{"id":10475,"date":"2018-04-06T14:15:00","date_gmt":"2018-04-06T21:15:00","guid":{"rendered":"https:\/\/dornsife.usc.edu\/chemistry\/?p=10475"},"modified":"2024-03-18T16:22:09","modified_gmt":"2024-03-18T23:22:09","slug":"hearing-loss-study-shows-hope-for-millions","status":"publish","type":"post","link":"https:\/\/dornsife.usc.edu\/chemistry\/2018\/04\/06\/hearing-loss-study-shows-hope-for-millions\/","title":{"rendered":"Hearing loss study shows hope for millions"},"content":{"rendered":"\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n      \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>  USC and Harvard researchers are working on a way to target and reverse damage in cells within the ear that are responsible for hearing loss.<\/p>\n<p>                      News<br \/>\n                      Faculty<\/p>\n<p>  Hearing loss study shows hope for millions<\/p>\n<p>  Charles McKenna of chemistry and collaborators at USC Dornsife and Harvard develop method to repair damaged structures deep inside the ear.<\/p>\n<p>           ByGary Polakovic<\/p>\n<p>          April 6, 2018<\/p>\n<p>        Share<\/p>\n<p>            Copy Link<\/p>\n<p>            Facebook<\/p>\n<p>            X<\/p>\n<p>            LinkedIn<\/p>\n<p>            Email<\/p>\n<p>  Researchers have developed a new approach to repair cells deep inside the ear \u2014 a potential remedy that could restore hearing for millions of elderly people and others who suffer hearing loss.<br \/>\nThe lab study, conducted by scientists at USC Dornsife and Harvard University, demonstrates a novel way for a drug to zero in on damaged nerves and cells inside the ear. It\u2019s a potential remedy for a problem that afflicts two-thirds of people over 70 years and 17 percent of all adults in the United States.<br \/>\n\u201cWhat\u2019s new here is we figured out how to deliver a drug into the inner ear so it actually stays put and does what it\u2019s supposed to do, and that\u2019s novel,\u201d said Charles E. McKenna, professor of chemistry at USC Dornsife and a corresponding author for the study. \u201cInside this part of the ear, there\u2019s fluid constantly flowing that would sweep dissolved drugs away, but our new approach addresses that problem. This is a first for hearing loss and the ear. It\u2019s also important because it may be adaptable for other drugs that need to be applied within the inner ear.\u201d<\/p>\n<p>Image by Matthew Savino<\/p>\n<p>The paper was published April 4 in the journal Bioconjugate Chemistry. McKenna co-authored it with David Jung of Harvard Medical School, among others. It is the latest achievement in USC\u2019s priority program to advance biomedicine, including the recent launching of the USC Michelson Center for Convergent Bioscience. The Michelson Center unites USC experts across disciplines to solve some of the most intractable research challenges related to health at the molecular level. The facility will house the new USC Center of Excellence in Drug Discovery, with McKenna as its director.<br \/>\nCaveats for consideration<br \/>\nThe research was conducted on animal tissues in a petri dish and has not yet been tested in living animals or humans. Yet the researchers are hopeful given the similarities of cells and mechanisms involved. McKenna says since the technique works in the laboratory, the findings provide \u201cstrong preliminary evidence\u201d it could work in living creatures. They are already planning the next phase involving animals and hearing loss.<br \/>\n\u2018Hidden hearing loss\u2019<br \/>\nHearing loss is projected to increase as the U.S. population ages. Previous research has shown that hearing loss is expected to nearly double in 40 years. Damage to the inner ear can lead to \u201chidden hearing loss,\u201d which is difficulty hearing whispers and soft sounds, especially in noisy places. The new research gives hope to many eager to avoid loss of hearing and quality of life.<br \/>\nThe authors include lead researcher Judith S. Kempfle as well as Christine Hamadani, Nicholas Koen, Albert S. Edge and David H. Jung of Harvard Medical School and The Eaton-Peabody Laboratories in Boston. Kempfle is also affiliated with the University of T\u00fcbingen Medical Center. Corresponding author McKenna as well as Kim Nguyen and Boris A. Kashemirov are at USC Dornsife.<br \/>\nThis work was supported by the American Academy of Otolaryngology-Head and Neck Surgery Herbert Silverstein Otology and Neurotology Research Award, the American Otological SocietyResearch Grant and by a $567,783 grant from the National Institute of Deafness and other Communicative Disorders (R01 DC007174).<\/p>\n<p>The post Hearing loss study shows hope for millions appeared first on News and Events.<\/p>\n\n\n\n<\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Charles McKenna of chemistry and collaborators at USC Dornsife and Harvard develop method to repair damaged structures deep inside the ear.<br \/>\nThe post Hearing loss study shows hope for millions appeared first on News and Events.<\/p>\n","protected":false},"author":106,"featured_media":10477,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[260],"tags":[25,22,32],"class_list":["post-10475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chemistry","tag-charles-mckenna","tag-usc-dornsife","tag-usc-michelson-center-for-convergent-bioscience"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hearing loss study shows hope for millions<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/news\/stories\/hearing-loss-study-shows-hope-for-millions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hearing loss study shows hope for millions - Department of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Charles McKenna of chemistry and collaborators at USC Dornsife and Harvard develop method to repair damaged structures deep inside the ear. 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