{"id":4,"date":"2022-11-02T18:09:55","date_gmt":"2022-11-02T18:09:55","guid":{"rendered":"https:\/\/dornsife.usc.edu\/kribelbauer\/?page_id=4"},"modified":"2026-04-13T16:23:51","modified_gmt":"2026-04-13T23:23:51","slug":"home","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/kribelbauer\/","title":{"rendered":"Home"},"content":{"rendered":"  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--intro-text align-center\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--intro-text\"\n    \n      >\n\n    \n          \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Welcome to the Kribelbauer Lab!\n      <\/h2>\n\n\n<\/div>\n  \n          \n<div class=\"f--field f--description\">\n\n    \n  <p>Each cell in the human body contains the same genetic material, our DNA (or hardware), yet is distinct in its molecular composition. This diversity is the result of different gene expression programs defined by unique epigenetic landscapes (i.e. the software written on top of our DNA). <\/p>\n<p>Transcription factors read the information encoded in our genomes by binding to specific DNA sequences, which ultimately results in epigenetic and gene expression changes. What molecular principles determine a transcription factor&#8217;s binding specificity, however, remain poorly understood. <\/p>\n<p>We seek to close critical gaps in our understanding of how transcription factors modulate gene expression using high-throughput, \u2018bottom-up\u2019 genetic engineering in health and disease settings.<\/p>\n\n\n\n<\/div>\n  \n\n  <\/div><\/div>\n\n\n\n\n\n                                                          \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--articles-carousel \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--articles-carousel\"\n    \n      >\n\n    \n<div class=\"inner-wrapper\">\n\n  \n\n\n  \n  <div class=\"articles-carousel-wrapper\">\n\n  <div class=\"title-controls-container\">\n          <h3>Areas of Focus<\/h3>\n    \n    <div class=\"controls-container\">\n      <button class=\"button-prev\" aria-label=\"Previous Article\">\n        <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\n        x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\" width=\"25\" height=\"25\">\n        <polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"15.7,27.5 5.7,17.5\n        15.7,7.5 18.7,10.4 13.6,15.4 28.3,15.4 28.3,19.6 13.6,19.6 18.7,24.6 \"\/>\n        <\/svg>\n      <\/button>\n      <button class=\"button-next\" aria-label=\"Next Article\">\n        <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\nx=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\" width=\"25\" height=\"25\"><polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"19.3,27.5 29.3,17.5\n19.3,7.5 16.3,10.4 21.4,15.4 6.7,15.4 6.7,19.6 21.4,19.6 16.3,24.6 \"\/>\n<\/svg>\n\n      <\/button>\n    <\/div>\n\n    <\/div>\n\n\n    <div class=\"swiper\">\n      <div class=\"swiper-wrapper\">\n        \n        \n          <article class=\"swiper-slide card\">\n            <div class=\"card-inner\">\n\n                                        \n                  \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img decoding=\"async\"\n                            src=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/TF_coop-768x432.jpg\"\n          srcset=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/TF_coop-1280x720.jpg 1280w,https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/TF_coop-768x432.jpg 768w\"          sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                <h4>\n                    \n                      TF Cooperativity &#038; Function\n\n                                      <\/h4>\n              \n              <div class=\"read-more\">\n                                      \n<div class=\"f--field f--description\">\n\n    \n  <p>We are building new experimental tools to map TF function and cooperativity one TF-motif at a time and across a range of cellular contexts.<\/p>\n\n\n\n<\/div>\n                \n                \n              <\/div>\n\n            <\/div> <!-- .text-container -->\n\n            <div class=\"expand-collapse-controls\">\n              <button class=\"expand-collapse swiper-no-swiping\" aria-label=\"Expand\/Collapse Description\">\n                <svg class=\"expand\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000000\" d=\"M28,7v7.9h-2.6l0-3.4l-4.3,4.3c-0.3,0.3-0.6,0.4-0.9,0.4s-0.7-0.1-0.9-0.4c-0.5-0.5-0.5-1.3,0-1.9l4.3-4.3h-3.4V7H28z M7,28v-7.9h2.6v3.4l4.3-4.3c0.5-0.5,1.3-0.5,1.9,0c0.5,0.5,0.5,1.3,0,1.9l-4.3,4.3h3.4V28H7z\"\/><\/svg>\n\n                <svg class=\"collapse\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\"\n   viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n  <polygon fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" points=\"26,10.4 24.6,9 17.5,16.1 10.4,9 9,10.4 16.1,17.5\n  9,24.6 10.4,26 17.5,18.9 24.6,26 26,24.6 18.9,17.5 \"\/>\n  <\/svg>\n\n              <\/button>\n            <\/div> <!-- .expand-collapse-controls -->\n\n            <\/div>\n\n          <\/article>\n\n                  \n        \n          <article class=\"swiper-slide card\">\n            <div class=\"card-inner\">\n\n                                        \n                  \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img decoding=\"async\"\n                            src=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/EXTRA-seq-768x432.jpg\"\n          srcset=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/EXTRA-seq-768x432.jpg 768w\"          sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                <h4>\n                    \n                      Enhancer-Promoter Communication\n\n                                      <\/h4>\n              \n              <div class=\"read-more\">\n                                      \n<div class=\"f--field f--description\">\n\n    \n  <p>We are probing the compatibility rules that guide the communication of TF-bound regulatory regions (enhancers) and gene promoters using EXTRA-seq, a tool we recently developed.