{"id":17952,"date":"2023-12-20T02:00:00","date_gmt":"2023-12-20T10:00:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/?p=17952"},"modified":"2023-12-19T15:12:27","modified_gmt":"2023-12-19T23:12:27","slug":"synthetic-chromosomes-faster-cheaper","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/","title":{"rendered":"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper"},"content":{"rendered":"\n\n\n    \n                                \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife-1920x1080.jpg 1920w,https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife-1280x720.jpg 1280w,https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  USC Dornsife researchers invented a way to efficiently create chromosomes from existing pieces. (Image source: iStock.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=science-and-technology\">Science and Technology<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  A new process to assemble DNA, developed by USC Dornsife scientists, could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">USC Dornsife News Staff<\/a><\/strong>\n    \n          <span class=\"post-date-field\">December 20, 2023<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 1.058837 1.0874543 2.51831502 1.6884158 4.03502747 1.6884158 1.44087681 0 2.80427251-.5423678 3.86936601-1.5289606l.1656615-.1594552 2.2321428-2.2321428-1.6311813-1.6311813-2.2321429 2.26076c-.6581959.658196-1.5167124 1.0016026-2.43246332 1.0016026s-1.7742674-.3434066-2.43246337-1.0016026c-.65819597-.6581959-1.00160257-1.5167124-1.00160257-2.4324633 0-.8547009.2991453-1.6595442.87416905-2.2981957l.12743352-.1342677 2.23214286-2.2321429zm6.88661855-.40736607-5.26116068 5.26116075 1.61881868 1.6188186 5.2611607-5.2611607zm1.3837569-5.54501488c-1.4408768 0-2.8042725.54236779-3.869366 1.52896062l-.1656615.15945513-2.23214282 2.23214286 1.63118132 1.63118132 2.2321429-2.23214286c.6581959-.65819597 1.5167124-1.00160256 2.4324633-1.00160256s1.7742674.34340659 2.4324634 1.00160256 1.0016026 1.51671246 1.0016026 2.43246337c0 .85470089-.2991453 1.65954419-.8741691 2.29819559l-.1274335.1342678-2.2321429 2.2321428 1.5739469 1.5739469 2.2321429-2.2321428c1.0874542-1.058837 1.6884157-2.5183151 1.6884157-4.03502751 0-1.51671245-.6009615-2.94757326-1.6884157-4.03502747-1.058837-1.08745421-2.518315-1.68841575-4.0350275-1.68841575z\" transform=\"translate(-3 -3)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Copy Link<\/span>\n          <\/a>\n                                <a class=\"a2a_button_facebook\" target=\"_blank\" href=\"\/#facebook\" rel=\"nofollow noopener\" title=\"Facebook\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_facebook\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m23.9512 6h-16.9024c-.57923625 0-1.0488.46956375-1.0488 1.0488v16.9024c0 .5792362.46956375 1.0488 1.0488 1.0488h9.10024v-7.34768h-2.46772v-2.87584h2.46772v-2.11508c0-2.45404 1.49872-3.79012 3.68828-3.79012.7389668-.00263323 1.4775241.03516995 2.21236.11324v2.56348h-1.51392c-1.18788 0-1.4174.56544-1.4174 1.39612v1.8316h2.84772l-.37088 2.87584h-2.47684v7.34844h4.83284c.5792362 0 1.0488-.4695638 1.0488-1.0488v-16.9024c0-.57923625-.4695638-1.0488-1.0488-1.0488z\" fill-rule=\"evenodd\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Facebook<\/span>\n          <\/a>\n                                <a class=\"a2a_button_twitter\" target=\"_blank\" href=\"\/#twitter\" rel=\"nofollow noopener\" title=\"X\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_twitter\">\n              <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\"\n\t y=\"0px\" viewBox=\"0 0 30 30\" enable-background=\"new 0 0 30 30\" xml:space=\"preserve\" width=\"19\" height=\"19\">\n<path fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M14.5,16.2l-0.8-1.1l-6.3-9h2.7l5.1,7.3l0.8,1.1\n\tl6.6,9.4h-2.7L14.5,16.2L14.5,16.2z M16.9,13.4l7.4-8.7h-1.8l-6.5,7.5L11,4.8H5l7.8,11.4L5,25.2h1.8l6.8-7.9l5.5,7.9h6L16.9,13.4\n\tL16.9,13.4z\"\/>\n<\/svg>\n\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">X<\/span>\n          <\/a>\n                                <a class=\"a2a_button_linkedin\" target=\"_blank\" href=\"\/#linkedin\" rel=\"nofollow noopener\" title=\"Linkedin\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_linkedin\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m25 