mice led by Valter Longo of biological sciences.<\/p>\n<p>The study, published in the journal <a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__universityofsoutherncalifornia.cmail19.com_t_j-2Dl-2Dkiaxt-2Dfulltkrih-2Dm_&amp;d=DQMFaQ&amp;c=clK7kQUTWtAVEOVIgvi0NU5BOUHhpN0H8p7CSfnc_gI&amp;r=mMhfay00LHFjk5proA8x4g&amp;m=LXD20JeaIXkT9XoTjxCUkv3C-7CavKHC8tUZptcSyB8&amp;s=u3wMwV8CD77rr1_LYgVco_j3N5_ab7UdM9IJloG5sU0&amp;e=\" target=\"_blank\"><em>Cancer Cell<\/em><\/a> on July 11, comes days after <a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__universityofsoutherncalifornia.cmail19.com_t_j-2Dl-2Dkiaxt-2Dfulltkrih-2Dc_&amp;d=DQMFaQ&amp;c=clK7kQUTWtAVEOVIgvi0NU5BOUHhpN0H8p7CSfnc_gI&amp;r=mMhfay00LHFjk5proA8x4g&amp;m=LXD20JeaIXkT9XoTjxCUkv3C-7CavKHC8tUZptcSyB8&amp;s=UNG98yYiBbZ0_edGfdrTrsMqZfiVAGf1AMDG5NHDpTQ&amp;e=\" target=\"_blank\"><em>BMC Cancer<\/em><\/a> published a separate study showing that a pilot trial of the three-day, fasting-like diet was &ldquo;safe and feasible&rdquo; for 18 cancer patients on chemotherapy.<\/p>\n<p>Both studies were led by Longo, who holds a joint appointment at the <a href=\"http:\/\/gero.usc.edu\/\" target=\"_blank\">USC Davis School of Gerontology<\/a>, where he directs the <a href=\"http:\/\/longevityinstitute.usc.edu\" target=\"_blank\">USC Longevity Institute<\/a>. He has found several health benefits of fasting-like diets, from weight loss to slowed aging. The clinical study was co-led by oncologist David Quinn of the Norris Comprehensive Cancer Center at the <a href=\"http:\/\/keck.usc.edu\/\" target=\"_blank\">Keck School of Medicine of USC<\/a>.<\/p>\n<p>&ldquo;The mouse study on skin and breast cancers is the first study to show that a diet that mimics fasting may activate the immune system and expose the cancer cells to the immune system,&rdquo; Longo said. &ldquo;This could be a very inexpensive way to make a wide range of cancer cells more vulnerable to an attack by the immune cells while also making the cancer more sensitive to the chemotherapy.&rdquo;<\/p>\n<p>The two studies&rsquo; findings build upon <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/1099\/fasting-weakens-cancer-in-mice\/\" target=\"_blank\">prior research<\/a> that showed a short-term fast starves cancer cells and enables the chemotherapy drugs to better target the cancer. Another <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/2361\/diet-that-mimics-fasting-may-also-reduce-multiple-sclerosis-symp\/\" target=\"_blank\">more recent study<\/a> showed that a low-calorie, fasting-mimicking diet can slow multiple sclerosis by killing off bad cells and generating new healthy ones.<\/p>\n<p>The results of this latest mouse study are striking since chemotherapy&rsquo;s side effects include immunosuppression. The researchers found that the fasting-mimicking diet, when used with chemotherapy drugs, raises the levels of bone marrow cells that generate immune system cells, such as T cells, B cells and &ldquo;natural killer&rdquo; cells that infiltrate tumors.<\/p>\n<p><strong>Deceptive T cells<\/strong><\/p>\n<p>In the mouse study, scientists saw another significant effect of the diet: the &ldquo;T regulatory&rdquo; cells which protect the cancer cells were expelled. The scientists traced this effect to a weakened enzyme, heme oxygenase or HO-1, inside the T regulatory cells&rsquo; mitochondria.<\/p>\n<p>Prior research has indicated that HO-1 levels are often elevated in tumors and is linked to several cancers.<\/p>\n<p>&ldquo;While it&rsquo;s more of a mechanism to keep the T cells away, in some ways the heme oxygenase tricks the immune system into thinking that the bad cells should not be killed,&rdquo; Longo said. &ldquo;By removing heme oxygenase, these T regulatory cells are also taken from the site of the cancer.&rdquo;<\/p>\n<p>In examining the effects on breast cancer, researchers found that putting the mice on four days of the low-calorie fasting-mimicking diet, with chemo drugs doxorubicin and cyclophosphamide, was as effective as two days of a water-only, short-term starvation diet. Both diets with the drugs slowed the growth of tumors while protecting healthy, normal cells. The scientists found similar effects on melanoma.<\/p>\n<p>They also found three cycles of the fasting diet, combined with doxorubicin, prompted a 33 percent increase in the levels of cancer-fighting white blood cells and doubled the number of progenitor cells in the bone marrow. The cancer-killing cells were also more effective at attacking and shrinking the tumors.<\/p>\n<p>The scientists found that short-term starvation (a two-day, water-only diet) and the low-calorie fasting-like diet in mice reduced the expression of the HO-1 gene in the T regulatory cells. This change made it easier for the chemotherapy drugs to attack the cancer.