{"id":500,"date":"2025-05-30T09:23:15","date_gmt":"2025-05-30T16:23:15","guid":{"rendered":"https:\/\/dornsife.usc.edu\/hklab\/?p=500"},"modified":"2026-04-29T12:20:37","modified_gmt":"2026-04-29T19:20:37","slug":"human-striatal-association-megaclusters","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/","title":{"rendered":"Human Striatal Association Megaclusters"},"content":{"rendered":"\n\n\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n \n \n \n \n \n \n \n\n \n \n \n \n\n<\/div>\n \n
\n \n
\n\n \n Association megaclusters observed in human striatum using precision functional connectivity MRI.\n\n\n<\/div>\n <\/div>\n \n
\n \n \n
\n\n \n

Human Striatal Association Megaclusters<\/h1>\n\n\n<\/div>\n \n
\n \n
\n\n \n Peer reviewed publication, Journal of Neurophysiology\n\n\n<\/div>\n <\/div>\n \n By<\/span>Kosakowski HL, Saadon-Grosman N, Du J, Eldaief MC, Buckner RL. (2024)<\/strong>\n \n May 30, 2025<\/span>\n <\/div>\n<\/div>\n\n\n <\/div><\/div>\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n \n Share\n <\/span>\n \n \n <\/svg>\n <\/span>\n Copy Link<\/span>\n <\/a>\n \n \n <\/svg>\n <\/span>\n Facebook<\/span>\n <\/a>\n \n \n \n\n<\/svg>\n\n <\/span>\n X<\/span>\n <\/a>\n \n \n <\/svg>\n <\/span>\n LinkedIn<\/span>\n <\/a>\n \n \n \n \n <\/svg>\n <\/span>\n Bluesky<\/span>\n <\/a>\n \n \n <\/svg>\n <\/span>\n Email<\/span>\n <\/a>\n <\/span>\n <\/div>\n\n <\/div><\/div>\n \n\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n \n
\n\n \n

Summary<\/h3>\n

An individualized precision neuroimaging approach reveals juxtaposed zones of the caudate that are coupled with five distinct networks in association cortex. The organization of these caudate zones recapitulates organization observed in the cerebral cortex and extends the notion of specialized basal ganglia circuits.<\/p>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

\n\n \n \n
\n\n \n

Published Resources<\/h3>\n

Peer reviewed manuscript published in Journal of Neurophysiology<\/em>.<\/a><\/p>\n

Preprint.<\/a><\/p>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

\n\n \n \n
\n\n \n

Open Source Materials<\/h3>\n

All data used to generate the figures and code used to analyze the data are available in an OSF repository<\/a>.<\/p>\n