21.4220779c0 1.974026-1.6038961 3.5779221-3.5779221 3.5779221h-11.84415582c-1.97402598 0-3.57792208-1.6038961-3.57792208-3.5779221v-11.84415582c0-1.97402598 1.6038961-3.57792208 3.57792208-3.57792208h11.84415582c1.974026 0 3.5779221 1.6038961 3.5779221 3.57792208zm-14.5584416-12.21428569c-.98701295 0-1.60389606.61688311-1.60389606 1.48051949-.12337663.8636364.49350649 1.4805195 1.48051946 1.4805195.987013 0 1.6038961-.6168831 1.6038961-1.4805195 0-.86363638-.6168831-1.48051949-1.4805195-1.48051949zm1.3571429 12.70779219v-8.6363636h-2.83766234v8.6363636zm10.2402597 0v-4.9350649c0-2.5909091-1.3571428-3.8246753-3.3311688-3.8246753-1.4805195 0-2.0974026.8636363-2.4675325 1.4805194v-1.2337662h-2.8376623v8.6363636h2.8376623v-4.9350649c0-.2467532 0-.4935065.1233767-.7402597.1233766-.4935065.6168831-.987013 1.4805194-.987013.987013 0 1.4805195.7402597 1.4805195 1.974026v4.564935z\" transform=\"translate(-6 -6)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">LinkedIn<\/span>\n          <\/a>\n                                <a class=\"a2a_button_bluesky\" target=\"_blank\" href=\"\/#bluesky\" rel=\"nofollow noopener\" title=\"Bluesky\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_bluesky\">\n              <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"50px\" height=\"50px\" viewBox=\"0 0 24 24\">\n                <path fill=\"#00000\" d=\"M12 10.8c-1.087-2.114-4.046-6.053-6.798-7.995C2.566.944 1.561 1.266.902 1.565C.139 1.908 0 3.08 0 3.768c0 .69.378 5.65.624 6.479c.815 2.736 3.713 3.66 6.383 3.364c.136-.02.275-.039.415-.056c-.138.022-.276.04-.415.056c-3.912.58-7.387 2.005-2.83 7.078c5.013 5.19 6.87-1.113 7.823-4.308c.953 3.195 2.05 9.271 7.733 4.308c4.267-4.308 1.172-6.498-2.74-7.078a8.741 8.741 0 0 1-.415-.056c.14.017.279.036.415.056c2.67.297 5.568-.628 6.383-3.364c.246-.828.624-5.79.624-6.478c0-.69-.139-1.861-.902-2.206c-.659-.298-1.664-.62-4.3 1.24C16.046 4.748 13.087 8.687 12 10.8\"  fill-rule=\"evenodd\" \/>\n              <\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Bluesky<\/span>\n          <\/a>\n                                <a class=\"a2a_button_email\" target=\"_blank\" href=\"\/#email\" rel=\"nofollow noopener\" title=\"E-mail\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_print\">\n              <svg height=\"12\" viewBox=\"0 0 18 12\" width=\"18\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n \n\n\n      \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-highlights \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-highlights\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Key points:\n      <\/h2>\n\n\n<\/div>\n    \n      <ul>\n              <li><p>A new technique to clone and reassemble DNA, dubbed CReATiNG, could simplify and lower the cost of making synthetic chromosomes.<\/p>\n<\/li>\n              <li><p>Potential applications are numerous, including pharmaceutical production, biofuel generation, cancer therapies, and environmental cleanup using modified organisms.<\/p>\n<\/li>\n              <li><p>The method adds a powerful, versatile tool to the burgeoning field of synthetic biology.<\/p>\n<\/li>\n          <\/ul>\n  <\/div>\n  \n\n  <\/div><\/div>\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>A groundbreaking new technique invented by researchers at the USC Dornsife College of Letters, Arts and Science may revolutionize the field of synthetic biology. Known as CReATiNG (Cloning Reprogramming and Assembling Tiled Natural Genomic DNA), the method offers a simpler and more cost-effective approach to constructing synthetic chromosomes. It could significantly advance genetic engineering and enable a wide range of advances in medicine, biotechnology, biofuel production and even space exploration.<\/p>\n<p>CReATiNG works by cloning and reassembling natural DNA segments from yeast, allowing scientists to create synthetic chromosomes that can replace their native counterparts in cells. The innovative technique enables researchers to combine chromosomes between different yeast strains and species, change chromosome structures, and delete multiple genes simultaneously.