<\/p>\n<p><strong>Natural mechanism?<\/strong><\/p>\n<p>Longo said it&rsquo;s unclear if the diet-prompted response in the immune system is an evolved mechanism to protect us from disease.<\/p>\n<p>&ldquo;It may be that by always being exposed to so much food, we are no longer taking advantage of natural protective systems which allow the body to kill cancer cells,&rdquo; Longo said. &ldquo;But by undergoing a fasting-mimicking diet, you are able to let the body use sophisticated mechanisms able to identify and destroy the bad but not good cells in a natural way.&rdquo;<\/p>\n<p>The results of the pilot clinical trial suggested that even water-only fasting in combination with chemotherapy is safe for humans. The research team also found that 72 hours of fasting is associated with lower side effects, compared with fasting for 24 hours. This raises the possibility that a doctor-monitored, fasting-like diet could bolster the effectiveness of immunotherapy on a wider range of cancers.<\/p>\n<p><strong>About the studies<\/strong><\/p>\n<p>The mouse study&rsquo;s first authors were Stefano Di Bias&eacute; and Changhan Lee, with co-authors Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Min Wei and Todd E. Morgan &ndash; all of the USC Longevity Institute; and Rafael de Cabo of the National Institute on Aging. Funding came from the National Institutes of Health (PO1 AG034906).<\/p>\n<p>The human pilot study was conducted by Tanya Dorff, assistant professor, and Quinn, associate professor and medical director &mdash; both of the Norris cancer center at the Keck School of Medicine.<\/p>\n<p>In addition to Longo, co-authors were Susan Groshen, Huyen Pham and Denice Tsao-Wei of the Keck School of Medicine; Agustin Garcia and Manali Shah of Norris cancer center; as well as Chia Wei-Cheng, Sebastian Brandhorst, USC Davis School Dean Pinchas Cohen and Min Wei &ndash; all of the USC Longevity Institute. The study was supported by the V Foundation and the National Cancer Institute.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A low-calorie, fasting-like diet plus chemotherapy enables the immune system to recognize and kill skin and breast cancer cells, according to a new study. A second study in human patients shows that fasting is safe and may protect against chemotherapy\u2019s side effects.<\/p>\n","protected":false},"author":0,"featured_media":5906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[614,81,96],"class_list":["post-5903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-aging","tag-cancer","tag-natural-sciences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fasting-like diet turns the immune system against cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fasting-like diet turns the immune system against cancer\" \/>\n<meta property=\"og:description\" content=\"A low-calorie, fasting-like diet plus chemotherapy enables the immune system to recognize and kill skin and breast cancer cells, according to a new study. A second study in human patients shows that fasting is safe and may protect against chemotherapy\u2019s side effects.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"USC Dornsife News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uscdornsife\" \/>\n<meta property=\"article:published_time\" content=\"2016-07-15T16:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-19T18:11:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dornsife.usc.edu\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"689\" \/>\n\t<meta property=\"og:image:height\" content=\"449\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uscdornsife\" \/>\n<meta name=\"twitter:site\" content=\"@uscdornsife\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Fasting-like diet turns the immune system against cancer\",\"datePublished\":\"2016-07-15T16:00:00+00:00\",\"dateModified\":\"2023-04-19T18:11:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/\"},\"wordCount\":8,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2023\\\/04\\\/story-2389.jpg\",\"keywords\":[\"aging\",\"cancer\",\"natural sciences\"],\"articleSection\":[\"Faculty\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/\",\"name\":\"Fasting-like diet turns the immune system against cancer\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2023\\\/04\\\/story-2389.jpg\",\"datePublished\":\"2016-07-15T16:00:00+00:00\",\"dateModified\":\"2023-04-19T18:11:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#primaryimage\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2023\\\/04\\\/story-2389.jpg\",\"contentUrl\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2023\\\/04\\\/story-2389.jpg\",\"width\":689,\"height\":449,\"caption\":\"Fasting-like diet turns the immune system against