{"id":271,"date":"2025-07-30T15:10:49","date_gmt":"2025-07-30T22:10:49","guid":{"rendered":"https:\/\/dornsife.usc.edu\/mckemy\/?page_id=271"},"modified":"2025-07-30T16:06:14","modified_gmt":"2025-07-30T23:06:14","slug":"publications","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/mckemy\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n\n \n \n\n\n\n\n\n\n\n
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Yang C, Wei C, Alam S, Chen X,\u00a0McKemy DD<\/b>. The neurotrophic factor artemin and its receptor GFRa3 mediate migraine-like pain via the ion channel TRPM8<\/strong>.\u00a0Cephalgia<\/a>.\u00a0<\/i>2024, 44(11).<\/p>\n

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Yang C, Yamaki S, Jung T, Kim B, Huyhn R, McKemy DD. Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRalpha3.<\/strong> Journal of Neuroscience<\/a>. 2023, 43(15): 2803-2814.<\/p>\n

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Jeong SL, Zhang H, Yamaki S, Yang C, McKemy DD, Lieber MR, Pham P, Goodman MF. (2022) Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization.<\/strong> Nucleic Acids Res<\/a>. Online ahead of print. PMID: 36321646<\/p>\n

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Wei C, Kim B, McKemy DD. (2022) Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induce migraine-like pain behaviors in mice. <\/strong>Pain<\/a>, 163:2380-2389. PMID: 36321646<\/p>\n

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Yamaki S, Chau A, Gonzales L, McKemy DD. (2021) Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFR\u03b13 and the menthol receptor transient receptor potential melastatin 8.<\/strong> Pain<\/a>, 162:609-618. PMID: 32826761. *Editors Choice*<\/strong><\/em><\/p>\n

Click here<\/a> for Video Abstract<\/p>\n

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Ramakrishna C, Corleto J, Ruegger PM, Logan GD, Peacock BB, Mendonca S, Yamaki S*, Adamson T, Ermel R, McKemy D, Borneman J, Cantin EM. (2019) Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain.<\/strong> Science Reports<\/a>, 9:20324. PMID: 31889131<\/p>\n

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McKemy DD. (2018) Molecular basis of peripheral innocuous cold sensitivity<\/strong>. Handbook of Clinical Neurology<\/a>. 156:57-67. PMID: 30454609<\/p>\n

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Ongun S, Sarkisian A, McKemy DD (2018) Selective inhibition of cold pain without alterations in basal cold sensations by targeted block of TRPM8-expressing neurons with the quaternary lidocaine derivative QX-314<\/strong>. Communications Biology<\/a>, 1:53. PMID:30271936<\/p>\n

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Palkar R, Ongun S, Catich E, Li N, Borad N, Sarkisian A, McKemy DD. (2017) Cooling relief of acute and chronic itch requires TRPM8 channels and neurons.<\/strong> J Invest Dermatol<\/a>. 2017 Dec 27. pii: S0022-202X(17)33364-X. PMID:29288650<\/p>\n

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McCoy DD, Palkar R, McKemy DD. (2017) Cellular permeation of large molecules via TRPM8 ion channels<\/strong>. Neurosci Lett.<\/a> 639:59-67. PMID:28038937<\/p>\n

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Lippoldt EK, Ongun S, Kusaka GK, McKemy DD. (2016) Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFR\u03b13.<\/strong> Proc Natl Acad Sci U S A<\/a>. 113(16):4506-11. PMID:27051069<\/p>\n

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von B\u00fcdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. (2015) The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.<\/strong> J Cell Biol. 210(6):891-8. PMID:26347141<\/p>\n

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Kim YS, Kim TH, McKemy DD, Bae YC. (2015) Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse.<\/strong> Neuroscience. 303:378-88. PMID:26166724<\/p>\n

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Kim YS, Park JH, Choi SJ, Bae JY, Ahn DK, McKemy DD, Bae YC. (2014) Central connectivity of transient receptor potential melastatin 8-expressing axons in the brain stem and spinal dorsal horn<\/strong>. PLoS One. 9(4):e94080. PMID:24710558<\/p>\n

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Lippoldt EK, Elmes R, McCoy DD, Knowlton WM, McKemy, DD. (2013) Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.<\/strong> Journal of Neuroscience 33(30):12543-52. PMID:23884957<\/p>\n

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McCoy DD, Zhou L, Nguyen AK, Watts AG, Donovan CM, McKemy DD (2013) Enhanced insulin clearance in mice lacking TRPM8 channels<\/strong>. Am J Physiol Endocrinol Metab. 305(1):E78-88. PMID:23651844.<\/p>\n

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Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD (2013). TRPM8 activation attenuates inflammatory responses in mouse models of colitis.<\/strong> Proc Natl Acad Sci U S A. 30;110(18):7476-81. PMID:23596210.<\/p>\n

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Knowlton WM, Palkar R, Lippoldt EK, McCoy DD, Baluch, F, Chen J, McKemy, DD (2013). A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia.<\/strong> Journal of Neuroscience. 33(7):2837-48. PMID:23407943<\/p>\n

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Osborne M, Gomez D, Feng Z, McEwen C, Beltran J, Cirillo K, El-Khodor B, Lin MY, Li Y*, Knowlton WM*, McKemy DD, Bogdanik L, Butts-Dehm K, Martens K, Davis C, Doty R, Wardwell K, Ghavami A, Kobayashi D, Ko CP, Ramboz S, Lutz C. 2012. Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models.<\/strong> Hum Mol Genet. 2012 Oct 15;21(20):4431-47. PMID:22802075<\/p>\n