<\/p>\n<p>Lead researcher <a href=\"https:\/\/dornsife.usc.edu\/profile\/ian-ehrenreich\/\">Ian Ehrenreich<\/a>, professor of <a href=\"https:\/\/dornsife.usc.edu\/bisc\/\">biological sciences<\/a> at USC Dornsife, said the method is a major improvement over current technology. \u201cWith CReATiNG, we can genetically reprogram organisms in complex ways previously deemed impossible, even with new tools like <a href=\"https:\/\/www.genome.gov\/genetics-glossary\/CRISPR\" target=\"_blank\">CRISPR<\/a>,\u201d he said. \u201cThis opens up a world of possibilities in synthetic biology, enhancing our fundamental understanding of life and paving the way for groundbreaking applications.\u201d<\/p>\n<p><a href=\"https:\/\/urldefense.com\/v3\/__https:\/www.nature.com\/articles\/s41467-023-44112-2__;!!LIr3w8kk_Xxm!v7VhnDRD9MbnziiZhos0-tl2mansMmHJj6_bQWggFHHjO5k4ro-qWDhME0l2DFfFwc1L1lTP2YrQDbbmW8Jkxc2zrX_FMHM7%24\">The study<\/a> was published Dec. 20 in <em>Nature Communications<\/em>.<\/p>\n<h2>CReATiNG makes difficult research easier, cheaper<\/h2>\n<p>The field of synthetic biology has emerged as a way for scientists to take control of living cells, such as yeast and bacteria, to better understand how they work and to enable them to produce useful compounds, such as new medicines.<\/p>\n<p>\u201cOver the last decade or so, a new form of synthetic biology has emerged called synthetic genomics, which involves synthesizing whole chromosomes or entire genomes of organisms,\u201d Ehrenreich said. \u201cThe thing about most synthetic genomics research is that it involves building chromosomes or genomes from scratch using chemically synthesized DNA pieces. This is a ton of work and extremely expensive.\u201d<\/p>\n<p>However, there have been no alternatives \u2014 until now. \u201cCReATiNG offers an opportunity to use natural pieces of DNA as parts to assemble whole chromosomes,\u201d said <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/usc-agilent-alliance\/\">Agilent postdoctoral fellow<\/a> Alessandro Coradini, who was study first author.<\/p>\n<p>The method makes advanced genetic research more accessible by significantly lowering costs and technical barriers so scientists can unlock new solutions to some of the most pressing challenges in science and medicine today.<\/p>\n<h2>CReATiNG could help medicine, space exploration and more<\/h2>\n<p>The findings are particularly significant for their potential applications in biotechnology and medicine. CReATiNG could lead to more efficient production of pharmaceuticals and biofuels, aid in the development of cell therapies for diseases like cancer and pave the way to methods of environmental bioremediation, such as creating bacteria that consume pollutants.<\/p>\n<p>The method might even extend to helping humans live for long periods in space or other harsh environments. Scientists could one day use CReATiNG to develop microorganisms or plants that could thrive in space stations or during long-distance space travel, though the researchers caution that this would require much future research.<\/p>\n<p>One of the most striking aspects of the study, according to the researchers, is how rearranging chromosome segments in yeast can alter their growth rates, with some modifications resulting in up to a 68% faster or slower growth. This discovery highlights the profound impact that genetic structure can have on biological function and opens up new research pathways to further explore these relationships.<\/p>\n<p><strong>About the study<\/strong><\/p>\n<p>In addition to Ehrenreich and Coradini, authors on the study include Christopher Ne Ville, Zachary Krieger, Joshua Roemer, Cara Hull, Shawn Yang and Daniel Lusk, all of USC Dornsife.<\/p>\n<p>The study was supported by National Science Foundation grant 2124400, National Institutes of Health grant R35GM130381 and an Agilent Postdoctoral Fellowship.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n\n\n\n  \n        \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-related-stories \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-related-stories\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n              \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Related Articles\n      <\/h2>\n\n\n<\/div>\n    \n                  <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/how-does-narcan-work\/\" \n                        class=\"\" \n      >How does Narcan work?