{"id":2648,"date":"2020-06-17T11:20:00","date_gmt":"2020-06-17T18:20:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/scientists-gain-detailed-images-of-how-a-protein-that-calms-brain-activity-works\/"},"modified":"2023-04-19T11:04:12","modified_gmt":"2023-04-19T18:04:12","slug":"gaba-receptor-structure-reveals-pam-drug-target-site","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/gaba-receptor-structure-reveals-pam-drug-target-site\/","title":{"rendered":"Scientists gain detailed images of how a protein that calms brain activity works"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3233-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3233-1280x720.jpg 1280w,https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3233-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"Scientists gain detailed images of how a protein that calms brain activity works\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  Illustration depicting a nerve cell synapse with structures GABAB, a neurotransmitter receptor protein, captured in four different conformations (background) and in the active state (close-up) with molecules (orange and magenta) bound to it. (Illustration: Yekaterina Kadyshevskaya.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Scientists gain detailed images of how a protein that calms brain activity works<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  The findings provide a clear path to uncovering new drugs to control addiction, pain and neurological disorders such as epilepsy and muscle spasticity. <strong>[2\u00be min read]<\/strong>\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Darrin S. Joy<\/a><\/strong>\n    \n          <span class=\"post-date-field\">June 17, 2020<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>As the body goes about its daily business, molecules called neurotransmitters control the level of electrical activity within the brain. Interacting with protein receptors nestled in the membrane that makes up the outer border of a nerve cell, or neuron, neurotransmitters open and close portals that control the flow of ions in and out of the cell.<\/p>\n<p>Gamma-aminobutyric acid, or GABA, dominates as one of the most important inhibitory neurotransmitters in the brain. Its primary role is to calm brain activity, lowering the number of signals firing in the brain in balance with the activity of other neurotransmitters that ramp up brain activity. (It&rsquo;s even sold as a nutritional supplement to promote calm and improve sleep.)<\/p>\n<p>When GABA is unable to inhibit brain signaling, the imbalance in activity can lead to a number of health issues including anxiety or mood disorders, increased pain, muscle spasms and, in extreme cases, even epilepsy.<\/p>\n<p>In a <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2408-4\">study published in <i>Nature<\/i><\/a> on June 17, scientists at USC Dornsife College of Letters, Arts and Sciences and the <a href=\"https:\/\/dornsife.usc.edu\/bridge-institute\/\">Bridge Institute<\/a> at the <a href=\"https:\/\/michelson.usc.edu\/\">USC Michelson Center for Convergent Bioscience<\/a> figured out how GABA interacts with a key protein receptor called GABAB.<\/p>\n<p>The study, done in collaboration with researchers at Stanford University, the Stanford Linear Accelerator Center and the Universit&eacute; de Montpellier in France, paints a clear picture of how GABA changes the shape of the GABAB protein and reveals a clear target site for new drugs.<\/p>\n<p><strong>Ultra-high definition views of a shape-shifter<\/strong><\/p>\n<p><div class=\"video-embed\"><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/YoU_Wq-sW80\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\" width=\"640\" height=\"360\" frameborder=\"0\"><\/iframe><\/div>\n<\/p>\n<p>The researchers used cryo-electron microscopy, or cryo-EM, to capture never-before-seen detailed snapshots of the GABAB receptor protein twisting and contorting as it interacts with GABA.<\/p>\n<p>The GABAB receptor protein rests across the cellular membrane of neurons and is composed of two subunits with similar shapes: GB1, which recognizes GABA, and GB2, which relays the signal from GB1 into the cell&rsquo;s interior.<\/p>\n<p>The cryo-EM images provide blueprints of how, as GABA interacts with GB1, a ripple effect moves through the entire protein until a cavity opens in the part of GB2 that faces inside the cell. Once revealed, this cavity in GB2 can interact with and activate proteins within the cell that control the neuron&rsquo;s activity.<\/p>\n<p>The three-dimensional structural images offer promise for improved therapies for neurological disorders, according to <a href=\"https:\/\/michelson.usc.edu\/vadim-cherezov\/\">Vadim Cherezov<\/a>, professor of <a href=\"http:\/\/chem.usc.edu\/\">chemistry<\/a> at USC Dornsife and a corresponding author on the study. &ldquo;These blueprints can be used to design new therapeutic drugs that could affect different conformational states and thus act more precisely.&rdquo;<\/p>\n<p>Equally important if not more so, the images also reveal a critical location on the GABAB receptor protein, where GB1 and GB2 meet within the cell membrane when the receptor is activated. Previously unknown, this GB1-GB2 interface is a prime target for a type of drug called a PAM (short for positive allosteric modulator).<\/p>\n<p>PAMs offer promise for the development of new therapeutic drugs because they don&rsquo;t replace the action of naturally occurring molecules such as GABA but rather fine-tune how the receptor behaves, leading to fewer side-effects, Cherezov said.<\/p>\n<p>&ldquo;There are many therapeutic areas in which targeting the GABAB receptor protein could be beneficial; however, such direct interventions may come with significant side-effects,&rdquo; he said. &ldquo;Developments of PAMs facilitated by our structure images could lead to a new generation of safer drugs targeting this receptor.&rdquo;<\/p>\n<p><strong>About the study<\/strong><\/p>\n<p>Authors on the study include USC Dornsife&rsquo;s Hamidreza Shaye, Andrii Ishchenko, Jordy Homing Lam, Gye Won Han, and Vsevolod Katritch; Cornelius Gati of Stanford University and SLAC; and Li Xue, Philippe Rondard and Jean-Philippe Pin of Universit&eacute; de Montpellier.<\/p>\n<p>The study was funded by National Institutes of Health grant R35 GM127086 (Cherezov); the Department of Energy, Laboratory Directed Research and Development program at SLAC National Accelerator Laboratory, under contract DE-AC02-76SF00515; and by the Fondation pour la Recherche M&eacute;dicale award DEQ20170336747 (Pin).<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The findings provide a clear path to uncovering new drugs to control addiction, pain and neurological disorders such as epilepsy and muscle spasticity. <strong>[2\u00be min read]<\/strong><\/p>\n","protected":false},"author":0,"featured_media":2651,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[113,399,78,202],"class_list":["post-2648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-brain","tag-bridge-institute","tag-chemistry","tag-michelson-center-for-convergent-bioscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Scientists gain detailed images of how a protein that calms brain activity works<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/gaba-receptor-structure-reveals-pam-drug-target-site\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists gain detailed images of how a protein that calms brain activity works\" \/>\n<meta property=\"og:description\" content=\"The findings provide a clear path to uncovering new drugs to control addiction, pain and neurological disorders such as epilepsy and muscle spasticity. 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