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Knowlton WM, Daniels RL* Palkar R, McCoy DD, McKemy DD: Pharmacological blockade of trpm8 ion channels alters cold and cold pain responses in mice.<\/strong> 2011 PLoS ONE 6(9): e25894. PMID:21984952<\/p>\n

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Daniels RL and McKemy DD: Design and construction of a two-temperature preference behavioral assay for undergraduate neuroscience laboratories.<\/strong> Journal for Undergraduate Neuroscience Education 2010, 9:A51-56.PMID:23494724<\/p>\n

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Takashima Y, Ma L, McKemy DD: The development of peripheral cold neural circuits based on TRPM8 expression.<\/strong> Neuroscience 2010, 169:828-842. PMID:20580783<\/p>\n

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Knowlton WM*, Bifolck-Fisher A, Bautista DM, McKemy DD: TRPM8, but not TRPA1, is required for neural and behavioral responses to noxious cold temperatures and cold-mimetics in vivo.<\/strong> Pain 2010, 150:340-350. PMID:20542379. (Work highlighted on the journal\u2019s cover)<\/p>\n

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Mandadi S, Nakanishi ST, Takashima Y*, Dhaka A, Patapoutian A, McKemy DD, Whelan PJ: Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.<\/strong> Neuroscience 2009, 162:1377-1397. PMID:19482068<\/p>\n

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Carr RW, Pianova S, McKemy DD, Brock JA: Action potential initiation in the peripheral terminals of cold-sensitive neurones innervating the guinea-pig cornea.<\/strong> J Physiol 2009, 587:1249-1264. PMID:19171652<\/p>\n

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Daniels RL, Takashima Y, McKemy DD: Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate.<\/strong> J Biol Chem 2009, 284:1570-1582. PMID:19019830<\/p>\n

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Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER: The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.<\/strong> J Biol Chem 2008, 283:32691-32703. PMID:18775987<\/p>\n

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Takashima Y, Daniels RL* Knowlton W, Teng J, Liman ER, McKemy DD: Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons.<\/strong> J Neurosci 2007, 27:14147-14157. PMID:18094254<\/p>\n

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McNamara N, Gallup M, Sucher A, Maltseva I, McKemy D, Basbaum C: AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1\/2.<\/strong> Am J Respir Cell Mol Biol 2006, 34:653-660. PMID:16439799<\/p>\n

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Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D: Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.<\/strong> Nature 2004, 427:260-265. PMID:14712238<\/p>\n

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Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR: Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.<\/strong> Blood 2003, 102:3224-3231. PMID:12869501<\/p>\n

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McKemy DD, Neuhausser WM, Julius D: Identification of a cold receptor reveals a general role for TRP channels in thermosensation.<\/strong> Nature 2002, 416:52-58. PMID:11882888<\/p>\n

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McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C: ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor.<\/strong> Proc Natl Acad Sci U S A 2001, 98:9086-9091. PMID:12869501<\/p>\n

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McKemy DD, Welch W, Airey JA, Sutko JL: Concentrations of caffeine greater than 20 mM increase the indo-1 fluorescence ratio in a Ca2+-independent manner.<\/strong> Cell Calcium 2000, 27:117-124. PMID:10756978<\/p>\n

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Oppenheim RW, Prevette D, Houenou LJ, Pincon-Raymond M, Dimitriadou V, Donevan A, O’Donovan M, Wenner P, McKemy DD, Allen PD: Neuromuscular development in the avian paralytic mutant crooked neck dwarf (cn\/cn): further evidence for the role of neuromuscular activity in motoneuron survival.<\/strong> J Comp Neurol 1997, 381:353-372. PMID:9133573<\/p>\n

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Kenyon JL, McKemy DD, Airey JA, Sutko JL: Interaction between ryanodine receptor function and sarcolemmal Ca2+ currents<\/strong>. Am J Physiol 1995, 269:C334-340. PMID:7653515<\/p>\n

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Ivanenko A#, McKemy DD#, Kenyon JL, Airey JA, Sutko JL: Embryonic chicken skeletal muscle cells fail to develop normal excitation-contraction coupling in the absence of the alpha ryanodine receptor. Implications for a two-ryanodine receptor system.<\/strong> J Biol Chem 1995, 270:4220-4223. PMID:7876181 (#denotes equal contribution)<\/p>\n

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Airey JA, Deerinck TJ, Ellisman MH, Houenou LJ, Ivanenko A, Kenyon JL, McKemy DD, Sutko JL: Crooked neck dwarf (cn) mutant chicken skeletal muscle cells in low density primary cultures fail to express normal alpha ryanodine receptor and exhibit a partial mutant phenotype.<\/strong> Dev Dyn 1993, 197:189-202. PMID:8219360<\/p>\n

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Airey JA, Baring MD, Beck CF, Chelliah Y, Deerinck TJ, Ellisman MH, Houenou LJ, McKemy DD, Sutko JL, Talvenheimo J: Failure to make normal alpha ryanodine receptor is an early event associated with the crooked neck dwarf (cn) mutation in chicken.<\/strong> Dev Dyn 1993, 197:169-188. PMID:8219359
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