{"id":1158,"date":"2025-03-05T15:32:09","date_gmt":"2025-03-05T23:32:09","guid":{"rendered":"https:\/\/dornsife.usc.edu\/news-briefs\/?p=1158"},"modified":"2025-04-07T13:49:36","modified_gmt":"2025-04-07T20:49:36","slug":"scientists-unlock-clues-to-new-treatments-for-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/news-briefs\/news-brief\/2025\/03\/scientists-unlock-clues-to-new-treatments-for-muscular-dystrophy\/","title":{"rendered":"Scientists unlock clues to new treatments for muscular dystrophy"},"content":{"rendered":"\n\n\n\n\n \n \n\n\n\n\n\n\n\n
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\n\n \n A \u201cheat map\u201d shows the distribution of the protein emerin within a cell nucleus, from highly dispersed (blue) to dense nanoclusters (red), as determined with experiments (left) and computer modeling (right). (Photo: Courtesy of Carlos Alas.)\n\n\n<\/div>\n <\/div>\n \n
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Scientists unlock clues to new treatments for muscular dystrophy<\/h1>\n\n\n<\/div>\n \n \n By<\/span>USC Dornsife News Staff<\/strong>\n \n March 5, 2025<\/span>\n <\/div>\n<\/div>\n\n\n <\/div><\/div>\n\n \n \n\n\n\n\n\n\n\n
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A new discovery about how tiny protein clusters form in cells could pave the way for treatments for Emery-Dreifuss muscular dystrophy<\/a> (EDMD), a rare genetic disorder that causes muscle weakness and heart problems.<\/p>\n

Researchers at the USC Dornsife College of Letters, Arts and Sciences combined advanced imaging techniques and theoretical physics to observe and explain how nanoclusters of the protein emerin form inside living cells. These clusters \u2014 about 100,000 times smaller than a human hair\u2019s width \u2014 play a crucial role in how cells sense and respond to mechanical forces like stretching or pressure, a process known as mechanotransduction. When this process fails, it can contribute to diseases like muscular dystrophy.<\/p>\n

The study, published in Physical Review Research<\/em><\/a>, uncovers the molecular \u201crules\u201d<\/strong> driving the arrangement of emerin into nanoclusters and the mechanisms leading to their defective assembly in people with EDMD. By identifying the physical principles behind those defects and why they disrupt mechanotransduction and trigger disease symptoms, scientists hope to develop new strategies to correct them.<\/p>\n

Fascinatingly, the researchers, led by Christoph Haselwandter<\/a>, professor of physics and astronomy and quantitative and computational biology, and Fabien Pinaud<\/a>, associate professor of biological sciences and physics and astronomy, applied principles first proposed by Alan Turing \u2014 the famed WWII codebreaker and computing pioneer \u2014 to understand how these nanoclusters form. Turing\u2019s work on pattern formation in nature(such as zebra stripes and leopard spots) revealed mathematical rules that also appear to govern protein assembly at a nanoscale level.<\/p>\n

\u201cThis research opens up exciting possibilities,\u201d said study first author Carlos Alas, who earned his physics PhD in 2023 from USC Dornsife. \u201cBy applying physics-based approaches, we can start thinking about ways to correct these defects and potentially help people with this debilitating disease.\u201d<\/p>\n

While the findings focus on muscular dystrophy, understanding how proteins like emerin function could also lead to breakthroughs in other diseases linked to cellular mechanics.<\/p>\n

About the study<\/h2>\n

In addition to Haselwandter, Pinaud and Alas, USC Dornsife PhD student Liying Wu also contributed to the research.<\/p>\n

The study was supported by National Science Foundation awards MCB-2202087 and DMR-2051681.<\/p>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

A new discovery about how tiny protein clusters form in cells could pave the way for treatments for Emery-Dreifuss muscular dystrophy (EDMD), a rare genetic disorder that causes muscle weakness and heart problems.<\/p>\n","protected":false},"author":13,"featured_media":1159,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13,21],"tags":[],"class_list":["post-1158","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-natural-sciences","category-news-brief"],"acf":[],"yoast_head":"\nScientists unlock clues to new treatments for muscular dystrophy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news-briefs\/news-brief\/2025\/03\/scientists-unlock-clues-to-new-treatments-for-muscular-dystrophy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists unlock clues to new treatments for muscular dystrophy - 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