{"id":1464,"date":"2021-08-11T14:35:00","date_gmt":"2021-08-11T21:35:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/a-new-microscopy-facility-at-usc-opens-a-world-of-possibilities-for-scientists\/"},"modified":"2025-09-29T12:07:12","modified_gmt":"2025-09-29T19:07:12","slug":"cryo-electron-microscopy-core-facility","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/cryo-electron-microscopy-core-facility\/","title":{"rendered":"A new microscopy facility at USC opens a world of possibilities for scientists"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3530-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3530-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"A new microscopy facility at USC opens a world of possibilities for scientists\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  New cryo-electron microscopy equipment finds a home in the USC Michelson Center for Convergent Bioscience. (Photos: Carolyn Marks.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=social-impact\">Social Impact<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>A new microscopy facility at USC opens a world of possibilities for scientists<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Building on a long-time relationship, USC and biotechnology giant Amgen team up to establish a cryo-electron microscopy core facility at USC\u2019s University Park campus. <strong>[4\u00bd min read]<\/strong>\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Darrin S. Joy<\/a><\/strong>\n    \n          <span class=\"post-date-field\">August 11, 2021<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m8.14285714 9.42857143c-.17142857 0-.34285714 0-.51428571.08571428l7.28571427 6.34285719c.3428572.2571428.6857143.2571428.9428572 0l7.2857142-6.34285719c-.0857142-.08571428-.2571428-.08571428-.4285714-.08571428zm-1.28571428 1.11428567v.1714286 8.5714286c0 .6857143.6 1.2857143 1.28571428 1.2857143h14.57142856c.6857143 0 1.2857143-.6 1.2857143-1.2857143v-8.5714286c0-.0857143 0-.0857143 0-.1714286l-7.2 6.3428572c-.7714286.6857143-1.8857143.6857143-2.6571429 0z\" fill-rule=\"evenodd\" transform=\"translate(-6 -9)\"\/><\/svg>\n            <\/span>\n            <span class=\"a2a_label visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n \n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>About 500 years ago, a Dutch maker of spectacles first paired two refractive lenses to magnify objects in his view, revealing a world so unexpected and new it could only be described by the instrument that revealed it. Ever since, scientists have endeavored to peer ever deeper into the microscopic universe, inventing new instruments and techniques to expand their view of this infinitesimal world.<\/p>\n<p>The benefits have been innumerable, particularly in the fields of biology and human health, as microscopic organisms, then individual cells and then cellular components came into focus. Now, even individual molecules can be visualized, thanks to electron microscopes.<\/p>\n<p>Imaging molecules has become increasingly important to a branch of science called structural biology. Knowing the shape of biological molecules such as proteins and DNA, and how their shapes change as they interact with other molecules, is key to understanding how they function within cells. And it can lead researchers to new drug targets.<\/p>\n<p><strong>A cool development in microscopes<\/strong><\/p>\n<p>One of the most significant advances in structural biology builds on the power of electron microscopy by cooling samples to extremely low temperatures approaching absolute zero, where molecules themselves stop moving altogether. Called cryo-electron microscopy, or cryo-EM, the technique enables scientists to take a snapshot of biological molecules in three dimensions \u2014 and it does so far more quickly than traditional methods.<\/p>\n<p>\u201cIt really is a game changer in biology,\u201d said <a href=\"https:\/\/dornsife.usc.edu\/stephen-bradforth\/\">Stephen Bradforth<\/a>, divisional dean for the physical sciences and mathematics at the USC Dornsife College of Letters, Arts and Sciences. \u201cIt enables us to very quickly do what used to be impossible.\u201d<\/p>\n<p>And now USC will be part of that game change thanks to a co-location agreement with Amgen, one of the world\u2019s largest biotechnology companies, which has resulted in not one, but two, of the world\u2019s most advanced cryo-EM systems being housed at the university.<\/p>\n<p><strong>Creative solutions to a necessary expense<\/strong><\/p>\n<div class=\"news-image-portrait news-image-right\">\n<figure style=\"width: 315px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/7\/migration-uploads\/CryoEm_Facility_InStoryA-3530.jpg\" alt=\"Creative Solution to necessary expense\" width=\"315\" height=\"490\" \/><figcaption class=\"wp-caption-text\">Creative Solution to necessary expense<\/figcaption><\/figure>\n<p>A technician adjusts cryo-EM components during installation.<\/p>\n<\/div>\n<p>Cryo-EM has become so important to structural biology research that some funding organizations, when deciding whom to award grants, are beginning to favor institutions that have direct access to the equipment.<\/p>\n<p>\u201cGrant reviewers will say, \u2018Well, this proposal doesn\u2019t have an attempt to collaborate with somebody doing structural biology, so therefore I\u2019m not going to fund it,\u2019\u201d explains Bradforth, professor of <a href=\"https:\/\/dornsife.usc.edu\/chemistry\/\">chemistry<\/a> at USC Dornsife. \u201cAnd suddenly everybody who\u2019s doing biology realizes they\u2019ve got to have some way to get access to this.