Publications

For an up-to-date of lab publications click here.

• Wei C, Kim B, McKemy DD (2022) Transient receptor potential 8 (TRPM8) is required for nitroglycerin- and calcitonin gene-related peptide-induced migrain-like pain behaviors in mice. Pain, PubMed

• Yamaki S, Chau A, Gonzales L, McKemy DD. (2021) Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor transient receptor potential melastatin 8. Pain, 162:609-618. Pubmed 

- Editor's Choice article. Click here for Shanni's video abstract.

• Ramakrishna C, Corleto J*, Ruegger PM, Logan GD, Peacock BB, Mendonca S, Yamaki S, Adamson T, Ermel R, McKemy D, Borneman J, Cantin EM. (2019) Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain. Science Reports, 9:20324. Pubmed
• McKemy DD. (2018) Molecular basis of peripheral innocuous cold sensitivity. Handbook of Clinical Neurology. 156:57-67. Pubmed

• Ongun S, Sarkisian A, McKemy DD(2018) Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314 Communications Biology, 1:53. Pubmed
• Palkar R, Ongun S, Catich E, Li N, Borad N, Sarkisian A, McKemy DD.(2018) Cooling relief of acute and chronic itch requires TRPM8 channels and neurons. J Invest Dermatol. 138(6):1391-1399. Pubmed

- Clicker here to see the great perspective article by Liu and Jordt on our itch study.

•  McCoy DD, Palkar R, Yang Y, Ongun S, McKemy DD. (2017) Cellular permeation of large molecules mediated by TRPM8 channels. Neurosci Lett. 639:59-67. Pubmed
• Lippoldt EK, Ongun S, Kusaka GK, McKemy DD. (2016) Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3. Proc Natl Acad Sci U S A. 2016 Apr 5.[Epub ahead of print]. Pubmed 

• von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. (2015) The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 210(6):891-8. Pubmed
• Kim YS, Kim TH, McKemy DD, Bae YC. (2015) Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse. Neuroscience. 303:378-88. Pubmed
• Palkar R, Lippoldt EK, McKemy DD. (2015) The molecular and cellular basis of thermosensation in mammals. Current Opinion in Neurobiology. 34:14-9. Pubmed
• Kim YS, Park JH, Choi SJ, Bae JY, Ahn DK, McKemy DD, Bae YC. (2014) Central connectivity of transient receptor potential melastatin 8-expressin axons in the brain stem and spinal dorsal horn. PLoS One. 9(4):e94080. Pubmed
• Lippoldt, E. K., Elmes, R., McCoy, D. D., Knowlton, W.M., McKemy, D.D. (2013) Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain. Journal of Neuroscience. 33(30):12543-52. Pubmed
• McCoy, D.D., Zhuo, L., Nguyen, A., Watts, A.G., Donovan, C.M., McKemy, D.D. (2013) Enhanced insulin clearance in mice lacking TRPM8 channels. Am J Physiol Endocrinol Metab. 2013 May 7. Epub ahead of print. PubMed
• Ramachandran, R., Hyun, E., Zhao, L., Lapointe, T.L., Chapman, K., Hirota, C.L., Ghosh, S., McKemy, D.D., Vergnolle, N., Beck, P.L., Altier, C., Hollenberg, M.D. (2013) TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc. Natl. Acad. Sci. 110(18):7476-81. PubMed
  
• Knowlton, W.M., Palkar, R., Lippoldt, E.K., McCoy, D.D., Baluch, F., Chen, J., McKemy, D.D. (2013) A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia. Journal of Neuroscience. 33(7):2837-48. -PubMed
• McKemy, D.D. (2013). The Molecular and Cellular Basis of Cold Sensation. ACS Chem. Neurosci., 4(2):238-47. -PubMed
• Osborne M, Gomez D, Feng Z, McEwen C, Beltran J, Cirillo K, El-Khodor B, Lin MY, Li Y, Knowlton WM, McKemy DD, Bogdanik L, Butts-Dehm K, Martens K, Davis C, Doty R, Wardwell K, Ghavami A, Kobayashi D, Ko CP, Ramboz S, Lutz C. (2012) Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models. Hum Mol Genet. 15;21(20):4431-47. Pubmed
• Knowlton WM, Daniels RL, Palkar R, McCoy DD, McKemy DD. (2011) Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS ONE 6(9): e25894. -PubMed

• McCoy DD, Knowlton WM, McKemy DD. Scraping through the ice: Uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol. 2011 Mar 16. [Epub ahead of print]. Journal

• McKemy DD. A spicy family tree: TRPV1 and its thermoceptive and nociceptive lineage. EMBO J. 2011 Feb 2;30(3):453-5. PubMed

