{"id":1856,"date":"2025-04-22T14:14:12","date_gmt":"2025-04-22T14:14:12","guid":{"rendered":"https:\/\/dornsife.usc.edu\/meb\/?p=1856"},"modified":"2025-04-22T14:14:13","modified_gmt":"2025-04-22T14:14:13","slug":"meb-seminar-dr-terry-hwa-4-22-2025","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/meb\/2025\/04\/22\/meb-seminar-dr-terry-hwa-4-22-2025\/","title":{"rendered":"MEB Seminar | Dr. Terry Hwa | 4\/22\/2025"},"content":{"rendered":"\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1857 size-full\" src=\"https:\/\/dornsife.usc.edu\/meb\/wp-content\/uploads\/sites\/117\/2025\/04\/2.jpg\" alt=\"\" width=\"481\" height=\"634\" srcset=\"https:\/\/dornsife.usc.edu\/meb\/wp-content\/uploads\/sites\/117\/2025\/04\/2.jpg 481w, https:\/\/dornsife.usc.edu\/meb\/wp-content\/uploads\/sites\/117\/2025\/04\/2-228x300.jpg 228w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Dr. Terry Hwa<\/strong><br \/>\nDistinguished Professor, UCSD, Department of Molecular Biology<br \/>\n<a href=\"https:\/\/matisse.ucsd.edu\/\">Faculty Profile<\/a><\/p>\n<p style=\"text-align: center;\"><strong>Distantly related bacteria share a rigid proteome allocation strategy with flexible enzyme kinetics<\/strong><\/p>\n<p style=\"text-align: center;\">Tuesday, April 22<br \/>\n11:30 AM<br \/>\nAHF 153 (Torrey Webb Room)<\/p>\n<p style=\"text-align: left;\">Abstract: Bacteria are known to allocate their proteomes according to how fast they grow, and the allocation strategies employed strongly affect bacterial adaptation to different environments. Much of what is currently known about proteome allocation is based on extensive studies of the model organism E. coli. It is not clear how much of E. coli\u2019s proteome allocation strategy is applicable to other species, particularly since different species can grow at vastly different rates even in the same growth condition. In this study we compare proteome allocation programs quantitatively between several distantly-related bacterial species, including V. natriegens, one of the fastest-growing bacteria known. Extensive characterization across conditions reveals an invariant allocation program in response to different nutrients despite systemic, species-specific differences in enzyme kinetics. This invariant program is not organized according to the growth rate but is based on a common internal metric of nutrient quality, with the faster species behaving as if it is growing under a higher temperature. The flexibility of enzyme kinetics across species and the rigidity of enzyme abundance across nutrient conditions defy common notions of evolvability and resource optimization. They suggest the existence of blueprint(s) of proteome allocation shared by diverse bacterial species organized independently of phylogeny.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":221,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-1856","post","type-post","status-publish","format-standard","hentry","category-events"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MEB Seminar | Dr. Terry Hwa | 4\/22\/2025<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/meb\/2025\/04\/22\/meb-seminar-dr-terry-hwa-4-22-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MEB Seminar | Dr. Terry Hwa | 4\/22\/2025 - Marine and Environmental Biology\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/meb\/2025\/04\/22\/meb-seminar-dr-terry-hwa-4-22-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"Marine and Environmental Biology\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-22T14:14:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-22T14:14:13+00:00\" \/>\n<meta name=\"author\" content=\"adolfode\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/meb\\\/2025\\\/04\\\/22\\\/meb-seminar-dr-terry-hwa-4-22-2025\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/meb\\\/2025\\\/04\\\/22\\\/meb-seminar-dr-terry-hwa-4-22-2025\\\/\"},\"author\":{\"name\":\"adolfode\",\"@id\":\"https:\\\/\\\/live-usc-dornsife.pantheonsite.io\\\/meb\\\/#\\\/schema\\\/person\\\/558c0dffad0645b5adffd226ae90f8bb\"},\"headline\":\"MEB Seminar | Dr. Terry Hwa | 4\\\/22\\\/2025\",\"datePublished\":\"2025-04-22T14:14:12+00:00\",\"dateModified\":\"2025-04-22T14:14:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/meb\\\/2025\\\/04\\\/22\\\/meb-seminar-dr-terry-hwa-4-22-2025\\\/\"},\"wordCount\":5,\"articleSection\":[\"Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/meb\\\/2025\\\/04\\\/22\\\/meb-seminar-dr-terry-hwa-4-22-2025\\\/\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/meb\\\/2025\\\/04\\\/22\\\/meb-seminar-dr-terry-hwa-4-22-2025\\\/\",\"name\":\"MEB Seminar | Dr. Terry Hwa | 4\\\/22\\\/2025 - 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