<\/p>\n\n\n\n<\/div>\n                \n                \n              <\/div>\n\n            <\/div> <!-- .text-container -->\n\n            <div class=\"expand-collapse-controls\">\n              <button class=\"expand-collapse swiper-no-swiping\" aria-label=\"Expand\/Collapse Description\">\n                <svg class=\"expand\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000000\" d=\"M28,7v7.9h-2.6l0-3.4l-4.3,4.3c-0.3,0.3-0.6,0.4-0.9,0.4s-0.7-0.1-0.9-0.4c-0.5-0.5-0.5-1.3,0-1.9l4.3-4.3h-3.4V7H28z M7,28v-7.9h2.6v3.4l4.3-4.3c0.5-0.5,1.3-0.5,1.9,0c0.5,0.5,0.5,1.3,0,1.9l-4.3,4.3h3.4V28H7z\"\/><\/svg>\n\n                <svg class=\"collapse\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\"\n   viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n  <polygon fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" points=\"26,10.4 24.6,9 17.5,16.1 10.4,9 9,10.4 16.1,17.5\n  9,24.6 10.4,26 17.5,18.9 24.6,26 26,24.6 18.9,17.5 \"\/>\n  <\/svg>\n\n              <\/button>\n            <\/div> <!-- .expand-collapse-controls -->\n\n            <\/div>\n\n          <\/article>\n\n                  \n        \n          <article class=\"swiper-slide card\">\n            <div class=\"card-inner\">\n\n                                        \n                  \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img decoding=\"async\"\n                            src=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/minihub4-768x432.jpg\"\n          srcset=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/minihub4-1280x720.jpg 1280w,https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/minihub4-768x432.jpg 768w\"          sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                <h4>\n                    \n                      Miniaturized\u00a0Gene Loci\n\n                                      <\/h4>\n              \n              <div class=\"read-more\">\n                                      \n<div class=\"f--field f--description\">\n\n    \n  <p>We are building a platform to create miniaturized, disease-relevant multi-enhancer promoter modules for the high-throughput screening of deleterious expression effects caused by genetic mutations.<\/p>\n\n\n\n<\/div>\n                \n                \n              <\/div>\n\n            <\/div> <!-- .text-container -->\n\n            <div class=\"expand-collapse-controls\">\n              <button class=\"expand-collapse swiper-no-swiping\" aria-label=\"Expand\/Collapse Description\">\n                <svg class=\"expand\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000000\" d=\"M28,7v7.9h-2.6l0-3.4l-4.3,4.3c-0.3,0.3-0.6,0.4-0.9,0.4s-0.7-0.1-0.9-0.4c-0.5-0.5-0.5-1.3,0-1.9l4.3-4.3h-3.4V7H28z M7,28v-7.9h2.6v3.4l4.3-4.3c0.5-0.5,1.3-0.5,1.9,0c0.5,0.5,0.5,1.3,0,1.9l-4.3,4.3h3.4V28H7z\"\/><\/svg>\n\n                <svg class=\"collapse\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\"\n   viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n  <polygon fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" points=\"26,10.4 24.6,9 17.5,16.1 10.4,9 9,10.4 16.1,17.5\n  9,24.6 10.4,26 17.5,18.9 24.6,26 26,24.6 18.9,17.5 \"\/>\n  <\/svg>\n\n              <\/button>\n            <\/div> <!-- .expand-collapse-controls -->\n\n            <\/div>\n\n          <\/article>\n\n                  \n        \n          <article class=\"swiper-slide card\">\n            <div class=\"card-inner\">\n\n                                        \n                  \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img decoding=\"async\"\n                            src=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/synthetic_drivers-1-768x432.jpg\"\n          srcset=\"https:\/\/dornsife.usc.edu\/kribelbauer\/wp-content\/uploads\/sites\/475\/2025\/02\/synthetic_drivers-1-768x432.jpg 768w\"          sizes=\"(min-width:1024px) 23vw, (min-width:768px) 39vw, 83vw\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n            \n            <div class=\"text-container\">\n                                <h4>\n                    \n                      Synthetic Drivers for Gene Therapy\n\n                                      <\/h4>\n              \n              <div class=\"read-more\">\n                                      \n<div class=\"f--field f--description\">\n\n    \n  <p>We strive to improve expression profiles of gene therapies by developing synthetic expression modules which are cell type-specific, tunable, and importantly, mimic native settings.<\/p>\n\n\n\n<\/div>\n                \n                \n              <\/div>\n\n            <\/div> <!-- .text-container -->\n\n            <div class=\"expand-collapse-controls\">\n              <button class=\"expand-collapse swiper-no-swiping\" aria-label=\"Expand\/Collapse Description\">\n                <svg class=\"expand\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000000\" d=\"M28,7v7.9h-2.6l0-3.4l-4.3,4.3c-0.3,0.3-0.6,0.4-0.9,0.4s-0.7-0.1-0.9-0.4c-0.5-0.5-0.5-1.3,0-1.9l4.3-4.3h-3.4V7H28z M7,28v-7.9h2.6v3.4l4.3-4.3c0.5-0.5,1.3-0.5,1.9,0c0.5,0.5,0.5,1.3,0,1.9l-4.3,4.3h3.4V28H7z\"\/><\/svg>\n\n                <svg class=\"collapse\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" 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