{"id":1152,"date":"2021-12-22T14:55:00","date_gmt":"2021-12-22T22:55:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/communication-between-cells-plays-a-major-role-in-deciding-their-fate\/"},"modified":"2026-03-27T19:51:19","modified_gmt":"2026-03-28T02:51:19","slug":"cell-fate-development-cell-to-cell-communication","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/cell-fate-development-cell-to-cell-communication\/","title":{"rendered":"Communication between cells plays a major role in deciding their fate"},"content":{"rendered":"\n\n\n    \n                                          \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3609-768x432.jpg\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/news\/wp-content\/uploads\/sites\/7\/2023\/04\/story-3609-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  alt=\"Communication between cells plays a major role in deciding their fate\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n      <div class=\"image-caption\">\n          \n<div class=\"f--field f--description\">\n\n    \n  In this schematic, cells (black spheres) within each well are committed to a specific fate, but external stimuli, such as cell-to-cell communication, can force cells out of one state and into another. (Illustration: Adam MacLean.)\n\n\n<\/div>\n    <\/div>\n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Communication between cells plays a major role in deciding their fate<\/h1>\n\n\n<\/div>\n    \n          <div class=\"subtitle\">\n            \n<div class=\"f--field f--description\">\n\n    \n  Findings from a new study could point the way to new treatments for blood diseases including cancers such as leukemia and lymphoma. <strong>[3 min read]<\/strong>\n\n\n<\/div>\n      <\/div>\n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Darrin S. Joy<\/a><\/strong>\n    \n          <span class=\"post-date-field\">December 22, 2021<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" target=\"_blank\" href=\"\/#copy_link\" rel=\"nofollow noopener\" title=\"Link\">\n            <span class=\"a2a_svg a2a_s__default a2a_s_copy_link\">\n              <svg height=\"19\" viewBox=\"0 0 19 19\" width=\"19\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"m7.43475275 9.52380952-2.17490843 2.26076008c-1.08745421 1.058837-1.68841575 2.518315-1.68841575 4.0350275 0 1.5167124.60096154 2.9475732 1.68841575 4.0350274 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<p>Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop.<\/p>\n<p>The <a href=\"https:\/\/journals.biologists.com\/dev\/article\/148\/24\/dev199779\/273837\/A-single-cell-resolved-cell-cell-communication\">study<\/a> from researchers at the USC Dornsife College of Letters, Arts and Sciences was published in the journal <i>Development<\/i> on Dec. 22.<\/p>\n<p>A little background:<\/p>\n<ul>\n<li>All cells within the body begin as stem cells.<\/li>\n<li>In simplest terms, blood forms when stem cells in bone marrow develop along one of three paths to become either oxygen-carrying red cells, immune-system white cells, or platelets, which clot to stop bleeding.<\/li>\n<li><strong>Scientists have long accepted that communication between cells can affect their fate, but they have largely found it too complex to study directly<\/strong>.<\/li>\n<li>Cells can communicate by sending growth factors, hormones or other molecules back and forth.<\/li>\n<\/ul>\n<p><strong>What\u2019s new:<\/strong><\/p>\n<ul>\n<li>USC Dornsife\u2019s <a href=\"https:\/\/dornsife.usc.edu\/cf\/faculty-and-staff\/faculty.cfm?pid=1086182\">Adam MacLean<\/a>, assistant professor of <a href=\"https:\/\/www.qcb-dornsife.usc.edu\/\">quantitative and computational biology<\/a>, and doctoral candidate Megan Rommelfanger, found a way to better understand how cell-to-cell communication affects the way blood stem cells develop.<\/li>\n<li>The scientists discovered that <strong>the communication process can change the formation of blood cell types dramatically<\/strong>.<\/li>\n<li>They also found that <strong>distance between cells matters<\/strong>.<\/li>\n<\/ul>\n<p>\u201cWe discovered that the communication process can change the formation of blood cell types dramatically, and that cells that are closer to one another have a greater influence on each other\u2019s fate,\u201d MacLean said.<\/p>\n<p><strong>A controversy resolved<\/strong><\/p>\n<p>Researchers trying to determine what early factors nudge a cell down one developmental path or another have wondered if random fluctuations within the cell are enough to decide which path is taken. Many models have suggested they were, but recent breakthrough studies showed that random fluctuations were not enough, that something else drives cells toward their fate.<\/p>\n<p>The model MacLean and Rommelfanger have developed appears to put an end to the controversy altogether. <strong>They show that cell-to-cell communication can, in fact, be the deciding factor that sets cells along a certain path<\/strong>.<\/p>\n<p><strong>Why it matters:<\/strong><\/p>\n<ul>\n<li>While focusing on understanding stem cells, the research can also help scientists <strong>understand how cancer arises<\/strong>.<\/li>\n<li>Leukemias, for example, develop when certain white blood cells begin growing and accumulating out of control.<\/li>\n<li>Determining the factors that push cells down the path to cancer can <strong>open avenues for prevention and therapy<\/strong>.<\/li>\n<\/ul>\n<p>\u201cBy understanding how blood cell fate decisions are made,\u201d MacLean said, \u201cwe get closer to being able to identify leukemia cells of origin, and in theory we can design strategies to control or alter cell fate decision-making and stop the development of cancer.\u201d<\/p>\n<p>The research could help <strong>improve cancer therapies such as bone marrow transplant<\/strong>.<\/p>\n<ul>\n<li>Bone marrow transplant involves infusing marrow \u2014 and the stem cells within \u2014 from a healthy donor into leukemia and lymphoma patients whose cancer and marrow has been obliterated by chemotherapy and radiation.<\/li>\n<li>Despite its success, scientists and clinicians still aren\u2019t fully sure how BMT works.<\/li>\n<\/ul>\n<p>\u201cBetter understanding stem cell fate decisions, as our study provides, could provide new insight to improve clinical outcomes for these diseases,\u201d MacLean said.<\/p>\n<p><strong>More than just blood<\/strong><\/p>\n<p>This new model has important implications beyond the blood system.<\/p>\n<p>\u201cOur model is broadly applicable, so researchers working on other cell types can apply it to find out for those other cells how important cell-to-cell communication may be,\u201d said MacLean.<\/p>\n<p><strong>What\u2019s next:<\/strong><\/p>\n<p>The role of cell-to-cell communication in determining cell fate is in its nascent stages, says MacLean, but further experiments \u2014 and future technologies to integrate these new types of data with sophisticated models \u2014 should help expand understanding.<\/p>\n<p>In addition, the team is developing methods to study the regulation of key genes involved in cell fate decisions, which should further advance their overall theoretical model.<\/p>\n<p><strong>About the study<\/strong><\/p>\n<p>This work was supported by National Science Foundation grant DMS 2045327 and a USC Women in Science and Engineering Top-up Fellowship.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n\n\n\n  \n        \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-related-stories \"\n\n  \n  \n  \n  \n  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read]<\/strong><\/p>\n","protected":false},"author":52,"featured_media":1155,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10,17],"tags":[319,317,318,86],"class_list":["post-1152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","category-student","tag-adam-maclean","tag-cell-biology","tag-developmental-biology","tag-quantitative-and-computational-biology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Communication between cells plays a major role in deciding their fate<\/title>\n<meta name=\"description\" content=\"Findings from a new study could point the way to new treatments for blood diseases including cancers such as leukemia and lymphoma.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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