cancer\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/stories\\\/fasting-like-diet-turns-the-immune-system-against-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Fasting-like diet turns the immune system against cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/\",\"name\":\"USC Dornsife News\",\"description\":\"USC Dornsife news and events\",\"publisher\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#organization\",\"name\":\"USC Dornsife News\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2024\\\/01\\\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"contentUrl\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2024\\\/01\\\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"width\":1000,\"height\":330,\"caption\":\"USC Dornsife News\"},\"image\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/uscdornsife\",\"https:\\\/\\\/x.com\\\/uscdornsife\",\"https:\\\/\\\/www.instagram.com\\\/uscdornsife\\\/\",\"https:\\\/\\\/www.youtube.com\\\/user\\\/USCCollege\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/uscdornsife\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fasting-like diet turns the immune system against cancer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Fasting-like diet turns the immune system against cancer","og_description":"A low-calorie, fasting-like diet plus chemotherapy enables the immune system to recognize and kill skin and breast cancer cells, according to a new study. A second study in human patients shows that fasting is safe and may protect against chemotherapy\u2019s side effects.","og_url":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/","og_site_name":"USC Dornsife News","article_publisher":"https:\/\/www.facebook.com\/uscdornsife","article_published_time":"2016-07-15T16:00:00+00:00","article_modified_time":"2023-04-19T18:11:12+00:00","og_image":[{"width":689,"height":449,"url":"https:\/\/dornsife.usc.edu\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_creator":"@uscdornsife","twitter_site":"@uscdornsife","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#article","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/"},"author":{"name":"","@id":""},"headline":"Fasting-like diet turns the immune system against cancer","datePublished":"2016-07-15T16:00:00+00:00","dateModified":"2023-04-19T18:11:12+00:00","mainEntityOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/"},"wordCount":8,"commentCount":0,"publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg","keywords":["aging","cancer","natural sciences"],"articleSection":["Faculty"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/","url":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/","name":"Fasting-like diet turns the immune system against cancer","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#primaryimage"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg","datePublished":"2016-07-15T16:00:00+00:00","dateModified":"2023-04-19T18:11:12+00:00","breadcrumb":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#primaryimage","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2389.jpg","width":689,"height":449,"caption":"Fasting-like diet turns the immune system against cancer"},{"@type":"BreadcrumbList","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/fasting-like-diet-turns-the-immune-system-against-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dornsife.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"Fasting-like diet turns the immune system against cancer"}]},{"@type":"WebSite","@id":"https:\/\/dornsife.usc.edu\/news\/#website","url":"https:\/\/dornsife.usc.edu\/news\/","name":"USC Dornsife News","description":"USC Dornsife news and events","publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dornsife.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dornsife.usc.edu\/news\/#organization","name":"USC Dornsife News","url":"https:\/\/dornsife.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","width":1000,"height":330,"caption":"USC Dornsife News"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uscdornsife","https:\/\/x.com\/uscdornsife","https:\/\/www.instagram.com\/uscdornsife\/","https:\/\/www.youtube.com\/user\/USCCollege","https:\/\/www.linkedin.com\/school\/uscdornsife"]}]}},"_links":{"self":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=5903"}],"version-history":[{"count":2,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5903\/revisions"}],"predecessor-version":[{"id":5905,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/5903\/revisions\/5905"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media\/5906"}],"wp:attachment":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=5903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=5903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=5903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}