Valery Fokin

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Valery Fokin

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Professor of Chemistry

Chemical Biology and Organic Chemistry

Valery Fokin, Professor of Chemistry at USC

Ph.D., 1998, University of Southern California

Office: MCB 359
Phone: (213) 740-5964

Selected Publications

1. Schwartz, E.; Breteinkamp, K.; Fokin, V. V. Synthesis and Post-polymerization Functionalization of Poly(5-iodo-1,2,3-triazole)s, Macromolecules, 2011, 44, 4735-41.

2.  Chuprakov, S.; Malik, J.; Zibinsky, M.; Fokin, V. V. Catalytic Asymmetric C–H Insertions of Rhodium(II) Azavinyl Carbenes., J. Am. Chem. Soc., 2011, 133, 10352-55.

3. Zibinsky, M., Fokin, V.V. Reactivity of N-(1,2,4-Triazolyl)-Substituted 1,2,3-Triazoles. Org. Lett., 2011, 13, 4870-4872.

4. Grimster, N.P., Stump, B., Fotsing, J.R., Weide, T., Talley, T.T., Yamauchi, J.G., Nemecz, A., Kim, C., Ho, K.-Y., Sharpless, K.B., Taylor, P., Fokin, V.V. Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors Via in Situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template. J. Am. Chem. Soc., 2012, 134, 6732-6740.

5. Selander, N., Fokin, V.V. Rhodium(II)-Catalyzed Asymmetric Sulfur(VI) Reduction of Diazo Sulfonylamidines. J. Am. Chem. Soc., 2012, 134, 2477-2480.

6. Selander, N., Worrell, B.T., Chuprakov, S., Velaparthi, S., Fokin, V.V. Arylation of Rhodium(II) Azavinyl Carbenes with Boronic Acids. J. Am. Chem. Soc., 2012, 134, 14670-14673.

7. Zibinsky, M., Fokin, V.V. 1-Sulfonyl-1,2,3-Triazoles: Convenient Synthones for Heterocyclic Compounds. Angew. Chem., Int. Ed., 2013, 52, 1507-1510.

8. Selander, N., Worrell, B.T., Fokin, V.V. Ring Expansion and Rearrangements of Rhodium(II) Azavinyl Carbenes. Angew. Chem. Int. Ed., 2012, 51, 13054-13057.

9. Rillahan, C.D., Schwartz, E., McBride, R., Fokin, V.V., Paulson, J.C. Click and Pick: Identification of Sialoside Analogues for Siglec-Based Cell Targeting. Angew. Chem. Int. Ed., 2012, 51, 11014-11018.

10. Chanda, A., Fokin, V.V., in Science of Synthesis. (Ed.: S. Kobayashi): Thieme, Stuttgart•New York, 2012, 2011/7, pp. 697-748.

11. Oakdale, J.S., Fokin, V.V. Preparation of 1,5-Disubstituted 1,2,3-Triazoles Via Ruthenium-Catalyzed Azide-Alkyne Cycloaddition. Org. Synth., 2013, 90, 96-104.

12. Kovarik, Z., Macek, N., Sit, R.K., Radic, Z., Fokin, V.V., Barry, S.K., Taylor, P. Centrally Acting Oximes in Reactivation of Tabun-Phosphoramidated AChE. Chem.-Biol. Interact., 2013, 203, 77-80.

13. Radic, Z., Sit, R.K., Garcia, E., Zhang, L., Berend, S., Kovarik, Z., Amitai, G., Fokin, V.V., Barry, S.K., Taylor, P. Mechanism of Interaction of Novel Uncharged, Centrally Active Reactivators with OP-hAChE Conjugates. Chem.-Biol. Interact., 2013, 203, 67-71.

14. Worrell, B.T.; Malik, J.A.; Fokin, V.V. Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide–Alkyne Cycloadditions. Science, 2013, 340, 457-460.

15. Chuprakov, S., Kwok, S.W., Fokin, V.V. Transannulation of 1-Sulfonyl-1,2,3-Triazoles with Heterocumulenes. J. Am. Chem. Soc., 2013, 135, 4652-4655.

16. Sanphanya, K., Wattanapitayakul, S.K., Phowichit, S., Fokin, V.V., Vajragupta, O. Novel VEGFR-2 Kinase Inhibitors Identified by the Back-to-Front Approach. Bioorg. Med. Chem. Lett., 2013, 23, 2962-2967.

17. Rillahan, C. D.; Schwartz, E.; Rademacher, C.; McBride, R.; Rangarajan, J.; Fokin, V. V.; Paulson, J. C. On-Chip Synthesis and Screening of a Sialoside Library Yields a High Affinity Ligand for Siglec-7. ACS Chem. Biol., 2013, 8, 1417.

18. Worrell, B. T.; Ellery, S. P.; Fokin, V. V. Copper(I)-Catalyzed Cycloaddition of Bismuth(III) Acetylides with Organic Azides: Synthesis of Stable Triazole Anion Equivalents. Angew. Chem., Int. Ed., 2013, 52, 13037.

19. Chuprakov, S.; Worrell, B. T.; Selander, N.; Sit, R. K.; Fokin, V. V. Stereoselective 1,3-Insertions of Rhodium(II) Azavinyl Carbenes. J. Am. Chem. Soc., 2014, 136, 195.

20. Kwok, S. W.; Zhang, L.; Grimster, N. P.; Fokin, V. V. Catalytic Asymmetric Transannulation of NH-1,2,3-Triazoles with Olefins. Angew. Chem. Int. Ed., 2014, 53, 3452.

21. Rillahan, C. D.; Macauley, M. S.; Schwartz, E.; He, Y.; McBride, R.; Arlian, B. M.; Rangarajan, J.; Fokin, V. V.; Paulson, J. C. Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas. Chem. Sci., 2014, 5, 2398.

22. Oakdale J.S.; Sit R.K., Fokin V.V. Ruthenium-Catalyzed Cycloadditions of 1-Haloalkynes with Nitrile Oxides and Organic Azides: Synthesis of 4-Haloisoxazoles and 5-Halotriazoles. Chem, Eur. J., 2014, 20, 11101.

23. Dong J., Sharpless K.B., Kwisnek L, Oakdale J.S., Fokin V.V. SuFEx-Based Synthesis of Polysulfates. Angew. Chem. Int. Ed., 2014, 53, 9466.

24. Sitnikov, N. S.; Kokisheva, A. S.; Fukin, G. K.; Neudoerfl, J.-M.; Sutorius, H.; Prokop, A.; Fokin, V. V.; Schmalz, H.-G.; Fedorov, A. Y. Synthesis of Indole‐Derived Allocolchicine Congeners through Pd‐Catalyzed Intramolecular C‐H Arylation Reaction. Eur. J. Org. Chem., 2014, 2014, 6481.

25. Voitovich, Y. V.; Shegravina, E. S.; Sitnikov, N. S.; Faerman, V. I.; Fokin, V. V.; Schmalz, H.-G.; Combes, S.; Allegro, D.; Barbier, P.; Beletskaya, I. P.; Svirshchevskaya, E. V.; Fedorov, A. Y. Synthesis and Biological Evaluation of Furanoallocolchicinoids. J. Med. Chem., 2015, 58, 692.

  • Department of Chemistry
  • University of Southern California
  • 3620 McClintock Avenue, SGM 418
  • Los Angeles, CA 90089-1062