{"id":10753,"date":"2012-01-27T13:30:00","date_gmt":"2012-01-27T21:30:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news\/stories\/usc-scientists-build-working-model-of-lifes-engine\/"},"modified":"2023-04-19T11:20:19","modified_gmt":"2023-04-19T18:20:19","slug":"usc-scientists-build-working-model-of-lifes-engine","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news\/stories\/usc-scientists-build-working-model-of-lifes-engine\/","title":{"rendered":"USC Scientists Build Working Model of Life\u2019s Engine"},"content":{"rendered":"\n\n\n    \n            \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n  \n  \n  <div class=\"text-wrapper\">\n          <nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\">\n        <ul>\n                      <li><a href=\"\/news\/stories\/\">News<\/a><\/li>\n                      <li><a href=\"\/news\/stories\/\/?category=faculty\">Faculty<\/a><\/li>\n                  <\/ul>\n      <\/nav>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>USC Scientists Build Working Model of Life\u2019s Engine<\/h1>\n\n\n<\/div>\n    \n    \n           <strong class=\"author-field\"><span >By<\/span><a href=\"mailto:communication@dornsife.usc.edu\">Robert Perkins<\/a><\/strong>\n    \n          <span class=\"post-date-field\">January 27, 2012<\/span>\n      <\/div>\n<\/div>\n\n\n  <\/div><\/div>\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--social-share \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--social-share\"\n    \n      >\n\n    \n  <div class=\"content-wrapper\">\n    <span class=\"a2a_kit a2a_kit_size_32 addtoany_list\" style=\"line-height: 32px;\">\n      <span class=\"title\">\n        Share\n      <\/span>\n                        <a class=\"a2a_button_copy_link\" 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visually-hidden\">Email<\/span>\n          <\/a>\n                  <\/span>\n  <\/div>\n\n  <\/div><\/div>\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Researchers at USC have built a theoretical working model of the cellular engine that powers all life.<\/p>\n<p>The model will allow scientists to better understand the forces of  life at the molecular level and potentially replicate them, including  designing miniscule mechanical motors for nanomachines and nanorobots.  The work was published online last month in <em>Proceedings of the National Academy of Sciences<\/em>.<\/p>\n<p>&ldquo;We were able to take a system that is very complicated and reproduce  the crucial action in the system,&rdquo; said Arieh Warshel, Distinguished Professor of Chemistry and Biochemistry in USC Dornsife. &ldquo;We still have a lot of  questions, but this is clearly a large step toward understanding the  action of such ubiquitous engines in living systems.&rdquo;<\/p>\n<p>The body&rsquo;s cellular engine is a protein molecule whose rotation  generates the universal &ldquo;fuel&rdquo;&nbsp;&mdash; adenosine triphosphate (ATP) &mdash; that  powers processes in living cells. The 1997 Nobel Prize in Chemistry was  awarded to the scientists who elucidated the structure of this protein  and outlined the principles of how it may operate.<\/p>\n<p>The protein rotates, drawing in raw materials and synthesizing them into  ATP. This fuel-generating engine can be divided into two parts, one of  which is a rotating piece called F1-ATPase.<\/p>\n<p>Warshel and research associate Shayantani Mukherjee built a  computer-generated model of F1-ATPase that was remarkably successful at  replicating the essential physical forces underlying the workings of the  engine, mirroring the cellular motor&rsquo;s unique unidirectional rotation.<\/p>\n<p>Previous attempts to build such models relied on complex systems in  which every atom was represented &mdash; making it difficult to determine why  the motor is working, Warshel said.<\/p>\n<p>Instead, Warshel and Mukherjee took a bare-bones approach,  simplifying the structure &mdash; a strategy known in the computational  biology world as &ldquo;coarse-graining.&rdquo;<\/p>\n<p>&ldquo;Make everything as simple as possible, but not simpler,&rdquo; Warshel said.<\/p>\n<p>Their simplified model rotated in the same manner as F1-ATPase, even  pausing at exactly the same places. It also provided the clearest  description yet of how the chemical energy of the ATP is used to rotate  the motor and why the motor actually works.<\/p>\n<p>The research was supported by the National Science Foundation and the National Institutes of Health.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":0,"featured_media":10756,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[960,601,1770,78,96],"class_list":["post-10753","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","tag-arieh-warshel","tag-biochemistry","tag-cell","tag-chemistry","tag-natural-sciences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>USC Scientists Build Working Model of 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