<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n              <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/usc-dornsife-phd-students-receive-prestigious-grants\/\" \n                        class=\"\" \n      >2 prestigious grants fund PhD research in marine and molecular biology<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n              <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/electric-bacteria-shewanella-oneidensis-electron-transfer\/\" \n                        class=\"\" \n      >\u2018Electric bacteria\u2019 are ready for their close-up<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n            <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A new process to assemble DNA, developed by USC Dornsife researchers, could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.<\/p>\n","protected":false},"author":13,"featured_media":17953,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[1500,1920,1935,206,96,60],"class_list":["post-17952","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-technology","tag-biolocial-sciences","tag-bisc","tag-mcb","tag-molecular-and-computational-biology","tag-natural-sciences","tag-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper<\/title>\n<meta name=\"description\" content=\"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists are \u201cCReATiNG\u201d synthetic chromosomes faster, cheaper\" \/>\n<meta property=\"og:description\" content=\"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\" \/>\n<meta property=\"og:site_name\" content=\"USC Dornsife News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uscdornsife\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-20T10:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2000\" \/>\n\t<meta property=\"og:image:height\" content=\"1150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Liu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uscdornsife\" \/>\n<meta name=\"twitter:site\" content=\"@uscdornsife\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\"},\"author\":{\"name\":\"Michael Liu\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/d03084ed5319ed7575c96017879a7447\"},\"headline\":\"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper\",\"datePublished\":\"2023-12-20T10:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\"},\"wordCount\":9,\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg\",\"keywords\":[\"biolocial sciences\",\"bisc\",\"mcb\",\"molecular and computational biology\",\"natural sciences\",\"research\"],\"articleSection\":[\"Science and Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\",\"name\":\"Scientists are \u201cCReATiNG\u201d synthetic chromosomes faster, cheaper\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg\",\"datePublished\":\"2023-12-20T10:00:00+00:00\",\"description\":\"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.\",\"breadcrumb\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg\",\"width\":2000,\"height\":1150},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dornsife.usc.edu\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#website\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/\",\"name\":\"USC Dornsife News\",\"description\":\"USC Dornsife news and events\",\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dornsife.usc.edu\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#organization\",\"name\":\"USC Dornsife News\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg\",\"width\":1000,\"height\":330,\"caption\":\"USC Dornsife News\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/uscdornsife\",\"https:\/\/x.com\/uscdornsife\",\"https:\/\/www.instagram.com\/uscdornsife\/\",\"https:\/\/www.youtube.com\/user\/USCCollege\",\"https:\/\/www.linkedin.com\/school\/uscdornsife\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/d03084ed5319ed7575c96017879a7447\",\"name\":\"Michael Liu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/16962c8d3900280cb2e47f931ab45f9c2432ea07c167e9c00a6c2f8a0ec3d61f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/16962c8d3900280cb2e47f931ab45f9c2432ea07c167e9c00a6c2f8a0ec3d61f?s=96&d=mm&r=g\",\"caption\":\"Michael Liu\"},\"url\":\"https:\/\/dornsife.usc.edu\/news\/stories\/author\/liumk\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper","description":"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/","og_locale":"en_US","og_type":"article","og_title":"Scientists