All correlation maps and parcellations are available on BALSA<\/a>.<\/p>\n

Supplemental figures are available on FigShare<\/a>.<\/p>\n

All MRI data are publicly available on NIMH Data Archive (NDA ID #3536; R01MH124004; PI Randy Buckner).<\/p>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":946,"featured_media":359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[89,58,8,138,10],"tags":[19,71,76,129,77,130,131,132,134,133,78,66,127,60,128,12],"class_list":["post-500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-methods","category-striatum","category-subcortex","category-subcortical-parcellation","category-whole-brain-networks","tag-association-megaclusters","tag-basal-ganglia","tag-caudate","tag-cognition","tag-default-network","tag-dn-a","tag-dn-b","tag-fpn-a","tag-fpn-b","tag-frontoparietal-network","tag-language-network","tag-putamen","tag-somatomotor","tag-striatum","tag-topography","tag-whole-brain-networks"],"acf":[],"yoast_head":"\nHuman Striatal Association Megaclusters<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Striatal Association Megaclusters - Kosakowski Lab\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\" \/>\n<meta property=\"og:site_name\" content=\"Kosakowski Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-30T16:23:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-29T19:20:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1050\" \/>\n\t<meta property=\"og:image:height\" content=\"591\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Heather L Kosakowski\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@heatherlkos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\"},\"author\":{\"name\":\"Heather L Kosakowski\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/ba9ae58d403d462b0447f7d6feb530ae\"},\"headline\":\"Human Striatal Association Megaclusters\",\"datePublished\":\"2025-05-30T16:23:15+00:00\",\"dateModified\":\"2026-04-29T19:20:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\"},\"wordCount\":4,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#organization\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png\",\"keywords\":[\"association megaclusters\",\"basal ganglia\",\"caudate\",\"cognition\",\"default network\",\"DN-A\",\"DN-B\",\"FPN-A\",\"FPN-B\",\"Frontoparietal network\",\"language network\",\"putamen\",\"somatomotor\",\"striatum\",\"topography\",\"whole-brain networks\"],\"articleSection\":[\"Methods\",\"striatum\",\"Subcortex\",\"Subcortical parcellation\",\"Whole-Brain Networks\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\",\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\",\"name\":\"Human Striatal Association Megaclusters - Kosakowski Lab\",\"isPartOf\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png\",\"datePublished\":\"2025-05-30T16:23:15+00:00\",\"dateModified\":\"2026-04-29T19:20:37+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage\",\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png\",\"width\":1050,\"height\":591},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dornsife.usc.edu\/hklab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Human Striatal Association Megaclusters\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#website\",\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/\",\"name\":\"Kosakowski Lab\",\"description\":\"Baby Brains\",\"publisher\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dornsife.usc.edu\/hklab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#organization\",\"name\":\"Kosakowski Lab\",\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/09\/ChatGPT-Image-May-6-2025-04_19_43-PM-e1759096737569.png\",\"contentUrl\":\"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/09\/ChatGPT-Image-May-6-2025-04_19_43-PM-e1759096737569.png\",\"width\":1024,\"height\":683,\"caption\":\"Kosakowski Lab\"},\"image\":{\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/ba9ae58d403d462b0447f7d6feb530ae\",\"name\":\"Heather L Kosakowski\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/368f4704d1a715fb8239b8ada03e64c7fbe3f44b63e1a2ce19b7e60a9d3bac05?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/368f4704d1a715fb8239b8ada03e64c7fbe3f44b63e1a2ce19b7e60a9d3bac05?s=96&d=mm&r=g\",\"caption\":\"Heather L Kosakowski\"},\"sameAs\":[\"http:\/\/heatherkosakowski.com\",\"https:\/\/x.com\/heatherlkos\"],\"url\":\"https:\/\/dornsife.usc.edu\/hklab\/author\/hkosakow\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Human Striatal Association Megaclusters","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/","og_locale":"en_US","og_type":"article","og_title":"Human Striatal Association Megaclusters - Kosakowski Lab","og_url":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/","og_site_name":"Kosakowski Lab","article_published_time":"2025-05-30T16:23:15+00:00","article_modified_time":"2026-04-29T19:20:37+00:00","og_image":[{"width":1050,"height":591,"url":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png","type":"image\/png"}],"author":"Heather L Kosakowski","twitter_card":"summary_large_image","twitter_creator":"@heatherlkos","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#article","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/"},"author":{"name":"Heather L Kosakowski","@id":"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/ba9ae58d403d462b0447f7d6feb530ae"},"headline":"Human Striatal Association Megaclusters","datePublished":"2025-05-30T16:23:15+00:00","dateModified":"2026-04-29T19:20:37+00:00","mainEntityOfPage":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/"},"wordCount":4,"commentCount":0,"publisher":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/#organization"},"image":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png","keywords":["association megaclusters","basal ganglia","caudate","cognition","default network","DN-A","DN-B","FPN-A","FPN-B","Frontoparietal network","language network","putamen","somatomotor","striatum","topography","whole-brain networks"],"articleSection":["Methods","striatum","Subcortex","Subcortical parcellation","Whole-Brain Networks"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/","url":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/","name":"Human Striatal Association Megaclusters - Kosakowski Lab","isPartOf":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage"},"image":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage"},"thumbnailUrl":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png","datePublished":"2025-05-30T16:23:15+00:00","dateModified":"2026-04-29T19:20:37+00:00","breadcrumb":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#primaryimage","url":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png","contentUrl":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/05\/\u200ewebsite_publications.\u200e005.png","width":1050,"height":591},{"@type":"BreadcrumbList","@id":"https:\/\/dornsife.usc.edu\/hklab\/2025\/05\/30\/human-striatal-association-megaclusters\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dornsife.usc.edu\/hklab\/"},{"@type":"ListItem","position":2,"name":"Human Striatal Association Megaclusters"}]},{"@type":"WebSite","@id":"https:\/\/dornsife.usc.edu\/hklab\/#website","url":"https:\/\/dornsife.usc.edu\/hklab\/","name":"Kosakowski Lab","description":"Baby Brains","publisher":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dornsife.usc.edu\/hklab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dornsife.usc.edu\/hklab\/#organization","name":"Kosakowski Lab","url":"https:\/\/dornsife.usc.edu\/hklab\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/logo\/image\/","url":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/09\/ChatGPT-Image-May-6-2025-04_19_43-PM-e1759096737569.png","contentUrl":"https:\/\/dornsife.usc.edu\/hklab\/wp-content\/uploads\/sites\/478\/2025\/09\/ChatGPT-Image-May-6-2025-04_19_43-PM-e1759096737569.png","width":1024,"height":683,"caption":"Kosakowski Lab"},"image":{"@id":"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/ba9ae58d403d462b0447f7d6feb530ae","name":"Heather L Kosakowski","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dornsife.usc.edu\/hklab\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/368f4704d1a715fb8239b8ada03e64c7fbe3f44b63e1a2ce19b7e60a9d3bac05?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/368f4704d1a715fb8239b8ada03e64c7fbe3f44b63e1a2ce19b7e60a9d3bac05?s=96&d=mm&r=g","caption":"Heather L Kosakowski"},"sameAs":["http:\/\/heatherkosakowski.com","https:\/\/x.com\/heatherlkos"],"url":"https:\/\/dornsife.usc.edu\/hklab\/author\/hkosakow\/"}]}},"_links":{"self":[{"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/posts\/500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/users\/946"}],"replies":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/comments?post=500"}],"version-history":[{"count":3,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/posts\/500\/revisions"}],"predecessor-version":[{"id":771,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/posts\/500\/revisions\/771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/media\/359"}],"wp:attachment":[{"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/media?parent=500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/categories?post=500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dornsife.usc.edu\/hklab\/wp-json\/wp\/v2\/tags?post=500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}