{"id":156,"date":"2023-11-21T12:18:48","date_gmt":"2023-11-21T20:18:48","guid":{"rendered":"https:\/\/dornsife.usc.edu\/ehrenreich-lab-at-usc\/?page_id=156"},"modified":"2025-03-31T08:44:44","modified_gmt":"2025-03-31T15:44:44","slug":"research","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/ehrenreich-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--intro-text align-center\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--intro-text\"\n    \n      >\n\n    \n          \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Complex trait genetics\n      <\/h2>\n\n\n<\/div>\n  \n          \n<div class=\"f--field f--description\">\n\n    \n  <p>We use large budding yeast crosses and chromosomally-encoded DNA barcodes to comprehensively dissect the genetic basis of complex traits in a key eukaryotic model organism. Presently, we are focused on two traits: response to new genetic perturbations and ability to persist inside mammalian hosts.<\/p>\n\n\n\n<\/div>\n  \n\n  <\/div><\/div>\n\n\n\n\n\n    \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--image-gallery \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--image-gallery\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n\n    \n      <div id=\"gallery-586469492\" class=\"gallery-container\">\n\n      <div class=\"swiper images\">\n        <div class=\"swiper-wrapper\">\n                                    <div class=\"swiper-slide\">\n                                      \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/ehrenreich-lab\/wp-content\/uploads\/sites\/315\/2023\/12\/Screenshot-2023-12-10-at-4.16.24-PM-768x432.png\"\n          data-srcset=\"https:\/\/dornsife.usc.edu\/ehrenreich-lab\/wp-content\/uploads\/sites\/315\/2023\/12\/Screenshot-2023-12-10-at-4.16.24-PM-1280x720.png 1280w,https:\/\/dornsife.usc.edu\/ehrenreich-lab\/wp-content\/uploads\/sites\/315\/2023\/12\/Screenshot-2023-12-10-at-4.16.24-PM-768x432.png 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n                              <\/div>\n                              <\/div>\n      <\/div>\n\n      <div class=\"swiper captions\">\n        <div class=\"controls-container\">\n          <button class=\"button-prev\" aria-label=\"Previous Image\">\n            <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\n            x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n            <polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"15.7,27.5 5.7,17.5 \n            15.7,7.5 18.7,10.4 13.6,15.4 28.3,15.4 28.3,19.6 13.6,19.6 18.7,24.6 \"\/>\n            <\/svg>\n          <\/button>\n          <button class=\"button-next\" aria-label=\"Next Image\">\n            <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\n\t x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"19.3,27.5 29.3,17.5 \n\t19.3,7.5 16.3,10.4 21.4,15.4 6.7,15.4 6.7,19.6 21.4,19.6 16.3,24.6 \"\/>\n<\/svg>\n          <\/button>\n        <\/div>\n\n        <div class=\"swiper-wrapper\">\n                                    <div class=\"swiper-slide\">\n                                  <div class=\"slide-caption\">\n                        \n<div class=\"f--field f--description\">\n\n    \n  <div class=\"page\" title=\"Page 8\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Experimental infections of mice using a pool of barcoded, haploid segregants. The effects of loci detected in whole-genome scans using aggregate data are shown. (Mullis et. al.)<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<\/div>\n                  <\/div>\n                              <\/div>\n                              <\/div>\n\n      <\/div>\n\n\n    <\/div>\n  \n  <\/div>\n\n\n  <\/div><\/div>\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--intro-text align-center\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--intro-text\"\n    \n      >\n\n    \n          \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Synthetic genomics\n      <\/h2>\n\n\n<\/div>\n  \n          \n<div class=\"f--field f--description\">\n\n    \n  <p>We build whole chromosomes, which allows us to examine how multifactorial changes to chromosomes impact viability, growth, and other phenotypes. We have a diversity of synthetic genomic projects in the lab, some focused on making chassis organisms for research and biotechnology, others focused on understanding the minimum genetic requirements for eukaryotic life, and others focused on understanding the genetic bases of phenotypes within and across species and genera.<\/p>\n\n\n\n<\/div>\n  \n\n  <\/div><\/div>\n\n\n\n\n\n    \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--image-gallery \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--image-gallery\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n\n    \n      <div id=\"gallery-881015872\" class=\"gallery-container\">\n\n      <div class=\"swiper images\">\n        <div class=\"swiper-wrapper\">\n                                    <div class=\"swiper-slide\">\n                                      \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/dornsife.usc.edu\/ehrenreich-lab\/wp-content\/uploads\/sites\/315\/2023\/12\/Screenshot-2023-12-10-at-4.42.13-PM-768x362.png\"\n                    data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                  role=\"none\"\n        \n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n                              <\/div>\n                              <\/div>\n      <\/div>\n\n      <div class=\"swiper captions\">\n        <div class=\"controls-container\">\n          <button class=\"button-prev\" aria-label=\"Previous Image\">\n            <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\n            x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n            <polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"15.7,27.5 5.7,17.5 \n            15.7,7.5 18.7,10.4 13.6,15.4 28.3,15.4 28.3,19.6 13.6,19.6 18.7,24.6 \"\/>\n            <\/svg>\n          <\/button>\n          <button class=\"button-next\" aria-label=\"Next Image\">\n            <svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"\n\t x=\"0px\" y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\"><polygon fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" points=\"19.3,27.5 29.3,17.5 \n\t19.3,7.5 16.3,10.4 21.4,15.4 6.7,15.4 6.7,19.6 21.4,19.6 16.3,24.6 \"\/>\n<\/svg>\n          <\/button>\n        <\/div>\n\n        <div class=\"swiper-wrapper\">\n                                    <div class=\"swiper-slide\">\n                                  <div class=\"slide-caption\">\n                        \n<div class=\"f--field f--description\">\n\n    \n  <p>Possible restructured versions of BY ChrI were created by altering the adapters appended to each segment. Growth analysis of the natural and five non-natural chromosome structures in a rich medium containing glucose at 30\u00baC. (Coradini et. al.)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n\n\n\n<\/div>\n                  <\/div>\n                              <\/div>\n                              <\/div>\n\n      <\/div>\n\n\n    <\/div>\n  \n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":252,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-156","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Ehrenreich Genome-Phenotype Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/ehrenreich-lab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - 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