\u201d<\/p>\n<p>But there\u2019s a catch: The technology comes with a significant financial burden. The least expensive systems cost millions of dollars, and that doesn\u2019t factor in the cost of building a facility capable of housing the sensitive instruments. In addition, they require a highly skilled person or team to operate them.<\/p>\n<p>In short, ownership of a cryo-EM system is beyond the financial means of many academic research institutions. And despite the technology\u2019s value in searching for potential new therapeutic drug targets, even biotechnology or pharmaceutical industry giants may have difficulty justifying some of the expense to their shareholders.<\/p>\n<p>But the USC-Amgen co-location agreement solved this problem by combining the company\u2019s capital with the university\u2019s commitment and expertise to run the instruments as well as space in which to locate them.<\/p>\n<p>Designed and manufactured by Thermo Fisher Scientific Inc., the Glacios and Krios cryo-EM instruments reside in the <a href=\"https:\/\/michelson.usc.edu\/\" target=\"_blank\" rel=\"noopener\">USC Michelson Center for Convergent Bioscience<\/a>, where scientists from both USC and Amgen will share access.<\/p>\n<p>The collaboration is part of a growing trend in research, says Amgen\u2019s Philip Tagari, vice president of research.<\/p>\n<p>\u201cWe are seeing the \u2018century of biology\u2019 unfolding. Advances are coming at unprecedented speed, as recently demonstrated by the pace of innovation related to COVID-19,\u201d Tagari said. \u201cThe biopharmaceutical industry, from \u2018virtual\u2019 startups to established major pharmaceutical companies, will need to partner with world-class academic institutions in order to best translate new discoveries into breakthrough therapies for unmet medical needs.\u201d<\/p>\n<p><strong>A font of research opportunities<\/strong><\/p>\n<p><a href=\"https:\/\/dornsife.usc.edu\/news\/stories\/3335\/scott-fraser-elected-member-national-academy-medicine\/\">Scott Fraser<\/a> is a renowned biological imaging expert who leads USC\u2019s <a href=\"https:\/\/bioimage.usc.edu\/\" target=\"_blank\" rel=\"noopener\">Translational Imaging Center<\/a>, a core facility at the university focused on creating new biological imaging technologies.<\/p>\n<p>Fraser, Provost Professor of <a href=\"https:\/\/dornsife.usc.edu\/bisc\/\">Biological Sciences<\/a>, Biomedical Engineering, Physiology and Biophysics, Stem Cell Biology and Regenerative Medicine, Pediatrics, Radiology and Ophthalmology at USC, sees the new cryo-EM facility as a central core for problem-solving.<\/p>\n<p>\u201cSomebody\u2019s got a problem \u2026 and they have no idea how to solve it, and they come to a facility like this with people that know about the field, and they go from a problem to a solution in maybe one-tenth the amount of time it would have taken on their own,\u201d he said.<\/p>\n<p>The benefits are both intellectual and financial, he says, noting that in a recent audit of the Translational Imaging Center, reviewers found that \u201cfor every dollar spent on that core, there were between $4 and $5 of new research grants generated.\u201d<\/p>\n<p><a href=\"https:\/\/dornsife.usc.edu\/mcb\/faculty-profile\/?Person_ID=1097797\">Cornelius Gati<\/a> leads the new cryo-EM core facility at USC. He joined the university in December 2020 as assistant professor of biological sciences after honing his cryo-EM skills at MRC Laboratory of Molecular Biology in the United Kingdom and Stanford University.<\/p>\n<p>Gati is excited by the potential for accelerating USC\u2019s research efforts with the new, in-house core facility, as well.<\/p>\n<p>\u201cThere are lots of structural biologists at USC who have been collaborating with people outside of the university because there were no instruments here yet,\u201d he said. Now, in much the same way those first microscopes transformed science, this new, on-campus facility opens a universe of possibilities for USC\u2019s research efforts.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Building on a long-time relationship, USC and biotechnology giant Amgen team up to establish a cryo-electron microscopy core facility at USC\u2019s University Park campus. <strong>[4\u00bd min read]<\/strong><\/p>\n","protected":false},"author":14,"featured_media":1467,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[117,78,203,202,314,299],"class_list":["post-1464","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-social-impact","tag-biology","tag-chemistry","tag-cornelius-gati","tag-michelson-center-for-convergent-bioscience","tag-scott-fraser","tag-stephen-bradforth"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A new microscopy facility at USC opens a world of possibilities for scientists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/cryo-electron-microscopy-core-facility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new microscopy facility at USC opens a world of possibilities for scientists\" \/>\n<meta property=\"og:description\" content=\"Building on a long-time relationship, USC and biotechnology giant Amgen team up to establish a cryo-electron microscopy core facility at USC\u2019s University Park campus. 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