{"id":4447,"date":"2018-03-23T11:25:00","date_gmt":"2018-03-23T18:25:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/molecular-biologist-earns-nsf-career-grant-to-study-dna-repair\/"},"modified":"2025-06-04T11:59:58","modified_gmt":"2025-06-04T18:59:58","slug":"molecular-biologist-earns-nsf-career-grant-to-study-dna-repair","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/molecular-biologist-earns-nsf-career-grant-to-study-dna-repair\/","title":{"rendered":"Molecular biologist earns NSF CAREER grant to study DNA repair"},"content":{"rendered":"\n\n\n    \n                                \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2770-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-2770-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"Molecular biologist earns NSF CAREER grant to study DNA repair\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  The fruit fly <em>Drosophila<\/em> is a common model for studying the dynamics of DNA. Irene Chiolo of biological sciences at USC Dornsife, supported by a National Science Foundation Faculty Early Career Development (CAREER) Program award, will use the insect to develop new techniques for understanding DNA repair.\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Molecular biologist earns NSF CAREER grant to study DNA repair<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Irene Chiolo of biological sciences at USC Dornsife will work with fruit flies to develop new technology to study how cells keep their DNA error-free.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Darrin S. Joy<\/a><\/strong>\n    \n          <span class=\"post-date-field\">March 23, 2018<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n \n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Irene Chiolo is all about integrity. Not only in her day to day work, but also in her research focus: understanding how cells keep their DNA intact, despite constant threats from the environment.<\/p>\n<p><a href=\"https:\/\/dornsife.usc.edu\/cf\/bisc\/faculty_display.cfm?Person_ID=1043597\" target=\"_blank\" rel=\"noopener\">Chiolo<\/a>, Gabilan Assistant Professor of Biological Sciences at USC Dornsife, focuses on DNA repair in heterochromatin, a dense mix of chromosomal DNA and protein that features multiple repeats of short DNA sequences.<\/p>\n<p>Those repeated sequences can be a real problem. If DNA breaks show up when the cell is duplicating its DNA during division and the cell fails to repair them, catastrophe looms.<\/p>\n<p>\u201cWhile repair failures in normal chromatin can lead to harmful mutations in specific genes,\u201d she said, \u201cincorrect repair within repetitive heterochromatic regions can trigger massive chromosome rearrangements causing cell death or genome instability.\u201d<\/p>\n<p>A cell\u2019s death, in most cases, won\u2019t affect the body overall, but genome instability is a leading cause of cancer and other diseases.<\/p>\n<div class=\"news-image-portrait news-image-right\">\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/7\/migration-uploads\/Chiolo220x350-2770.jpg\" alt=\"Portrait Right\" \/><\/p>\n<p>Irene Chiolo<\/p>\n<\/div>\n<p>To avoid these adverse outcomes, cells must have robust mechanisms to ensure heterochromatin is faithfully repaired during cell division. Chiolo recently received a <a href=\"https:\/\/www.nsf.gov\/funding\/pgm_summ.jsp?pims_id=503214\" target=\"_blank\" rel=\"noopener\">Faculty Early Career Development (CAREER) Program<\/a> award from the National Science Foundation to further her studies of these processes. CAREER awards are among the NSF\u2019s most prestigious, supporting early-career faculty who can serve as academic role models in research and education and lead advances in their organization<\/p>\n<p>The grant will allow her to develop and use new experimental methods with the fruit fly <i>Drosophila<\/i>, a commonly used subject for genetic research, to study what happens to heterochromatin when it undergoes repair.<\/p>\n<p>Nearly 30% of the human genome is composed of heterochromatin surrounding centromeres, the bundles of DNA and protein that bind pairs of chromosomes together. Heterochromatin is a hotspot where defective repair of broken DNA strands can lead to harmful rearrangement of the genome.<\/p>\n<p>Chiolo has previously uncovered unexpected mechanisms that cells use to help ensure proper repair takes place in heterochromatin. These sequences belonging to different chromosomes tend to cluster in a specific area of the nucleus, called the \u201cheterochromatin domain.\u201d Her earlier studies have shown that cells unravel strands with broken segments and thrust them outward, away from this domain, where they have room to be mended, then draw them back in safely.<\/p>\n<p>She\u2019s <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/2215\/nuclear-membrane-repairs-the-dark-matter-of-dna\/\" target=\"_blank\" rel=\"noopener\">also shown<\/a> that the nuclear membrane, a fatty layer that holds the DNA within the nucleus, aids in this repair.<\/p>\n<p>With the CAREER award, she will use cutting-edge tools to break the DNA at specific, targeted sites coupled with powerful next-generation genomic sequencing technology to learn more about the repair process.<\/p>\n<p>\u201cThis combination of approaches will enable the first high-resolution profiling of chromatin dynamics responsible for heterochromatic repair,\u201d she said, shedding a finer light on the mechanisms that keep the genome healthy and stable.<\/p>\n<p>The grant also will enable students, including undergraduates and high school students, to gain experience in the lab. \u201cThe project creates excellent educational opportunities for junior researchers to participate in training, teaching, mentoring and outreach activities, launching their careers in science while inspiring others.\u201d<\/p>\n<p>She hopes to use the award to advance understanding of genomic stability beyond USC Dornsife through an annual symposium gathering researchers to study the topic, as well.<\/p>\n<p>\u201cThe symposium will enhance the dissemination of knowledge, open new networking, research and career opportunities for junior and senior scientists at colleges and universities across Southern California,\u201d she said.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Irene Chiolo of biological sciences at USC Dornsife will work with fruit flies to develop new technology to study how cells keep their DNA error-free.<\/p>\n","protected":false},"author":14,"featured_media":4450,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[117,853,821,852],"class_list":["post-4447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-biology","tag-faculty-early-career-development-program","tag-irene-chiolo","tag-national-science-foundation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Molecular biologist earns NSF CAREER grant to study DNA repair<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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