are \u201cCReATiNG\u201d synthetic chromosomes faster, cheaper","og_description":"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.","og_url":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/","og_site_name":"USC Dornsife News","article_publisher":"https:\/\/www.facebook.com\/uscdornsife","article_published_time":"2023-12-20T10:00:00+00:00","og_image":[{"width":2000,"height":1150,"url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg","type":"image\/jpeg"}],"author":"Michael Liu","twitter_card":"summary_large_image","twitter_creator":"@uscdornsife","twitter_site":"@uscdornsife","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#article","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/"},"author":{"name":"Michael Liu","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/d03084ed5319ed7575c96017879a7447"},"headline":"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper","datePublished":"2023-12-20T10:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/"},"wordCount":9,"publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg","keywords":["biolocial sciences","bisc","mcb","molecular and computational biology","natural sciences","research"],"articleSection":["Science and Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/","url":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/","name":"Scientists are \u201cCReATiNG\u201d synthetic chromosomes faster, cheaper","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg","datePublished":"2023-12-20T10:00:00+00:00","description":"USC Dornsife scientists have a new way to assemble DNA that could vastly improve production of pharmaceuticals, cancer therapies, biofuels and more.","breadcrumb":{"@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#primaryimage","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/12\/Synthetic_Chromosomes_Hero_Dornsife.jpg","width":2000,"height":1150},{"@type":"BreadcrumbList","@id":"https:\/\/dornsife.usc.edu\/news\/stories\/synthetic-chromosomes-faster-cheaper\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dornsife.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"How researchers are \u201cCReATiNG\u201d synthetic chromosomes faster and cheaper"}]},{"@type":"WebSite","@id":"https:\/\/dornsife.usc.edu\/news\/#website","url":"https:\/\/dornsife.usc.edu\/news\/","name":"USC Dornsife News","description":"USC Dornsife news and events","publisher":{"@id":"https:\/\/dornsife.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dornsife.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dornsife.usc.edu\/news\/#organization","name":"USC Dornsife News","url":"https:\/\/dornsife.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","contentUrl":"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2024\/01\/USC-Dornsife-Cardinal-Black-on-White-RGB.jpg","width":1000,"height":330,"caption":"USC Dornsife News"},"image":{"@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uscdornsife","https:\/\/x.com\/uscdornsife","https:\/\/www.instagram.com\/uscdornsife\/","https:\/\/www.youtube.com\/user\/USCCollege","https:\/\/www.linkedin.com\/school\/uscdornsife"]},{"@type":"Person","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/d03084ed5319ed7575c96017879a7447","name":"Michael Liu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/16962c8d3900280cb2e47f931ab45f9c2432ea07c167e9c00a6c2f8a0ec3d61f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/16962c8d3900280cb2e47f931ab45f9c2432ea07c167e9c00a6c2f8a0ec3d61f?s=96&d=mm&r=g","caption":"Michael Liu"},"url":"https:\/\/dornsife.usc.edu\/news\/stories\/author\/liumk\/"}]}},"_links":{"self":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/17952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=17952"}],"version-history":[{"count":3,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/17952\/revisions"}],"predecessor-version":[{"id":17956,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/posts\/17952\/revisions\/17956"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media\/17953"}],"wp:attachment":[{"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=17952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=17952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=17952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}