{"id":17124,"date":"2023-10-17T08:05:00","date_gmt":"2023-10-17T15:05:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/?p=17124"},"modified":"2023-11-21T17:45:47","modified_gmt":"2023-11-22T01:45:47","slug":"cryo-electron-immune-secrets","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/cryo-electron-immune-secrets\/","title":{"rendered":"Unlocking secrets of immune system proteins: A potential path to new treatments"},"content":{"rendered":"\n\n\n    \n                                          \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/10\/Cryo_Em_Top-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/10\/Cryo_Em_Top-1920x1080.jpg 1920w,https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/10\/Cryo_Em_Top-1280x720.jpg 1280w,https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/10\/Cryo_Em_Top-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  Researchers peering into the workings of cells reveal how immune system proteins interact to mount an immune response. (Illustration: Jagannath Maharana\/IIT Kanpur.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=science-and-technology\">Science and Technology<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Unlocking secrets of immune system proteins: A potential path to new treatments<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Detailed imaging reveals intricate workings of key receptors, offering fresh insights into combating disease.\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">By USC Dornsife News Staff<\/a><\/strong>\n    \n          <span class=\"post-date-field\">October 17, 2023<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n \n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>In the intricate dance of our body\u2019s defenses against harmful invaders, certain immune system proteins play pivotal roles. New research from the <a href=\"https:\/\/dornsife.usc.edu\/bridge-institute\/\">Bridge Institute<\/a> at the <a href=\"https:\/\/michelson.usc.edu\/\" target=\"_blank\" rel=\"noopener\">USC Michelson Center for Convergent Bioscience<\/a>, in collaboration with international teams from India, Australia and Switzerland, has shed light on these proteins.<\/p>\n<p>The work potentially paves the way for innovative treatments for a range of diseases, including severe cases of COVID-19, rheumatoid arthritis, neurodegenerative diseases and cancer.<\/p>\n<p>Central to our immune response is the complement cascade, a series of events activated when potential threats are detected. This process produces protein messengers, C3a and C5a, which in turn activate specific receptors on cells, setting off a cascade of internal signals. The precise mechanisms of these receptors, especially the elusive C5aR1, have remained a mystery.<\/p>\n<p>Using the advanced technique of <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/cryo-electron-microscopy-core-facility\/\">cryo-electron microscopy<\/a> (cryo-EM), the researchers captured detailed images of these receptors in action. These images unveil how the receptors interact with molecules, change shape upon activation and transmit signals within the cell.<\/p>\n<p>The study\u2019s lead author, <a href=\"https:\/\/dornsife.usc.edu\/profile\/cornelius-gati\/\">Cornelius Gati<\/a>, assistant professor of biological sciences, chemistry, and quantitative and computational biology at the USC Dornsife College of Letters, Arts and Sciences, remarked on the findings, noting, \u201cThis research offers significant and comprehensive insights into a crucial receptor family within the immune system.\u201d<\/p>\n<p>The study\u2019s revelations suggest potential avenues for the development of drugs targeting these receptors to treat various diseases, added Gati, who heads USC\u2019s cryo-EM facility, which is <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/cryogenic-electron-microscopy-facility-opens\/\">available for use<\/a> by researchers around the globe.<\/p>\n<p>As the global community continues to grapple with diseases that impact millions, understanding the nuances of our immune system becomes ever more critical. <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2023.09.020\" target=\"_blank\" rel=\"noopener\">This research<\/a>, published in the journal <em>Cell<\/em> on Oct. 17, contributes to that understanding, providing a foundation for future studies aiming to harness the power of our body\u2019s natural defenses.<\/p>\n<hr \/>\n<p><strong>About the study<\/strong><\/p>\n<p>Authors on the study include Gati and Postdoctoral Fellow Ravi Yadav of USC Dornsife\u2019s Department of Molecular and Computational Biology; Htet Khant of USC Viterbi School of Engineering; Manish Yadav, Jagannath Maharana, Shirsha Saha, Parishmita Sarma, Chahat Soni, Vinay Singh, Sayantan Saha, Manisankar Ganguly, Samanwita Mahapatra, Sudha Mishra, Ramanuj Banerjee and Arun Shukla of the Indian Institute of Technology; Xaria Li and Trent Woodruff of the University of Queensland; and Mohamed Chami of Universit\u00e4t Basel.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n\n\n\n  \n        \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-related-stories \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-related-stories\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n              \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Related Articles\n      <\/h2>\n\n\n<\/div>\n    \n                  <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/mu-opioid-receptor-structural-change-revealed-by-cryo-em\/\" \n                        class=\"\" \n      >A path to safer painkillers \u2013 revealed by freezing opioids and their protein receptors in motion<\/a>\n      <\/h3>\n\n\n<\/div>\n        <\/article>\n              <article>\n              \n<div class=\"f--field f--cta-title\">\n\n    \n  <h3>\n          <a 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disease.<\/p>\n","protected":false},"author":13,"featured_media":17125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,16],"tags":[1923,1925,202,96,1924],"class_list":["post-17124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science-and-technology","tag-bridge","tag-cemma","tag-michelson-center-for-convergent-bioscience","tag-natural-sciences","tag-qcb"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Unlocking secrets of immune system proteins: A potential path to new treatments<\/title>\n<meta name=\"description\" content=\"Detailed imaging reveals intricate workings of key receptors, offering fresh insights into combating disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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