• Daniels RL, McKemy DD. Design and Construction of a Two-Temperature Preference Behavioral Assay for Undergraduate Neuroscience Laboratories. J of Undergraduate Neuroscience Education. 2010, 9:A51-A56. Journal
• Knowlton WM, McKemy DD. TRPM8: From Cold to Cancer, Peppermint to Pain. Curr Pharm Biotechnol. 2010, Epub ahead of print, Nov. 8. PubMed
• McKemy, DD: Therapeutic potential of TRPM8 modulators. The Open Access Drug Discovery Journal. 2010, 2:81-88. Journal
• Takashima Y, Ma L, McKemy DD: The development of peripheral cold neural circuits based on TRPM8 expression. Neuroscience 2010,169:828-842. Epub May 24. PubMed
• Knowlton WM, Bifolck-Fisher A, Bautista DM, McKemy DD: TRPM8, but not TRPA1, is required for neural and behavioral responses to noxious cold temperatures and cold-mimetics in vivo. Pain 2010 150(2):340-350. Epub 2010 Jun 12 PubMed

• Mandadi S, Nakanishi ST, Takashima Y, Dhaka A, Patapoutian A, McKemy DD, Whelan PJ: Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Neuroscience 2009, 162:1377-1397. PubMed
• Stucky CL, Dubin AE, Jeske NA, Malin SA, McKemy DD, Story GM: Roles of transient receptor potential channels in pain. Brain Res Rev 2009, 60:2-23. PubMed
• Daniels RL, Takashima Y, McKemy DD: Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem 2009, 284:1570-1582. PubMed
• Carr RW, Pianova S, McKemy DD, Brock JA: Action potential initiation in the peripheral terminals of cold-sensitive neurones innervating the guinea-pig cornea. J Physiol 2009, 587:1249-1264. PubMed
• Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER: The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem 2008, 283:32691-32703. PubMed
• Takashima, Y., Daniels, R. L., Knowlton, W., Teng, J., Liman, E. R., and McKemy, D. D. (2007). Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci 27, 14147-14157. PubMed (Highlighted in Nature Reviews Neuroscience 9, 79)
• Daniels, R. L., and McKemy, D. D. (2007). Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. Mol Pain 3, 23. PubMed
• McKemy, D. D. (2007). Temperature sensing across species. Pflugers Arch 454, 777-791. PubMed
• McNamara, N., Gallup, M., Sucher, A., Maltseva, I., McKemy, D., and Basbaum, C. (2006). ASIALOGM1 and TLR5 Cooperate in Flagellin-Induced Nucleotide Signaling to Activate ERK1/2. Am J Respir Cell Mol Biol.
• McKemy, D. D. (2005). How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain 1, 16. PubMed
• Jordt, S. E., Bautista, D. M., Chuang, H. H., McKemy, D. D., Zygmunt, P. M., Hogestatt, E. D., Meng, I. D., and Julius, D. (2004). Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265. PubMed
• Kataoka, H., Hamilton, J. R., McKemy, D. D., Camerer, E., Zheng, Y. W., Cheng, A., Griffin, C., and Coughlin, S. R. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102, 3224-3231.
• Jordt, S. E., McKemy, D. D., and Julius, D. (2003). Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol 13, 487-492. PubMed
• McKemy, D. D., Neuhausser, W. M., and Julius, D. (2002). Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58. PubMed

The identification of TRPM8 was part of the research awarded the Nobel Prize in Physiology or Medicine in 2021! Click here for details. 

• McNamara, N., Khong, A., McKemy, D., Caterina, M., Boyer, J., Julius, D., and Basbaum, C. (2001). ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A 98, 9086-9091.
• McKemy, D. D., Welch, W., Airey, J. A., and Sutko, J. L. (2000). Concentrations of caffeine greater than 20 mM increase the indo-1 fluorescence ratio in a Ca(2+)-independent manner. Cell Calcium 27, 117-124.
• Oppenheim, R. W., Prevette, D., Houenou, L. J., Pincon-Raymond, M., Dimitriadou, V., Donevan, A., O'Donovan, M., Wenner, P., McKemy, D. D., and Allen, P. D. (1997). Neuromuscular development in the avian paralytic mutant crooked neck dwarf (cn/cn): further evidence for the role of neuromuscular activity in motoneuron survival. J Comp Neurol 381, 353-372.
• Kenyon, J. L., McKemy, D. D., Airey, J. A., and Sutko, J. L. (1995). Interaction between ryanodine receptor function and sarcolemmal Ca2+ currents. Am J Physiol 269, C334-340.
• Ivanenko, A., McKemy, D. D., Kenyon, J. L., Airey, J. A., and Sutko, J. L. (1995). Embryonic chicken skeletal muscle cells fail to develop normal excitation-contraction coupling in the absence of the alpha ryanodine receptor. Implications for a two-ryanodine receptor system. J Biol Chem 270, 4220-4223.
• Airey, J. A., Baring, M. D., Beck, C. F., Chelliah, Y., Deerinck, T. J., Ellisman, M. H., Houenou, L. J., McKemy, D. D., Sutko, J. L., and Talvenheimo, J. (1993a). Failure to make normal alpha ryanodine receptor is an early event associated with the crooked neck dwarf (cn) mutation in chicken. Dev Dyn 197, 169-188.
• Airey, J. A., Deerinck, T. J., Ellisman, M. H., Houenou, L. J., Ivanenko, A., Kenyon, J. L., McKemy, D. D., and Sutko, J. L. (1993b). Crooked neck dwarf (cn) mutant chicken skeletal muscle cells in low density primary cultures fail to express normal alpha ryanodine receptor and exhibit a partial mutant phenotype. Dev Dyn 197, 189-202.